Trpv4

Summary

Gene Symbol: Trpv4
Description: transient receptor potential cation channel, subfamily V, member 4
Alias: 0610033B08Rik, OTRPC4, Trp12, VR-OAC, VRL-2, VROAC, transient receptor potential cation channel subfamily V member 4, osm-9-like TRP channel 4, osmosensitive transient receptor potential channel 4, transient receptor potential protein 12, trpv4 channel, vanilloid receptor-like channel 2, vanilloid receptor-like protein 2, vanilloid receptor-related osmotically-activated channel
Species: mouse

Top Publications

  1. pmc Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia
    Lucia Seminario-Vidal
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:26277-86. 2011
  2. doi Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain
    Y Chen
    Department of Biopharmaceutical Sciences and Cancer Center, University of Illinois, Chicago, IL 60612, USA
    Neuroscience 193:440-51. 2011
  3. doi Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx
    Xin Ma
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Arterioscler Thromb Vasc Biol 30:851-8. 2010
  4. ncbi OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
    R Strotmann
    Institut fur Pharmakologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Thielallee 67 73, 14195 Berlin, Germany
    Nat Cell Biol 2:695-702. 2000
  5. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
  6. ncbi Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:13569-77. 2002
  7. ncbi Molecular determinants of permeation through the cation channel TRPV4
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 277:33704-10. 2002
  8. ncbi Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:47044-51. 2002
  9. ncbi Impaired pressure sensation in mice lacking TRPV4
    Makoto Suzuki
    Department of Pharmacology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    J Biol Chem 278:22664-8. 2003
  10. ncbi Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways
    Xiaochong Gao
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 278:27129-37. 2003

Research Grants

Scientific Experts

Detail Information

Publications113 found, 100 shown here

  1. pmc Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia
    Lucia Seminario-Vidal
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:26277-86. 2011
    ..and Rho activation were reduced by highly selective inhibitors of transient receptor potential vanilloid 4 (TRPV4). Lastly, knocking down TRPV4 impaired hypotonicity-evoked airway epithelial ATP release...
  2. doi Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain
    Y Chen
    Department of Biopharmaceutical Sciences and Cancer Center, University of Illinois, Chicago, IL 60612, USA
    Neuroscience 193:440-51. 2011
    ..sensitized pain response was selectively inhibited by antagonists of transient receptor potential (TRP) V1, TRPV4, or TRPA1...
  3. doi Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx
    Xin Ma
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Arterioscler Thromb Vasc Biol 30:851-8. 2010
    The present study is aimed at investigating the interaction of TRPV4 with TRPC1 and the functional role of such an interaction in flow-induced Ca(2+) influx...
  4. ncbi OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
    R Strotmann
    Institut fur Pharmakologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Thielallee 67 73, 14195 Berlin, Germany
    Nat Cell Biol 2:695-702. 2000
    ..Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart...
  5. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells...
  6. ncbi Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:13569-77. 2002
    ..human VRL-2, and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the human and murine OTRPC4 channel...
  7. ncbi Molecular determinants of permeation through the cation channel TRPV4
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 277:33704-10. 2002
    We have studied the molecular determinants of ion permeation through the TRPV4 channel (VRL-2, TRP12, VR-OAC, and OTRPC4)...
  8. ncbi Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:47044-51. 2002
    We have compared activation by heat of TRPV4 channels, heterogeneously expressed in HEK293 cells, and endogenous channels in mouse aorta endothelium (MAEC)...
  9. ncbi Impaired pressure sensation in mice lacking TRPV4
    Makoto Suzuki
    Department of Pharmacology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    J Biol Chem 278:22664-8. 2003
    ..However, the mouse still retained olfaction, taste sensation, and heat avoidance. The TRPV4 channel expressed in vitro in Chinese hamster ovary cells was opened by low pH, citrate, and inflation but not by heat ..
  10. ncbi Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways
    Xiaochong Gao
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 278:27129-37. 2003
    ..It is concluded that temperature is a critical modulator of TRPV4 channel gating, leading to activation of the channel by a diverse range of microenvironmental chemical and physical ..
  11. ncbi Impaired osmotic sensation in mice lacking TRPV4
    Atsuko Mizuno
    Department of Pharmacology, Jichi Medical School, Minamikawachi, Tochigi, 329 0498, Japan
    Am J Physiol Cell Physiol 285:C96-101. 2003
    The Ca2+-permeable cation channel TRPV4, which is part of the Trp family located in the circumventricular organs, is activated by cell swelling...
  12. ncbi Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 424:434-8. 2003
    b>TRPV4 is a widely expressed cation channel of the 'transient receptor potential' (TRP) family that is related to the vanilloid receptor VR1 (TRPV1)...
  13. pmc Abnormal osmotic regulation in trpv4-/- mice
    Wolfgang Liedtke
    Laboratory of Molecular Genetics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:13698-703. 2003
    ..The transient receptor potential channel, vanilloid subfamily (TRPV4), is an osmotically activated ion channel that is expressed in circumventricular organs in the mammalian CNS, ..
  14. ncbi Localization of mechanosensitive channel TRPV4 in mouse skin
    Makoto Suzuki
    Department of Pharmacology, Jichi Medical School, Kawachi, Tochigi 329 0498, Japan
    Neurosci Lett 353:189-92. 2003
    ..The distribution suggests that the sensation of pressure by mechanosensitive TRPV4 channel is transmitted through A- as well as C-fiber.
  15. pmc Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
    J Vriens
    Department of Physiology, Campus Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 101:396-401. 2004
    b>TRPV4 is a Ca(2+)- and Mg(2+)-permeable cation channel within the vanilloid receptor subgroup of the transient receptor potential (TRP) family, and it has been implicated in Ca(2+)-dependent signal transduction in several tissues, ..
  16. ncbi TRPV4 calcium entry channel: a paradigm for gating diversity
    Bernd Nilius
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    Am J Physiol Cell Physiol 286:C195-205. 2004
    ..b>TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is ..
  17. ncbi TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes
    Man Kyo Chung
    Department of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 279:21569-75. 2004
    ..Two of these proteins, TRPV3 and TRPV4, are ion channels activated by modest increases in ambient temperature...
  18. ncbi Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia
    Hiroshi Todaka
    Department of Pharmacology, Division of Molecular Pharmacology, Jichi Medical School 3311 1, Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    J Biol Chem 279:35133-8. 2004
    ..Animals sense various ranges of temperatures by cutaneous thermal stimuli. Transient receptor potential vanilloid 4 (TRPV4) is a cation channel activated at a warm temperature (over 30 degrees C) in exogenously expressed cells...
  19. ncbi Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4
    Hyosang Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:1304-10. 2005
    Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4-/- mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia...
  20. ncbi Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs
    Stefan C Teilmann
    Laboratory of Reproductive Biology, Rigshospitalet, Denmark
    Mol Reprod Dev 71:444-52. 2005
    ..Further, the Ca2+ permeable cation channel, TRP vaniloid 4 (TRPV4), localizes to a sub-population of motile cilia on the epithelial cells of the ampulla and isthmus with high ..
  21. ncbi Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium
    J Vriens
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Belgium
    Circ Res 97:908-15. 2005
    b>TRPV4 is a broadly expressed Ca2+-permeable cation channel in the vanilloid subfamily of transient receptor potential channels...
  22. ncbi A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators
    Nicole Alessandri-Haber
    Division of Neurosciences, Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Neurosci 26:3864-74. 2006
    The transient receptor potential vanilloid 4 (TRPV4) is a primary afferent transducer that plays a crucial role in neuropathic hyperalgesia for osmotic and mechanical stimuli, as well as in inflammatory mediator-induced hyperalgesia for ..
  23. pmc Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury
    Diego F Alvarez
    Department of Physiology, Center for Lung Biology, University of South Alabama, Mobile, AL 36688, USA
    Circ Res 99:988-95. 2006
    ..We hypothesized that activation of the vanilloid transient receptor potential channel TRPV4 disrupts the alveolar septal barrier...
  24. pmc The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels
    Tomasz Wegierski
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany
    EMBO J 25:5659-69. 2006
    b>TRPV4 is a widely expressed member of the transient receptor potential (TRP) family that facilitates Ca(2+) entry into nonexcitable cells...
  25. pmc Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
    Andrew D Grant
    Department of Surgery, UCSF, 513 Parnassus Ave, Room S1268, San Francisco, CA 94143 0660, USA
    J Physiol 578:715-33. 2007
    ..mechanical hyperalgesia requires sensitization of the ion channel transient receptor potential vanilloid 4 (TRPV4)...
  26. ncbi Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells
    Ling Wu
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA
    Am J Physiol Renal Physiol 293:F1699-713. 2007
    Gain/loss of function studies were utilized to assess the potential role of the endogenous vanilloid receptor TRPV4 as a sensor of flow and osmolality in M-1 collecting duct cells (CCD)...
  27. pmc Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
    Thomas Gevaert
    Department of Urology, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Invest 117:3453-62. 2007
    ..we provide evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function...
  28. pmc Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion
    Sergio A Gradilone
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 104:19138-43. 2007
    ..b>TRPV4, a Ca(2+)-permeable ion channel, has been implicated in signal transduction of osmotic stimuli...
  29. doi Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia
    Nicole Alessandri-Haber
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, California 94143 0440, USA
    J Neurosci 28:1046-57. 2008
    Although the transient receptor potential vanilloid 4 (TRPV4) has been implicated in the process of osmomechanical transduction, it appears to make little contribution to the normal somatosensory detection of mechanical stimuli...
  30. pmc Selective role for TRPV4 ion channels in visceral sensory pathways
    Stuart M Brierley
    Discipline of Physiology, School of Molecular and Biomedical Sciences, The University of Adelaide, Adelaide, Australia
    Gastroenterology 134:2059-69. 2008
    ..Here, we show that colonic afferents express a specific molecular transducer that underlies their specialized mechanosensory function: the transient receptor potential channel, vanilloid 4 (TRPV4).
  31. pmc TRPP2 and TRPV4 form a polymodal sensory channel complex
    Michael Köttgen
    Renal Division, University Hospital Freiburg, 79106 Freiburg, Germany
    J Cell Biol 182:437-47. 2008
    ..We find here that TRPP2 utilizes TRPV4 to form a mechano- and thermosensitive molecular sensor in the cilium...
  32. pmc Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo
    David X Zhang
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 53:532-8. 2009
    ..The transient receptor potential vanilloid type 4 (TRPV4) channel, a Ca2+-permeant cation channel, is expressed in endothelial cells and involved in the regulation of ..
  33. pmc TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization
    Nicole Alessandri-Haber
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Neurosci 29:6217-28. 2009
    The transient receptor potential vanilloid 4 (TRPV4) contributes to mechanical hyperalgesia of diverse etiologies, presumably as part of a mechanoreceptor signaling complex (Alessandri-Haber et al., 2008)...
  34. pmc The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures
    Tsutomu Mochizuki
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    J Biol Chem 284:21257-64. 2009
    ..In this study, we investigated the role of transient receptor potential vanilloid 4 (TRPV4) channels in a stretch sensing mechanism in mouse primary urothelial cell cultures...
  35. pmc TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure
    Scott Earley
    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 297:H1096-102. 2009
    Transient receptor potential vanilloid 4 (TRPV4) channels have been implicated as mediators of calcium influx in both endothelial and vascular smooth muscle cells and are potentially important modulators of vascular tone...
  36. pmc TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress
    Suelhem A Mendoza
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 298:H466-76. 2010
    ..shear was observed to produce rapid Ca(2+) influx in endothelial cells, which was markedly inhibited by the TRPV4 channel blocker ruthenium red and TRPV4-specific short interfering RNA...
  37. pmc The TRPV4 channel contributes to intercellular junction formation in keratinocytes
    Takaaki Sokabe
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 285:18749-58. 2010
    Transient receptor potential vanilloid 4 (TRPV4) channel is a physiological sensor for hypo-osmolarity, mechanical deformation, and warm temperature. The channel activation leads to various cellular effects involving Ca(2+) dynamics...
  38. pmc Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer
    Andrew P Stewart
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    Biophys J 99:790-7. 2010
    ..polycystin-2 (TRPP2) interacts with two other members of the transient receptor potential (TRP) family, TRPC1 and TRPV4. We have previously shown that TRPP2 forms a heteromeric complex with TRPC1, with a 2:2 stoichiometry and an ..
  39. doi Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue
    Bernd W Pritschow
    Institute of Pathophysiology, University of Greifswald, Greifswald, Germany
    Pflugers Arch 461:115-22. 2011
    ..Here we show that TRPV4, an osmo-sensitive cation channel of the vanilloid subfamily of TRP channels is functionally expressed in mouse ..
  40. pmc Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis
    Wouter Everaerts
    Laboratory of Ion Channel Research, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 107:19084-9. 2010
    ..Recent work has demonstrated that the cation channel TRPV4 is highly expressed in urothelial cells and plays a role in sensing the normal filling state of the bladder...
  41. doi The molecular and cellular identity of peripheral osmoreceptors
    Stefan G Lechner
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rössle Straße 10, D 13092 Berlin Buch, Germany
    Neuron 69:332-44. 2011
    ..In mice lacking the osmotically activated ion channel, TRPV4, hepatic sensory neurons no longer exhibit osmosensitive inward currents and activation of peripheral ..
  42. pmc Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes
    Hiroshi Mihara
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    J Physiol 589:3471-82. 2011
    ..Transient receptor potential channel vanilloid 4 (TRPV4) can detect various stimuli such as warm temperature, stretch and some chemicals, including 4α-phorbol 12,13-..
  43. pmc Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+-activated K+ channels
    Min Jin
    Dept of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, TX 77030, USA
    Cell Calcium 51:131-9. 2012
    ..It is concluded that a synergistic cross-talk exists between the TRPV4 channel and SK3 and BK-α channels to provide a tight functional regulation between the channel groups...
  44. doi TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity
    Tatsuya Kusudo
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan
    J Appl Physiol (1985) 112:1223-32. 2012
    Transient receptor potential channel V4 (TRPV4) functions as a nonselective cation channel in various cells and plays physiological roles in osmotic and thermal sensation. However, the function of TRPV4 in energy metabolism is unknown...
  45. pmc Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system
    Jonathan Berrout
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 287:8782-91. 2012
    The TRPV4 Ca(2+)-permeable channel is sensitive to mechanical stimuli...
  46. pmc Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function
    Swapnil K Sonkusare
    Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Science 336:597-601. 2012
    ..sparklets") in the vascular endothelium of resistance arteries that represent Ca(2+) influx through single TRPV4 cation channels...
  47. ncbi PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4
    Math P Cuajungco
    Department of Otolaryngology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 281:18753-62. 2006
    b>TRPV4 is a cation channel that responds to a variety of stimuli including mechanical forces, temperature, and ligand binding...
  48. ncbi TRPV4-mediated regulation of epithelial permeability
    Bettina Reiter
    Institut fur Pharmakologie, Charite Campus Benjamin Franklin, Berlin, Germany
    FASEB J 20:1802-12. 2006
    b>TRPV4 is a calcium-permeable channel activated by extracellular hypotonicity, polyunsaturated fatty acids, phorbol esters, and heat. We show that TRPV4 is localized in the basolateral membrane of the mouse mammary cell line HC11...
  49. ncbi Expression of transient receptor potential vanilloid (TRPV) families 1, 2, 3 and 4 in the mouse olfactory epithelium
    Mohamed Khalifa Ahmed
    Department of Otorhinolaryngology, Head and Neck Surgery, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima City, Japan
    Rhinology 47:242-7. 2009
    ..TRPVs in respiratory mucosa may play a significant role in nasal nociception, ciliary movement and the regulation of mucous secretion...
  50. ncbi TRPV4 as a flow sensor in flow-dependent K+ secretion from the cortical collecting duct
    Junichi Taniguchi
    Division of Molecular Pharmacology, Dept of Pharmacology, Jichi Medical University, Tochigi, Japan
    Am J Physiol Renal Physiol 292:F667-73. 2007
    The transient receptor vanilloid-4 (TRPV4) is a mechanosensitive, swell-activated cation channel that is abundant in the renal distal tubules...
  51. doi Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton
    Chandan Goswami
    Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    FEBS J 275:4684-99. 2008
    ..Thereby, we point out the functional importance of cytoskeleton components both as modulator and as modulated downstream effector. The resulting implications for patho-biological situations are discussed...
  52. doi Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4
    Sorana Ciura
    Center for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada
    J Neurosci 31:14669-76. 2011
    ..However other experiments have indicated that channels encoded by Trpv4 also contribute to central osmosensation in mice (Liedtke and Friedman, 2003; Mizuno et al., 2003)...
  53. pmc Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth
    Yongwoo Jang
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    J Biol Chem 287:6014-24. 2012
    ..Recent advances in genetics have resulted in the identification of missense mutations in TRPV4 in patients with these hereditary neuropathies...
  54. pmc Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension
    Xiao ru Yang
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 302:L555-68. 2012
    ..Here we found that TRPV4 was the only member of the TRPV and TRPM subfamilies upregulated in PAs of chronic hypoxic rats...
  55. doi Vascular hypoxic preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication
    Geraldine Rath
    Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, University of Louvain Medical School, 52, Avenue Mounier, B 1200 Brussels, Belgium
    Arterioscler Thromb Vasc Biol 32:2241-9. 2012
    ..on endothelial relaxation and aimed to clarify the role of transient receptor potential cation channels V4 (TRPV4) and gap junctions in the protective effect associated with hypoxic preconditioning on the vascular function.
  56. doi An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
    Kevin S Thorneloe
    Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapy Area Unit, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA
    Sci Transl Med 4:159ra148. 2012
    ..of this mechanism, we evaluated TRPV4 expression in human congestive HF lungs and developed small-molecule TRPV4 channel blockers for testing in animal models of HF...
  57. pmc Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
    Christopher J O'Conor
    Department of Orthopaedic Surgery, Duke University Medical Center, 375 MSRB, Box 3093, Durham, NC 27710, USA
    Ann Rheum Dis 72:300-4. 2013
    To test the hypotheses that: (1) the transient receptor potential vanilloid 4 (TRPV4) ion channel is protective in the obesity model of osteoarthritis (OA), resulting in more severe obesity-induced OA in Trpv4 knockout (Trpv4(-/-)) mice; ..
  58. pmc Primary cilia signaling mediates intraocular pressure sensation
    Na Luo
    Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN 46202 Department of Ophthalmology
    Proc Natl Acad Sci U S A 111:12871-6. 2014
    ..The interaction of OCRL with transient receptor potential vanilloid 4 (TRPV4), a ciliary mechanosensory channel, suggests that OCRL may act through regulation of this channel...
  59. pmc Role of MMP2 and MMP9 in TRPV4-induced lung injury
    Patricia C Villalta
    Department of Physiology and Center for Lung Biology, University of South Alabama, Mobile, Alabama
    Am J Physiol Lung Cell Mol Physiol 307:L652-9. 2014
    Ca(2+) entry through transient receptor potential vanilloid 4 (TRPV4) results in swelling, blebbing, and detachment of the epithelium and capillary endothelium in the intact lung...
  60. pmc GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature
    Mahmoud Saifeddine
    Department of Physiology and Pharmacology, Inflammation Research Network and Snyder Institute for Chronic Disease, University of Calgary, Calgary, AB, Canada
    Br J Pharmacol 172:2493-506. 2015
    Transient receptor potential vanilloid-4 (TRPV4) is a calcium-permeant ion channel that is known to affect vascular function. The ability of TRPV4 to cause a vasoconstriction in blood vessels has not yet been mechanistically examined...
  61. doi Hippocampal neuronal maturation triggers post-synaptic clustering of brain temperature-sensor TRPV4
    Koji Shibasaki
    Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan Electronic address
    Biochem Biophys Res Commun 458:168-73. 2015
    ..We previously revealed that the thermo-sensor TRPV4 (activated above 34 °C) is gated by physiological brain temperatures in hippocampal neurons and thereby controls ..
  62. pmc TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis
    Rachel G Scheraga
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195 Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195 and
    J Immunol 196:428-36. 2016
    ..Intriguingly, matrix stiffness in the range seen in inflamed or fibrotic lung is required to sensitize the TRPV4 channel to mediate the LPS-induced increment in macrophage phagocytosis...
  63. doi In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis
    Clémence O Henry
    INSERM U1100, Centre d Etude des Pathologies Respiratoires, Tours, France Université François Rabelais, Tours, France
    Am J Physiol Lung Cell Mol Physiol 311:L664-75. 2016
    ..Here, we focused on the potential role of "transient receptor potential vanilloid-4" (TRPV4), a nonselective calcium channel...
  64. doi Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben
    Sangsu Bang
    Korea University Graduate School of Medicine, Seoul 136 705, Republic of Korea
    Neurosci Lett 506:297-302. 2012
    ..In Ca(2+) imaging and whole cell electrophysiology, TRPA1 and TRPV4 were blocked by micromolar butamben. Butamben also activated TRPA1 at millimolar concentrations...
  65. pmc Nociceptive and pro-inflammatory effects of dimethylallyl pyrophosphate via TRPV4 activation
    S Bang
    Korea University Graduate School of Medicine, Seoul, Korea
    Br J Pharmacol 166:1433-43. 2012
    ..and synthetic ligands for sensory TRPs have been identified, little is known about the endogenous activator for TRPV4. Recently, we reported that endogenous metabolites produced by the mevalonate pathway regulate the activities of ..
  66. pmc Evidence TRPV4 contributes to mechanosensitive ion channels in mouse skeletal muscle fibers
    Tiffany C Ho
    Department of Cellular and Molecular Pharmacology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Channels (Austin) 6:246-54. 2012
    ..Recordings from skeletal muscle isolated from TRPV4 knockout mice failed to show MS channel activity, consistent with a contribution of TRPV4...
  67. pmc Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation
    Liana Merrill
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:744-56. 2012
    ..transcriptional and translational plasticity of three transient receptor potential (TRP) channels (TRPA1, TRPV1, TRPV4) with established neuronal and non-neuronal expression and functional roles in the lower urinary tract...
  68. pmc TRPV4 activation in mouse submandibular gland modulates Ca2+ influx and salivation
    Yan Zhang
    Secretory Mechanisms and Dysfunction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 303:G1365-72. 2012
    Transient receptor potential vanilloid subtype 4 (TRPV4) is a ligand-gated nonselective cation channel that participates in the transduction of mechanical and osmotic stimuli in different tissues...
  69. pmc A TRPV4 channel C-terminal folding recognition domain critical for trafficking and function
    Lei Lei
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, Beijing 100191, China
    J Biol Chem 288:10427-39. 2013
    The Ca(2+)-permeable transient receptor potential vanilloid subtype 4 (TRPV4) channel mediates crucial physiological functions, such as calcium signaling, temperature sensing, and maintaining cell volume and energy homeostasis...
  70. pmc TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses
    Kathryn M Dunn
    Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 110:6157-62. 2013
    ..Transient receptor potential vanilloid 4 (TRPV4) channels--nonselective cation channels with considerable Ca(2+) conductance--have been identified in astrocytes, ..
  71. pmc Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C
    Mykola Mamenko
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 288:20306-14. 2013
    We have recently documented that the Ca(2+)-permeable TRPV4 channel, which is abundantly expressed in distal nephron cells, mediates cellular Ca(2+) responses to elevated luminal flow...
  72. ncbi Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress
    Hongshi Xu
    Division of Nephrology, Department of Medicine, Oregon Health and Science University and the Portland Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Biol Chem 278:11520-7. 2003
    The recently identified transient receptor potential (TRP) channel family member, TRPV4 (formerly known as OTRPC4, VR-OAC, TRP12, and VRL-2) is activated by hypotonicity...
  73. ncbi Warm temperatures activate TRPV4 in mouse 308 keratinocytes
    Man Kyo Chung
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:32037-46. 2003
    ..of ion channels have been identified that can be gated by increases in temperature into the warm (TRPV3 and TRPV4) or painfully hot (TRPV1 and TRPV2) range...
  74. ncbi Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)
    Makoto Suzuki
    Department of Pharmacology, Jichi Medical School 3311 1, Yakushiji, Minamikawachi, Tochigi, 329 0498, Japan
    J Biol Chem 278:51448-53. 2003
    ..Transient receptor potential vanilloid 4 (TRPV4) is a candidate in the calcium-permeable, swelling-activated mechanosensitive channel in heterogeneously expressed ..
  75. ncbi Hearing impairment in TRPV4 knockout mice
    Keiji Tabuchi
    Department of Otolaryngology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Neurosci Lett 382:304-8. 2005
    Transient receptor potential channel vanilloid subfamily 4 (TRPV4), a member of TRP family, is a mechanosensitive non-selective cation channel...
  76. ncbi A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery
    Xibao Liu
    Secretory Physiology Section, Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:15485-95. 2006
    ..of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water ..
  77. ncbi Bisandrographolide from Andrographis paniculata activates TRPV4 channels
    Paula L Smith
    Department of Cardiology, Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 281:29897-904. 2006
    ..of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant Andrographis paniculata potently activated TRPV4 channels...
  78. ncbi Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4
    Koji Shibasaki
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurosci 27:1566-75. 2007
    ..Here, we show that hippocampal neurons express functional transient receptor potential vanilloid 4 (TRPV4), one of the thermosensitive TRP (transient receptor potential) channels, and that TRPV4 is constitutively active ..
  79. ncbi TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs
    Kazutoshi Hamanaka
    Department of Physiology, College of Medicine, MSB 3074, University of South Alabama, 307 Univ Blvd, Mobile, AL 36688, USA
    Am J Physiol Lung Cell Mol Physiol 293:L923-32. 2007
    ..We hypothesized that the transient receptor potential vanilloid-4 (TRPV4) channel may initiate this acute permeability increase because endothelial calcium entry through TRPV4 channels ..
  80. ncbi Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation
    Shuji Muramatsu
    Laboratory for Drug Discovery, Research Center, Asahi Kasei Pharma Corp, 2 1 Samejima, Fuji, Shizuoka 416 8501, Japan
    J Biol Chem 282:32158-67. 2007
    ..Screening revealed that TRPV4 (transient receptor potential vanilloid 4), a cation channel molecule, significantly elevates SOX9-dependent ..
  81. pmc Marked attenuation of inflammatory mediator-induced C-fiber sensitization for mechanical and hypotonic stimuli in TRPV4-/- mice
    Xiaojie Chen
    Department of Anatomy, Division of Neuroscience, University of California, San Francisco, CA 94143, USA
    Mol Pain 3:31. 2007
    ..The transient receptor potential vanilloid 4 (TRPV4) ligand-gated ion channel has been implicated in the hyperalgesia for mechanical and osmotic stimuli associated ..
  82. doi Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3
    Dieter D'Hoedt
    Department of Physiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O and N 1, Herestraat 49 bus 802, Leuven, Belgium
    J Biol Chem 283:6272-80. 2008
    ..Taken together, these data suggest that PACSIN 3 acts as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-..
  83. pmc Shear stress regulates aquaporin-5 and airway epithelial barrier function
    Venkataramana K Sidhaye
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:3345-50. 2008
    ..These findings have direct relevance to the regulation of epithelial barrier function, membrane permeability, and water homeostasis in the respiratory epithelia...
  84. doi Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia
    Walter E B Sipe
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 0660, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1288-98. 2008
    ..We evaluated the role of the transient receptor potential vanilloid 4 (TRPV4) in PAR(2)-induced mechanical hyperalgesia of the mouse colon...
  85. doi Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms
    Nicolas Cenac
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 135:937-46, 946.e1-2. 2008
    The transient receptor potential vanilloid-4 (TRPV4) is an osmosensitive channel that responds to mechanical stimulation. We hypothesized that TRPV4 could be important in visceral nociception and in the development of hypersensitivity.
  86. doi Expression of transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 in mouse inner ear
    Takuya Ishibashi
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 128:1286-93. 2008
    ..It is suggested that transient receptor potential vanilloids (TRPVs) may play a functional role in cell physiology and TRPV-4 and -2 may play an important part in fluid homeostasis in the inner ear...
  87. pmc TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 121:2871-9. 2008
    ..by a point mutation within the crucial pore region of the channel, suggesting that GTTR permeates the TRPV4 channel. In an endolymph-like extracellular environment, clearance of GTTR was attenuated from KPT2-TRPV4 cells in a ..
  88. doi Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4
    S Casas
    Endocrinology and Diabetes Unit, Laboratory of Diabetes and Obesity, IDIBAPS Fundació Clínic, Hospital Clinic, Barcelona, Spain
    Diabetologia 51:2252-62. 2008
    ..To investigate the mechanism by which human islet amyloid polypeptide (hIAPP) fibril formation results in calcium influx across the plasma membrane of pancreatic beta cells, and its association with apoptosis...
  89. doi Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli
    Tomasz Wegierski
    Renal Division, University Hospital Freiburg, Freiburg, Germany
    J Biol Chem 284:2923-33. 2009
    ..potential (TRP) family members, yet their role in the regulation of the vanilloid subfamily member 4 protein (TRPV4) remains controversial. TRPV4 is a calcium-permeable channel activated by numerous physical and chemical stimuli...
  90. pmc Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
    Hongzhen Hu
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 106:1626-31. 2009
    ..b>TRPV4, a related thermoTRP, is 2-APB insensitive and has variant sequences at both residues identified here...
  91. pmc Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium
    Songwei Wu
    Center for Lung Biology and Dept of Pharmacology, Univ of South Alabama College of Medicine, Mobile, AL 36688 0002, USA
    Am J Physiol Lung Cell Mol Physiol 297:L650-7. 2009
    ..in mouse lung to address whether the alpha(1G) T-type Ca(2+) channel and the transient receptor potential channel TRPV4 have discrete functional roles in pulmonary capillary endothelium...
  92. pmc Functional characterization of transient receptor potential channels in mouse urothelial cells
    Wouter Everaerts
    Department of Molecular Cell Biology, Laboratory Ion Channel Research, Campus Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Physiol Renal Physiol 298:F692-701. 2010
    ..Urothelial cells from control and trpv4-/- mice were isolated, cultured (12-48 h), and used for quantitative real-time PCR, immunocytochemistry, calcium ..
  93. pmc A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation
    N Vergnolle
    INSERM, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Br J Pharmacol 159:1161-73. 2010
    ..Here, we investigated whether the osmosensitive channel, transient receptor potential vanilloid 4 (TRPV4), mediates inflammation to hypotonic stimuli by a neurogenic mechanism.
  94. pmc TRPV4 channels augment macrophage activation and ventilator-induced lung injury
    Kazutoshi Hamanaka
    Department of Physiology, University of South Alabama, Mobile, Alabama 36688, USA
    Am J Physiol Lung Cell Mol Physiol 299:L353-62. 2010
    We have previously implicated transient receptor potential vanilloid 4 (TRPV4) channels and alveolar macrophages in initiating the permeability increase in response to high peak inflation pressure (PIP) ventilation...
  95. pmc Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice
    Andrea L Clark
    Duke University Medical Center, Durham, North Carolina
    Arthritis Rheum 62:2973-83. 2010
    ..Transient receptor potential vanilloid 4 (TRPV4) is a Ca(++)-permeable ion channel that is highly expressed by articular chondrocytes and can be gated by osmotic ..
  96. doi Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice
    Emilie D'Aldebert
    INSERM Unité 563 Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Gastroenterology 140:275-85. 2011
    ..One family member, transient receptor potential vanilloid 4 (TRPV4), is activated by arachidonic acid derivatives that might be released on inflammation, yet its role in ..
  97. pmc The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells
    Daniel A Ryskamp
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, Interdepartmental Program in Neuroscience, and Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Neurosci 31:7089-101. 2011
    ..show that the mouse retina expresses mRNA and protein for the polymodal transient receptor potential vanilloid 4 (TRPV4) cation channel known to mediate osmotransduction and mechanotransduction...
  98. pmc PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells
    Ravi K Adapala
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272, USA
    Am J Physiol Heart Circ Physiol 301:H757-65. 2011
    Transient receptor potential vanilloid channel 4 (TRPV4) is a polymodally activated nonselective cationic channel implicated in the regulation of vasodilation and hypertension...
  99. ncbi Trp12, a novel Trp related protein from kidney
    U Wissenbach
    Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, D 66421 Homburg, Germany
    FEBS Lett 485:127-34. 2000
    A novel member of the transient receptor potential (Trp) family of ion channels, Trp12, was identified. The Trp12 mRNA is abundantly expressed in mouse kidney and encodes a protein of 871 amino acid residues...
  100. ncbi TRPV4 as osmosensor: a transgenic approach
    Wolfgang Liedtke
    Center for Translational Neuroscience, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Pflugers Arch 451:176-80. 2005
    The transient receptor potential vanilloid 4 (TRPV4) ion channel was named initially vanilloid-receptor-related osmotically activated channel (VR-OAC)...
  101. ncbi Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 282:12796-803. 2007
    b>TRPV4, a Ca(2+)-permeable member of the vanilloid subgroup of the transient receptor potential (TRP) channels, is activated by cell swelling and moderate heat (>27 degrees C) as well as by diverse chemical compounds including ..

Research Grants2

  1. Role of TRPV channels in pain and temperature sensation
    Michael Caterina; Fiscal Year: 2009
    ..Three related channels, TRPV2, TRPV3, and TRPV4, can also be activated by elevated temperatures and therefore may contribute to the detection of painful heat...
  2. Agonist-evoked changes in TRPV ion channel selectivity
    Michael J Caterina; Fiscal Year: 2011
    ..Several of these channels (TRPV1, TRPV3, TRPV4) have been shown to participate in heat-evoked pain sensation in mice...