Gene Symbol: Trpv1
Description: transient receptor potential cation channel, subfamily V, member 1
Alias: OTRPC1, TRPV1alpha, TRPV1beta, VR-1, Vr1, transient receptor potential cation channel subfamily V member 1, capsaicin receptor, cation channel, deltaN-TRPv1, osm-9-like TRP channel 1, transient receptor potential cation channel V1, vanilloid receptor 1, vanilloid receptor subtype 1
Species: mouse
Products:     Trpv1

Top Publications

  1. Guler A, Rainwater A, Parker J, Jones G, Argilli E, Arenkiel B, et al. Transient activation of specific neurons in mice by selective expression of the capsaicin receptor. Nat Commun. 2012;3:746 pubmed publisher
    ..Confined expression of the capsaicin receptor, TRPV1, allows cell-specific activation after peripheral or oral delivery of ligand in freely moving mice...
  2. Liu T, Berta T, Xu Z, Park C, Zhang L, Lu N, et al. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest. 2012;122:2195-207 pubmed publisher
    ..Our findings demonstrate a critical role of TLR3 in regulating sensory neuronal excitability, spinal cord synaptic transmission, and central sensitization. TLR3 may serve as a new target for developing anti-itch treatment. ..
  3. Guarini G, Ohanyan V, Kmetz J, Dellostritto D, Thoppil R, Thodeti C, et al. Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels. Am J Physiol Heart Circ Physiol. 2012;303:H216-23 pubmed publisher
    We have previously shown transient receptor potential vanilloid subtype 1 (TRPV1) channel-dependent coronary function is compromised in pigs with metabolic syndrome (MetS)...
  4. Ahern G, Brooks I, Miyares R, Wang X. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci. 2005;25:5109-16 pubmed
    ..form of ion channel modulation by which extracellular Na+, Mg2+, and Ca2+ ions sensitize and activate the capsaicin receptor, TRPV1...
  5. Maione S, Cristino L, Migliozzi A, Georgiou A, Starowicz K, Salt T, et al. TRPV1 channels control synaptic plasticity in the developing superior colliculus. J Physiol. 2009;587:2521-35 pubmed publisher
    ..We investigated the role of transient receptor potential vanilloid type-1 (TRPV1) channels in this type of synaptic plasticity...
  6. Kim S, Park G, Kim D, Lee J, Min H, Wall E, et al. Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons. Proc Natl Acad Sci U S A. 2011;108:3371-6 pubmed publisher
    ..Nevertheless, as for other pruritogens, IQ requires the presence of transient receptor potential vanilloid 1 (TRPV1)-expressing neurons for itch-associated responses...
  7. Kim Y, Back S, Davies A, Jeong H, Jo H, Chung G, et al. TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord. Neuron. 2012;74:640-7 pubmed publisher
    ..central sensitization resulting from long-term depression (LTD) of GABAergic interneurons as a consequence of TRPV1 activation in the spinal cord...
  8. Russell F, Fernandes E, Courade J, Keeble J, Brain S. Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling. Pain. 2009;142:264-74 pubmed publisher
    ..We have established a murine model of TNFalpha-induced TRPV1-dependent bilateral thermal hyperalgesia that then allowed us to identify distinct peripheral mechanisms involved ..
  9. Taylor Clark T, McAlexander M, Nassenstein C, Sheardown S, Wilson S, Thornton J, et al. Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol. 2008;586:3447-59 pubmed publisher
    ..channels are cation channels found preferentially on nociceptive sensory neurones, including capsaicin-sensitive TRPV1-expressing vagal bronchopulmonary C-fibres, and are activated by electrophilic compounds such as mustard oil and ..

More Information


  1. Shim W, Tak M, Lee M, Kim M, Kim M, Koo J, et al. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci. 2007;27:2331-7 pubmed
    ..Because the metabolic products of lipoxygenases (LOs) activate transient receptor potential vanilloid receptor-1 (TRPV1) in sensory neurons, we hypothesized that histamine excites sensory neurons by activating TRPV1 via phospholipase ..
  2. Musella A, De Chiara V, Rossi S, Prosperetti C, Bernardi G, Maccarrone M, et al. TRPV1 channels facilitate glutamate transmission in the striatum. Mol Cell Neurosci. 2009;40:89-97 pubmed publisher
    Transient receptor potential vanilloid 1 (TRPV1) channels participate in the modulation of synaptic transmission in the periphery and in central structures...
  3. Gibson H, Edwards J, Page R, Van Hook M, Kauer J. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 2008;57:746-59 pubmed publisher
    b>TRPV1 receptors have classically been defined as heat-sensitive, ligand-gated, nonselective cation channels that integrate nociceptive stimuli in sensory neurons...
  4. Lukacs V, Yudin Y, Hammond G, Sharma E, Fukami K, Rohacs T. Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons. J Neurosci. 2013;33:11451-63 pubmed publisher
    Transient Receptor Potential Vanilloid 1 (TRPV1) is a polymodal, Ca(2+)-permeable cation channel crucial to regulation of nociceptor responsiveness...
  5. Simonetti M, Fabbro A, D Arco M, Zweyer M, Nistri A, Giniatullin R, et al. Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin. Mol Pain. 2006;2:11 pubmed
    ..mechanisms of pain transduction typically involving activation of ATP-sensitive P2X or capsaicin-sensitive TRPV1 receptors. This applies also to trigeminal ganglion neurons that convey pain inputs from head tissues...
  6. Loo L, Shepherd A, Mickle A, Lorca R, Shutov L, Usachev Y, et al. The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical G??-dependent modulation of TRPV1 channel. J Neurosci. 2012;32:11942-55 pubmed publisher
    ..We found that NPR-C is coexpressed in transient receptor potential vanilloid-1 (TRPV1)-expressing mouse dorsal root ganglia (DRG) neurons...
  7. Ogawa H, Takahashi K, Miura S, Imagawa T, Saito S, Tominaga M, et al. H(2)S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation. Neuroscience. 2012;218:335-43 pubmed publisher
    ..Ca(2+)](i) responses to H(2)S were observed in neurons from transient receptor potential vanilloid 1 (TRPV1(-/-)) mice but not from TRPA1(-/-) mice...
  8. Zsombok A, Bhaskaran M, Gao H, Derbenev A, Smith B. Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. J Neurosci. 2011;31:14024-31 pubmed publisher
    ..We tested the hypothesis that synaptic modulation by transient receptor potential vanilloid type 1 (TRPV1) receptors is reduced in the DMV in slices from a murine model of type 1 diabetes...
  9. Elitt C, McIlwrath S, Lawson J, Malin S, Molliver D, Cornuet P, et al. Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. J Neurosci. 2006;26:8578-87 pubmed
    ..root ganglia (DRGs) that coexpress the Ret and TrkA receptor tyrosine kinases and the thermosensitive channel TRPV1. To determine how artemin affects sensory neuron properties, transgenic mice that overexpress artemin in skin ..
  10. Walder R, Radhakrishnan R, Loo L, Rasmussen L, Mohapatra D, Wilson S, et al. TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain. 2012;153:1664-72 pubmed publisher
    Inflammatory thermal hyperalgesia is principally mediated through transient receptor potential vanilloid 1 (TRPV1) channels, as demonstrated by prior studies using models of cutaneous inflammation...
  11. Christoph T, Bahrenberg G, De Vry J, Englberger W, Erdmann V, Frech M, et al. Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. Mol Cell Neurosci. 2008;37:579-89 pubmed publisher
    The function of the transient receptor potential vanilloid 1 (TRPV1) cation channel was analyzed with RNA interference technologies and compared to TRPV1 knockout mice...
  12. Daly D, Rong W, Chess Williams R, Chapple C, Grundy D. Bladder afferent sensitivity in wild-type and TRPV1 knockout mice. J Physiol. 2007;583:663-74 pubmed
    ..One such candidate is the transient receptor potential vanilloid 1 (TRPV1) ion channel...
  13. Park C, Lu N, Xu Z, Liu T, Serhan C, Ji R. Resolving TRPV1- and TNF-?-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. J Neurosci. 2011;31:15072-85 pubmed publisher
    Mechanisms of inflammatory pain are not fully understood. We investigated the role of TRPV1 (transient receptor potential subtype V1) and TNF-?, two critical mediators for inflammatory pain, in regulating spinal cord synaptic ..
  14. Salazar H, Llorente I, Jara Oseguera A, García Villegas R, Munari M, Gordon S, et al. A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci. 2008;11:255-61 pubmed publisher
    ..channels are activated by pungent compounds found in garlic, onion, mustard and cinnamon extracts, activation of TRPV1 by these extracts remains controversial...
  15. Zsombok A, Gao H, Miyata K, Issa A, Derbenev A. Immunohistochemical localization of transient receptor potential vanilloid type 1 and insulin receptor substrate 2 and their co-localization with liver-related neurons in the hypothalamus and brainstem. Brain Res. 2011;1398:30-9 pubmed publisher
    ..Furthermore, insulin enhances transient receptor potential vanilloid type 1 (TRPV1) mediated currents...
  16. Lawson J, McIlwrath S, Woodbury C, Davis B, Koerber H. TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat. J Pain. 2008;9:298-308 pubmed publisher
    ..was used to determine the response characteristics of cutaneous sensory neurons staining positively for TRPV1 or TRPV2...
  17. Shen Y, Heimel J, Kamermans M, Peachey N, Gregg R, Nawy S. A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. J Neurosci. 2009;29:6088-93 pubmed publisher
    ..The transduction current was suppressed by ruthenium red and the TRPV1 antagonists capsazepine and SB-366791...
  18. Garami A, Pakai E, Oliveira D, Steiner A, Wanner S, Almeida M, et al. Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci. 2011;31:1721-33 pubmed publisher
    ..aimed at determining the thermoregulatory phenotype of mice lacking transient receptor potential vanilloid-1 (TRPV1) channels...
  19. Tóth D, Szoke E, Bölcskei K, Kvell K, Bender B, Bosze Z, et al. Nociception, neurogenic inflammation and thermoregulation in TRPV1 knockdown transgenic mice. Cell Mol Life Sci. 2011;68:2589-601 pubmed publisher
    ..with a small hairpin RNA construct interfering with the expression of transient receptor potential vanilloid 1 (TRPV1) were created by lentiviral transgenesis...
  20. Farfariello V, Amantini C, Santoni G. Transient receptor potential vanilloid 1 activation induces autophagy in thymocytes through ROS-regulated AMPK and Atg4C pathways. J Leukoc Biol. 2012;92:421-31 pubmed publisher
    ..Herein, we demonstrated for the first time that triggering of TRPV1 by the specific agonist CPS induces autophagy in mouse thymocytes...
  21. Ota H, Katanosaka K, Murase S, Kashio M, Tominaga M, Mizumura K. TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness. PLoS ONE. 2013;8:e65751 pubmed publisher
    ..Here we examined whether and how TRPV1 and/or TRPV4 are involved in DOMS...
  22. Leffler A, Monter B, Koltzenburg M. The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice. Neuroscience. 2006;139:699-709 pubmed
    ..Expression patterns and functional properties of the capsaicin receptor and acid-sensing ion channels suggest that they may be the main molecular substrates underlying this proton ..
  23. Wei Z, Wang L, Han J, Song J, Yao L, Shao L, et al. Decreased expression of transient receptor potential vanilloid 1 impaires the postischemic recovery of diabetic mouse hearts. Circ J. 2009;73:1127-32 pubmed
    We hypothesized that the transient receptor potential vanilloid type 1 (TRPV1), which is found in the sensory nerve fibers, could modulate the cardiac function, be impaired by diabetes and could contribute to further severe postischemic ..
  24. Ma L, Zhong J, Zhao Z, Luo Z, Ma S, Sun J, et al. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. Cardiovasc Res. 2011;92:504-13 pubmed publisher
    Activation of transient receptor potential vanilloid type-1 (TRPV1) channels may affect lipid storage and the cellular inflammatory response...
  25. Chen C, Broom D, Liu Y, de Nooij J, Li Z, Cen C, et al. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006;49:365-77 pubmed
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy. ..
  26. Pogatzki Zahn E, Shimizu I, Caterina M, Raja S. Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain. Pain. 2005;115:296-307 pubmed
    ..Behavioral experiments involving TRPV1 KO mice demonstrate that, as previously observed in inflammatory models, TRPV1 is necessary for heat (but not ..
  27. Chávez A, Hernández V, Rodenas Ruano A, Chan C, Castillo P. Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus. J Neurosci. 2014;34:16621-9 pubmed publisher
    The transient receptor potential TRPV1 or vanilloid receptor is a nonselective ligand-gated channel highly expressed in primary sensory neurons where it mediates nociception...
  28. Pabbidi R, Cao D, Parihar A, Pauza M, Premkumar L. Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons. Mol Pharmacol. 2008;73:995-1004 pubmed
    ..While studying the influence of transient receptor potential vanilloid 1 (TRPV1) on DPN in the STZ-induced diabetic mouse model, we found that a proportion of STZ-treated mice was nondiabetic ..
  29. Wang L, Wang D. TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice. Circulation. 2005;112:3617-23 pubmed
    Although pharmacological studies suggest that the transient receptor potential vanilloid type 1 (TRPV1) channels expressed in sensory nerve fibers innervating the heart may exert a cardioprotective effect, definitive evidence supporting ..
  30. Cho H, Yang Y, Lee J, Lee B, Kim T, Jang Y, et al. The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci. 2012;15:1015-21 pubmed publisher
    ..These results indicate that ANO1 is a heat sensor that detects nociceptive thermal stimuli in sensory neurons and possibly mediates nociception. ..
  31. Grueter B, Brasnjo G, Malenka R. Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens. Nat Neurosci. 2010;13:1519-25 pubmed publisher
    ..long-term depression (eCB-LTD) as well as postsynaptic transient receptor potential vanilloid 1 (TRPV1) channels to trigger a form of LTD resulting from endocytosis of AMPA receptors...
  32. Helyes Z, Elekes K, Nemeth J, Pozsgai G, Sandor K, Kereskai L, et al. Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouse. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1173-81 pubmed
    ..are densely innervated by capsaicin-sensitive sensory neurons expressing transient receptor potential vanilloid 1 (TRPV1) receptors/ion channels, which play an important regulatory role in inflammatory processes via the release of ..
  33. Wei J, Ching L, Zhao J, Shyue S, Lee H, Kou Y, et al. Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis. Acta Physiol (Oxf). 2013;207:299-307 pubmed publisher
    We investigated whether transient receptor potential vanilloid type 1 (TRPV1) was involved in the therapeutic effect of evodiamine, a main bioactive component in the fruit of Evodiae rutaecarpa, on the development of atherosclerosis in ..
  34. Ching L, Kou Y, Shyue S, Su K, Wei J, Cheng L, et al. Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1. Cardiovasc Res. 2011;91:492-501 pubmed publisher
    ..underlying the role of transient receptor potential vanilloid type 1 (TRPV1), a Ca(2+)-permeable non-selective cation channel, in the activation of endothelial nitric oxide (NO) synthase (eNOS) in endothelial cells (ECs) and mice. ..
  35. Ohanyan V, Guarini G, Thodeti C, Talasila P, Raman P, Haney R, et al. Endothelin-mediated in vivo pressor responses following TRPV1 activation. Am J Physiol Heart Circ Physiol. 2011;301:H1135-42 pubmed publisher
    Transient receptor potential vanilliod 1 (TRPV1) channels have recently been postulated to play a role in the vascular complications/consequences associated with diabetes despite the fact that the mechanisms through which TRPV1 regulates ..
  36. Bölcskei K, Helyes Z, Szabó A, Sandor K, Elekes K, Nemeth J, et al. Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. Pain. 2005;117:368-76 pubmed
    Capsaicin-sensitive, TRPV1 (transient receptor potential vanilloid 1) receptor-expressing primary sensory neurons exert local and systemic efferent effects besides the classical afferent function...
  37. Christoph T, Grünweller A, Mika J, Schafer M, Wade E, Weihe E, et al. Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biochem Biophys Res Commun. 2006;350:238-43 pubmed
    ..Here, we report that intrathecal injection of an siRNA against the transient receptor potential vanilloid receptor 1 (TRPV1) reduced cold allodynia of mononeuropathic rats by more than 50% over a time period of approximately ..
  38. Imamachi N, Park G, Lee H, Anderson D, Simon M, Basbaum A, et al. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A. 2009;106:11330-5 pubmed publisher
    ..c. injection of various pruritogens in PLCbeta3- or TRPV1-deficient mice...
  39. Cristino L, De Petrocellis L, Pryce G, Baker D, Guglielmotti V, Di Marzo V. Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain. Neuroscience. 2006;139:1405-15 pubmed
    ..These data support the hypothesis of a functional relationship between the two receptor types in the CNS. ..
  40. Patwardhan A, Akopian A, Ruparel N, Diogenes A, Weintraub S, Uhlson C, et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest. 2010;120:1617-26 pubmed publisher
    The transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat in the peripheral nervous system...
  41. Vriens J, Owsianik G, Hofmann T, Philipp S, Stab J, Chen X, et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron. 2011;70:482-94 pubmed publisher
    Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca(2+)-permeable nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 by the neuroactive steroid pregnenolone sulfate (PS), but its ..
  42. Yang F, Cui Y, Wang K, Zheng J. Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc Natl Acad Sci U S A. 2010;107:7083-8 pubmed publisher fluorescence recordings we observed that temperature change induces a significant rearrangement of TRPV1 pore turret that is coupled to channel opening...
  43. Hensellek S, Brell P, Schaible H, Bräuer R, Segond von Banchet G. The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci. 2007;36:381-91 pubmed
    ..The pronociceptive action of TNFalpha may be mediated at least in part by activation of the TRPV1 receptor which transduces heat stimuli in primary nociceptive afferents and mediates thermal hyperalgesia...
  44. Ni D, Lee L. Lack of potentiating effect of increasing temperature on responses to chemical activators in vagal sensory neurons isolated from TRPV1-null mice. Am J Physiol Lung Cell Mol Physiol. 2008;295:L897-904 pubmed publisher
    ..nodose/jugular sensory neurons to chemical activators and increasing temperature between wild-type (WT) and TRPV1-null (TRPV1-/-) mice...
  45. Wang Z, Wang P, Merriam F, Bjorling D. Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice. Pain. 2008;139:158-67 pubmed publisher
    Transient receptor potential vanilloid 1 (TRPV1) is highly expressed in primary afferent neurons...
  46. Szallasi A, Cruz F, Geppetti P. TRPV1: a therapeutic target for novel analgesic drugs?. Trends Mol Med. 2006;12:545-54 pubmed
    The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of TRPV1 represents a new strategy in pain relief...
  47. Stein A, Ufret Vincenty C, Hua L, Santana L, Gordon S. Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol. 2006;128:509-22 pubmed
    Sensitization of the pain-transducing ion channel TRPV1 underlies thermal hyperalgesia by proalgesic agents such as nerve growth factor (NGF)...
  48. Fernandes E, Liang L, Smillie S, Kaiser F, Purcell R, Rivett D, et al. TRPV1 deletion enhances local inflammation and accelerates the onset of systemic inflammatory response syndrome. J Immunol. 2012;188:5741-51 pubmed publisher
    The transient receptor potential vanilloid 1 (TRPV1) is primarily localized to sensory nerve fibers and is associated with the stimulation of pain and inflammation...
  49. Shimizu I, Iida T, Guan Y, Zhao C, Raja S, Jarvis M, et al. Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain. 2005;116:96-108 pubmed
    P2X3 is an ATP-gated cation channel subtype expressed by a subpopulation of primary sensory neurons...
  50. Szitter I, Pozsgai G, Sandor K, Elekes K, Kemeny A, Perkecz A, et al. The role of transient receptor potential vanilloid 1 (TRPV1) receptors in dextran sulfate-induced colitis in mice. J Mol Neurosci. 2010;42:80-8 pubmed publisher
    The aim of this study was to investigate the involvement of transient receptor potential vanilloid 1 (TRPV1) receptors in oral dextran sulfate sodium-induced (DSS) colitis using TRPV1 knockout mice and their wild-type C57BL/6 ..
  51. Jones R, Xu L, Gebhart G. The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J Neurosci. 2005;25:10981-9 pubmed
    ..We tested the hypothesis that transient receptor potential vanilloid 1 (TRPV1) and acid-sensing ion channel 3 (ASIC3) are peripheral mechanosensors in colon afferent neuronal fibers that ..
  52. Miyamoto T, Dubin A, Petrus M, Patapoutian A. TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice. PLoS ONE. 2009;4:e7596 pubmed publisher
    ..It has recently been suggested that TRPV1 and TRPA1, two polymodal ion channels that sense noxious stimuli impinging on peripheral nociceptors, are ..
  53. Lotteau S, Ducreux S, Romestaing C, Legrand C, Van Coppenolle F. Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle. PLoS ONE. 2013;8:e58673 pubmed publisher
    TRPV1 represents a non-selective cation channel activated by capsaicin, acidosis and high temperature. In the central nervous system where TRPV1 is highly expressed, its physiological role in nociception is clearly identified...
  54. Fischer M, Leffler A, Niedermirtl F, Kistner K, Eberhardt M, Reeh P, et al. The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors. J Biol Chem. 2010;285:34781-92 pubmed publisher
    ..concentrations of propofol activated the recombinant transient receptor potential (TRP) receptors TRPA1 and TRPV1 heterologously expressed in HEK293t cells...
  55. Cui Y, Yang F, Cao X, Yarov Yarovoy V, Wang K, Zheng J. Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol. 2012;139:273-83 pubmed publisher
    The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel...
  56. Mishra S, Hoon M. Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. Mol Cell Neurosci. 2010;43:157-63 pubmed publisher
    Here we make use of neural ablation to investigate the properties of the TrpV1-expressing neurons in the trigeminal and dorsal root ganglia of mice...
  57. Keeble J, Russell F, Curtis B, Starr A, Pinter E, Brain S. Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation. Arthritis Rheum. 2005;52:3248-56 pubmed
    To investigate the endogenous involvement of transient receptor potential vanilloid 1 (TRPV1) in a model of knee joint inflammation in the mouse...
  58. Marshall N, Liang L, Bodkin J, Dessapt Baradez C, Nandi M, Collot Teixeira S, et al. A role for TRPV1 in influencing the onset of cardiovascular disease in obesity. Hypertension. 2013;61:246-52 pubmed publisher
    ..a murine model of diet-induced obesity to determine the effect of transient potential receptor vanilloid 1 (TRPV1) deletion on hypertension and metabolic syndrome...
  59. Cao X, Cao X, Xie H, Yang R, Lei G, Li F, et al. Effects of capsaicin on VGSCs in TRPV1-/- mice. Brain Res. 2007;1163:33-43 pubmed
    ..voltage-gated sodium channels (VGSCs) were found by using knockout mice for the transient receptor potential V1 (TRPV1(-/-))...
  60. Hao X, Chen J, Luo Z, He H, Yu H, Ma L, et al. TRPV1 activation prevents high-salt diet-induced nocturnal hypertension in mice. Pflugers Arch. 2011;461:345-53 pubmed publisher
    ..Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, is proposed to be involved in Dahl salt-sensitive hypertension, as determined ..
  61. Vilceanu D, Honore P, Hogan Q, Stucky C. Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors. J Pain. 2010;11:588-99 pubmed publisher
    Peripheral nerve injury leads to neuropathic pain, but the underlying mechanisms are not clear. The TRPV1 channel expressed by nociceptors is one receptor for noxious heat and inflammatory molecules...
  62. Park U, Vastani N, Guan Y, Raja S, Koltzenburg M, Caterina M. TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J Neurosci. 2011;31:11425-36 pubmed publisher
    TRP vanilloid 2 (TRPV2) is a nonselective cation channel expressed prominently in medium- to large-diameter sensory neurons that can be activated by extreme heat (>52°C)...
  63. Elg S, Marmigere F, Mattsson J, Ernfors P. Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion. J Comp Neurol. 2007;503:35-46 pubmed
    ..was almost exclusively present in nonpeptidergic isolectin B4 (IB4)-positive small size neurons that were largely TRPV1-negative...
  64. Musumeci G, Grasselli G, Rossi S, De Chiara V, Musella A, Motta C, et al. Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-? and of IL-1? in experimental autoimmune encephalomyelitis. Neurobiol Dis. 2011;43:669-77 pubmed publisher
    Transient receptor potential vanilloid 1 (TRPV1) channels are involved in several inflammatory diseases. However, their action is still controversial, and both pro-inflammatory and anti-inflammatory roles have been described...
  65. Cavanaugh D, Chesler A, Braz J, Shah N, Julius D, Basbaum A. Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci. 2011;31:10119-27 pubmed publisher
    ..Whether the heat and capsaicin receptor transient receptor potential vanilloid-1 (TRPV1) is expressed heterogeneously across several sensory ..
  66. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    ..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways. ..
  67. Zhang X, Huang J, McNaughton P. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J. 2005;24:4211-23 pubmed noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion channel, TRPV1. Several different mechanisms for sensitization of TRPV1 have been proposed...
  68. Ufret Vincenty C, Klein R, Hua L, Angueyra J, Gordon S. Localization of the PIP2 sensor of TRPV1 ion channels. J Biol Chem. 2011;286:9688-98 pubmed publisher
    ..Here we show that Pirt does not alter the phosphoinositide sensitivity of TRPV1 in HEK-293 cells, that there is no FRET between TRPV1 and Pirt, and that dissociated dorsal root ganglion neurons ..
  69. Klein R, Ufret Vincenty C, Hua L, Gordon S. Determinants of molecular specificity in phosphoinositide regulation. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the endogenous lipid regulating TRPV1. J Biol Chem. 2008;283:26208-16 pubmed publisher
    ..b>TRPV1 is a good example; although phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P(2)) can potently regulate its ..
  70. Li L, Chen J, Ni Y, Feng X, Zhao Z, Wang P, et al. TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice. Pflugers Arch. 2012;463:727-32 pubmed publisher, we report the effect of capsaicin on its receptor, transient receptor potential vanilloid 1 (TRPV1) cation channel, in preventing fatty liver formation. Functional TRPV1 has been detected in hepatocytes and liver tissues...
  71. Razavi R, Chan Y, Afifiyan F, Liu X, Wan X, Yantha J, et al. TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes. Cell. 2006;127:1123-35 pubmed
    ..We report that TRPV1(+) pancreatic sensory neurons control islet inflammation and insulin resistance...
  72. Ye L, Kleiner S, Wu J, Sah R, Gupta R, Banks A, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012;151:96-110 pubmed publisher
    ..This role of TRPV4 as a cell-autonomous mediator for both the thermogenic and proinflammatory programs in adipocytes could offer a target for treating obesity and related metabolic diseases. ..
  73. Lagerström M, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, et al. VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron. 2010;68:529-42 pubmed publisher
    ..glutamate transporter (VGLUT) 2 in a subpopulation of neurons partly overlapping with the vanilloid receptor (TRPV1) primary afferents resulted in a dramatic increase in itch behavior accompanied by a reduced responsiveness to ..
  74. Ching L, Zhao J, Su K, Shyue S, Hsu C, Lu T, et al. Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C. Acta Physiol (Oxf). 2013;209:124-35 pubmed publisher
    ..mechanism of transient receptor potential vanilloid 1 (TRPV1), a calcium (Ca(2+) )-permeable non-selective cation channel, on phosphorylation of endothelial nitric oxide synthase (eNOS) at threonine 497 (Thr497) in bovine aortic ..
  75. Xu X, Wang P, Zhao Z, Cao T, He H, Luo Z, et al. Activation of transient receptor potential vanilloid 1 by dietary capsaicin delays the onset of stroke in stroke-prone spontaneously hypertensive rats. Stroke. 2011;42:3245-51 pubmed publisher
    ..capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp)...
  76. Steiner A, Turek V, Almeida M, Burmeister J, Oliveira D, Roberts J, et al. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci. 2007;27:7459-68 pubmed
    ..We synthesized a new TRPV1 antagonist, AMG0347 [(E)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)..
  77. Movahed P, Jonsson B, Birnir B, Wingstrand J, Jørgensen T, Ermund A, et al. Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. J Biol Chem. 2005;280:38496-504 pubmed
    ..This study shows that several endogenous non-cannabinoid NAEs, many of which are more abundant than anandamide in rat tissues, activate TRPV(1) and thus may play a role as endogenous TRPV(1) modulators. ..