Tslp

Summary

Gene Symbol: Tslp
Description: thymic stromal lymphopoietin
Alias: thymic stromal lymphopoietin, thymic stroma-derived lymphopoietin
Species: mouse
Products:     Tslp

Top Publications

  1. Larson R, Zimmerli S, Comeau M, Itano A, Omori M, Iseki M, et al. Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses. J Immunol. 2010;184:2974-84 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine, produced by epithelial cells, that has been linked to atopic dermatitis and asthma; however, it remains unclear how TSLP shapes the adaptive immune response that causes ..
  2. Osborn M, Ryan P, Kirchhof N, Panoskaltsis Mortari A, Mortari F, Tudor K. Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis. Blood. 2004;103:843-51 pubmed
    The role of thymic stromal cell-derived lymphopoietin (TSLP) in regulating hematopoiesis is poorly characterized, so we investigated its regulatory effects in vivo using TSLP transgenic mice...
  3. Headley M, Zhou B, Shih W, Aye T, Comeau M, Ziegler S. TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses. J Immunol. 2009;182:1641-7 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is crucial for the development of atopic diseases in humans and mice...
  4. Chappaz S, Flueck L, Farr A, Rolink A, Finke D. Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice. Blood. 2007;110:3862-70 pubmed
    ..IL-7) plays a crucial role in adult lymphopoiesis, while in fetal life its effect can be partially compensated by TSLP. Whether adult hematopoietic progenitor cells are unresponsive to TSLP or whether TSLP is less available in adult ..
  5. Siracusa M, Saenz S, Hill D, Kim B, Headley M, Doering T, et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature. 2011;477:229-33 pubmed publisher
    ..Polymorphisms in the gene encoding the cytokine thymic stromal lymphopoietin (TSLP) are associated with the development of multiple allergic disorders in humans, indicating that ..
  6. Demehri S, Morimoto M, Holtzman M, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol. 2009;7:e1000067 pubmed publisher
    ..Furthermore, we show that thymic stromal lymphopoietin (TSLP), overexpressed by skin keratinocytes, is the systemic driver of this bronchial hyper-..
  7. Nakamura Y, Miyata M, Ohba T, Ando T, Hatsushika K, Suenaga F, et al. Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H)2-type immune responses and airway inflammation. J Allergy Clin Immunol. 2008;122:1208-14 pubmed publisher
    ..However, the precise mechanisms involved remain elusive. Recently, thymic stromal lymphopoietin (TSLP) has been shown to play a key role in the development of T(H)2-type allergic inflammation in ..
  8. Demehri S, Turkoz A, Manivasagam S, Yockey L, Turkoz M, Kopan R. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell. 2012;22:494-505 pubmed publisher
    b>Thymic Stromal Lymphopoietin (TSLP), a cytokine implicated in induction of T helper 2 (Th2)-mediated allergic inflammation, has recently been shown to stimulate solid tumor growth and metastasis...
  9. Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard W. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol. 2011;187:1207-11 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a type 1 cytokine that contributes to lymphopoiesis and the development of asthma and atopic dermatitis...

More Information

Publications78

  1. Mazzucchelli R, Hixon J, Spolski R, Chen X, Li W, Hall V, et al. Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Blood. 2008;112:3283-92 pubmed publisher
    ..There are 2 known ligands for IL-7Ralpha: IL-7 itself and thymic stromal lymphopoietin (TSLP)...
  2. Kitajima M, Lee H, Nakayama T, Ziegler S. TSLP enhances the function of helper type 2 cells. Eur J Immunol. 2011;41:1862-71 pubmed publisher
    The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development and progression of allergic inflammation in both humans and mice...
  3. Vosshenrich C, Cumano A, Muller W, Di Santo J, Vieira P. Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment. Proc Natl Acad Sci U S A. 2004;101:11070-5 pubmed
    IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail...
  4. Wilson S, Thé L, Batia L, Beattie K, Katibah G, McClain S, et al. The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell. 2013;155:285-95 pubmed publisher
    ..quot; Signaling between epithelial cells and innate immune cells via the cytokine thymic stromal lymphopoietin (TSLP) is thought to drive AD and the atopic march...
  5. Ray R, Furlonger C, Williams D, Paige C. Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur J Immunol. 1996;26:10-6 pubmed
    ..We report here that a novel growth factor thymic stromal-derived lymphopoietin (TSLP) can replace the activity of interleukin-7 (IL-7) in supporting B cell development in vitro...
  6. Di Piazza M, Nowell C, Koch U, Durham A, Radtke F. Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting. Cancer Cell. 2012;22:479-93 pubmed publisher
    ..In this study we have addressed the role of the proinflammatory cytokine thymic stromal lymphopoietin (TSLP) during skin carcinogenesis...
  7. Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A. 2006;103:11736-41 pubmed
    We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyte-selective ablation of retinoid X receptors (RXRs) -alpha and -beta in the mouse (RXRalphabeta(ep-/-) mice), ..
  8. Zhang Z, Hener P, Frossard N, Kato S, Metzger D, Li M, et al. Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A. 2009;106:1536-41 pubmed publisher
    ..In the present study, we show that induced expression of thymic stromal lymphopoietin (TSLP) in mouse epidermal keratinocytes upon topical application of MC903 (a low calcemic analogue of ..
  9. Al Shami A, Spolski R, Kelly J, Keane Myers A, Leonard W. A role for TSLP in the development of inflammation in an asthma model. J Exp Med. 2005;202:829-39 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is a cytokine that promotes CD4+ T cell homeostasis. We now demonstrate that TSLP is required to mount a normal CD4+ T cell-mediated inflammatory response...
  10. Rochman Y, Leonard W. The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J Immunol. 2008;181:7699-705 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is a cytokine produced by stromal cells, epithelial cells, and basophils that acts on dendritic cells, mast cells, and CD4(+) T cells...
  11. Miyata M, Hatsushika K, Ando T, Shimokawa N, Ohnuma Y, Katoh R, et al. Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol. 2008;38:1487-92 pubmed publisher
    Epithelial cell-derived thymic stromal lymphopoietin (TSLP) is a master switch for asthma or atopic dermatitis by inducing a dendritic cell-mediated Th2-type allergic inflammation...
  12. Li Y, Li H, Ji F, Zhang X, Wang R, Hao J, et al. Thymic stromal lymphopoietin promotes lung inflammation through activation of dendritic cells. J Asthma. 2010;47:117-23 pubmed publisher
    ..Recent studies indicated that a cytokine, thymic stromal lymphopoietin (TSLP), is essential for the development of antigen-induced asthma...
  13. Jiang Q, Su H, Knudsen G, Helms W, Su L. Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP. BMC Immunol. 2006;7:6 pubmed
    ..Treatment of FTOCs with thymic stromal derived lymphopoietin (TSLP) enhanced expression of FoxP3, and blocking the TSLP receptor reduces FoxP3 expression in FTOC...
  14. Li M, Hener P, Zhang Z, Ganti K, Metzger D, Chambon P. Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin. J Invest Dermatol. 2009;129:498-502 pubmed publisher
  15. Spadoni I, Iliev I, Rossi G, Rescigno M. Dendritic cells produce TSLP that limits the differentiation of Th17 cells, fosters Treg development, and protects against colitis. Mucosal Immunol. 2012;5:184-93 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is produced by epithelial cells and keratinocytes, and is involved in immune homeostasis or inflammation. The mechanism through which TSLP regulates intestinal inflammation is unclear...
  16. Seshasayee D, Lee W, Zhou M, Shu J, Suto E, Zhang J, et al. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J Clin Invest. 2007;117:3868-78 pubmed
    b>Thymic stromal lymphopoietin (TSLP) potently induces deregulation of Th2 responses, a hallmark feature of allergic inflammatory diseases such as asthma, atopic dermatitis, and allergic rhinitis...
  17. Omori M, Ziegler S. Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. J Immunol. 2007;178:1396-404 pubmed
    The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development and progression of allergic inflammation in both humans and mice...
  18. Lee H, Ziegler S. Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc Natl Acad Sci U S A. 2007;104:914-9 pubmed
    The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) is important for the initiation of allergic airway inflammation through a dendritic cell-mediated T helper 2 response...
  19. Blazquez A, Mayer L, Berin M. Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance. Gastroenterology. 2010;139:1301-9 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells that acts on dendritic cells, mast cells, T cells, and B cells...
  20. Li D, Zhang L, Pflugfelder S, de Paiva C, Zhang X, Zhao G, et al. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol. 2011;128:1318-1325.e2 pubmed publisher
    ..However, the underlying mechanism by which pollen induces thymic stromal lymphopoietin (TSLP)-triggered allergic inflammation through epithelial innate immunity is largely unknown...
  21. Demehri S, Liu Z, Lee J, Lin M, Crosby S, Roberts C, et al. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol. 2008;6:e123 pubmed publisher
    ..In response, high levels of thymic stromal lymphopoietin (TSLP) were released into systemic circulation by Notch-deficient keratinocytes that failed to ..
  22. Han H, Xu W, Headley M, Jessup H, Lee K, Omori M, et al. Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma. Mucosal Immunol. 2012;5:342-51 pubmed publisher
    ..underlying cause of the atopic march remains unknown, recent evidence suggests a role for the cytokine thymic stromal lymphopoietin (TSLP)...
  23. Chen Z, Zhang T, Li H, Chen F, Zou X, Ji J, et al. Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. PLoS ONE. 2013;8:e51268 pubmed publisher
    ..However, the initiating factor that links airway inflammation to remodeling is unknown. Thymic stromal lymphopoietin (TSLP), an epithelium-derived cytokine, can strongly activate lung dendritic cells (DCs) through the ..
  24. Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, et al. Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur J Immunol. 2009;39:3078-83 pubmed publisher
    Both thymic stromal lymphopoietin (TSLP) and IL-13 are essential cytokines for the development of allergic inflammation. However, a causal link between TSLP and IL-13 has not yet been fully elucidated...
  25. Ramalingam T, Pesce J, Mentink Kane M, Madala S, Cheever A, Comeau M, et al. Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. J Immunol. 2009;182:6452-9 pubmed publisher
    b>Thymic stromal lymphopoietin was recently identified as a master switch for the development of allergen-driven Th2 responses...
  26. He R, Oyoshi M, Garibyan L, Kumar L, Ziegler S, Geha R. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A. 2008;105:11875-80 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation...
  27. Massacand J, Stettler R, Meier R, Humphreys N, Grencis R, Marsland B, et al. Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc Natl Acad Sci U S A. 2009;106:13968-73 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine, mainly expressed by epithelial cells, and key to the development of allergic responses...
  28. Rochman Y, Kashyap M, Robinson G, Sakamoto K, Gomez Rodriguez J, Wagner K, et al. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A. 2010;107:19455-60 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays essential roles in allergic/inflammatory skin and airway disorders, in helminth infections, and in regulating intestinal immunity...
  29. Sims J, Williams D, Morrissey P, Garka K, Foxworthe D, Price V, et al. Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J Exp Med. 2000;192:671-80 pubmed
    ..This factor, termed thymic stromal lymphopoietin (TSLP), is a protein of 140 amino acids. The gene encoding TSLP was mapped to murine chromosome 18...
  30. Ziegler S, Liu Y. Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nat Immunol. 2006;7:709-14 pubmed
    b>Thymic stromal lymphopoietin, a four helix-bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells...
  31. Taylor B, Zaph C, Troy A, Du Y, Guild K, Comeau M, et al. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med. 2009;206:655-67 pubmed publisher
    Intestinal epithelial cells (IECs) produce thymic stromal lymphopoietin (TSLP); however, the in vivo influence of TSLP-TSLP receptor (TSLPR) interactions on immunity and inflammation in the intestine remains unclear...
  32. Al Shami A, Spolski R, Kelly J, Fry T, Schwartzberg P, Pandey A, et al. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med. 2004;200:159-68 pubmed
    b>Thymic stromal lymphopoietin (TSLP) signals via a receptor comprising the interleukin (IL)-7 receptor alpha chain and a distinctive subunit, TSLP receptor (TSLPR), which is most related to the common cytokine receptor gamma chain, gamma(c)..
  33. Jessup H, Brewer A, Omori M, Rickel E, Budelsky A, Yoon B, et al. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol. 2008;181:4311-9 pubmed
    The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) is sufficient to induce asthma or atopic dermatitis-like phenotypes when selectively overexpressed in transgenic mice, or when driven by topical application of vitamin D3 ..
  34. Jiang Q, Coffield V, Kondo M, Su L. TSLP is involved in expansion of early thymocyte progenitors. BMC Immunol. 2007;8:11 pubmed
    Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear...
  35. Kuethe J, Prakash P, Midura E, Johnson B, Kasten K, Caldwell C. Thymic stromal lymphopoietin mediates the host response and increases mortality during sepsis. J Surg Res. 2014;191:19-24 pubmed publisher
    ..Sepsis and subsequent multiorgan system failure is associated with high rates of mortality and morbidity. Thymic stromal lymphopoietin (TSLP) is a cytokine that can be produced by keratinocytes and epithelial cells...
  36. Berthault C, Ramond C, Burlen Defranoux O, Soubigou G, Chea S, Golub R, et al. Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver. Nat Immunol. 2017;18:1139-1149 pubmed publisher
  37. Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, et al. Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat Struct Mol Biol. 2014;21:375-82 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis...
  38. Eckhardt J, Döbbeler M, König C, Kuczera K, Kuhnt C, Ostalecki C, et al. Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis. Clin Exp Immunol. 2015;181:51-64 pubmed publisher
    In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE)...
  39. Han H, Thelen T, Comeau M, Ziegler S. Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. J Clin Invest. 2014;124:5442-52 pubmed publisher
    ..Here, we determined that exposure of mice that have been epicutaneously sensitized with thymic stromal lymphopoietin (TSLP) and antigen to repeated oral doses of the same antigen induced acute diarrhea and anaphylaxis...
  40. Xia H, Cai S, Tong W, Luo L, Yu H. [Respiratory syncytial virus infection promotes the production of thymic stromal lymphopoietin and accelerates Th2 inflammation in mouse airway]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:724-8 pubmed
    To investigate the effect of respiratory syncytial virus (RSV) infection on the production of thymic stromal lymphopoietin (TSLP) and Th1/Th2 balance in asthmatic mice...
  41. Segawa R, Hirasawa N. Exacerbation of allergic diseases by chemicals: role of TSLP. J Pharmacol Sci. 2014;124:301-6 pubmed
    ..However, the exacerbation mechanisms induced by these chemicals are not yet fully understood. Thymic stromal lymphopoietin (TSLP) is produced mainly by epithelial cells and plays an important role as a master switch of ..
  42. Oh H, Seo J, Jeong H, Kim H. Ginsenoside Rg1 inhibits the TSLP production in allergic rhinitis mice. Immunopharmacol Immunotoxicol. 2013;35:678-86 pubmed publisher
    ..RG1 significantly reduced the levels of thymic stromal lymphopoietin (TSLP) and interleukin (IL)-1? compared with the AR control mice...
  43. Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, et al. Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes. Allergol Int. 2012;61:563-72 pubmed publisher
    ..that periostin promoted survival and proliferation of keratinocytes and directly induced production of thymic stromal lymphopoietin (TSLP)...
  44. Noti M, Wojno E, Kim B, Siracusa M, Giacomin P, Nair M, et al. Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med. 2013;19:1005-13 pubmed publisher
    ..EoE is associated with polymorphisms in the gene that encodes thymic stromal lymphopoietin (TSLP), a cytokine that promotes allergic inflammation, but how TSLP might contribute to EoE disease ..
  45. Sokulsky L, Collison A, Nightingale S, Fevre A, Percival E, Starkey M, et al. TRAIL deficiency and PP2A activation with salmeterol ameliorates egg allergen-driven eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2016;311:G998-G1008 pubmed publisher
    ..mice were largely protected from esophageal fibrosis, eosinophilic inflammation, and the upregulation of TSLP, IL-5, IL-13, and CCL11 when compared with wild-type mice...
  46. Kamekura R, Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, et al. Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells. Histochem Cell Biol. 2010;133:339-48 pubmed publisher
    Epithelial-derived thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell (DC)-mediated Th2-type inflammatory responses...
  47. Yockey L, Demehri S, Turkoz M, Turkoz A, Ahern P, Jassim O, et al. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol. 2013;133:2714-2721 pubmed publisher
    ..GF mutant animals expressed significantly higher levels of thymic stromal lymphopoietin, a major proinflammatory cytokine released by skin with defective barrier function, resulting in a more ..
  48. Kim B, Siracusa M, Saenz S, Noti M, Monticelli L, Sonnenberg G, et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med. 2013;5:170ra16 pubmed publisher
    ..lymph nodes were independent of these canonical cytokines but were critically dependent on thymic stromal lymphopoietin (TSLP)...
  49. Knisz J, Banks A, McKeag L, Metcalfe D, Rothman P, Brown J. Loss of SOCS7 in mice results in severe cutaneous disease and increased mast cell activation. Clin Immunol. 2009;132:277-84 pubmed publisher
    ..Cytokine production by bone marrow derived mast cells was determined by ELISA. Mast cell thymic stromal lymphopoietin (TSLP) production was assessed by quantitative real-time PCR...
  50. Sevilla L, Latorre V, Sanchis A, Perez P. Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammation. J Invest Dermatol. 2013;133:361-70 pubmed publisher
    ..Many upregulated genes, including S100a8/a9 and Tslp, also have increased expression in inflammatory skin diseases...
  51. Yu K, Dong Q, Mao X, Meng K, Zhao X, Ji Q, et al. Disruption of the TSLP-TSLPR-LAP signaling between epithelial and dendritic cells through hyperlipidemia contributes to regulatory T-Cell defects in atherosclerotic mice. Atherosclerosis. 2015;238:278-88 pubmed publisher
    Regulatory T-Cells (Tregs) play a protective role against the development of atherosclerosis. Moreover, thymic stromal lymphopoietin (TSLP)/thymic stromal lymphopoietin receptor (TSLPR) signaling in myeloid dendritic cells (DCs) promote ..
  52. Wang Q, Du J, Zhu J, Yang X, Zhou B. Thymic stromal lymphopoietin signaling in CD4(+) T cells is required for TH2 memory. J Allergy Clin Immunol. 2015;135:781-91.e3 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a key factor in the development of allergic asthma...
  53. Moniaga C, Jeong S, Egawa G, Nakajima S, Hara Chikuma M, Jeon J, et al. Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice. Am J Pathol. 2013;182:841-51 pubmed publisher
    ..In addition, the expression of thymic stromal lymphopoietin (TSLP) in keratinocytes (KCs), induced by barrier disruption, can promote type 2 helper T-cell ..
  54. Vang K, Yang J, Mahmud S, Burchill M, Vegoe A, Farrar M. IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J Immunol. 2008;181:3285-90 pubmed
    ..However, it is unclear which gammac-dependent cytokines are involved in this process. Furthermore, thymic stromal lymphopoietin (TSLP) has also been suggested to play a role in Treg development...
  55. Chorro L, Sarde A, Li M, Woollard K, Chambon P, Malissen B, et al. Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med. 2009;206:3089-100 pubmed publisher
    ..This mechanism may be relevant in locations where leukocyte trafficking is limited. ..
  56. Segawa R, Mizuno N, Hatayama T, Jiangxu D, Hiratsuka M, Endo Y, et al. Lipopolysaccharide-Activated Leukocytes Enhance Thymic Stromal Lymphopoietin Production in a Mouse Air-Pouch-Type Inflammation Model. Inflammation. 2016;39:1527-37 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a key cytokine that exacerbates allergic and fibrotic reactions. Several microbes and virus components have been shown to induce TSLP production, mainly in epithelial cells...
  57. Nagata Y, Kamijuku H, Taniguchi M, Ziegler S, Seino K. Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function. Int Arch Allergy Immunol. 2007;144:305-14 pubmed
    ..Also, recent reports indicated that a cytokine, thymic stromal lymphopoietin (TSLP), is essential for the development of antigen-induced asthma...
  58. Ashrin M, Arakaki R, Yamada A, Kondo T, Kurosawa M, Kudo Y, et al. A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice. J Immunol. 2014;192:4025-31 pubmed publisher
    ..Among the proteins expressed at higher levels in mice with Ni-induced allergy, we focused on thymic stromal lymphopoietin (TSLP), which is produced in abundance by keratinocytes...
  59. Iseki M, Omori Miyake M, Xu W, Sun X, Takaki S, Rawlings D, et al. Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4. Int Immunol. 2012;24:183-95 pubmed publisher
    The cytokine thymic stromal lymphopoietin (TSLP) functions as a regulator of bone marrow B-cell development and a key initiator of allergic inflammation...
  60. Turkoz M, Townsend R, Kopan R. The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. J Invest Dermatol. 2016;136:1106-1115 pubmed publisher
    ..first hair follicles is responsible for a delay in follicular destruction, which results in lower serum thymic stromal lymphopoietin levels, milder B-cell lymphoproliferative disease, and improved survival in Msx2-Cre(+/tg);Rbpj(f/f) ..
  61. Plumb A, Patton D, Seo J, Loveday E, Jean F, Ziegler S, et al. Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus. PLoS ONE. 2012;7:e50199 pubmed publisher
    ..In contrast, the IL-7-related cytokine thymic stromal lymphopoietin (TSLP) has a limited role in lymphocyte development but is important in the immune response to ..
  62. Du Q, Gu X, Feng G, Shen L, Cui J, Cai J, et al. [Effects of astragaloside IV on the expressions of transforming growth factor-?1 and thymic stromal lymphopoietin in a murine model of asthma]. Zhonghua Yi Xue Za Zhi. 2011;91:3139-42 pubmed
    ..IV on the airway remodeling and the expressions of transforming growth factor (TGF)-?1 and thymic stromal lymphopoietin (TSLP) in a murine model of asthma. Forty-eight BALB/c mice were randomly divided into 4 groups, i.e...
  63. Quentmeier H, Drexler H, Fleckenstein D, Zaborski M, Armstrong A, Sims J, et al. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia. 2001;15:1286-92 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is a novel cytokine that was found to promote the development of murine B cells in vitro. Here we describe the cloning and characterization of the human homologue of murine TSLP...
  64. Jensen C, Kharazi S, Böiers C, Cheng M, Lübking A, Sitnicka E, et al. FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis. Blood. 2008;112:2297-304 pubmed publisher
    ..Although thymic stromal lymphopoietin (TSLP) has been proposed to be the main factor driving IL-7-independent B lymphopoiesis and to ..
  65. Ochiai S, Roediger B, Abtin A, Shklovskaya E, Fazekas de St Groth B, Yamane H, et al. CD326(lo)CD103(lo)CD11b(lo) dermal dendritic cells are activated by thymic stromal lymphopoietin during contact sensitization in mice. J Immunol. 2014;193:2504-11 pubmed publisher
    The cytokine thymic stromal lymphopoietin (TSLP) is produced by epithelia exposed to the contact sensitizer dibutyl phthalate (DBP), and it is critical for the induction of Th2 immune responses by DBP-FITC...
  66. Li X, Han X, Wang S, Duan Z. Development and characterization of monoclonal antibodies against mouse TSLP. Hybridoma (Larchmt). 2010;29:425-30 pubmed publisher
    Epithelial-derived thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that is mainly produced by epithelial cells. It has been shown to play a key role in the development of Th2-type allergic inflammation...
  67. Stier M, Bloodworth M, Toki S, Newcomb D, Goleniewska K, Boyd K, et al. Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. J Allergy Clin Immunol. 2016;138:814-824.e11 pubmed publisher
    ..Wild-type (WT) BALB/c, thymic stromal lymphopoietin receptor (TSLPR) knockout (KO), or WT mice receiving an anti-TSLP neutralizing antibody were infected ..
  68. Li J, Leyva Castillo J, Hener P, Eisenmann A, Zaafouri S, Jonca N, et al. Counterregulation between thymic stromal lymphopoietin- and IL-23-driven immune axes shapes skin inflammation in mice with epidermal barrier defects. J Allergy Clin Immunol. 2016;138:150-161.e13 pubmed publisher
    ..corneum barrier, type 2 and type 17 inflammatory responses are developed simultaneously, driven by thymic stromal lymphopoietin (TSLP) and IL-23, respectively...
  69. Joo S, Fukuyama Y, Park E, Yuki Y, Kurashima Y, Ouchida R, et al. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunol. 2017;10:901-911 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7)-like cytokine involved in T helper 2 type immune responses...