Trpm4

Summary

Gene Symbol: Trpm4
Description: transient receptor potential cation channel, subfamily M, member 4
Alias: 1110030C19Rik, AW047689, LTRPC4, LTrpC-4, TRPM4B, transient receptor potential cation channel subfamily M member 4, calcium-activated non-selective cation channel 1, long transient receptor potential channel 4, transient receptor potential ion channel melastatin subgroup member 4
Species: mouse
Products:     Trpm4

Top Publications

  1. Murakami M, Xu F, Miyoshi I, Sato E, Ono K, Iijima T. Identification and characterization of the murine TRPM4 channel. Biochem Biophys Res Commun. 2003;307:522-8 pubmed
    ..Both TRPM4 variants integrated into the plasma membrane. Furthermore, FRET analysis revealed that TRPM4a and TRPM4b localized close together, suggesting a multimerization of the two molecules.
  2. Enklaar T, Brixel L, Zabel B, Prawitt D. Adding efficiency: the role of the CAN ion channels TRPM4 and TRPM5 in pancreatic islets. Islets. 2010;2:337-8 pubmed
    ..Recently two calcium activated nonselective (CAN) cation channels (TRPM4 and TRPM5) have been shown to influence efficient insulin response upon glucose stimulation...
  3. Serafini N, Dahdah A, Barbet G, Demion M, Attout T, Gautier G, et al. The TRPM4 channel controls monocyte and macrophage, but not neutrophil, function for survival in sepsis. J Immunol. 2012;189:3689-99 pubmed
    ..In this study, we report that the ablation of the Trpm4 gene dramatically increased mouse mortality in a model of sepsis induced by cecal ligation and puncture...
  4. Mathar I, Kecskés M, Van der Mieren G, Jacobs G, Camacho Londoño J, Uhl S, et al. Increased ?-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice. Circ Res. 2014;114:283-94 pubmed publisher
    The Trpm4 gene has recently been associated with several disorders, including cardiac conduction diseases and Brugada syndrome...
  5. Sala Rabanal M, Wang S, Nichols C. On potential interactions between non-selective cation channel TRPM4 and sulfonylurea receptor SUR1. J Biol Chem. 2012;287:8746-56 pubmed publisher
    ..physical coupling of SUR1 with Kir6 subunits appears exclusive, but recent studies argue that SUR1 also modulates TRPM4, a member of the transient receptor potential family of non-selective cation channels...
  6. Barbet G, Demion M, Moura I, Serafini N, Léger T, Vrtovsnik F, et al. The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nat Immunol. 2008;9:1148-56 pubmed publisher
    ..Here we report that the Ca(2+)-activated nonselective cation channel TRPM4 was expressed in and controlled the Ca(2+) homeostasis of mouse DCs...
  7. Nilius B, Prenen J, Droogmans G, Voets T, Vennekens R, Freichel M, et al. Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem. 2003;278:30813-20 pubmed
    b>TRPM4 is a Ca2+-activated but Ca2+-impermeable cation channel. An increase of [Ca2+]i induces activation and subsequent reduction of currents through TRPM4 channels. This inactivation is strikingly decreased in cell-free patches...
  8. Simard C, Hof T, Keddache Z, Launay P, Guinamard R. The TRPM4 non-selective cation channel contributes to the mammalian atrial action potential. J Mol Cell Cardiol. 2013;59:11-9 pubmed publisher
    The TRPM4 calcium-activated non-selective monovalent cation channel has been reported in mammalian atrial cardiomyocytes, but its implication in this tissue remains unknown...
  9. Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, Camacho Londoño J, et al. Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J Clin Invest. 2010;120:3267-79 pubmed publisher
    ..The melastatin TRP channels TRPM4 and TRPM5 have distinct properties within the TRP channel family: they form nonselective cation channels activated ..

More Information

Publications35

  1. Staaf S, Franck M, Marmigere F, Mattsson J, Ernfors P. Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. Gene Expr Patterns. 2010;10:65-74 pubmed publisher
  2. Gerzanich V, Woo S, Vennekens R, Tsymbalyuk O, Ivanova S, Ivanov A, et al. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med. 2009;15:185-91 pubmed publisher
    The role of transient receptor potential M4 (Trpm4), an unusual member of the Trp family of ion channels, is poorly understood...
  3. Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp S, et al. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol. 2007;8:312-20 pubmed
    ..Here we show that transient receptor potential TRPM4 proteins acted as calcium-activated nonselective cation channels and critically determined the driving force for ..
  4. Demion M, Bois P, Launay P, Guinamard R. TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells. Cardiovasc Res. 2007;73:531-8 pubmed
    ..Also, RT-PCR and Western-blotting studies were used to probe for TRPM4 mRNA and protein expression. In these cells, an NSC(Ca) activity was detected...
  5. Ullrich N, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, et al. Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium. 2005;37:267-78 pubmed
    ..b>TRPM4 and TRPM5, two Ca2+-activated cation channels of the TRP superfamily, are potential molecular correlates of NSC ..
  6. Kecskés M, Jacobs G, Kerselaers S, Syam N, Menigoz A, Vangheluwe P, et al. The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy. Basic Res Cardiol. 2015;110:43 pubmed publisher
    ..Transient receptor potential melastatin 4 protein (TRPM4) is a calcium-activated non-selective cation channel, which plays a role in regulating calcium influx and calcium-..
  7. Shigeto M, Ramracheya R, Tarasov A, Cha C, Chibalina M, Hastoy B, et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest. 2015;125:4714-28 pubmed publisher
    ..effect of GLP-1 on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca(2+) from thapsigargin-sensitive Ca(2+) stores...
  8. Vandewauw I, Owsianik G, Voets T. Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse. BMC Neurosci. 2013;14:21 pubmed publisher
    ..At the mRNA level, 17 of the 28 TRP channel genes, TRPA1, TRPC1, TRPC3, TRPC4, TRPC5, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, TRPV1, TRPV2, TRPV4, TRPML1 and TRPP2, were detectable in every tested ganglion...
  9. Woo S, Kwon M, Ivanov A, Gerzanich V, Simard J. The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm4) channel. J Biol Chem. 2013;288:3655-67 pubmed publisher
    ..that Sur1-NC(Ca-ATP) channels are formed by co-assembly of Sur1 and transient receptor potential melastatin 4 (Trpm4)...
  10. Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, et al. TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med. 2012;18:1805-11 pubmed publisher
    ..Here we show that the transient receptor potential melastatin 4 (TRPM4) cation channel is crucial in this process...
  11. Demion M, Thireau J, Gueffier M, Finan A, Khoueiry Z, Cassan C, et al. Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations. PLoS ONE. 2014;9:e115256 pubmed publisher
    b>TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue...
  12. Wu J, Peng S, Wu R, Hao Y, Ji G, Yuan Z. Generation of Calhm1 knockout mouse and characterization of calhm1 gene expression. Protein Cell. 2012;3:470-80 pubmed publisher
    ..In sum, we found that mouse Calhm1 was of rare abundance in brain tissues. So it might not be suitable to utilize the knockout murine model to explore biological function of Calhm1 in the pathogenesis of AD. ..
  13. Menigoz A, Ahmed T, Sabanov V, Philippaert K, Pinto S, Kerselaers S, et al. TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons. Pflugers Arch. 2016;468:593-607 pubmed publisher
    b>TRPM4 is a calcium-activated but calcium-impermeable non-selective cation (CAN) channel...
  14. Nelson P, Zolochevska O, Figueiredo M, Soliman A, Hsu W, Feng J, et al. Regulation of Ca(2+)-entry in pancreatic ?-cell line by transient receptor potential melastatin 4 plays a vital role in glucagon release. Mol Cell Endocrinol. 2011;335:126-34 pubmed publisher
    ..The Transient Receptor Potential Melastatin 4 channel (TRPM4) is critical for Ca(2+) signaling. However, its role in glucagon secreting ?-cells has not been investigated...
  15. Jacobs G, Oosterlinck W, Dresselaers T, Geenens R, Kerselaers S, Himmelreich U, et al. Enhanced β-adrenergic cardiac reserve in Trpm4⁻/⁻ mice with ischaemic heart failure. Cardiovasc Res. 2015;105:330-9 pubmed publisher
    ..We have shown previously that Transient Receptor Potential Melastatin 4 protein (TRPM4) functions as a Ca(2+)-activated non-selective cation channel and constitutes a novel regulator of ventricular ..
  16. Flannery R, Kleene N, Kleene S. A TRPM4-dependent current in murine renal primary cilia. Am J Physiol Renal Physiol. 2015;309:F697-707 pubmed publisher
    ..channel in the ciliary membrane: the transient receptor potential cation channel, subfamily M, member 4 (TRPM4)...
  17. Cho C, Kim E, Lee Y, Yarishkin O, Yoo J, Park J, et al. Depletion of 14-3-3? reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death. Mol Brain. 2014;7:52 pubmed publisher
    ..We have found the 14-3-3? as a binding partner for TRPM4b using its N-terminal fragment from the yeast-two hybrid screening...
  18. Uhl S, Mathar I, Vennekens R, Freichel M. Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice. J Mol Cell Cardiol. 2014;74:307-17 pubmed publisher
    b>TRPM4 and TRPM5 proteins belong to the Transient Receptor Potential (TRP) ion channel family and form Ca(2+)-activated nonselective cation channels...
  19. Woo S, Kwon M, Ivanov A, Geng Z, Gerzanich V, Simard J. Complex N-glycosylation stabilizes surface expression of transient receptor potential melastatin 4b protein. J Biol Chem. 2013;288:36409-17 pubmed publisher
    ..b>Trpm4b was expressed in vivo in all rat tissues examined...
  20. Weber K, Hildner K, Murphy K, Allen P. Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. J Immunol. 2010;185:2836-46 pubmed publisher
    ..b>Trpm4 is a Ca(2+)-activated cation channel that we found is expressed at higher levels in Th2 cells compared with Th1 ..
  21. Crnich R, Amberg G, Leo M, Gonzales A, Tamkun M, Jaggar J, et al. Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2010;299:C682-94 pubmed publisher
    The melastatin (M) transient receptor potential (TRP) channel TRPM4 mediates pressure and protein kinase C (PKC)-induced smooth muscle cell depolarization and vasoconstriction of cerebral arteries...
  22. Zhang Z, Okawa H, Wang Y, Liman E. Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. J Biol Chem. 2005;280:39185-92 pubmed
    b>TRPM4 is a Ca(2+)-activated nonselective cation channel that regulates membrane potential in response to intracellular Ca(2+) signaling...
  23. Sakuraba M, Murata J, Teruyama R, Kamiya K, Yamaguchi J, Okano H, et al. Spatiotemporal expression of TRPM4 in the mouse cochlea. J Neurosci Res. 2014;92:1409-18 pubmed publisher
    The present study was conducted to elucidate the presence of the transient receptor potential cation channel subfamily M member 4, TRPM4, in the mouse inner ear...
  24. Guo J, She J, Zeng W, Chen Q, Bai X, Jiang Y. Structures of the calcium-activated, non-selective cation channel TRPM4. Nature. 2017;552:205-209 pubmed publisher
    b>TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) -modulated, non-selective cation channel that belongs to the family of melastatin-related transient receptor potential (TRPM) channels...
  25. Marigo V, Courville K, Hsu W, Feng J, Cheng H. TRPM4 impacts on Ca2+ signals during agonist-induced insulin secretion in pancreatic beta-cells. Mol Cell Endocrinol. 2009;299:194-203 pubmed publisher
    b>TRPM4 is a Ca(2+)-activated non-selective cation (CAN) channel that functions in cell depolarization, which is important for Ca(2+) influx and insulin secretion in pancreatic beta-cells...
  26. Shimizu T, Owsianik G, Freichel M, Flockerzi V, Nilius B, Vennekens R. TRPM4 regulates migration of mast cells in mice. Cell Calcium. 2009;45:226-32 pubmed publisher
    We demonstrate here that the transient receptor potential melastatin subfamily channel, TRPM4, controls migration of bone marrow-derived mast cells (BMMCs), triggered by dinitrophenylated human serum albumin (DNP-HSA) or stem cell factor ..