Gene Symbol: Ttyh1
Description: tweety family member 1
Alias: 4930459B04Rik, 6330408P11Rik, TTY1, mTTY1, tty, protein tweety homolog 1, tweety homolog 1
Matthews C, Shaw J, Hooper J, Young I, Crouch M, Campbell H. Expression and evolution of the mammalian brain gene Ttyh1. J Neurochem. 2007;100:693-707 pubmed
..expressed sequence tag data indicate that expression of the mammalian Ttyh1 gene is restricted mainly to neural tissue and is up-regulated in astrocytoma, glioma and several other cancers...
Abramova N, Charniga C, Goderie S, Temple S. Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells. Dev Biol. 2005;283:269-81 pubmed
..These data indicate that progenitor cells change during development and that adult and embryonic neural progenitor cells are intrinsically different. ..
YOON J, Ng A, Kim B, Bianco A, Xavier R, Elledge S. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010;24:1507-18 pubmed publisher
..Our results identify a key component of the mitochondrial regulatory apparatus with a potentially important link to metabolic and degenerative disorders. ..
Campbell H, Kamei M, Claudianos C, Woollatt E, Sutherland G, Suzuki Y, et al
. Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins. Genomics. 2000;68:89-92 pubmed
We have cloned cDNA for TTYH1, a human homologue of the Drosophila melanogaster tweety (tty) gene...
Rae F, Hooper J, Eyre H, Sutherland G, Nicol D, Clements J. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. Genomics. 2001;77:200-7 pubmed
..In addition to a putative role in brain and testis, the over-expression of TTYH2 in renal cell carcinoma suggests that it may have an important role in kidney tumorigenesis. ..
Suzuki M, Mizuno A. A novel human Cl(-) channel family related to Drosophila flightless locus. J Biol Chem. 2004;279:22461-8 pubmed
..Similarly, hTTYH2 encoded an ionomycin-induced maxi-Cl(-) channel, but TTYH1 encoded a Ca(2+)-independent and swelling-activated maxi-Cl(-) channel...
Jung E, Osswald M, Blaes J, Wiestler B, Sahm F, Schmenger T, et al
. Tweety-Homolog 1 Drives Brain Colonization of Gliomas. J Neurosci. 2017;37:6837-6850 pubmed publisher
..One of the genes scoring highest in tests related to the outgrowth of TMs was tweety-homolog 1 (TTYH1), which was highly expressed in a fraction of TMs in mice and patients...
Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, et al
. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 2010;239:2233-45 pubmed publisher
..with oligonucleotide arrays, we identified an endoplasmic reticulum (ER) -resident protein, Tweety homologue 1 (ttyh1)...