Trpm5

Summary

Gene Symbol: Trpm5
Description: transient receptor potential cation channel, subfamily M, member 5
Alias: 9430099A16Rik, LTrpC-5, Ltrpc5, Mtr1, transient receptor potential cation channel subfamily M member 5, MLSN1- and TRP-related gene 1 protein, long transient receptor potential channel 5, long transient receptor potential-related channel 5
Species: mouse
Products:     Trpm5

Top Publications

  1. Thompson J, Salcedo E, Restrepo D, Finger T. Second-order input to the medial amygdala from olfactory sensory neurons expressing the transduction channel TRPM5. J Comp Neurol. 2012;520:1819-30 pubmed publisher
    ..In addition, olfactory sensory neurons (OSNs) that express the transient receptor potential M5 (TRPM5) channel innervate a subset of glomeruli that respond to putative semiochemical stimuli...
  2. Ogura T, Krosnowski K, Zhang L, Bekkerman M, Lin W. Chemoreception regulates chemical access to mouse vomeronasal organ: role of solitary chemosensory cells. PLoS ONE. 2010;5:e11924 pubmed publisher
    ..These SCCs express transient receptor potential channel M5 (TRPM5) and the phospholipase C (PLC) beta2 signaling pathway...
  3. Lin W, Ezekwe E, Zhao Z, Liman E, Restrepo D. TRPM5-expressing microvillous cells in the main olfactory epithelium. BMC Neurosci. 2008;9:114 pubmed publisher
    ..We previously found that in a mouse strain in which the TRPM5 promoter drives expression of the green fluorescent protein (GFP), a population of ciliated olfactory sensory ..
  4. de Araujo I, Oliveira Maia A, Sotnikova T, Gainetdinov R, Caron M, Nicolelis M, et al. Food reward in the absence of taste receptor signaling. Neuron. 2008;57:930-41 pubmed publisher
    ..Here we show that trpm5-/- mice, which lack the cellular machinery required for sweet taste transduction, can develop a robust preference ..
  5. Kaske S, Krasteva G, Konig P, Kummer W, Hofmann T, Gudermann T, et al. TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells. BMC Neurosci. 2007;8:49 pubmed
    ..b>TRPM5 is known to be abundantly expressed in taste receptor cells where it participates in sweet, amino acid and bitter ..
  6. Lin W, Margolskee R, Donnert G, Hell S, Restrepo D. Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals. Proc Natl Acad Sci U S A. 2007;104:2471-6 pubmed
    ..that a downstream signaling component of the phospholipase C pathway, the transient receptor potential channel M5 (TRPM5), is coexpressed with the cyclic nucleotide-gated channel subunit A2 in a subset of mature OSNs...
  7. Tizzano M, Gulbransen B, Vandenbeuch A, Clapp T, Herman J, Sibhatu H, et al. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc Natl Acad Sci U S A. 2010;107:3210-5 pubmed publisher
    ..Genetic ablation of either G alpha-gustducin or TrpM5, essential elements of the T2R transduction cascade, eliminates the trigeminal response...
  8. Lin W, Ogura T, Margolskee R, Finger T, Restrepo D. TRPM5-expressing solitary chemosensory cells respond to odorous irritants. J Neurophysiol. 2008;99:1451-60 pubmed
    ..a large population of solitary chemosensory cells expressing the transient receptor potential channel M5 (TRPM5) using transgenic mice where the promoter of TRPM5 drives the expression of green fluorescent protein (GFP)...
  9. Liu D, Liman E. Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci U S A. 2003;100:15160-5 pubmed
    ..The ion channel, TRPM5, is an essential component of this cascade; however, the mechanism by which it is activated is not known...

More Information

Publications74

  1. Zhang Z, Zhao Z, Margolskee R, Liman E. The transduction channel TRPM5 is gated by intracellular calcium in taste cells. J Neurosci. 2007;27:5777-86 pubmed
    ..second-messenger cascade involving gustducin, phospholipase C beta2, and the transient receptor potential M5 (TRPM5) ion channel...
  2. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Perez C, Shigemura N, et al. Trpm5 null mice respond to bitter, sweet, and umami compounds. Chem Senses. 2006;31:253-64 pubmed
    b>Trpm5 is a calcium-activated cation channel expressed selectively in taste receptor cells...
  3. Enklaar T, Esswein M, Oswald M, Hilbert K, Winterpacht A, Higgins M, et al. Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family. Genomics. 2000;67:179-87 pubmed
    We recently described a novel putative Ca(2+) channel gene, MTR1, which shows a high level of homology to the human TRPC7 gene and the melastatin 1 (MLSN1) gene, another Trp (transient receptor potential protein)-related gene whose ..
  4. Riera C, Vogel H, Simon S, Damak S, le Coutre J. Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels. J Neurosci. 2009;29:2654-62 pubmed publisher
    ..in wild-type (WT) mice and in mice lacking (1) the T1R3 receptor, (2) TRPV1, the capsaicin receptor, or (3) the TRPM5 channel, the latter being necessary for the perception of sweet, bitter, and umami tasting stimuli...
  5. Liman E. TRPM5 and taste transduction. Handb Exp Pharmacol. 2007;:287-98 pubmed
    b>TRPM5 is a cation channel that it is essential for transduction of bitter, sweet and umami tastes...
  6. Clapp T, Medler K, Damak S, Margolskee R, Kinnamon S. Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25. BMC Biol. 2006;4:7 pubmed
    ..in subsets of Type II cells: T1R3-GFP mice were used to identify sweet- and umami-sensitive taste cells, while TRPM5-GFP mice were used to identify all cells that utilize the PLC signaling pathway for transduction...
  7. Ren X, Ferreira J, Zhou L, Shammah Lagnado S, Yeckel C, de Araujo I. Nutrient selection in the absence of taste receptor signaling. J Neurosci. 2010;30:8012-23 pubmed publisher
    ..Here we show that Trpm5(-/-) mice, which lack the cellular mechanisms required for sweet and several forms of l-amino acid taste ..
  8. Perez C, Huang L, Rong M, Kozak J, Preuss A, Zhang H, et al. A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci. 2002;5:1169-76 pubmed
    ..Among the differentially expressed clones, one encoded Trpm5, a member of the mammalian family of transient receptor potential (TRP) channels...
  9. Talavera K, Yasumatsu K, Voets T, Droogmans G, Shigemura N, Ninomiya Y, et al. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature. 2005;438:1022-5 pubmed
    b>TRPM5, a cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes...
  10. Hofmann T, Chubanov V, Gudermann T, Montell C. TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol. 2003;13:1153-8 pubmed
    ..One member of this subfamily, TRPM5, functions in taste receptor cells and has been reported to be activated through G protein-coupled receptors ..
  11. Ren Z, Rhyu M, Phan T, Mummalaneni S, Murthy K, Grider J, et al. TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. Am J Physiol Gastrointest Liver Physiol. 2013;305:G106-17 pubmed publisher
    Transient receptor potential (TRP) subfamily M member 5 (TRPM5) cation channel is involved in sensing sweet, bitter, umami, and fat taste stimuli, complex-tasting divalent salts, and temperature-induced changes in sweet taste...
  12. Enklaar T, Brixel L, Zabel B, Prawitt D. Adding efficiency: the role of the CAN ion channels TRPM4 and TRPM5 in pancreatic islets. Islets. 2010;2:337-8 pubmed
    ..Recently two calcium activated nonselective (CAN) cation channels (TRPM4 and TRPM5) have been shown to influence efficient insulin response upon glucose stimulation...
  13. Uhl S, Mathar I, Vennekens R, Freichel M. Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice. J Mol Cell Cardiol. 2014;74:307-17 pubmed publisher
    TRPM4 and TRPM5 proteins belong to the Transient Receptor Potential (TRP) ion channel family and form Ca(2+)-activated nonselective cation channels...
  14. Lemons K, Fu Z, Aoudé I, Ogura T, Sun J, Chang J, et al. Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment. Eneuro. 2017;4: pubmed publisher
    ..Previously, a population of non-neuronal, transient receptor potential M5-expressing microvillous cells (TRPM5-MCs) was identified in the MOE, and the initial characterization of these cells showed that they are cholinergic ..
  15. Sclafani A, Zukerman S, Glendinning J, Margolskee R. Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1504-13 pubmed
    b>Trpm5 and alpha-gustducin are key to the transduction of tastes of sugars, amino acids, and bitter compounds...
  16. Hisatsune C, Yasumatsu K, Takahashi Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, et al. Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor. J Biol Chem. 2007;282:37225-31 pubmed
    ..We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation.
  17. Eddy M, Eschle B, Peterson D, Lauras N, Margolskee R, Delay E. A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice. Chem Senses. 2012;37:391-401 pubmed publisher
    Previously, published studies have reported mixed results regarding the role of the TRPM5 cation channel in signaling sweet taste by taste sensory cells...
  18. Domingos A, Sordillo A, Dietrich M, Liu Z, Tellez L, Vaynshteyn J, et al. Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. elife. 2013;2:e01462 pubmed publisher
    ..neurons project to reward areas and are required for the post-ingestive rewarding effect of sucrose in sweet-blind Trpm5(-/-) mice...
  19. Prandi S, Bromke M, Hübner S, Voigt A, Boehm U, Meyerhof W, et al. A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS ONE. 2013;8:e82820 pubmed publisher
    ..Expression in colonic goblet cells is consistent with a role of Tas2rs in defense mechanisms against potentially harmful xenobiotics. ..
  20. Colsoul B, Schraenen A, Lemaire K, Quintens R, Van Lommel L, Segal A, et al. Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A. 2010;107:5208-13 pubmed publisher
    ..We propose that TRPM5, a Ca(2+)-activated monovalent cation channel, is a positive regulator of glucose-induced insulin release...
  21. Ota M, Kaneko Y, Kondo K, Ogishima S, Tanaka H, Eto K, et al. Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation. PLoS Genet. 2009;5:e1000443 pubmed publisher
    ..Thus, according to our composite analyses, Hes1 is likely to play a role in orchestrating taste cell differentiation in developing taste buds. ..
  22. Onyango P, Miller W, Lehoczky J, Leung C, Birren B, Wheelan S, et al. Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain. Genome Res. 2000;10:1697-710 pubmed
    ..This study provides the first global view of the architecture of an entire imprinted domain and provides candidate sequence elements for subsequent functional analyses. ..
  23. Staaf S, Franck M, Marmigere F, Mattsson J, Ernfors P. Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. Gene Expr Patterns. 2010;10:65-74 pubmed publisher
    ..For most channels, the expression increased from E14 to adult with the exception of TRPM5, which displayed transient high levels during embryonic and early postnatal stages...
  24. Yamaguchi T, Yamashita J, Ohmoto M, Aoudé I, Ogura T, Luo W, et al. Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium. BMC Neurosci. 2014;15:13 pubmed publisher
    ..Recent studies have shown that a population of microvillous cells expresses the monovalent cation channel Trpm5 (transient receptor potential channel M5)...
  25. Brixel L, Monteilh Zoller M, Ingenbrandt C, Fleig A, Penner R, Enklaar T, et al. TRPM5 regulates glucose-stimulated insulin secretion. Pflugers Arch. 2010;460:69-76 pubmed publisher
    ..b>TRPM5 is a cation channel expressed in beta-cells and proposed to be involved in coupling intracellular Ca(2+) release ..
  26. Paulsen M, El Maarri O, Engemann S, Strödicke M, Franck O, Davies K, et al. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. Hum Mol Genet. 2000;9:1829-41 pubmed
    ..Third, two of the orthologous gene pairs Tssc4/TSSC4 and Ltrpc5/LTRPC5 showed apparent differences in imprinting between human and mouse, whereas others like Tssc6/TSSC6 were not ..
  27. Liu D, Zhang Z, Liman E. Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains. J Biol Chem. 2005;280:20691-9 pubmed
    b>TRPM5, a member of the superfamily of transient receptor potential ion channels, is essential for the detection of bitter, sweet, and amino acid tastes...
  28. Rong M, He W, Yasumatsu K, Kokrashvili Z, Perez C, Mosinger B, et al. Signal transduction of umami taste: insights from knockout mice. Chem Senses. 2005;30 Suppl 1:i33-4 pubmed
  29. Oike H, Wakamori M, Mori Y, Nakanishi H, Taguchi R, Misaka T, et al. Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells. Biochim Biophys Acta. 2006;1761:1078-84 pubmed
    ..As a result of activation of G protein and phospholipase Cbeta2, the TRPM5 channel is activated...
  30. Glendinning J, Gillman J, Zamer H, Margolskee R, Sclafani A. The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice. Physiol Behav. 2012;107:50-8 pubmed publisher
    We examined the role of T1r3 and Trpm5 taste signaling proteins in carbohydrate-induced overeating and obesity...
  31. Ullrich N, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, et al. Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium. 2005;37:267-78 pubmed
    ..TRPM4 and TRPM5, two Ca2+-activated cation channels of the TRP superfamily, are potential molecular correlates of NSC channels...
  32. Kokrashvili Z, Rodriguez D, Yevshayeva V, Zhou H, Margolskee R, Mosinger B. Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5. Gastroenterology. 2009;137:598-606, 606.e1-2 pubmed publisher
    ..cells in duodenum that produce several peptides, including endogenous opioids, and that also express the Trpm5 cation channel...
  33. Sclafani A, Ackroff K. Flavor preference conditioning by different sugars in sweet ageusic Trpm5 knockout mice. Physiol Behav. 2015;140:156-63 pubmed publisher
    Knockout (KO) mice missing the taste signaling protein Trpm5 have greatly attenuated sweetener preferences but develop strong preferences for glucose in 24-h tests, which is attributed to post-oral sugar conditioning...
  34. Shigeto M, Ramracheya R, Tarasov A, Cha C, Chibalina M, Hastoy B, et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest. 2015;125:4714-28 pubmed publisher
    ..of GLP-1 on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca(2+) from thapsigargin-sensitive Ca(2+) stores...
  35. Howitt M, Lavoie S, Michaud M, Blum A, Tran S, Weinstock J, et al. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016;351:1329-33 pubmed publisher
    ..Our results identify intestinal tuft cells as critical sentinels in the gut epithelium that promote type 2 immunity in response to intestinal parasites. ..
  36. Zukerman S, Glendinning J, Margolskee R, Sclafani A. Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice. Chem Senses. 2013;38:421-37 pubmed publisher
    Knockout (KO) mice missing the sweet taste receptor subunit T1r3 or the signaling protein Trpm5 have greatly attenuated sweetener preferences but learn to prefer sucrose in 24-h tests...
  37. Nishiguchi Y, Ohmoto M, Koki J, Enomoto T, Kominami R, Matsumoto I, et al. Bcl11b/Ctip2 is required for development of lingual papillae in mice. Dev Biol. 2016;416:98-110 pubmed publisher
    ..These results indicate that Bcl11b regulates the differentiation of keratinocytes in the tongue and identify Bcl11b as an essential factor for the lingual papilla morphogenesis. ..
  38. López F, Delgado R, Lopez R, Bacigalupo J, Restrepo D. Transduction for pheromones in the main olfactory epithelium is mediated by the Ca2+ -activated channel TRPM5. J Neurosci. 2014;34:3268-78 pubmed publisher
    ..One candidate subpopulation expresses the calcium activated cation channel TRPM5 (transient receptor potential channel M5)...
  39. Saunders C, Christensen M, Finger T, Tizzano M. Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation. Proc Natl Acad Sci U S A. 2014;111:6075-80 pubmed publisher
    ..Taken together, these results show that SCCs use cholinergic neurotransmission to trigger peptidergic trigeminal nociceptors, which link SCCs to the neurogenic inflammatory pathway. ..
  40. Oliveira Maia A, Stapleton Kotloski J, Lyall V, Phan T, Mummalaneni S, Melone P, et al. Nicotine activates TRPM5-dependent and independent taste pathways. Proc Natl Acad Sci U S A. 2009;106:1596-601 pubmed publisher
    ..Here, rats and mice were used to determine whether nicotine activates peripheral and central taste pathways via TRPM5-dependent mechanisms, which are essential for responses to other bitter tastants such as quinine, and/or via ..
  41. Fitzpatrick G, Soloway P, Higgins M. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet. 2002;32:426-31 pubmed
    ..These findings support the hypothesis that loss of methylation in BWS patients activates the repressive function of KvDMR1 on the maternal chromosome, resulting in abnormal silencing of CDKN1C and the development of BWS. ..
  42. Qian J, Mummalaneni S, Grider J, Damaj M, Lyall V. Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs). PLoS ONE. 2018;13:e0190465 pubmed publisher
    Nicotine evokes chorda tympani (CT) taste nerve responses and an aversive behavior in Trpm5 knockout (KO) mice...
  43. Yasumatsu K, Ogiwara Y, Takai S, Yoshida R, Iwatsuki K, Torii K, et al. Umami taste in mice uses multiple receptors and transduction pathways. J Physiol. 2012;590:1155-70 pubmed publisher
    ..from wild-type mice and mice genetically lacking T1R3 or its downstream transduction molecule, the ion channel TRPM5. Our results indicate that single umami-sensitive fibres in wild-type mice fall into two major groups: sucrose-..
  44. Shindo Y, Morishita K, Kotake E, Miura H, Carninci P, Kawai J, et al. FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells. Biosci Biotechnol Biochem. 2011;75:1061-6 pubmed
    ..showed that Fxyd6 was coexpressed with transient receptor potential cation channel, subfamily M, member 5 (Trpm5), a critical component of the sweet, bitter, and umami taste signal transduction pathways and that it was ..
  45. Engemann S, Strödicke M, Paulsen M, Franck O, Reinhardt R, Lane N, et al. Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting. Hum Mol Genet. 2000;9:2691-706 pubmed
    ..One of the genes outside the cluster, Obph1, is imprinted in mouse placenta indicating that at least in extra-embryonic tissues the imprinting cluster extends into a larger domain. ..
  46. Shah B, Liu P, Yu T, Hansen D, Gilbertson T. TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. Am J Physiol Cell Physiol. 2012;302:C210-9 pubmed publisher
    ..LA leads to activation of monovalent cation-specific transient receptor potential channel type M5 (TRPM5) in STC-1 cells...
  47. Ruf N, Dünzinger U, Brinckmann A, Haaf T, Nurnberg P, Zechner U. Expression profiling of uniparental mouse embryos is inefficient in identifying novel imprinted genes. Genomics. 2006;87:509-19 pubmed
  48. Devantier H, Long D, Brennan F, Carlucci S, Hendrix C, Bryant R, et al. Quantitative assessment of TRPM5-dependent oral aversiveness of pharmaceuticals using a mouse brief-access taste aversion assay. Behav Pharmacol. 2008;19:673-82 pubmed publisher
    ..T2R G-protein coupled receptors through a peripheral signaling pathway critically dependent upon function of the TRPM5 ion channel...
  49. Deckmann K, Filipski K, Krasteva Christ G, Fronius M, Althaus M, Rafiq A, et al. Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. Proc Natl Acad Sci U S A. 2014;111:8287-92 pubmed publisher
    ..We propose a concept of urinary bladder control involving a previously unidentified cholinergic chemosensory cell monitoring the chemical composition of the urethral luminal microenvironment for potential hazardous content. ..
  50. Bjerknes M, Khandanpour C, Moroy T, Fujiyama T, Hoshino M, Klisch T, et al. Origin of the brush cell lineage in the mouse intestinal epithelium. Dev Biol. 2012;362:194-218 pubmed publisher
  51. Yamashita J, Ohmoto M, Yamaguchi T, Matsumoto I, Hirota J. Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice. PLoS ONE. 2017;12:e0189340 pubmed publisher
    Transient receptor potential channel M5 (Trpm5)-expressing cells, such as sweet, umami, and bitter taste cells in the oropharyngeal epithelium, solitary chemosensory cells in the nasal respiratory epithelium, and tuft cells in the small ..
  52. Zocchi D, Wennemuth G, Oka Y. The cellular mechanism for water detection in the mammalian taste system. Nat Neurosci. 2017;20:927-933 pubmed publisher
    ..Taken together, this study revealed a function of mammalian acid-sensing TRCs that provide a cue for external water. ..
  53. Kyriazis G, Smith K, Tyrberg B, Hussain T, Pratley R. Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice. Endocrinology. 2014;155:2112-21 pubmed publisher
    ..These observations further suggest that STRs might be a promising therapeutic target to prevent and treat type 2 diabetes. ..
  54. Ohkuri T, Yasumatsu K, Horio N, Jyotaki M, Margolskee R, Ninomiya Y. Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity. Am J Physiol Regul Integr Comp Physiol. 2009;296:R960-71 pubmed publisher
    ..involves taste receptor type 1, member 2 (T1R2), taste receptor type 1, member 3 (T1R3), gustducin, and TRPM5. Because knockout (KO) mice lacking T1R3, gustducin's Galpha subunit (Galphagust), or TRPM5 exhibited greatly ..
  55. Talavera K, Yasumatsu K, Yoshida R, Margolskee R, Voets T, Ninomiya Y, et al. The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions. FASEB J. 2008;22:1343-55 pubmed
    ..Here we report that TRPM5, a cation channel involved in sweet taste transduction, is inhibited by quinine (EC(50)=50 microM at -50 mV) owing ..
  56. Oka Y, Butnaru M, von Buchholtz L, Ryba N, Zuker C. High salt recruits aversive taste pathways. Nature. 2013;494:472-5 pubmed publisher
    ..We propose that the 'co-opting' of sour and bitter neural pathways evolved as a means to ensure that high levels of salt reliably trigger robust behavioural rejection, thus preventing its potentially detrimental effects on health. ..
  57. Uchida K, Tominaga M. Extracellular zinc ion regulates transient receptor potential melastatin 5 (TRPM5) channel activation through its interaction with a pore loop domain. J Biol Chem. 2013;288:25950-5 pubmed publisher
    The transient receptor potential melastatin 5 (TRPM5) channel is a monovalent cation channel activated by intracellular Ca(2+)...
  58. Yatsuki H, Watanabe H, Hattori M, Joh K, Soejima H, Komoda H, et al. Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and. DNA Res. 2000;7:195-206 pubmed
    ..Many expressed sequence tags (ESTs) were mapped on this locus. Three genes, Lit1 (Kvlqt1-AS), Mtr1 and Tssc4, were identified and characterized...
  59. Saqui Salces M, Keeley T, Grosse A, Qiao X, El Zaatari M, Gumucio D, et al. Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochem Cell Biol. 2011;136:191-204 pubmed publisher
    ..In the adult GI tract, the tuft cell marker acTub co-expressed with DCKL1 and chemosensory markers, e.g.,TRPM5. In summary, tuft cells appear in the gastric antrum and intestine at E18...
  60. Pyrski M, Eckstein E, Schmid A, Bufe B, Weiss J, Chubanov V, et al. Trpm5 expression in the olfactory epithelium. Mol Cell Neurosci. 2017;80:75-88 pubmed publisher
    The Ca2+-activated monovalent cation channel Trpm5 is a key element in chemotransduction of taste receptor cells of the tongue, but the extent to which Trpm5 channels are expressed in olfactory sensory neurons (OSNs) of the ..
  61. Oshimoto A, Wakabayashi Y, Garske A, Lopez R, Rolen S, Flowers M, et al. Potential role of transient receptor potential channel M5 in sensing putative pheromones in mouse olfactory sensory neurons. PLoS ONE. 2013;8:e61990 pubmed publisher
    Based on pharmacological studies of chemosensory transduction in transient receptor potential channel M5 (TRPM5) knockout mice it was hypothesized that this channel is involved in transduction for a subset of putative pheromones in mouse ..
  62. Huang Y, Roper S. Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells. J Physiol. 2010;588:2343-50 pubmed publisher
    ..Taste-evoked ATP secretion is absent in receptor cells isolated from TRPM5 knockout mice or in taste cells from wild type mice where current through TRPM5 channels has been eliminated...
  63. Koudelka J, Horn J, Vatanashevanopakorn C, Minichiello L. Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21 pubmed publisher
    ..These results advance our knowledge of the biology of the taste system, one of the fundamental sensory systems crucial for an organism to relate to the environment. ..
  64. Barbet G, Demion M, Moura I, Serafini N, Léger T, Vrtovsnik F, et al. The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nat Immunol. 2008;9:1148-56 pubmed publisher
    ..Our results establish TRPM4-regulated Ca(2+) homeostasis as crucial for DC mobility but not maturation and emphasize that DC maturation and migration are independently regulated. ..
  65. Blednov Y, Walker D, Martinez M, Levine M, Damak S, Margolskee R. Perception of sweet taste is important for voluntary alcohol consumption in mice. Genes Brain Behav. 2008;7:1-13 pubmed
    ..each lacking a gene expressed in taste buds and critical to taste transduction: alpha-gustducin (Gnat3), Tas1r3 or Trpm5. Null mutant mice lacking any of these three genes showed lower preference score for alcohol and consumed less ..