Gene Symbol: Trpm3
Description: transient receptor potential cation channel, subfamily M, member 3
Alias: 6330504P12Rik, 9330180E14, AU018608, B930001P07Rik, LTRPC3, MLSN2, transient receptor potential cation channel subfamily M member 3, melastatin 2, transient receptor potential melastatin 3 beta 1
Species: mouse
Products:     Trpm3

Top Publications

  1. Frühwald J, Camacho Londoño J, Dembla S, Mannebach S, Lis A, Drews A, et al. Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels. J Biol Chem. 2012;287:36663-72 pubmed publisher
    b>TRPM3 channels form ionotropic steroid receptors in the plasma membrane of pancreatic ? and dorsal root ganglion cells and link steroid hormone signaling to insulin release and pain perception, respectively...
  2. Vriens J, Owsianik G, Hofmann T, Philipp S, Stab J, Chen X, et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron. 2011;70:482-94 pubmed publisher
    Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca(2+)-permeable nonselective cation channel...
  3. Deo M, Yu J, Chung K, Tippens M, Turner D. Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides. Dev Dyn. 2006;235:2538-48 pubmed
    ..miR-204 is located in an intron of the TRPM3 gene, and the TRPM3 mRNA is coexpressed with miR-204 in the choroid plexus...
  4. Karali M, Peluso I, Marigo V, Banfi S. Identification and characterization of microRNAs expressed in the mouse eye. Invest Ophthalmol Vis Sci. 2007;48:509-15 pubmed
    ..Knowledge of the spatiotemporal distribution of miRNAs is an essential step toward the identification of their targets and eventually the elucidation of their biological role in eye development and function. ..
  5. Shaham O, Gueta K, Mor E, Oren Giladi P, Grinberg D, Xie Q, et al. Pax6 regulates gene expression in the vertebrate lens through miR-204. PLoS Genet. 2013;9:e1003357 pubmed publisher
    ..Here, we reveal that Trpm3 and the intronic microRNA gene miR-204 are co-regulated by Pax6 during eye development...
  6. Xie Q, Yang Y, Huang J, Ninkovic J, Walcher T, Wolf L, et al. Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. PLoS ONE. 2013;8:e54507 pubmed publisher
    ..5 wild type and Pax6?/? lens placodes that suggested Efnb2, Fat4, Has2, Nav1, and Trpm3 as novel Pax6-direct targets...
  7. Oberwinkler J, Lis A, Giehl K, Flockerzi V, Philipp S. Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem. 2005;280:22540-8 pubmed
    b>TRPM3 is a poorly understood member of the large family of transient receptor potential (TRP) ion channels. Here we describe five novel splice variants of TRPM3, TRPM3alpha1-5...
  8. Hughes S, Pothecary C, Jagannath A, Foster R, Hankins M, Peirson S. Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception. Eur J Neurosci. 2012;35:34-43 pubmed publisher
    ..However, previous microarray studies have shown that Trpm1 and Trpm3 are acutely regulated by light in the eyes of mice lacking rods and cones (rd/rd cl), a finding consistent with a ..
  9. Wagner T, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol. 2008;10:1421-30 pubmed publisher
    ..We show here that TRPM3, a divalent-permeable cation channel, is rapidly and reversibly activated by extracellular pregnenolone sulphate, ..

More Information


  1. Siroky B, Kleene N, Kleene S, Varnell C, Comer R, Liu J, et al. Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. Am J Physiol Renal Physiol. 2017;312:F791-F805 pubmed publisher
    ..The transient receptor potential (TRP) channels TRPV4 and TRPM3 are osmoresponsive...
  2. Dembla S, Behrendt M, Mohr F, Goecke C, Sondermann J, Schneider F, et al. Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels. elife. 2017;6: pubmed publisher
    ..Here, we show in neurons of murine dorsal root ganglia that pro-nociceptive TRPM3 channels, present in the peripheral parts of nociceptors, are strongly inhibited by µOR activation, much more ..
  3. Mayer S, Muller I, Mannebach S, Endo T, Thiel G. Signal transduction of pregnenolone sulfate in insulinoma cells: activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors. J Biol Chem. 2011;286:10084-96 pubmed publisher
    ..Together, these data show that pregnenolone sulfate induces a signaling cascade in insulinoma cells that is very similar to the signaling cascade induced by glucose in ?-cells. ..
  4. Naylor J, Li J, Milligan C, Zeng F, Sukumar P, Hou B, et al. Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circ Res. 2010;106:1507-15 pubmed publisher
    ..Although vascular TRPM3 mRNA has been reported, there is no knowledge of TRPM3 protein or its regulation and function in the ..
  5. Held K, Kichko T, De Clercq K, Klaassen H, Van Bree R, Vanherck J, et al. Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc Natl Acad Sci U S A. 2015;112:E1363-72 pubmed publisher
    Transient receptor potential (TRP) cation channel subfamily M member 3 (TRPM3), a member of the TRP channel superfamily, was recently identified as a nociceptor channel in the somatosensory system, where it is involved in the detection ..
  6. Avery J, Etzion S, DeBosch B, Jin X, Lupu T, Beitinjaneh B, et al. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106:1516-23 pubmed publisher
    ..These results demonstrate that TRB3 induction is a significant aspect of the ER stress response in cardiac myocytes and that TRB3 antagonizes cardiac glucose metabolism and cardiac myocyte survival. ..
  7. Hackler L, Wan J, Swaroop A, Qian J, Zack D. MicroRNA profile of the developing mouse retina. Invest Ophthalmol Vis Sci. 2010;51:1823-31 pubmed publisher
    ..Conclusions. Global expression profiling revealed dozens of miRNAs with significant expression changes in the developing retina. Precise patterns of expression of miRNAs suggest their specific roles in development. ..
  8. Staaf S, Franck M, Marmigere F, Mattsson J, Ernfors P. Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. Gene Expr Patterns. 2010;10:65-74 pubmed publisher
  9. Xie Q, Ung D, Khafizov K, Fiser A, Cvekl A. Gene regulation by PAX6: structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204. Mol Vis. 2014;20:270-82 pubmed
    ..We also identified the Trpm3 gene as a Pax6-direct target containing the miR-204 gene located in intron 6...
  10. Kim S, Avila J, Massett M. Strain survey and genetic analysis of vasoreactivity in mouse aorta. Physiol Genomics. 2016;48:861-873 pubmed publisher
    ..This study represents the first step toward the unbiased comprehensive discovery of genetic determinants that regulate intrinsic vascular function, particularly endothelial function. ..
  11. Brown R, Xiong W, Peters J, Tekmen Clark M, Strycharska Orczyk I, REED B, et al. TRPM3 expression in mouse retina. PLoS ONE. 2015;10:e0117615 pubmed publisher
    ..Within the retina, two closely related members of the melastatin TRP family, TRPM1 and TRPM3, are highly expressed...
  12. Ohana R, Weiman Kelman B, Raviv S, Tamm E, Pasmanik Chor M, Rinon A, et al. MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors. Development. 2015;142:2487-98 pubmed publisher
    ..This study reveals the combined regulatory activity of miRNAs that is required for RPE differentiation and for the development of the adjacent neuroretina. ..