Gene Symbol: Ttc21b
Description: tetratricopeptide repeat domain 21B
Alias: 2410066K11Rik, Thm1, aln, mKIAA1992, tetratricopeptide repeat protein 21B, TPR repeat protein 21B, intraflagellar transport 139 homolog, line 158, tetratricopeptide repeat-containing hedgehog modulator 1
Species: mouse
Products:     Ttc21b

Top Publications

  1. Herron B, Lu W, Rao C, Liu S, Peters H, Bronson R, et al. Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet. 2002;30:185-9 pubmed
    ..Using a hierarchical approach, it is possible to maximize the efficiency of this analysis so that it can be carried out easily with modest infrastructure and resources. ..
  2. Tran P, Haycraft C, Besschetnova T, Turbe Doan A, Stottmann R, Herron B, et al. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet. 2008;40:403-410 pubmed publisher
    ..RNA-interference knockdown of Ttc21b (which we call Thm1 and which encodes THM1) in mouse inner medullary collecting duct cells expressing an IFT88-..
  3. Mukhopadhyay S, Wen X, Chih B, Nelson C, Lane W, Scales S, et al. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev. 2010;24:2180-93 pubmed publisher
    ..TULP3 and IFT-A proteins both negatively regulate Hedgehog signaling in the mouse embryo, and the TULP3-IFT-A interaction suggests how these proteins cooperate during neural tube patterning. ..
  4. Tran P, Talbott G, Turbe Doan A, Jacobs D, Schonfeld M, Silva L, et al. Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models. J Am Soc Nephrol. 2014;25:2201-12 pubmed publisher
    ..The ciliary gene, Thm1(Ttc21b), negatively regulates Hedgehog signaling and is most commonly mutated in ciliopathies...
  5. Snedeker J, Schock E, Struve J, Chang C, Cionni M, Tran P, et al. Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development. PLoS ONE. 2017;12:e0173258 pubmed publisher
    ..We have genetically ablated Kif3a, Ift88, and Ttc21b in a series of specific spatiotemporal domains. The resulting phenotypes allow us to draw several conclusions...
  6. Hou Y, Qin H, Follit J, Pazour G, Rosenbaum J, Witman G. Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella. J Cell Biol. 2007;176:653-65 pubmed
    ..Axonemal ultrastructure is restored, except that the outer arms are still missing, although outer arm subunits are present in the cytoplasm. Thus, IFT46 is specifically required for transporting outer arms into the flagellum. ..
  7. Patterson V, Damrau C, Paudyal A, Reeve B, Grimes D, Stewart M, et al. Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet. 2009;18:1719-39 pubmed publisher
    ..processing of Gli3, and we demonstrate that transcriptional regulation of other negative regulators (Rab23, Fkbp8, Thm1, Sufu and PKA) is not affected...
  8. Stottmann R, Tran P, Turbe Doan A, Beier D. Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Dev Biol. 2009;335:166-78 pubmed publisher
    ..Here we characterize the forebrain phenotype caused by loss of Ttc21b, a gene we identified in an ENU mutagenesis screen as a novel ciliary gene required for retrograde intraflagellar ..
  9. Hong W, Li J, Wang B, Chen L, Niu W, Yao Z, et al. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation. Biochem Biophys Res Commun. 2011;415:650-5 pubmed publisher
    ..Taken together, our data indicate that ESET is involved in TR?1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation. ..

More Information


  1. Jacobs D, Silva L, Allard B, Schonfeld M, Chatterjee A, Talbott G, et al. Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome. Dis Model Mech. 2016;9:789-98 pubmed publisher
    ..THM1 (also termed TTC21B or IFT139) encodes a component of the intraflagellar transport-A complex and mutations in THM1 have been ..
  2. Schock E, Struve J, Chang C, Williams T, Snedeker J, Attia A, et al. A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS ONE. 2017;12:e0174206 pubmed publisher
    ..craniofacial development we conditionally deleted three separate intraflagellar transport genes, Kif3a, Ift88 and Ttc21b with three distinct drivers, Wnt1-Cre, Crect and AP2-Cre which drive recombination in neural crest, surface ..