Trpv2

Summary

Gene Symbol: Trpv2
Description: transient receptor potential cation channel, subfamily V, member 2
Alias: GRC, OTRPC2, VRL-1, Vrl1, transient receptor potential cation channel subfamily V member 2, growth factor regulated channel, growth factor-regulated calcium channel, osm-9-like TRP channel 2, vanilloid receptor-like protein 1
Species: mouse
Products:     Trpv2

Top Publications

  1. Zanou N, Iwata Y, Schakman O, Lebacq J, Wakabayashi S, Gailly P. Essential role of TRPV2 ion channel in the sensitivity of dystrophic muscle to eccentric contractions. FEBS Lett. 2009;583:3600-4 pubmed publisher
    ..muscles are largely protected from eccentric work-induced damage by overexpressing a dominant negative mutant of TRPV2 ion channel...
  2. Kanzaki M, Zhang Y, Mashima H, Li L, Shibata H, Kojima I. Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat Cell Biol. 1999;1:165-70 pubmed
    ..This channel, which we name growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular pools under basal conditions...
  3. Boels K, Glassmeier G, Herrmann D, Riedel I, Hampe W, Kojima I, et al. The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC. J Cell Sci. 2001;114:3599-606 pubmed
    ..Ca(2+) influx for which, as we show in this paper, the growth-factor-regulated Ca(2+)-permeable cation channel, GRC, is responsible. GRC is a member of the transient receptor potential channel family...
  4. Caterina M, Rosen T, Tominaga M, Brake A, Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999;398:436-41 pubmed
    ..We propose that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities. ..
  5. Monet M, Gkika D, Lehen kyi V, Pourtier A, Vanden Abeele F, Bidaux G, et al. Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009;1793:528-39 pubmed publisher
    ..role, the mechanisms of activation, as well as the endogenous regulators for the non-selective cationic channel TRPV2 are not known so far...
  6. Yamashiro K, Sasano T, Tojo K, Namekata I, Kurokawa J, Sawada N, et al. Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem Biophys Res Commun. 2010;398:284-9 pubmed publisher
    ..RT-PCR and immunoblot analyses showed that TRPV2 is the sole member of TRPV family expressed in macrophages...
  7. Park U, Vastani N, Guan Y, Raja S, Koltzenburg M, Caterina M. TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J Neurosci. 2011;31:11425-36 pubmed publisher
    TRP vanilloid 2 (TRPV2) is a nonselective cation channel expressed prominently in medium- to large-diameter sensory neurons that can be activated by extreme heat (>52°C)...
  8. Iwata Y, Katanosaka Y, Arai Y, Shigekawa M, Wakabayashi S. Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models. Hum Mol Genet. 2009;18:824-34 pubmed publisher
    ..6 hamsters by dominant-negative inhibition of the transient receptor potential cation channel, TRPV2, a principal candidate for Ca(2+)-entry pathways...
  9. Laragione T, Cheng K, Tanner M, He M, Beeton C, Al Abed Y, et al. The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. Clin Immunol. 2015;158:183-92 pubmed publisher
    ..synoviocytes (FLS) have a central role in joint damage and express increased levels of the cation channel Trpv2. We aimed at determining the role of Trpv2 in arthritis...

More Information

Publications49

  1. Kurth F, Franco Obregón A, Casarosa M, Küster S, Wuertz Kozak K, Dittrich P. Transient receptor potential vanilloid 2-mediated shear-stress responses in C2C12 myoblasts are regulated by serum and extracellular matrix. FASEB J. 2015;29:4726-37 pubmed publisher
    ..shear stress with increments in cytosolic calcium that are largely initiated by the mechanosensitive opening of TRPV2 channels. Response to fluid flow was augmented by growth in low extracellular serum concentration (5 vs...
  2. Lorin C, Vögeli I, Niggli E. Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage. Cardiovasc Res. 2015;106:153-62 pubmed publisher
    ..Our aim was to investigate whether transient receptor potential vanilloid channels type 2 (TRPV2) form subunits of the dysregulated SACs in cardiac dystrophy...
  3. Iwata Y, Ohtake H, Suzuki O, Matsuda J, Komamura K, Wakabayashi S. Blockade of sarcolemmal TRPV2 accumulation inhibits progression of dilated cardiomyopathy. Cardiovasc Res. 2013;99:760-8 pubmed publisher
    ..The transient receptor potential vanilloid 2 (TRPV2) has been previously suggested as a candidate pathway for enhanced Ca(2+) entry...
  4. Nagasawa M, Kojima I. Translocation of calcium-permeable TRPV2 channel to the podosome: Its role in the regulation of podosome assembly. Cell Calcium. 2012;51:186-93 pubmed publisher
    The present study was conducted to investigate localization and function of TRPV2 channel in a mouse macrophage cell line, TtT/M87. We infected an adenovirus vector encoding TRPV2 tagged with c-Myc in the extracellular domain...
  5. Sun W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, et al. Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue. EMBO Rep. 2016;17:383-99 pubmed publisher
    ..Transient receptor potential vanilloid 2 (TRPV2), a Ca(2+)-permeable non-selective cation channel, plays vital roles in the regulation of various cellular ..
  6. Jahnel R, Bender O, Münter L, Dreger M, Gillen C, Hucho F. Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression. Eur J Biochem. 2003;270:4264-71 pubmed
    The vanilloid-like TRP-channel VRL-1 (TRPV2) is a nonselective cation channel expressed by primary sensory neurons and non-neuronal tissues [Caterina, M.J., Rosen, T.A., Tominaga, M., Brake, A.J and Julius, D. (1999) Nature 398, 436-441]...
  7. Mihara H, Suzuki N, Yamawaki H, Tominaga M, Sugiyama T. TRPV2 ion channels expressed in inhibitory motor neurons of gastric myenteric plexus contribute to gastric adaptive relaxation and gastric emptying in mice. Am J Physiol Gastrointest Liver Physiol. 2013;304:G235-40 pubmed publisher
    ..the underlying molecular mechanism of GAR is poorly understood, transient receptor potential channel vanilloid 2 (TRPV2) mechano- and chemoreceptors are expressed in mouse intestinal inhibitory motor neurons and are involved in ..
  8. Harada K, Kitaguchi T, Kamiya T, Aung K, Nakamura K, Ohta K, et al. Lysophosphatidylinositol-induced activation of the cation channel TRPV2 triggers glucagon-like peptide-1 secretion in enteroendocrine L cells. J Biol Chem. 2017;292:10855-10864 pubmed publisher
    ..Of note, blockage or silencing of transient receptor potential cation channel subfamily V member 2 (TRPV2) channels suppressed both the LPI-induced [Ca2+] i..
  9. Peier A, Reeve A, Andersson D, Moqrich A, Earley T, Hergarden A, et al. A heat-sensitive TRP channel expressed in keratinocytes. Science. 2002;296:2046-9 pubmed
    ..TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons...
  10. Shibasaki K, Murayama N, Ono K, Ishizaki Y, Tominaga M. TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J Neurosci. 2010;30:4601-12 pubmed publisher
    ..Interestingly, TRPV2 expression was detected in spinal motor neurons in addition to the dorsal root ganglia from embryonic day 10...
  11. Woodbury C, Zwick M, Wang S, Lawson J, Caterina M, Koltzenburg M, et al. Nociceptors lacking TRPV1 and TRPV2 have normal heat responses. J Neurosci. 2004;24:6410-5 pubmed
    ..Moreover, in TRPV1(-/-) mice, 82% of heat-responsive neurons did not express immunoreactivity for TRPV2, another putative noxious heat channel.
  12. Chen C, Broom D, Liu Y, de Nooij J, Li Z, Cen C, et al. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006;49:365-77 pubmed
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy. ..
  13. Matsui H, Noguchi T, Takakusaki K, Kashiwayanagi M. Co-localization of TRPV2 and insulin-like growth factor-I receptor in olfactory neurons in adult and fetal mouse. Biol Pharm Bull. 2014;37:1907-12 pubmed
    b>TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat...
  14. Ren A, Wang K, Zhang H, Liu A, Ma X, Liang Q, et al. ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Nat Commun. 2014;5:4984 pubmed publisher
    ..Our findings point to ZBTB20 as a critical regulator of nociception and pain sensation by modulating TRP channels expression in nociceptors. ..
  15. Rubinstein J, Lasko V, Koch S, Singh V, Carreira V, Robbins N, et al. Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. Am J Physiol Heart Circ Physiol. 2014;306:H574-84 pubmed publisher
    ..the regulation of cardiovascular function, but only recently has our laboratory described the vanilloid-2 subtype (TRPV2) in the cardiomyocyte, though its exact mechanism of action has not yet been established...
  16. Shibasaki K, Ishizaki Y, Mandadi S. Astrocytes express functional TRPV2 ion channels. Biochem Biophys Res Commun. 2013;441:327-32 pubmed publisher
    ..Among them, TRPV2 has an interesting characteristic of being activated by very high temperature (>52 °C)...
  17. Hu H, Gu Q, Wang C, Colton C, Tang J, Kinoshita Kawada M, et al. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem. 2004;279:35741-8 pubmed
    ..Among the six TRPV members, TRPV1, TRPV2, TRPV3, and TRPV4 form heat-activated cation channels, which serve diverse functions ranging from nociception to ..
  18. Naticchioni M, Karani R, Smith M, Onusko E, Robbins N, Jiang M, et al. Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise. PLoS ONE. 2015;10:e0136901 pubmed publisher
    ..Our laboratory has previously found that the stretch sensitive TRPV2 channels are active regulators of calcium handling and cardiac function under baseline conditions based on our ..
  19. Tamura S, Morikawa Y, Senba E. TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neuroscience. 2005;130:223-8 pubmed
    b>TRPV2, a member of transient receptor potential ion channels, responds to high-threshold noxious heat, but neither to capsaicin nor to proton...
  20. Hisanaga E, Nagasawa M, Ueki K, Kulkarni R, Mori M, Kojima I. Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes. 2009;58:174-84 pubmed publisher
    Calcium-permeable cation channel TRPV2 is expressed in pancreatic beta-cells. We investigated regulation and function of TRPV2 in beta-cells...
  21. Ahmed M, Takumida M, Ishibashi T, Hamamoto T, Hirakawa K. Expression of transient receptor potential vanilloid (TRPV) families 1, 2, 3 and 4 in the mouse olfactory epithelium. Rhinology. 2009;47:242-7 pubmed
    ..TRPVs in respiratory mucosa may play a significant role in nasal nociception, ciliary movement and the regulation of mucous secretion...
  22. Entin Meer M, Cohen L, Hertzberg Bigelman E, Levy R, Ben Shoshan J, Keren G. TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages. PLoS ONE. 2017;12:e0177132 pubmed publisher
    We have recently shown that the expression of the transient receptor potential vanilloid 2 channel, TRPV2, is upregulated in the peri-infarct zone 3-5 days following an acute myocardial infarction (AMI)...
  23. Aoyagi K, Ohara Imaizumi M, Nishiwaki C, Nakamichi Y, Nagamatsu S. Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic ?-cells. Biochem J. 2010;432:375-86 pubmed publisher
    ..exocytotic response induced by insulin were accompanied by the translocation of the Ca2+-permeable channel TrpV2 (transient receptor potential V2) in a PI3K-dependent manner...
  24. Barro Soria R, Stindl J, Müller C, Foeckler R, Todorov V, Castrop H, et al. Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel. PLoS ONE. 2012;7:e49624 pubmed publisher
    ..in its AT1R form, angiotensin-receptor-associated protein (Atrap), and transient-receptor-potential channel-V2 (TRPV2). AT1R and Atrap co-localize to the basolateral membrane of the RPE, as shown by immunostaining...
  25. Issa C, Hambly B, Wang Y, Maleki S, Wang W, Fei J, et al. TRPV2 in the development of experimental colitis. Scand J Immunol. 2014;80:307-12 pubmed publisher
    ..Using a DSS-induced colitis mouse model, the function of TRPV2 in the development of colitis was investigated, utilizing TRPV2(-/-) and Wt mice...
  26. Kajiya H, Okamoto F, Nemoto T, Kimachi K, Toh Goto K, Nakayana S, et al. RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations. Cell Calcium. 2010;48:260-9 pubmed publisher
    ..Using a DNA microarray, we found that Transient Receptor Potential Vanilloid channels 2 (TRPV2) are expressed significantly in RANKL-treated RAW264.7 cells (preosteoclasts) compared to untreated cells...
  27. Koch S, Gao X, Haar L, Jiang M, Lasko V, Robbins N, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012;53:134-44 pubmed publisher
    ..It has recently been found to be a potent agonist of transient receptor potential vanilloid 2 (TRPV2). We have shown that this receptor is in the cardiomyocyte and report a positive inotropic effect of the drug...
  28. Ishibashi T, Takumida M, Akagi N, Hirakawa K, Anniko M. Expression of transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 in mouse inner ear. Acta Otolaryngol. 2008;128:1286-93 pubmed publisher
  29. Zanou N, Mondin L, Fuster C, Seghers F, Dufour I, de Clippele M, et al. Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres. J Physiol. 2015;593:3849-63 pubmed publisher
    ..Hyperosmotic shock also induces phosphorylation of STE20/SPS1-related proline/alanine-rich kinase (SPAK). TRPV2 dominant negative expressing fibres challenged with hyperosmotic shock present a slower membrane depolarization, a ..
  30. Nedungadi T, Dutta M, Bathina C, Caterina M, Cunningham J. Expression and distribution of TRPV2 in rat brain. Exp Neurol. 2012;237:223-37 pubmed publisher
    ..The neuroanatomical localization and the physiological roles of isoform TRPV2 in the rodent brain are largely unknown...
  31. Bang S, Kim K, Yoo S, Lee S, Hwang S. Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci Lett. 2007;425:120-5 pubmed
    ..In contrast, specific agents for another vanilloid subtype channel, TRPV2 have been lacking...
  32. Koch S, Mann A, Jones S, Robbins N, Alkhattabi A, Worley M, et al. Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation. J Hypertens. 2017;35:602-611 pubmed publisher
    ..This study was performed to test the hypothesis that transient receptor potential vanilloid 2 subtype (TRPV2) function regulates hypertrophy under increased afterload conditions...
  33. Lin Y, Sun Z. Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 ?-cells. Endocrinology. 2012;153:3029-39 pubmed publisher
    ..of mouse Klotho protein also significantly increased plasma membrane levels of transient receptor potential V2 (TRPV2), calcium entry, and the glucose-induced increase in intracellular calcium...
  34. Link T, Park U, Vonakis B, Raben D, Soloski M, Caterina M. TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol. 2010;11:232-9 pubmed publisher
    ..and complement-mediated particle binding and phagocytosis were impaired in macrophages lacking the cation channel TRPV2. TRPV2 was recruited to the nascent phagosome and depolarized the plasma membrane...
  35. Sun W, Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, et al. Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. Pflugers Arch. 2016;468:1527-40 pubmed publisher
    Transient receptor potential vanilloid 2 (TRPV2) acts as a Ca(2+)-permeable non-selective cation channel that has been reported to be sensitive to temperature, mechanical force, and some chemicals...
  36. Aguettaz E, Lopez J, Krzesiak A, Lipskaia L, Adnot S, Hajjar R, et al. Axial stretch-dependent cation entry in dystrophic cardiomyopathy: Involvement of several TRPs channels. Cell Calcium. 2016;59:145-155 pubmed publisher
    ..At rest, our results suggest that activation of TRPV2 channels participates to a constitutive basal cation entry in mdx cardiomyocytes...
  37. Everaerts W, Vriens J, Owsianik G, Appendino G, Voets T, De Ridder D, et al. Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol Renal Physiol. 2010;298:F692-701 pubmed publisher
    ..At the mRNA level, TRPV4, TRPV2, and TRPM7 were the most abundantly expressed TRP genes...
  38. Ip W, Medzhitov R. Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Nat Commun. 2015;6:6931 pubmed publisher
    ..Our findings identify an unknown function of the inflammasome as a sensor of hyperosmotic stress, which is crucial for the induction of inflammatory Th17 response. ..
  39. Ma L, Lee B, Clifton H, Schaefer S, Zheng J. Nicotinic acid is a common regulator of heat-sensing TRPV1-4 ion channels. Sci Rep. 2015;5:8906 pubmed publisher
    ..The finding calls into question whether NA might also interact with the homologous heat-sensitive TRPV2-4 channels, particularly given that TRPV3 and TRPV4 are abundantly expressed in keratinocytes of the skin where ..
  40. Hassan S, Eldeeb K, Millns P, Bennett A, Alexander S, Kendall D. Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation. Br J Pharmacol. 2014;171:2426-39 pubmed publisher
    ..CBD rapidly increased the expression of TRPV2 and TRPV1 proteins and caused a translocation of TRPV2 to the cell membrane...