Trpm2

Summary

Gene Symbol: Trpm2
Description: transient receptor potential cation channel, subfamily M, member 2
Alias: 9830168K16Rik, C79133, LTRPC2, TRPC7, Trp7, Trrp7, transient receptor potential cation channel subfamily M member 2, LTrpC-2, long transient receptor potential channel 2, transient receptor potential channel 7, transient receptor protein 7
Species: mouse
Products:     Trpm2

Top Publications

  1. Vennekens R, Voets T, Bindels R, Droogmans G, Nilius B. Current understanding of mammalian TRP homologues. Cell Calcium. 2002;31:253-64 pubmed
    ..This review summarizes the currently available information concerning members of the TRP family expressed in mammalian tissues. ..
  2. Zhang Z, Zhang W, Jung D, Ko H, Lee Y, Friedline R, et al. TRPM2 Ca2+ channel regulates energy balance and glucose metabolism. Am J Physiol Endocrinol Metab. 2012;302:E807-16 pubmed publisher
    b>TRPM2 Ca(2+)-permeable cation channel is widely expressed and activated by markers of cellular stress...
  3. Olah M, Jackson M, Li H, Perez Y, Sun H, Kiyonaka S, et al. Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol. 2009;587:965-79 pubmed publisher
    b>TRPM2 is a Ca(2+)-permeable member of the transient receptor potential melastatin family of cation channels whose activation by reactive oxygen/nitrogen species (ROS/RNS) and ADP-ribose (ADPR) is linked to cell death...
  4. Knowles H, Heizer J, Li Y, Chapman K, Ogden C, Andreasen K, et al. Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011;108:11578-83 pubmed publisher
    ..Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable channel gated via binding of ADP-ribose, a metabolite formed under conditions of cellular ..
  5. Hill K, Tigue N, Kelsell R, Benham C, McNulty S, Schaefer M, et al. Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology. 2006;50:89-97 pubmed
    b>TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress...
  6. Lange I, Yamamoto S, Partida Sanchez S, Mori Y, Fleig A, Penner R. TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal. 2009;2:ra23 pubmed publisher
    b>TRPM2 is a Ca2+-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca2+ influx and has been linked to apoptotic mechanisms...
  7. Sumoza Toledo A, Lange I, Cortado H, Bhagat H, Mori Y, Fleig A, et al. Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release. FASEB J. 2011;25:3529-42 pubmed publisher
    ..Ca(2+) release and store-operated Ca(2+) entry (SOCE), the transient receptor potential melastatin 2 (TRPM2) channel contributes to Ca(2+) release but not Ca(2+) influx in mouse DCs...
  8. Alim I, Teves L, Li R, Mori Y, Tymianski M. Modulation of NMDAR subunit expression by TRPM2 channels regulates neuronal vulnerability to ischemic cell death. J Neurosci. 2013;33:17264-77 pubmed publisher
    ..One such conductance, the Transient receptor potential melastatin type-2 (TRPM2) channel, is a nonspecific cation channel having homology to TRPM7, a conductance reported to play a key role in ..
  9. Verma S, Quillinan N, Yang Y, Nakayama S, Cheng J, Kelley M, et al. TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death. Neurosci Lett. 2012;530:41-6 pubmed publisher
    ..In recent years transient receptor potential M2 (TRPM2) channels have been identified as mediators of ischemic damage...

More Information

Publications78

  1. Haraguchi K, Kawamoto A, Isami K, Maeda S, Kusano A, Asakura K, et al. TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice. J Neurosci. 2012;32:3931-41 pubmed publisher
    ..Transient receptor potential melastatin 2 (TRPM2) is a nonselective Ca²?-permeable cation channel that acts as a sensor for reactive oxygen species...
  2. Di A, Gao X, Qian F, Kawamura T, Han J, Hecquet C, et al. The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat Immunol. 2011;13:29-34 pubmed publisher
    ..Here we report that TRPM2, a nonselective and redox-sensitive cation channel, inhibited ROS production in phagocytic cells and prevented ..
  3. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, et al. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. 2002;9:163-73 pubmed
    ..We report here a widely expressed Ca2+-permeable cation channel, LTRPC2, activated by micromolar levels of H2O2 and agents that produce reactive oxygen/nitrogen species...
  4. Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, et al. TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med. 2008;14:738-47 pubmed publisher
    ..Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes...
  5. Melzer N, Hicking G, Göbel K, Wiendl H. TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation. PLoS ONE. 2012;7:e47617 pubmed publisher
    b>TRPM2, a highly Ca(2+)-permeable member of the transient receptor potential melastatin-related (TRPM) family of cation channels, is expressed in cells of the immune system...
  6. Kashio M, Sokabe T, Shintaku K, Uematsu T, Fukuta N, Kobayashi N, et al. Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions. Proc Natl Acad Sci U S A. 2012;109:6745-50 pubmed publisher
    ..Transient receptor potential melastatin 2 (TRPM2) is a thermosensitive, Ca(2+)-permeable cation channel expressed in a wide range of immunocytes...
  7. Xie Y, Belrose J, Lei G, Tymianski M, Mori Y, MacDonald J, et al. Dependence of NMDA/GSK-3? mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Mol Brain. 2011;4:44 pubmed publisher
    Transient receptor potential melastatin 2 (TRPM2) is a calcium permeable non-selective cation channel that functions as a sensor of cellular redox status...
  8. Buelow B, Song Y, Scharenberg A. The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem. 2008;283:24571-83 pubmed publisher
    b>TRPM2 cation channels are widely expressed in the immune system and are thought to play a role in immune cell responses to oxidative stress...
  9. Liu X, Gong B, de Souza L, Ong H, Subedi K, Cheng K, et al. Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway. Sci Signal. 2017;10: pubmed publisher
    ..We report that radiation treatment caused persistent salivary gland dysfunction by activating a TRPM2-dependent mitochondrial pathway, leading to caspase-3-mediated cleavage of stromal interaction molecule 1 (STIM1) ..
  10. Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, et al. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes. 2011;60:119-26 pubmed publisher
    b>TRPM2 is a Ca²(+)-permeable nonselective cation channel activated by adenosine dinucleotides...
  11. Di A, Kiya T, Gong H, Gao X, Malik A. Role of the phagosomal redox-sensitive TRP channel TRPM2 in regulating bactericidal activity of macrophages. J Cell Sci. 2017;130:735-744 pubmed publisher
    ..We show here that the redox-sensitive transient receptor potential (TRP) cation channel TRPM2 is expressed in the phagosomal membrane and regulates macrophage bactericidal activity through the activation of ..
  12. Yosida M, Dezaki K, Uchida K, Kodera S, Lam N, Ito K, et al. Involvement of cAMP/EPAC/TRPM2 activation in glucose- and incretin-induced insulin secretion. Diabetes. 2014;63:3394-403 pubmed publisher
    ..by glucose and GLP-1 was a consequence of the activated cAMP/EPAC-mediated pathway and was attenuated in TRPM2-deficient mice...
  13. Liu H, Ma S, Nan Y, Yang W. Transient receptor potential melastatin-2 and temperature participate in the process of CD38-regulated oxytocin secretion. Neuroreport. 2016;27:935-9 pubmed publisher
    ..The temperature-sensitive cation channel, transient receptor potential melastatin-2 (TRPM2), is a cation-nonselective cation and has been shown to affect oxytocin indirectly...
  14. Liu Q, Liu X, Wen Z, Hondowicz B, King L, Monroe J, et al. Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli. J Immunol. 2005;174:68-79 pubmed
    ..Thus, CRAC and distinct Ca(2+) permeant NSCCs are differentially activated by the BCR and mechanical stimuli and regulate distinct aspects of B cell physiology. ..
  15. Shimizu T, Macey T, Quillinan N, Klawitter J, Perraud A, Traystman R, et al. Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury. J Cereb Blood Flow Metab. 2013;33:1549-55 pubmed publisher
    The calcium-permeable transient receptor potential M2 (TRPM2) ion channel was recently demonstrated to have a sexually dimorphic contribution to ischemic brain injury, with inhibition or knockdown of the channel protecting male brain ..
  16. Belrose J, Xie Y, Gierszewski L, MacDonald J, Jackson M. Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons. Mol Brain. 2012;5:11 pubmed publisher
    ..Transient receptor potential melastatin type 2 (TRPM2) is a Ca2+ permeable non-selective cation channel expressed in several cell types including hippocampal pyramidal ..
  17. Miyanohara J, Kakae M, Nagayasu K, Nakagawa T, Mori Y, Arai K, et al. TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion. J Neurosci. 2018;38:3520-3533 pubmed publisher
    ..Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable channel that is abundantly expressed in immune cells and is involved in ..
  18. Keino H, Masaki S, Kawarada Y, Naruse I. Apoptotic degeneration in the arhinencephalic brain of the mouse mutant Pdn/Pdn. Brain Res Dev Brain Res. 1994;78:161-8 pubmed
    ..From these facts, it was suggested that the abnormal apoptosis caused a large amount of cell loss in the arhinencephalic mouse brain, and this cell loss induced the expansion of the ventricle, followed by the hydrocephaly. ..
  19. Gally F, Rao D, Schmitz C, Colvin K, Yeager M, Perraud A. The TRPM2 ion channel contributes to cytokine hyperproduction in a mouse model of Down Syndrome. Biochim Biophys Acta Mol Basis Dis. 2018;1864:126-132 pubmed publisher
    ..Together with ROS, the second messenger ion Ca2+ plays a central role in immune regulation. TRPM2 (Transient Receptor Potential Melastatin 2) is a Ca2+-permeable ion channel that is activated under ..
  20. Uemura T, Kudoh J, Noda S, Kanba S, Shimizu N. Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. Biochem Biophys Res Commun. 2005;328:1232-43 pubmed
    Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable cation channel activated by ADP-ribose or reactive oxygen species. In human, a major transcript of 6...
  21. Matsumoto K, Takagi K, Kato A, Ishibashi T, Mori Y, Tashima K, et al. Role of transient receptor potential melastatin 2 (TRPM2) channels in visceral nociception and hypersensitivity. Exp Neurol. 2016;285:41-50 pubmed publisher
    Transient receptor potential melastatin 2 (TRPM2) is a thermosensitive, Ca2+-permeable cation channel. TRPM2 contributes to the pathogenesis of inflammatory bowel disease, and inflammatory and neuropathic pain...
  22. Tan C, McNaughton P. The TRPM2 ion channel is required for sensitivity to warmth. Nature. 2016;536:460-3 pubmed
    ..electrophysiology and RNA sequencing to show that the ion channel generating heat sensitivity in these neurons is TRPM2. Autonomic neurons, usually thought of as exclusively motor, also express TRPM2 and respond directly to heat...
  23. Ostapchenko V, Chen M, Guzman M, Xie Y, Lavine N, Fan J, et al. The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment. J Neurosci. 2015;35:15157-69 pubmed publisher
    ..The transient receptor potential melastatin 2 (TRPM2) channel, a Ca(2+)-permeable nonselective cation channel activated by oxidative stress, has been implicated in ..
  24. Shakerley N, Chandrasekaran A, Trebak M, Miller B, Melendez J. Francisella tularensis Catalase Restricts Immune Function by Impairing TRPM2 Channel Activity. J Biol Chem. 2016;291:3871-81 pubmed publisher
    ..secretion, suggesting a role for H2O2-mediated Ca(2+) entry through the transient receptor potential melastatin 2 (TRPM2) channel in macrophages...
  25. Kashio M, Tominaga M. Redox Signal-mediated Enhancement of the Temperature Sensitivity of Transient Receptor Potential Melastatin 2 (TRPM2) Elevates Glucose-induced Insulin Secretion from Pancreatic Islets. J Biol Chem. 2015;290:12435-42 pubmed publisher
    Transient receptor potential melastatin 2 (TRPM2) is a thermosensitive Ca(2+)-permeable cation channel expressed by pancreatic β cells where channel function is constantly affected by body temperature...
  26. Carter R, Tolhurst G, Walmsley G, Vizuete Forster M, Miller N, Mahaut Smith M. Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte. J Physiol. 2006;576:151-62 pubmed
    ..messages for TRPC6 and TRPC1, which have been reported in platelets and megakaryocytic cell lines, and TRPM1, TRPM2 and TRPM7, which to date have not been demonstrated in cells of megakaryocytic/platelet lineage...
  27. Staaf S, Franck M, Marmigere F, Mattsson J, Ernfors P. Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. Gene Expr Patterns. 2010;10:65-74 pubmed publisher
  28. Ru X, Zheng C, Zhao Q, Lan H, Huang Y, Wan S, et al. Transient receptor potential channel M2 contributes to neointimal hyperplasia in vascular walls. Biochim Biophys Acta. 2015;1852:1360-71 pubmed publisher
    ..In the present study, we investigated the role of TRPM2, a ROS-sensitive Ca2+ entry channel, in neointimal hyperplasia...
  29. Liu X, Cotrim A, Teos L, Zheng C, Swaim W, Mitchell J, et al. Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction. Nat Commun. 2013;4:1515 pubmed publisher
    ..irradiation treatment leads to activation of the calcium-permeable channel, transient potential melastatin-like 2 (TRPM2), via stimulation of poly-ADP-ribose polymerase...
  30. Zou J, Yang W, Beech D, Jiang L. A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH. Pflugers Arch. 2011;462:293-302 pubmed publisher
    ..of the hTRPM2 channels by extracellular acidic pH and compared the sensitivity of human (h) and mouse (m) TRPM2 channel to such an inhibition...
  31. Nakagawa T, Isami K, Haraguchi K, So K, Asakura K, Shirakawa H, et al. [Involvement of spinally-infiltrated immune cells in peripheral nerve injury-induced neuropathic pain: roles of TRPM2]. Nihon Yakurigaku Zasshi. 2013;142:215-20 pubmed
  32. Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala F, et al. TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun. 2013;4:1611 pubmed publisher
    ..we find that stimulation with liposomes/crystals induced reactive oxygen species-dependent calcium influx via the TRPM2 channel and that macrophages deficient in TRPM2 display drastically impaired NLRP3 inflammasome activation and ..
  33. Mittal M, Urao N, Hecquet C, Zhang M, Sudhahar V, Gao X, et al. Novel role of reactive oxygen species-activated Trp melastatin channel-2 in mediating angiogenesis and postischemic neovascularization. Arterioscler Thromb Vasc Biol. 2015;35:877-87 pubmed publisher
    Transient receptor potential melastatin-2 (TRPM2) channel is a nonselective cation channel that mediates influx of Ca(2+) and Na(+) with relative permeability of PCa:PNa ≈0.6 in response to cellular oxidative stress...
  34. Gao G, Wang W, Tadagavadi R, Briley N, Love M, Miller B, et al. TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1. J Clin Invest. 2014;124:4989-5001 pubmed publisher
    ..Here, we evaluated the nonselective cation channel transient receptor potential melastatin 2 (TRPM2) in a murine model of kidney ischemia/reperfusion (I/R) injury...
  35. Yu P, Li J, Jiang J, Zhao Z, Hui Z, Zhang J, et al. A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles. Sci Rep. 2015;5:18171 pubmed publisher
    ..Transient receptor potential melastatin 2 (TRPM2) channel is known to be a cellular redox potential sensor that provides an important pathway for increasing the [..
  36. Jang Y, Lee S, Lee B, Jung S, Khalid A, Uchida K, et al. TRPM2, a Susceptibility Gene for Bipolar Disorder, Regulates Glycogen Synthase Kinase-3 Activity in the Brain. J Neurosci. 2015;35:11811-23 pubmed publisher
    ..Although genetic linkage studies have shown an association between BD and TRPM2, a Ca(2+)-permeable cation channel, the nature of this association is unknown...
  37. Isami K, Haraguchi K, So K, Asakura K, Shirakawa H, Mori Y, et al. Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model. PLoS ONE. 2013;8:e66410 pubmed publisher
    Recent evidence suggests that transient receptor potential melastatin 2 (TRPM2) expressed in immune cells plays an important role in immune and inflammatory responses...
  38. Wu X, Indzhykulian A, Niksch P, Webber R, Garcia Gonzalez M, Watnick T, et al. Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. PLoS ONE. 2016;11:e0155577 pubmed publisher
    ..We then characterized mice lacking functional Trpm2, Pkd2, Pkd2l1, Pkd2l2 and Pkd1l3, using scanning electron microscopy, auditory brainstem response, permeant dye ..
  39. Wyrsch P, Blenn C, Bader J, Althaus F. Cell death and autophagy under oxidative stress: roles of poly(ADP-Ribose) polymerases and Ca(2+). Mol Cell Biol. 2012;32:3541-53 pubmed publisher
    ..The different Ca(2+) signals arise from the transient receptor potential melastatin 2 (TRPM2) channels located in the cellular and lysosomal membranes...
  40. Ye M, Yang W, Ainscough J, Hu X, Li X, Sedo A, et al. TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia. Cell Death Dis. 2014;5:e1541 pubmed publisher
    ..Here we investigated the role of ROS-sensitive TRPM2 (transient receptor potential melastatin-related 2) channel...
  41. Yang W, Manna P, Zou J, Luo J, Beech D, Sivaprasadarao A, et al. Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore. J Biol Chem. 2011;286:23789-98 pubmed publisher
    ..we used patch clamp recording to study the effects of Zn(2+) on the melastatin transient receptor potential 2 (TRPM2) channel...
  42. Roberge S, Roussel J, Andersson D, Meli A, Vidal B, Blandel F, et al. TNF-?-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes. Cardiovasc Res. 2014;103:90-9 pubmed publisher
    b>TRPM2 is a Ca(2+)-permeable cationic channel of the transient receptor potential (TRP) superfamily that is linked to apoptotic signalling. Its involvement in cardiac pathophysiology is unknown...
  43. Huang S, Turlova E, Li F, Bao M, Szeto V, Wong R, et al. Transient receptor potential melastatin 2 channels (TRPM2) mediate neonatal hypoxic-ischemic brain injury in mice. Exp Neurol. 2017;296:32-40 pubmed publisher
    Transient receptor potential melastatin 2 (TRPM2), a calcium-permeable non-selective cation channel, is reported to mediate brain damage following ischemic insults in adult mice...
  44. Oda S, Uchida K, Wang X, Lee J, Shimada Y, Tominaga M, et al. TRPM2 contributes to antigen-stimulated Ca²? influx in mucosal mast cells. Pflugers Arch. 2013;465:1023-30 pubmed publisher
    ..Recent reports have highlighted the functions of the transient receptor potential melastatin 2 (TRPM2) channel in immunocytes, including its role in monocyte chemokine production and macrophage phagocytic activity...
  45. Sun L, Yau H, Wong W, Li R, Huang Y, Yao X. Role of TRPM2 in H(2)O(2)-induced cell apoptosis in endothelial cells. PLoS ONE. 2012;7:e43186 pubmed publisher
    Melastatin-like transient receptor potential channel 2 (TRPM2) is an oxidant-sensitive and cationic non-selective channel that is expressed in mammalian vascular endothelium...
  46. Yonezawa R, Yamamoto S, Takenaka M, Kage Y, Negoro T, Toda T, et al. TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation. Free Radic Biol Med. 2016;90:101-13 pubmed publisher
    ..Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable channel that is activated by oxidative stress through the production of ADP-ribose...
  47. Qian X, Numata T, Zhang K, Li C, Hou J, Mori Y, et al. Transient receptor potential melastatin 2 protects mice against polymicrobial sepsis by enhancing bacterial clearance. Anesthesiology. 2014;121:336-51 pubmed publisher
    Recent studies suggest that the transient receptor potential melastatin 2 (TRPM2) channel plays an important role in inflammation and immune response. However, the role and mechanism of TRPM2 in polymicrobial sepsis remain unclear...
  48. Wang H, Zhou X, Li H, Qian X, Wang Y, Ma L. Transient Receptor Potential Melastatin 2 Negatively Regulates LPS-ATP-Induced Caspase-1-Dependent Pyroptosis of Bone Marrow-Derived Macrophage by Modulating ROS Production. Biomed Res Int. 2017;2017:2975648 pubmed publisher
    ..ROS is a common activator of NLR/caspase-1. Transient receptor potential melastatin 2 (TRPM2), a selective cation channel, is involved in inflammatory regulation...
  49. Manna P, Munsey T, Abuarab N, Li F, Asipu A, Howell G, et al. TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death. Biochem J. 2015;466:537-46 pubmed publisher
    ..species (ROS) can cause pancreatic β-cell death by activating transient receptor potential (melastatin) 2 (TRPM2) channels. Cell death has been attributed to the ability of these channels to raise cytosolic Ca2+...
  50. Gelderblom M, Melzer N, Schattling B, Göb E, Hicking G, Arunachalam P, et al. Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cell invasion in ischemic stroke. Stroke. 2014;45:3395-402 pubmed publisher
    ..of the extracellular milieu change the activity of transient receptor potential melastatin subfamily member 2 (TRPM2), a nonselective cation channel expressed in the central nervous system and the immune system...
  51. Jang Y, Lee M, Lee J, Jung J, Lee S, Yang D, et al. TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain. Pflugers Arch. 2014;466:1987-98 pubmed publisher
    ..Among the TRP channels, the Trpm2 level was inversely associated with neurite growth. TRPM2 was highly expressed in embryonic brain...
  52. Kheradpezhouh E, Ma L, Morphett A, Barritt G, Rychkov G. TRPM2 channels mediate acetaminophen-induced liver damage. Proc Natl Acad Sci U S A. 2014;111:3176-81 pubmed publisher
    ..for Ca(2+) entry in hepatocytes in acetaminophen overdose is the Transient Receptor Potential Melanostatine 2 (TRPM2) cation channel...
  53. Wolf I, Diercks B, Gattkowski E, Czarniak F, Kempski J, Werner R, et al. Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor. Sci Signal. 2015;8:ra102 pubmed publisher
    ..In contrast, TRPM2 (transient receptor potential channel, subtype melastatin 2), a potential NAADP target channel, was not required ..
  54. Hoffman N, Miller B, Wang J, Elrod J, Rajan S, Gao E, et al. Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance. Am J Physiol Heart Circ Physiol. 2015;308:H637-50 pubmed publisher
    Ubiquitously expressed Trpm2 channel limits oxidative stress and preserves mitochondrial function...
  55. Miller B, Hoffman N, Merali S, Zhang X, Wang J, Rajan S, et al. TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria. J Biol Chem. 2014;289:7615-29 pubmed publisher
    Cardiac TRPM2 channels were activated by intracellular adenosine diphosphate-ribose and blocked by flufenamic acid. In adult cardiac myocytes the ratio of GCa to GNa of TRPM2 channels was 0.56 ± 0.02...
  56. Zou J, Ainscough J, Yang W, Sedo A, Yu S, Mei Z, et al. A differential role of macrophage TRPM2 channels in Ca²? signaling and cell death in early responses to H?O?. Am J Physiol Cell Physiol. 2013;305:C61-9 pubmed publisher
    ..represents the primary mechanism by which H?O? activate the transient receptor potential melastatin-related 2 (TRPM2) channel as a Ca²?-permeable channel present in the plasma membrane or an intracellular Ca²?-release channel...
  57. Hiroi T, Wajima T, Negoro T, Ishii M, Nakano Y, Kiuchi Y, et al. Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury. Cardiovasc Res. 2013;97:271-81 pubmed publisher
    Transient receptor potential melastatin 2 (TRPM2) highly expressed in immunocytes is a Ca(2+)-permeable non-selective cation channel activated by oxidative stress...
  58. Etem E, Bal R, Akağaç A, Kuloglu T, Tuzcu M, Andrievsky G, et al. The effects of hydrated C(60) fullerene on gene expression profile of TRPM2 and TRPM7 in hyperhomocysteinemic mice. J Recept Signal Transduct Res. 2014;34:317-24 pubmed publisher
    Hyperhomocysteinemia (HHcy) is associated with neurodegenerative diseases. Transient receptor potential melastatin (TRPM2) and TRPM7 channels may be activated by oxidative stress...
  59. Katano M, Numata T, Aguan K, Hara Y, Kiyonaka S, Yamamoto S, et al. The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death. Cell Calcium. 2012;51:179-85 pubmed publisher
    The transient receptor potential M2 channel (TRPM2) is the Ca(2+)-permeable cation channel controlled by cellular redox status via ?-NAD(+) and ADP-ribose (ADPR)...
  60. Mittal M, Nepal S, Tsukasaki Y, Hecquet C, Soni D, Rehman J, et al. Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury. Circ Res. 2017;121:1081-1091 pubmed publisher
    b>TRPM2 (transient receptor potential melastatin-2) expressed in endothelial cells (ECs) is a cation channel mediating Ca2+ entry in response to intracellular generation of adenosine diphosphoribose-the TRPM2 ligand...
  61. Park L, Wang G, Moore J, Girouard H, Zhou P, Anrather J, et al. The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction. Nat Commun. 2014;5:5318 pubmed publisher
    ..The resulting increase in ADP ribose opens transient receptor potential melastatin-2 (TRPM2) channels in endothelial cells leading to intracellular Ca(2+) overload and endothelial dysfunction...
  62. Scharenberg A. TRPM2 and pancreatic ?-cell responses to oxidative stress. Islets. 2009;1:165-6 pubmed publisher
    Recent reports have linked the adenine nucleotide 2nd messenger gated Ca (2+) channel TRPM2 with hydrogen peroxide-induced pancreatic ?-cell death in mouse and rat systems...
  63. Hecquet C, Zhang M, Mittal M, Vogel S, Di A, Gao X, et al. Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis. Circ Res. 2014;114:469-79 pubmed publisher
    ..The melastatin-family transient receptor potential 2 (TRPM2) channel is an oxidant-sensitive Ca2+ permeable channel implicated in mediating apoptosis; however, the mechanisms ..
  64. Shimizu K, Quillinan N, Orfila J, Herson P. Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels. Exp Neurol. 2016;275 Pt 1:78-83 pubmed publisher
    ..O-acetylated-ADPribose (OAADPr) which can act as a ligand for transient receptor potential cation channel, M2 (TRPM2)...
  65. Beceiro S, Radin J, Chatuvedi R, Piazuelo M, Horvarth D, Cortado H, et al. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017;10:493-507 pubmed publisher
    ..in phagocytes, we investigated the function of the cation channel transient receptor potential melastatin 2 (TRPM2) in macrophages during oxidative stress responses induced by Helicobacter pylori infection...
  66. Miller B, Wang J, Hirschler Laszkiewicz I, Gao E, Song J, Zhang X, et al. The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2013;304:H1010-22 pubmed publisher
    The second member of the transient receptor potential-melastatin channel family (TRPM2) is expressed in the heart and vasculature...
  67. Haladyna J, Pastuer T, Riedel S, Perraud A, Bernt K. Transient potential receptor melastatin-2 (Trpm2) does not influence murine MLL-AF9-driven AML leukemogenesis or in vitro response to chemotherapy. Exp Hematol. 2016;44:596-602.e3 pubmed publisher
    Transient potential receptor melastatin-2 (TRPM2) is a nonselective cationic, Ca(2+)-permeable transmembrane pore that is preferentially expressed in cells of the myeloid lineage and modulates signaling pathways converging into NF-kB...
  68. Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita R, et al. Endogenous ?2A-Adrenoceptor-Operated Sympathoadrenergic Tones Attenuate Insulin Secretion via cAMP/TRPM2 Signaling. Diabetes. 2017;66:699-709 pubmed publisher
    ..physiological insulinostatic adrenaline action is mediated via the transient receptor potential melastatin 2 (TRPM2) channel, a type of NSCC, in ?-cells...
  69. Miyake T, Shirakawa H, Kusano A, Sakimoto S, Konno M, Nakagawa T, et al. TRPM2 contributes to LPS/IFN?-induced production of nitric oxide via the p38/JNK pathway in microglia. Biochem Biophys Res Commun. 2014;444:212-7 pubmed publisher
    ..from wild-type (WT) mice is significantly reduced in microglia from transient receptor potential melastatin 2 (TRPM2)-knockout (KO) mice...