Trpm8

Summary

Gene Symbol: Trpm8
Description: transient receptor potential cation channel, subfamily M, member 8
Alias: CMR1, LTRPC6, LTrpC-6, TRPP8, Trp-p8, transient receptor potential cation channel subfamily M member 8, TRP ion channel TRPM8, long transient receptor potential channel 6, transient receptor potential p8
Species: mouse
Products:     Trpm8

Top Publications

  1. Peier A, Moqrich A, Hergarden A, Reeve A, Andersson D, Story G, et al. A TRP channel that senses cold stimuli and menthol. Cell. 2002;108:705-15 pubmed
    ..Here we describe the cloning and characterization of TRPM8, a distant relative of VR1. TRPM8 is specifically expressed in a subset of pain- and temperature-sensing neurons...
  2. Almeida M, Hew Butler T, Soriano R, Rao S, Wang W, Wang J, et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012;32:2086-99 pubmed publisher
    ..hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel...
  3. Bautista D, Siemens J, Glazer J, Tsuruda P, Basbaum A, Stucky C, et al. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007;448:204-8 pubmed
    ..One such channel--TRP melastatin 8 (TRPM8) or cold and menthol receptor 1 (CMR1)--is activated by chemical cooling agents (such as menthol) or when ambient ..
  4. Knowlton W, Palkar R, Lippoldt E, McCoy D, Baluch F, Chen J, et al. A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia. J Neurosci. 2013;33:2837-48 pubmed publisher
    ..Here we provide evidence that neurons expressing TRPM8, a cold- and menthol-gated channel required for normal cold responses in mammals, represents a labeled line solely ..
  5. Story G, Peier A, Reeve A, Eid S, Mosbacher J, Hricik T, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003;112:819-29 pubmed
    ..of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8...
  6. Parra A, Madrid R, Echevarria D, del Olmo S, Morenilla Palao C, Acosta M, et al. Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nat Med. 2010;16:1396-9 pubmed publisher
    ..Deletion of the cold-transducing ion channel Transient receptor potential cation channel subfamily M member 8 (TRPM8) in mice abrogates cold responsiveness and reduces basal tearing without ..
  7. Chen C, Broom D, Liu Y, de Nooij J, Li Z, Cen C, et al. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006;49:365-77 pubmed
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy. ..
  8. Persson A, Gebauer M, Jordan S, Metz Weidmann C, Schulte A, Schneider H, et al. Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic pain. Mol Pain. 2009;5:7 pubmed publisher
    ..alpha subunit Scn11a correlated with levels of spontaneous pain behavior, and regulation of the cool receptor Trpm8 correlated with heat hypersensibility...
  9. Ma S, G G, Ak V, Jf D, H H. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci. 2008;21:370-8 pubmed
    Transient receptor potential melastatin-8 (TRPM8), a cationic ion channel is involved in detection of normal cooling-sensation in mammals...

More Information

Publications80

  1. Daniels R, McKemy D. Mice left out in the cold: commentary on the phenotype of TRPM8-nulls. Mol Pain. 2007;3:23 pubmed
    ..For temperatures considered cold, the menthol receptor TRPM8 is activated when temperatures drop below approximately 26 degrees C, thus making it an intriguing candidate as ..
  2. McKemy D, Neuhausser W, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002;416:52-8 pubmed
    ..This cold- and menthol-sensitive receptor, CMR1, is a member of the TRP family of excitatory ion channels, and we propose that it functions as a transducer of cold ..
  3. Staaf S, Franck M, Marmigere F, Mattsson J, Ernfors P. Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. Gene Expr Patterns. 2010;10:65-74 pubmed publisher
    ..In order to find out if the eight TRPM subgroup members (TRPM1-TRPM8) have a possible role in the sensory nervous system, we characterized the developmental regulation of their ..
  4. Madrid R, De La Pena E, Donovan Rodriguez T, Belmonte C, Viana F. Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels. J Neurosci. 2009;29:3120-31 pubmed publisher
    ..expression of I(KD), a current dependent on Shaker-like Kv1 channels that acts as an excitability brake, and I(TRPM8), a cold-activated excitatory current...
  5. De La Pena E, Malkia A, Cabedo H, Belmonte C, Viana F. The contribution of TRPM8 channels to cold sensing in mammalian neurones. J Physiol. 2005;567:415-26 pubmed
    ..A major candidate is TRPM8, a non-selective cation channel of the transient receptor potential family, activated by menthol and low ..
  6. Colburn R, Lubin M, Stone D, Wang Y, Lawrence D, D Andrea M, et al. Attenuated cold sensitivity in TRPM8 null mice. Neuron. 2007;54:379-86 pubmed
    ..One of its members, TRPM8 (CMR1), a ligand-gated, nonselective cation channel, is activated by both cold and chemical stimuli in vitro...
  7. Dhaka A, Murray A, Mathur J, Earley T, Petrus M, Patapoutian A. TRPM8 is required for cold sensation in mice. Neuron. 2007;54:371-8 pubmed
    ..b>TRPM8 and TRPA1 are both activated by cooling; however, it is unclear whether either ion channel is required for ..
  8. Feketa V, Balasubramanian A, Flores C, Player M, Marrelli S. Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. Am J Physiol Regul Integr Comp Physiol. 2013;305:R1040-50 pubmed publisher
    ..Although multiple thermoregulatory responses may be altered by modulators of thermosensitive ion channels, TRPM8 (transient receptor potential melastatin 8) and TRPV1 (TRP vanilloid 1), it is unknown whether these agents affect ..
  9. Kim A, Tang Z, Liu Q, Patel K, Maag D, Geng Y, et al. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell. 2008;133:475-85 pubmed publisher
    ..Importantly, the enhancement of TRPV1 by PIP2 requires Pirt. Therefore, Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity. ..
  10. Andersson D, Chase H, Bevan S. TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci. 2004;24:5364-9 pubmed
    b>TRPM8 is a nonselective cation channel activated by cold and the cooling compounds menthol and icilin (Peier et al., 2002)...
  11. Tajino K, Hosokawa H, Maegawa S, Matsumura K, Dhaka A, Kobayashi S. Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. PLoS ONE. 2011;6:e17504 pubmed publisher
    ..However, molecule of the thermostat is not known. Here, we studied whether cooling-sensitive TRPM8 channels act as thermostats...
  12. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    ..Moreover, NGF controls expression of several other genes characteristic of nonpeptidergic neurons, such as TrpC3, TrpM8, MrgD, and the transcription factor Runx1, via a Ret-independent signaling pathway...
  13. Knowlton W, Bifolck Fisher A, Bautista D, McKemy D. TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain. 2010;150:340-50 pubmed publisher
    ..The detection of cold is proposed to be mediated by the ion channels TRPM8 and TRPA1...
  14. Bandell M, Dubin A, Petrus M, Orth A, Mathur J, Hwang S, et al. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nat Neurosci. 2006;9:493-500 pubmed
    ..Menthol activates transient receptor potential melastatin 8 (TRPM8), an ion channel also activated by cold, voltage and phosphatidylinositol-4,5-bisphosphate (PIP2)...
  15. Dhaka A, Earley T, Watson J, Patapoutian A. Visualizing cold spots: TRPM8-expressing sensory neurons and their projections. J Neurosci. 2008;28:566-75 pubmed publisher
    ..b>TRPM8 is activated by cooling, and TRPM8-deficient mice have severe deficits in cool thermosensation...
  16. Moraes M, de Assis L, Henriques F, Batista M, Guler A, Castrucci A. Cold-sensing TRPM8 channel participates in circadian control of the brown adipose tissue. Biochim Biophys Acta Mol Cell Res. 2017;1864:2415-2427 pubmed publisher
    Transient receptor potential (TRP) channels are known to regulate energy metabolism, and TRPM8 has become an interesting player in this context...
  17. Yudin Y, Lutz B, Tao Y, Rohacs T. Phospholipase C ?4 regulates cold sensitivity in mice. J Physiol. 2016;594:3609-28 pubmed publisher
    The cold- and menthol-activated transient receptor potential melastatin 8 (TRPM8) channels are thought to be regulated by phospholipase C (PLC), but neither the specific PLC isoform nor the in vivo relevance of this regulation has been ..
  18. Mandadi S, Nakanishi S, Takashima Y, Dhaka A, Patapoutian A, McKemy D, et al. Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels. Neuroscience. 2009;162:1377-97 pubmed publisher
    ..and peripheral transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential melastatin 8 (TRPM8) afferent terminals modulates central pattern generators (CPGs)...
  19. Caspani O, Zurborg S, Labuz D, Heppenstall P. The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain. PLoS ONE. 2009;4:e7383 pubmed publisher
    ..Recently the transient receptor potential (TRP) channels TRPM8 and TRPA1 have been identified and proposed to be molecular sensors for cold...
  20. Munns C, AlQatari M, Koltzenburg M. Many cold sensitive peripheral neurons of the mouse do not express TRPM8 or TRPA1. Cell Calcium. 2007;41:331-42 pubmed
    ..Members of the transient receptor potential family TRPM8 and TRPA1 are candidates for the principal transducers of cold stimuli...
  21. Klasen K, Hollatz D, Zielke S, Gisselmann G, Hatt H, Wetzel C. The TRPM8 ion channel comprises direct Gq protein-activating capacity. Pflugers Arch. 2012;463:779-97 pubmed publisher
    ..Investigating cascades stimulated downstream of the cold and menthol receptor TRPM8, we found evidence for both, functional and structural interaction of TRPM8 with G?q...
  22. Brenner D, Golden J, Vogt S, Dhaka A, Story G, Gereau R. A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain. 2014;155:2124-33 pubmed publisher
    ..The adjustment of this set point requires transient receptor potential cation channel, subfamily member 8 (TRPM8), but not transient receptor potential cation channel, subfamily A, member 1 (TRPA1), and is regulated by ..
  23. Kido Nakahara M, Buddenkotte J, Kempkes C, Ikoma A, Cevikbas F, Akiyama T, et al. Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus. J Clin Invest. 2014;124:2683-95 pubmed publisher
    ..Furthermore, these results implicate the ET-1/ECE-1/ERK1/2 pathway as a therapeutic target to treat pruritus in humans. ..
  24. Tang Z, Kim A, Masuch T, Park K, Weng H, Wetzel C, et al. Pirt functions as an endogenous regulator of TRPM8. Nat Commun. 2013;4:2179 pubmed publisher
    ..neurons suggests it may modulate other transient receptor potentials, such as the menthol and cooling sensor TRPM8. The discrepancies in the channel properties of TRPM8 in native neurons versus heterologous cells indicate the ..
  25. Gibbs G, Orta G, Reddy T, Koppers A, Martínez López P, de la Vega Beltrán J, et al. Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function. Proc Natl Acad Sci U S A. 2011;108:7034-9 pubmed publisher
    ..testicular sperm, the CRISP4 CRISP domain was shown to inhibit the transient receptor potential (TRP) ion channel TRPM8. These data were confirmed using a stably transfected CHO cell line...
  26. Nersesyan Y, Demirkhanyan L, Cabezas Bratesco D, Oakes V, Kusuda R, Dawson T, et al. Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1. Cell Rep. 2017;21:1681-1691 pubmed publisher
    ..Together, our findings suggest the existence of endogenous regulatory pathways that modulate nociception via direct action of oxytocin on TRPV1, implying its analgesic effect via channel desensitization. ..
  27. Ren A, Wang K, Zhang H, Liu A, Ma X, Liang Q, et al. ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Nat Commun. 2014;5:4984 pubmed publisher
    ..Disruption of ZBTB20 in nociceptors led to a marked decrease in the expression levels of TRPV1, TRPA1 and TRPM8 and the response of calcium flux and whole-cell currents evoked by their respective specific agonists...
  28. Hu H, Gu Q, Wang C, Colton C, Tang J, Kinoshita Kawada M, et al. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem. 2004;279:35741-8 pubmed
    ..In contrast, 2APB inhibits the activity of TRPC6 and TRPM8 evoked by 1-oleolyl-2-acetyl-sn-glycerol and menthol, respectively...
  29. Denda M, Tsutsumi M, Denda S. Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis. Exp Dermatol. 2010;19:791-5 pubmed publisher
    TRPA1 and TRPM8 receptors are activated at low temperature (A1: below 17 degrees C and M8: below 22 degrees C). Recently, we observed that low temperature (below 22 degrees C) induced elevation of intracellular calcium in keratinocytes...
  30. Zhang X, Mak S, Li L, Parra A, Denlinger B, Belmonte C, et al. Direct inhibition of the cold-activated TRPM8 ion channel by G?q. Nat Cell Biol. 2012;14:851-8 pubmed publisher
    Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of pleasant coolness...
  31. Ren L, Dhaka A, Cao Y. Function and postnatal changes of dural afferent fibers expressing TRPM8 channels. Mol Pain. 2015;11:37 pubmed publisher
    Genome-wide association studies have identified TRPM8 (transient receptor potential melastatin 8) as one of the susceptibility genes for common migraine...
  32. McCoy E, Zylka M. Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8. Mol Pain. 2014;10:69 pubmed publisher
    ..that the enhanced cold responses were due to disinhibition of spinal neurons that receive inputs from cold-sensing/TRPM8 primary afferents; although a direct role for TRPM8 was not examined at the time...
  33. Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M, et al. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. J Cell Biol. 2015;208:89-107 pubmed publisher
    b>TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-temperature-sensing organs, and is regulated by downstream receptor-activated signaling pathways...
  34. Gorokhova S, Gaillard S, Urien L, Malapert P, Legha W, Baronian G, et al. Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. PLoS Genet. 2014;10:e1004081 pubmed publisher
    ..Moreover, adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk mouse mutant with a pain phenotype. ..
  35. Huang D, Li S, Dhaka A, Story G, Cao Y. Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura. Mol Pain. 2012;8:66 pubmed publisher
    ..To examine the distribution of TRPM8 channels, we labeled dural afferent neurons in mice expressing farnesylated enhanced green fluorescent protein (..
  36. Zhang L, Barritt G. Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells. Cancer Res. 2004;64:8365-73 pubmed
    The Ca(2+)-permeable channel TRPM8 is thought to play an important role in the pathophysiology of prostate cancer...
  37. Takashima Y, Ma L, McKemy D. The development of peripheral cold neural circuits based on TRPM8 expression. Neuroscience. 2010;169:828-42 pubmed publisher
    ..The cold and menthol receptor TRPM8 is responsible for detection of cold and, unlike other thermosensors, detects both innocuous and noxious ..
  38. Janssens A, Gees M, Tóth B, Ghosh D, Mulier M, Vennekens R, et al. Definition of two agonist types at the mammalian cold-activated channel TRPM8. elife. 2016;5: pubmed publisher
    ..isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammalian cold sensor TRPM8. Kinetic analysis of channel gating revealed that AITC acts by destabilizing the closed channel, whereas menthol ..
  39. Daniels R, Takashima Y, McKemy D. Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem. 2009;284:1570-82 pubmed publisher
    ..At the molecular level, cold is detected by transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel expressed on a subset of peripheral afferent fibers...
  40. Nocchi L, Daly D, Chapple C, Grundy D. Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging. Aging Cell. 2014;13:540-50 pubmed publisher
    ..These functional changes were concurrent with upregulation of TRPM8 in the urothelium...
  41. Malkia A, Pertusa M, Fernandez Ballester G, Ferrer Montiel A, Viana F. Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels. Mol Pain. 2009;5:62 pubmed publisher
    b>TRPM8 is a non-selective cation channel that belongs to the melastatin subfamily of the transient receptor potential (TRP) ion channels. TRPM8 is activated by voltage, cold and cooling compounds such as menthol...
  42. de Jong P, Takahashi N, Peiris M, Bertin S, Lee J, Gareau M, et al. TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP. Mucosal Immunol. 2015;8:491-504 pubmed publisher
    b>TRPM8 is the molecular sensor for cold; however, the physiological role of TRPM8+ neurons at mucosal surfaces is unclear...
  43. Ramachandran R, Hyun E, Zhao L, Lapointe T, Chapman K, Hirota C, et al. TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc Natl Acad Sci U S A. 2013;110:7476-81 pubmed publisher
    Transient Receptor Potential Melastatin-8 (TRPM8), a recently identified member of the transient receptor potential (TRP) family of ion channels, is activated by mild cooling and by chemical compounds such as the supercooling agent, ..
  44. Urata T, Mori N, Fukuwatari T. Vagus nerve is involved in the changes in body temperature induced by intragastric administration of 1,8-cineole via TRPM8 in mice. Neurosci Lett. 2017;650:65-71 pubmed publisher
    Transient Receptor Potential Melastatin 8 (TRPM8) is a cold receptor activated by mild cold temperature (<28°C). TRPM8 expressed in cutaneous sensory nerves is involved in cold sensation and thermoregulation...
  45. Ghosh D, Pinto S, Danglot L, Vandewauw I, Segal A, Van Ranst N, et al. VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Nat Commun. 2016;7:10489 pubmed publisher
    The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents...
  46. Gauchan P, Andoh T, Kato A, Kuraishi Y. Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice. Neurosci Lett. 2009;458:93-5 pubmed publisher
    ..In the present study, we investigated in mice whether transient receptor potential melastatin 8 (TRPM8), which is activated by cooling temperature, would be involved in cold allodynia induced by oxaliplatin...
  47. Milenkovic N, Zhao W, Walcher J, Albert T, Siemens J, Lewin G, et al. A somatosensory circuit for cooling perception in mice. Nat Neurosci. 2014;17:1560-6 pubmed publisher
    ..Our results identify parts of a neural circuit underlying cold perception in mice and provide a new model system for the analysis of thermal processing and perception and multimodal integration. ..
  48. McCoy D, Zhou L, Nguyen A, Watts A, Donovan C, McKemy D. Enhanced insulin clearance in mice lacking TRPM8 channels. Am J Physiol Endocrinol Metab. 2013;305:E78-88 pubmed publisher
    ..Here, we report the novel finding that the cold and menthol-gated channel TRPM8 is necessary for proper insulin homeostasis...
  49. Fujita T, Liu Y, Higashitsuji H, Itoh K, Shibasaki K, Fujita J, et al. Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins. Biochem Biophys Res Commun. 2018;495:935-940 pubmed publisher
    ..We herein report that in addition to TRPV4, TRPV3 and TRPM8 are necessary for the induction of CIPs...
  50. Ramos Filho A, Shah A, Augusto T, Barbosa G, Leiria L, de Carvalho H, et al. Menthol inhibits detrusor contractility independently of TRPM8 activation. PLoS ONE. 2014;9:e111616 pubmed publisher
    Agonists such as icilin and menthol can activate the cool temperature-sensitive ion channel TRPM8. However, biological responses to menthol may occur independently of TRPM8 activation...
  51. Gavva N, Davis C, Lehto S, Rao S, Wang W, Zhu D. Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol Pain. 2012;8:36 pubmed publisher
    b>Transient receptor potential cation channel subfamily M member 8 (TRPM8) is activated by cold temperature in vitro and has been demonstrated to act as a 'cold temperature sensor' in vivo...
  52. Sun J, Yang T, Wang P, Ma S, Zhu Z, Pu Y, et al. Activation of cold-sensing transient receptor potential melastatin subtype 8 antagonizes vasoconstriction and hypertension through attenuating RhoA/Rho kinase pathway. Hypertension. 2014;63:1354-63 pubmed publisher
    Environmental cold is a nonmodifiable hypertension risk factor. Transient receptor potential melastatin subtype 8 (TRPM8) is a cold-sensing cation channel that can be activated by menthol, a compound with a naturally cold sensation in ..
  53. Gong K, Jasmin L. Sustained Morphine Administration Induces TRPM8-Dependent Cold Hyperalgesia. J Pain. 2017;18:212-221 pubmed publisher
    ..Here we present evidence that the cold sensor TRPM8 channel is involved in opioid-induced hyperalgesia...
  54. Martínez López P, Trevino C, de la Vega Beltrán J, De Blas G, Monroy E, Beltrán C, et al. TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction. J Cell Physiol. 2011;226:1620-31 pubmed publisher
    ..Here we document using RT-PCR experiments the presence of Trpm2, 4, 7, and 8 in mouse spermatogenic cells. Trpm8 transcription is up-regulated after day 30...
  55. Borowiec A, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, et al. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. FASEB J. 2016;30:3155-70 pubmed publisher
    ..knockout mouse model of the cold and menthol receptors, dubbed transient receptor potential melastatine 8 (TRPM8) channels, we found that TRPM8 initiated the cold-shock response by differentially modulating cold- and heat-shock ..
  56. Vanden Abeele F, Kondratskyi A, Dubois C, Shapovalov G, Gkika D, Busserolles J, et al. Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia. J Cell Sci. 2013;126:4479-89 pubmed publisher
    ..Here, we show that the cold receptor transient receptor potential melastatin 8 (TRPM8) undergoes a complex modulation by clinical concentrations of VAs in dorsal root ganglion neurons and HEK-293 ..
  57. Lopes C, Liu Z, Xu Y, Ma Q. Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. J Neurosci. 2012;32:9706-15 pubmed publisher
    ..Collectively, these studies suggest that genetically Tlx3 acts in combination with Runx1 to control the development of a cohort of nociceptors, thermoceptors, and pruriceptors in mice. ..
  58. Kim Y, Kim T, McKemy D, Bae Y. Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse. Neuroscience. 2015;303:378-88 pubmed publisher
    Transient receptor potential melastatin 8 (TRPM8) is activated by innocuous cool and noxious cold and plays a crucial role in cold-induced acute pain and pain hypersensitivity...
  59. Morenilla Palao C, Pertusa M, Meseguer V, Cabedo H, Viana F. Lipid raft segregation modulates TRPM8 channel activity. J Biol Chem. 2009;284:9215-24 pubmed publisher
    ..Most of these channels are expressed in the nervous system and play a key role in sensory physiology. TRPM8 (transient receptor potential melastatine 8), a member of this family, is activated by cold, cooling substances ..
  60. Uvin P, Franken J, Pinto S, Rietjens R, Grammet L, Deruyver Y, et al. Essential role of transient receptor potential M8 (TRPM8) in a model of acute cold-induced urinary urgency. Eur Urol. 2015;68:655-61 pubmed publisher
    ..Intravesical pressure and micturition were monitored in female mice (wild-type C57BL/6J, Trpa1(-/-), Trpm8(+/+), and Trpm8(-/-)) and Sprague Dawley rats. An intravesical catheter was implanted...
  61. Khalil M, Babes A, Lakra R, Försch S, Reeh P, Wirtz S, et al. Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production. Mucosal Immunol. 2016;9:1500-1513 pubmed publisher
    ..Here we show that the cold-sensing TRPM8 has an unexpected role in innate immunity...
  62. Than J, Li L, Hasan R, Zhang X. Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine. J Biol Chem. 2013;288:12818-27 pubmed publisher
    ..TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 transduces cold. The pruritogen chloroquine (CQ) was reported to excite TRPA1, leading to the sensation of itch...
  63. Ran C, Hoon M, Chen X. The coding of cutaneous temperature in the spinal cord. Nat Neurosci. 2016;19:1201-9 pubmed publisher
    ..These neurons received TRP channel M8 (TRPM8)-positive DRG inputs as well as novel TRPV1(+) DRG inputs that were selectively activated by intense cooling...
  64. Quallo T, Vastani N, Horridge E, Gentry C, Parra A, Moss S, et al. TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Nat Commun. 2015;6:7150 pubmed publisher
    ..isolated mouse dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons expressing the cold-sensitive TRPM8 channel (transient receptor potential channel, subfamily M, member 8)...
  65. Jankowski M, Rau K, Koerber H. Cutaneous TRPM8-expressing sensory afferents are a small population of neurons with unique firing properties. Physiol Rep. 2017;5: pubmed publisher
    It has been well documented that the transient receptor potential melastatin 8 (TRPM8) receptor is involved in environmental cold detection...
  66. Tamura S, Morikawa Y, Senba E. TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neuroscience. 2005;130:223-8 pubmed
    ..5, when neither TRPV1 nor TRPM8 was detected yet...
  67. Li C, Li J, Xiong X, Liu Y, Lv Y, Qin S, et al. TRPM8 activation improves energy expenditure in skeletal muscle and exercise endurance in mice. Gene. 2018;641:111-116 pubmed publisher
    ..Transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable non-selective cation channel, plays vital roles in the regulation of various ..
  68. Pogorzala L, Mishra S, Hoon M. The cellular code for mammalian thermosensation. J Neurosci. 2013;33:5533-41 pubmed publisher
    ..neurons are responsible for all behavioral responses to temperatures between 40 and 50°C, whereas TRPM8 neurons are required for cold aversion...
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    ..mouse to cold, but desensitizes and partially blocks heterologously expressed TRPM8 (transient receptor potential cation channel subfamily M member 8)...
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    ..we sought to investigate the effect of praziquantel on three mammalian TRP channels, TRP melastatin type 8 (TRPM8), TRP vanilloid type 1 (TRPV1) and TRP ankyrin type 1 (TRPA1)...
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    ..Menthol induces the sensation of cooling by activating TRPM8, an ion channel in cold-sensitive peripheral sensory neurons...