Trpv4

Summary

Gene Symbol: Trpv4
Description: transient receptor potential cation channel, subfamily V, member 4
Alias: 0610033B08Rik, OTRPC4, Trp12, VR-OAC, VRL-2, VROAC, transient receptor potential cation channel subfamily V member 4, osm-9-like TRP channel 4, osmosensitive transient receptor potential channel 4, transient receptor potential protein 12, trpv4 channel, vanilloid receptor-like channel 2, vanilloid receptor-like protein 2, vanilloid receptor-related osmotically-activated channel
Species: mouse
Products:     Trpv4

Top Publications

  1. Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature. 2003;424:434-8 pubmed
    b>TRPV4 is a widely expressed cation channel of the 'transient receptor potential' (TRP) family that is related to the vanilloid receptor VR1 (TRPV1)...
  2. Watanabe H, Davis J, Smart D, Jerman J, Smith G, Hayes P, et al. Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002;277:13569-77 pubmed
    ..human VRL-2, and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the human and murine OTRPC4 channel...
  3. Gevaert T, Vriens J, Segal A, Everaerts W, Roskams T, Talavera K, et al. Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest. 2007;117:3453-62 pubmed
    ..we provide evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function...
  4. Alessandri Haber N, Dina O, Joseph E, Reichling D, Levine J. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J Neurosci. 2008;28:1046-57 pubmed publisher
    Although the transient receptor potential vanilloid 4 (TRPV4) has been implicated in the process of osmomechanical transduction, it appears to make little contribution to the normal somatosensory detection of mechanical stimuli...
  5. Gao X, Wu L, O Neil R. Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J Biol Chem. 2003;278:27129-37 pubmed
    ..It is concluded that temperature is a critical modulator of TRPV4 channel gating, leading to activation of the channel by a diverse range of microenvironmental chemical and physical ..
  6. Kinsman B, Cowles J, Lay J, Simmonds S, Browning K, Stocker S. Osmoregulatory thirst in mice lacking the transient receptor potential vanilloid type 1 (TRPV1) and/or type 4 (TRPV4) receptor. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1092-100 pubmed publisher
    ..is mediated by products of the genes encoding the transient receptor potential vanilloid-1 (TRPV1) or vanilloid-4 (TRPV4) channel...
  7. Brierley S, Page A, Hughes P, Adam B, Liebregts T, Cooper N, et al. Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology. 2008;134:2059-69 pubmed publisher
    ..that underlies their specialized mechanosensory function: the transient receptor potential channel, vanilloid 4 (TRPV4)...
  8. Chung M, Lee H, Mizuno A, Suzuki M, Caterina M. TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem. 2004;279:21569-75 pubmed
    ..Two of these proteins, TRPV3 and TRPV4, are ion channels activated by modest increases in ambient temperature...
  9. Ye L, Kleiner S, Wu J, Sah R, Gupta R, Banks A, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012;151:96-110 pubmed publisher
    ..In particular, TRPV4 negatively regulated the expression of PGC1?, UCP1, and cellular respiration...
  10. Suzuki M, Watanabe Y, Oyama Y, Mizuno A, Kusano E, Hirao A, et al. Localization of mechanosensitive channel TRPV4 in mouse skin. Neurosci Lett. 2003;353:189-92 pubmed
    ..The distribution suggests that the sensation of pressure by mechanosensitive TRPV4 channel is transmitted through A- as well as C-fiber.

Detail Information

Publications73

  1. Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature. 2003;424:434-8 pubmed
    b>TRPV4 is a widely expressed cation channel of the 'transient receptor potential' (TRP) family that is related to the vanilloid receptor VR1 (TRPV1)...
  2. Watanabe H, Davis J, Smart D, Jerman J, Smith G, Hayes P, et al. Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002;277:13569-77 pubmed
    ..human VRL-2, and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the human and murine OTRPC4 channel...
  3. Gevaert T, Vriens J, Segal A, Everaerts W, Roskams T, Talavera K, et al. Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest. 2007;117:3453-62 pubmed
    ..we provide evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function...
  4. Alessandri Haber N, Dina O, Joseph E, Reichling D, Levine J. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J Neurosci. 2008;28:1046-57 pubmed publisher
    Although the transient receptor potential vanilloid 4 (TRPV4) has been implicated in the process of osmomechanical transduction, it appears to make little contribution to the normal somatosensory detection of mechanical stimuli...
  5. Gao X, Wu L, O Neil R. Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J Biol Chem. 2003;278:27129-37 pubmed
    ..It is concluded that temperature is a critical modulator of TRPV4 channel gating, leading to activation of the channel by a diverse range of microenvironmental chemical and physical ..
  6. Kinsman B, Cowles J, Lay J, Simmonds S, Browning K, Stocker S. Osmoregulatory thirst in mice lacking the transient receptor potential vanilloid type 1 (TRPV1) and/or type 4 (TRPV4) receptor. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1092-100 pubmed publisher
    ..is mediated by products of the genes encoding the transient receptor potential vanilloid-1 (TRPV1) or vanilloid-4 (TRPV4) channel...
  7. Brierley S, Page A, Hughes P, Adam B, Liebregts T, Cooper N, et al. Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology. 2008;134:2059-69 pubmed publisher
    ..that underlies their specialized mechanosensory function: the transient receptor potential channel, vanilloid 4 (TRPV4)...
  8. Chung M, Lee H, Mizuno A, Suzuki M, Caterina M. TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem. 2004;279:21569-75 pubmed
    ..Two of these proteins, TRPV3 and TRPV4, are ion channels activated by modest increases in ambient temperature...
  9. Ye L, Kleiner S, Wu J, Sah R, Gupta R, Banks A, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012;151:96-110 pubmed publisher
    ..In particular, TRPV4 negatively regulated the expression of PGC1?, UCP1, and cellular respiration...
  10. Suzuki M, Watanabe Y, Oyama Y, Mizuno A, Kusano E, Hirao A, et al. Localization of mechanosensitive channel TRPV4 in mouse skin. Neurosci Lett. 2003;353:189-92 pubmed
    ..The distribution suggests that the sensation of pressure by mechanosensitive TRPV4 channel is transmitted through A- as well as C-fiber.
  11. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant T. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol. 2000;2:695-702 pubmed
    ..Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart...
  12. Watanabe H, Vriens J, Suh S, Benham C, Droogmans G, Nilius B. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem. 2002;277:47044-51 pubmed
    We have compared activation by heat of TRPV4 channels, heterogeneously expressed in HEK293 cells, and endogenous channels in mouse aorta endothelium (MAEC)...
  13. Berrout J, Jin M, Mamenko M, Zaika O, Pochynyuk O, O Neil R. Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system. J Biol Chem. 2012;287:8782-91 pubmed publisher
    The TRPV4 Ca(2+)-permeable channel is sensitive to mechanical stimuli...
  14. Cuajungco M, Grimm C, Oshima K, D hoedt D, Nilius B, Mensenkamp A, et al. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem. 2006;281:18753-62 pubmed
    b>TRPV4 is a cation channel that responds to a variety of stimuli including mechanical forces, temperature, and ligand binding...
  15. Sonkusare S, Bonev A, Ledoux J, Liedtke W, Kotlikoff M, Heppner T, et al. Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science. 2012;336:597-601 pubmed publisher
    ..in the vascular endothelium of resistance arteries that represent Ca(2+) influx through single TRPV4 cation channels...
  16. Sokabe T, Fukumi Tominaga T, Yonemura S, Mizuno A, Tominaga M. The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem. 2010;285:18749-58 pubmed publisher
    Transient receptor potential vanilloid 4 (TRPV4) channel is a physiological sensor for hypo-osmolarity, mechanical deformation, and warm temperature. The channel activation leads to various cellular effects involving Ca(2+) dynamics...
  17. Grant A, Cottrell G, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, et al. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol. 2007;578:715-33 pubmed
    ..mechanical hyperalgesia requires sensitization of the ion channel transient receptor potential vanilloid 4 (TRPV4)...
  18. Nilius B, Vriens J, Prenen J, Droogmans G, Voets T. TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol. 2004;286:C195-205 pubmed
    ..b>TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is ..
  19. Stewart A, Smith G, Sandford R, Edwardson J. Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer. Biophys J. 2010;99:790-7 pubmed publisher
    ..polycystin-2 (TRPP2) interacts with two other members of the transient receptor potential (TRP) family, TRPC1 and TRPV4. We have previously shown that TRPP2 forms a heteromeric complex with TRPC1, with a 2:2 stoichiometry and an ..
  20. Wu L, Gao X, Brown R, Heller S, O Neil R. Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. Am J Physiol Renal Physiol. 2007;293:F1699-713 pubmed
    Gain/loss of function studies were utilized to assess the potential role of the endogenous vanilloid receptor TRPV4 as a sensor of flow and osmolality in M-1 collecting duct cells (CCD)...
  21. Todaka H, Taniguchi J, Satoh J, Mizuno A, Suzuki M. Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia. J Biol Chem. 2004;279:35133-8 pubmed
    ..Animals sense various ranges of temperatures by cutaneous thermal stimuli. Transient receptor potential vanilloid 4 (TRPV4) is a cation channel activated at a warm temperature (over 30 degrees C) in exogenously expressed cells...
  22. Zhang D, Mendoza S, Bubolz A, Mizuno A, Ge Z, Li R, et al. Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension. 2009;53:532-8 pubmed publisher
    ..The transient receptor potential vanilloid type 4 (TRPV4) channel, a Ca2+-permeant cation channel, is expressed in endothelial cells and involved in the regulation of ..
  23. Casas S, Novials A, Reimann F, Gomis R, Gribble F. Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia. 2008;51:2252-62 pubmed publisher
    ..001). By RT-PCR, we detected expression of the mechanosensitive TRP cation channel subfamily V member 4 (Trpv4) in MIN6 cells and mouse pancreas...
  24. Kusudo T, Wang Z, Mizuno A, Suzuki M, Yamashita H. TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity. J Appl Physiol (1985). 2012;112:1223-32 pubmed publisher
    Transient receptor potential channel V4 (TRPV4) functions as a nonselective cation channel in various cells and plays physiological roles in osmotic and thermal sensation. However, the function of TRPV4 in energy metabolism is unknown...
  25. Pritschow B, Lange T, Kasch J, Kunert Keil C, Liedtke W, Brinkmeier H. Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue. Pflugers Arch. 2011;461:115-22 pubmed publisher
    ..Here we show that TRPV4, an osmo-sensitive cation channel of the vanilloid subfamily of TRP channels is functionally expressed in mouse ..
  26. Suzuki M, Mizuno A, Kodaira K, Imai M. Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003;278:22664-8 pubmed
    ..However, the mouse still retained olfaction, taste sensation, and heat avoidance. The TRPV4 channel expressed in vitro in Chinese hamster ovary cells was opened by low pH, citrate, and inflation but not by heat ..
  27. Reiter B, Kraft R, Gunzel D, Zeissig S, Schulzke J, Fromm M, et al. TRPV4-mediated regulation of epithelial permeability. FASEB J. 2006;20:1802-12 pubmed
    b>TRPV4 is a calcium-permeable channel activated by extracellular hypotonicity, polyunsaturated fatty acids, phorbol esters, and heat. We show that TRPV4 is localized in the basolateral membrane of the mouse mammary cell line HC11...
  28. Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, et al. Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res. 2005;97:908-15 pubmed
    b>TRPV4 is a broadly expressed Ca2+-permeable cation channel in the vanilloid subfamily of transient receptor potential channels...
  29. Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B. Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A. 2004;101:396-401 pubmed
    b>TRPV4 is a Ca(2+)- and Mg(2+)-permeable cation channel within the vanilloid receptor subgroup of the transient receptor potential (TRP) family, and it has been implicated in Ca(2+)-dependent signal transduction in several tissues, ..
  30. Lee H, Iida T, Mizuno A, Suzuki M, Caterina M. Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci. 2005;25:1304-10 pubmed
    Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4-/- mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia...
  31. Wegierski T, Hill K, Schaefer M, Walz G. The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J. 2006;25:5659-69 pubmed
    b>TRPV4 is a widely expressed member of the transient receptor potential (TRP) family that facilitates Ca(2+) entry into nonexcitable cells...
  32. Liedtke W, Friedman J. Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A. 2003;100:13698-703 pubmed
    ..The transient receptor potential channel, vanilloid subfamily (TRPV4), is an osmotically activated ion channel that is expressed in circumventricular organs in the mammalian CNS, ..
  33. Ryskamp D, Witkovsky P, Barabas P, Huang W, Koehler C, Akimov N, et al. The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. J Neurosci. 2011;31:7089-101 pubmed publisher
    ..show that the mouse retina expresses mRNA and protein for the polymodal transient receptor potential vanilloid 4 (TRPV4) cation channel known to mediate osmotransduction and mechanotransduction...
  34. Mendoza S, Fang J, Gutterman D, Wilcox D, Bubolz A, Li R, et al. TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol. 2010;298:H466-76 pubmed publisher
    ..shear was observed to produce rapid Ca(2+) influx in endothelial cells, which was markedly inhibited by the TRPV4 channel blocker ruthenium red and TRPV4-specific short interfering RNA...
  35. Benfenati V, Caprini M, Dovizio M, Mylonakou M, Ferroni S, Ottersen O, et al. An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Proc Natl Acad Sci U S A. 2011;108:2563-8 pubmed publisher
    ..Here we show that a complex containing aquaporin-4 (AQP4) and transient receptor potential vanilloid 4 (TRPV4) is essential for RVD in astrocytes...
  36. Jin M, Berrout J, Chen L, O Neil R. Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+-activated K+ channels. Cell Calcium. 2012;51:131-9 pubmed publisher
    ..It is concluded that a synergistic cross-talk exists between the TRPV4 channel and SK3 and BK-? channels to provide a tight functional regulation between the channel groups...
  37. Taniguchi J, Tsuruoka S, Mizuno A, Sato J, Fujimura A, Suzuki M. TRPV4 as a flow sensor in flow-dependent K+ secretion from the cortical collecting duct. Am J Physiol Renal Physiol. 2007;292:F667-73 pubmed
    The transient receptor vanilloid-4 (TRPV4) is a mechanosensitive, swell-activated cation channel that is abundant in the renal distal tubules...
  38. Mochizuki T, Sokabe T, Araki I, Fujishita K, Shibasaki K, Uchida K, et al. The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures. J Biol Chem. 2009;284:21257-64 pubmed publisher
    ..In this study, we investigated the role of transient receptor potential vanilloid 4 (TRPV4) channels in a stretch sensing mechanism in mouse primary urothelial cell cultures...
  39. Everaerts W, Zhen X, Ghosh D, Vriens J, Gevaert T, Gilbert J, et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A. 2010;107:19084-9 pubmed publisher
    ..Recent work has demonstrated that the cation channel TRPV4 is highly expressed in urothelial cells and plays a role in sensing the normal filling state of the bladder...
  40. Lechner S, Markworth S, Poole K, Smith E, Lapatsina L, Frahm S, et al. The molecular and cellular identity of peripheral osmoreceptors. Neuron. 2011;69:332-44 pubmed publisher
    ..In mice lacking the osmotically activated ion channel, TRPV4, hepatic sensory neurons no longer exhibit osmosensitive inward currents and activation of peripheral ..
  41. Earley S, Pauyo T, Drapp R, Tavares M, Liedtke W, Brayden J. TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. Am J Physiol Heart Circ Physiol. 2009;297:H1096-102 pubmed publisher
    Transient receptor potential vanilloid 4 (TRPV4) channels have been implicated as mediators of calcium influx in both endothelial and vascular smooth muscle cells and are potentially important modulators of vascular tone...
  42. Teilmann S, Byskov A, Pedersen P, Wheatley D, Pazour G, Christensen S. Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev. 2005;71:444-52 pubmed
    ..Further, the Ca2+ permeable cation channel, TRP vaniloid 4 (TRPV4), localizes to a sub-population of motile cilia on the epithelial cells of the ampulla and isthmus with high ..
  43. Liedtke W, Choe Y, Martí Renom M, Bell A, Denis C, Sali A, et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell. 2000;103:525-35 pubmed
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells. ..
  44. Gradilone S, Masyuk A, Splinter P, Banales J, Huang B, Tietz P, et al. Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A. 2007;104:19138-43 pubmed
    ..b>TRPV4, a Ca(2+)-permeable ion channel, has been implicated in signal transduction of osmotic stimuli...
  45. Voets T, Prenen J, Vriens J, Watanabe H, Janssens A, Wissenbach U, et al. Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem. 2002;277:33704-10 pubmed
    We have studied the molecular determinants of ion permeation through the TRPV4 channel (VRL-2, TRP12, VR-OAC, and OTRPC4)...
  46. Alvarez D, King J, Weber D, Addison E, Liedtke W, Townsley M. Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circ Res. 2006;99:988-95 pubmed
    ..We hypothesized that activation of the vanilloid transient receptor potential channel TRPV4 disrupts the alveolar septal barrier...
  47. Alessandri Haber N, Dina O, Joseph E, Reichling D, Levine J. A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J Neurosci. 2006;26:3864-74 pubmed
    The transient receptor potential vanilloid 4 (TRPV4) is a primary afferent transducer that plays a crucial role in neuropathic hyperalgesia for osmotic and mechanical stimuli, as well as in inflammatory mediator-induced hyperalgesia for ..
  48. Mihara H, Boudaka A, Sugiyama T, Moriyama Y, Tominaga M. Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J Physiol. 2011;589:3471-82 pubmed publisher
    ..Transient receptor potential channel vanilloid 4 (TRPV4) can detect various stimuli such as warm temperature, stretch and some chemicals, including 4?-phorbol 12,13-..
  49. Alessandri Haber N, Dina O, Chen X, Levine J. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci. 2009;29:6217-28 pubmed publisher
    The transient receptor potential vanilloid 4 (TRPV4) contributes to mechanical hyperalgesia of diverse etiologies, presumably as part of a mechanoreceptor signaling complex (Alessandri-Haber et al., 2008)...
  50. Mizuno A, Matsumoto N, Imai M, Suzuki M. Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol. 2003;285:C96-101 pubmed
    The Ca2+-permeable cation channel TRPV4, which is part of the Trp family located in the circumventricular organs, is activated by cell swelling...
  51. Köttgen M, Buchholz B, Garcia Gonzalez M, Kotsis F, Fu X, Doerken M, et al. TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol. 2008;182:437-47 pubmed publisher
    ..We find here that TRPP2 utilizes TRPV4 to form a mechano- and thermosensitive molecular sensor in the cilium...
  52. Arora P, Di Gregorio M, He P, McCulloch C. TRPV4 mediates the Ca2+ influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling. J Cell Sci. 2017;130:2196-2208 pubmed publisher
    ..We conclude that Ca2+ influx through the TRPV4 channel regulates FliI-NMMIIA interaction, which in turn enables generation of the cell extensions essential for ..
  53. Henry C, Dalloneau E, Pérez Berezo M, Plata C, Wu Y, Guillon A, et al. In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016;311:L664-75 pubmed publisher
    ..Here, we focused on the potential role of "transient receptor potential vanilloid-4" (TRPV4), a nonselective calcium channel...
  54. Jo A, Ryskamp D, Phuong T, Verkman A, Yarishkin O, MacAulay N, et al. TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. J Neurosci. 2015;35:13525-37 pubmed publisher
    ..cooperation between the glial water channel aquaporin 4 (AQP4) and the transient receptor potential isoform 4 (TRPV4), a polymodal swelling-sensitive cation channel...
  55. Sonkusare S, Dalsgaard T, Bonev A, Hill Eubanks D, Kotlikoff M, Scott J, et al. AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension. Sci Signal. 2014;7:ra66 pubmed publisher
    ..b>TRPV4 channels play a major role in endothelial-dependent vasodilation, a function mediated by local Ca(2+) influx ..
  56. Wang Y, Fu X, Gaiser S, Köttgen M, Kramer Zucker A, Walz G, et al. OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. J Biol Chem. 2007;282:36561-70 pubmed
    ..expressed endoplasmic reticulum (ER)-associated protein, interacts with the cytosolic N-terminal tail of TRPV4. Using a combination of co-expression and knockdown approaches we have found that OS-9 impedes the release of ..
  57. Masuyama R, Vriens J, Voets T, Karashima Y, Owsianik G, Vennekens R, et al. TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab. 2008;8:257-65 pubmed publisher
    ..However, the Ca(2+) channels involved remain largely unidentified. Here we show that genetic ablation in mice of Trpv4, a Ca(2+)-permeable channel of the transient receptor potential (TRP) family, increases bone mass by impairing ..
  58. Ma X, Cheng K, Wong C, O Neil R, Birnbaumer L, Ambudkar I, et al. Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells. Cell Calcium. 2011;50:502-9 pubmed publisher
    ..Our recent study has demonstrated that TRPC1 forms heteromeric channels with TRPV4 in vascular endothelial cells and that Ca(2+) store depletion enhances the vesicle trafficking of heteromeric ..
  59. Ma X, Qiu S, Luo J, Ma Y, Ngai C, Shen B, et al. Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol. 2010;30:851-8 pubmed publisher
    The present study is aimed at investigating the interaction of TRPV4 with TRPC1 and the functional role of such an interaction in flow-induced Ca(2+) influx...
  60. Jie P, Hong Z, Tian Y, Li Y, Lin L, Zhou L, et al. Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways. Cell Death Dis. 2015;6:e1775 pubmed publisher
    Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that is sensitive to cell swelling, arachidonic acid and its metabolites, epoxyeicosatrienoic acids, which are associated with cerebral ischemia...
  61. Ceppa E, Cattaruzza F, Lyo V, Amadesi S, Pelayo J, Poole D, et al. Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2010;299:G556-71 pubmed publisher
    ..We report a major role for TRPV4, which detects osmotic pressure and arachidonic acid metabolites, and TRPA1, which responds to 4-hydroxynonenal ..
  62. Sakuta H, Nishihara E, Hiyama T, Lin C, Noda M. Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation. Am J Physiol Regul Integr Comp Physiol. 2016;311:R299-306 pubmed publisher
    ..sodium (Na(+)) level sensor in the brain, and the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 have been proposed to function as osmosensors...
  63. Mamenko M, Zaika O, Jin M, O Neil R, Pochynyuk O. Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron. PLoS ONE. 2011;6:e22824 pubmed publisher
    ..We further demonstrated that activation of mechano-sensitive TRPV4 channel plays a major role in the sustained [Ca(2+)](i) elevation during purinergic stimulation...
  64. Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis N, Jensen D, et al. Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. J Biol Chem. 2014;289:27215-34 pubmed publisher
    ..Cat-S caused PAR2-dependent activation of transient receptor potential vanilloid 4 (TRPV4) in Xenopus laevis oocytes, HEK cells and nociceptive neurons, and stimulated neuronal hyperexcitability by ..
  65. Hamanaka K, Jian M, Weber D, Alvarez D, Townsley M, Al Mehdi A, et al. TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2007;293:L923-32 pubmed
    ..We hypothesized that the transient receptor potential vanilloid-4 (TRPV4) channel may initiate this acute permeability increase because endothelial calcium entry through TRPV4 channels ..
  66. Clark A, Votta B, Kumar S, Liedtke W, Guilak F. Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis Rheum. 2010;62:2973-83 pubmed publisher
    ..Transient receptor potential vanilloid 4 (TRPV4) is a Ca(++)-permeable ion channel that is highly expressed by articular chondrocytes and can be gated by osmotic ..
  67. Aijima R, Wang B, Takao T, Mihara H, Kashio M, Ohsaki Y, et al. The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia. FASEB J. 2015;29:182-92 pubmed publisher
    ..We identified TRPV3 as an essential receptor in heat-induced oral epithelia proliferation and wound healing. Our findings suggest that TRPV3 activation could be a potential therapeutic target for wound healing in skin and oral mucosa. ..
  68. Merrill L, Girard B, May V, Vizzard M. Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation. J Mol Neurosci. 2012;48:744-56 pubmed
    ..transcriptional and translational plasticity of three transient receptor potential (TRP) channels (TRPA1, TRPV1, TRPV4) with established neuronal and non-neuronal expression and functional roles in the lower urinary tract...
  69. Mola M, Sparaneo A, Gargano C, Spray D, Svelto M, Frigeri A, et al. The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins. Glia. 2016;64:139-54 pubmed publisher
    ..inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium...
  70. Gradilone S, Masyuk T, Huang B, Banales J, Lehmann G, Radtke B, et al. Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD. Gastroenterology. 2010;139:304-14.e2 pubmed publisher
    ..We recently showed transient receptor potential vanilloid 4 (Trpv4), a calcium-entry channel, is expressed in normal cholangiocytes and its activation leads to [Ca(2+)](i) increase...
  71. Hamanaka K, Jian M, Townsley M, King J, Liedtke W, Weber D, et al. TRPV4 channels augment macrophage activation and ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2010;299:L353-62 pubmed publisher
    We have previously implicated transient receptor potential vanilloid 4 (TRPV4) channels and alveolar macrophages in initiating the permeability increase in response to high peak inflation pressure (PIP) ventilation...
  72. Luo N, Conwell M, Chen X, Kettenhofen C, Westlake C, Cantor L, et al. Primary cilia signaling mediates intraocular pressure sensation. Proc Natl Acad Sci U S A. 2014;111:12871-6 pubmed publisher
    ..The interaction of OCRL with transient receptor potential vanilloid 4 (TRPV4), a ciliary mechanosensory channel, suggests that OCRL may act through regulation of this channel...