Tuba8

Summary

Gene Symbol: Tuba8
Description: tubulin, alpha 8
Alias: tubulin alpha-8 chain, alpha tubulin 8
Species: mouse
Products:     Tuba8

Top Publications

  1. Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, et al. TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. Biochem Biophys Res Commun. 2000;270:1111-8 pubmed
    ..sequenced a cDNA from a human adult skeletal muscle cDNA library, encoding for a novel isoform of alpha-tubulin (tuba8) that is preferentially expressed in heart, skeletal muscle, and testis...
  2. Abdollahi M, Morrison E, Sirey T, Molnar Z, Hayward B, Carr I, et al. Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia. Am J Hum Genet. 2009;85:737-44 pubmed publisher
    ..By autozygosity mapping, we show that the molecular basis for this condition is mutation of the TUBA8 gene, encoding a variant alpha-tubulin of unknown function that is not susceptible to the lysine 40 acetylation ..
  3. Braun A, Breuss M, Salzer M, Flint J, Cowan N, Keays D. Tuba8 is expressed at low levels in the developing mouse and human brain. Am J Hum Genet. 2010;86:819-22; author reply 822-3 pubmed publisher
  4. Diggle C, Martinez Garay I, Molnar Z, Brinkworth M, White E, Fowler E, et al. A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development. PLoS ONE. 2017;12:e0174264 pubmed publisher
    Tubulin alpha 8 (Tuba8) is the most divergent member of the highly conserved alpha tubulin family, and uniquely lacks two key post-translational modification sites...
  5. Blacque O, Perens E, Boroevich K, Inglis P, Li C, Warner A, et al. Functional genomics of the cilium, a sensory organelle. Curr Biol. 2005;15:935-41 pubmed
    ..7a. Together, our findings help define a ciliary transcriptome and suggest that DYF-13, an evolutionarily conserved protein, is a novel core IFT component required for cilia function. ..
  6. Kamino H, Moore R, Negishi M. Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines. Cancer Genet. 2011;204:382-91 pubmed publisher
    ..We identified tubulin alpha 8 (TUBA8) as one of the candidate genes that may be involved in liver tumor promotion...
  7. Rein Fischboeck L, Pohl R, Haberl E, Zimny S, Neumann M, Eisinger K, et al. Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes. Mol Cell Biochem. 2017;428:161-170 pubmed publisher
    Tubulin alpha 8 (TUBA8) is highly abundant in murine liver tumors suggesting a role in hepatocellular carcinoma (HCC). Non-alcoholic steatohepatitis (NASH) is a risk factor for HCC...