Trpc6

Summary

Gene Symbol: Trpc6
Description: transient receptor potential cation channel, subfamily C, member 6
Alias: AV025995, LLHWJM002, LLHWJM003, LLHWJM004, TRP-6, Trrp6, mtrp6, short transient receptor potential channel 6, calcium entry channel, transient receptor protein 6
Species: mouse
Products:     Trpc6

Top Publications

  1. Eckel J, Lavin P, FINCH E, Mukerji N, Burch J, Gbadegesin R, et al. TRPC6 enhances angiotensin II-induced albuminuria. J Am Soc Nephrol. 2011;22:526-35 pubmed publisher
    Mutations in the canonical transient receptor potential cation channel 6 (TRPC6) are responsible for familial forms of adult onset focal segmental glomerulosclerosis (FSGS)...
  2. Zhou J, Du W, Zhou K, Tai Y, Yao H, Jia Y, et al. Critical role of TRPC6 channels in the formation of excitatory synapses. Nat Neurosci. 2008;11:741-3 pubmed publisher
    ..Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB-dependent pathway...
  3. Wu X, Eder P, Chang B, Molkentin J. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc Natl Acad Sci U S A. 2010;107:7000-5 pubmed publisher
    ..Thus, TRPC channels are necessary mediators of pathologic cardiac hypertrophy, in part through a calcineurin-NFAT signaling pathway. ..
  4. Sel S, Rost B, Yildirim A, Sel B, Kalwa H, Fehrenbach H, et al. Loss of classical transient receptor potential 6 channel reduces allergic airway response. Clin Exp Allergy. 2008;38:1548-58 pubmed publisher
    ..b>TRPC6 is highly expressed in the lung, but its role in allergic processes is still poorly understood...
  5. Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, et al. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci. 2008;121:2301-7 pubmed publisher
    ..Here, we report that TRPC6, a member of the TRPC family, promotes hippocampal neuron dendritic growth...
  6. Liao Y, Erxleben C, Yildirim E, Abramowitz J, Armstrong D, Birnbaumer L. Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proc Natl Acad Sci U S A. 2007;104:4682-7 pubmed
    ..Here we show that Orai1 physically interacts with the N and C termini of TRPC3 and TRPC6, and that in cells overexpressing either TRPC3 or TRPC6 in a store-depletion insensitive manner, these TRPCs ..
  7. Dietrich A, Mederos y Schnitzler M, Gollasch M, Gross V, Storch U, Dubrovska G, et al. Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol. 2005;25:6980-9 pubmed
    ..Since TRPC6 is highly expressed in pulmonary and vascular smooth muscle cells, it represents a likely molecular candidate for ..
  8. Reiser J, Polu K, Möller C, Kenlan P, Altintas M, Wei C, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005;37:739-44 pubmed
    ..Here, we show that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm...
  9. Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, et al. Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem. 2004;279:18887-94 pubmed
    ..direct tyrosine phosphorylation by Src family protein-tyrosine kinases (PTKs) is a novel mechanism for modulating TRPC6 channel activity...

More Information

Publications62

  1. Weissmann N, Dietrich A, Fuchs B, Kalwa H, Ay M, Dumitrascu R, et al. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci U S A. 2006;103:19093-8 pubmed
    ..Using transient receptor potential channel 6 (TRPC6)-deficient mice, we show that this channel is a key regulator of acute HPV as this regulatory mechanism was absent ..
  2. Boulay G, Zhu X, Peyton M, Jiang M, Hurst R, Stefani E, et al. Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J Biol Chem. 1997;272:29672-80 pubmed
    ..as template, we report here the polymerase chain reaction-based cloning and functional expression of a novel Trp, mTrp6. The cDNA encodes a protein of 930 amino acids, the sequence of which is 36.8, 36.3, 43.1, 38.6, and 74...
  3. Krall P, Canales C, Kairath P, Carmona Mora P, Molina J, Carpio J, et al. Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease. PLoS ONE. 2010;5:e12859 pubmed publisher
    Mutations in the TRPC6 calcium channel (Transient receptor potential channel 6) gene have been associated with familiar forms of Focal and Segmental Glomerulosclerosis (FSGS) affecting children and adults...
  4. Ding Y, Winters A, Ding M, Graham S, Akopova I, Muallem S, et al. Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone. J Biol Chem. 2011;286:31799-809 pubmed publisher
    Both TRPC6 and reactive oxygen species (ROS) play an important role in regulating vascular function. However, their interplay has not been explored...
  5. Koitabashi N, Aiba T, Hesketh G, Rowell J, Zhang M, Takimoto E, et al. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition. J Mol Cell Cardiol. 2010;48:713-24 pubmed publisher
    ..activation of Cn/NFAT by calcium entering via transient receptor potential canonical (TRPC) channels (notably TRPC6)...
  6. Nijenhuis T, Sloan A, Hoenderop J, Flesche J, van Goor H, Kistler A, et al. Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol. 2011;179:1719-32 pubmed publisher
    The transient receptor potential channel C6 (TRPC6) is a slit diaphragm-associated protein in podocytes involved in regulating glomerular filter function...
  7. Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, et al. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996;85:661-71 pubmed
    ..This identifies mammalian gene products that participate in CCE. We propose that trp homologs are subunits of CCE channels, not unlike those of classical voltage-gated ion channels. ..
  8. Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, et al. Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun. 2012;3:649 pubmed publisher
    ..dinucleotide phosphate (NADPH) oxidase (Nox2(y/-)) or the classical transient receptor potential channel 6 (TRPC6(-/-)) are protected from LIR-induced oedema (LIRE)...
  9. Elg S, Marmigere F, Mattsson J, Ernfors P. Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion. J Comp Neurol. 2007;503:35-46 pubmed
    ..Our results suggest important roles of the TRPC family of channels in sensory physiology of both nociceptive as well as nonnociceptive classes of neurons. ..
  10. Freichel M, Vennekens R, Olausson J, Hoffmann M, Muller C, Stolz S, et al. Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models. Biochem Biophys Res Commun. 2004;322:1352-8 pubmed
    ..mouse lines a striking number of biological functions could already be ascribed to TRPC2, TRPC4, and TRPC6, not only on the cellular level but also for complex organ functions and integrative physiology...
  11. Quick K, Zhao J, Eijkelkamp N, Linley J, Rugiero F, Cox J, et al. TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol. 2012;2:120068 pubmed publisher
    Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells...
  12. Kim E, Anderson M, Dryer S. Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species. Am J Physiol Renal Physiol. 2012;302:F298-307 pubmed publisher
    ..insulin evokes a rapid increase in the surface expression of canonical transient receptor potential-6 channel (TRPC6) channels in cultured podocytes, but caused a decrease in surface expression of TRPC5...
  13. Wu Y, Xie J, An S, Oliver N, Barrezueta N, Lin M, et al. Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho. Kidney Int. 2017;91:830-841 pubmed publisher
    ..Increased calcium ion entry through the TRPC6 channel has been associated with the pathogenesis of heart and glomerular diseases, but its role in renal ..
  14. Xie J, Cha S, An S, Kuro O M, Birnbaumer L, Huang C. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun. 2012;3:1238 pubmed publisher
    ..Cardioprotection by Klotho in normal mice is mediated by downregulation of TRPC6 channels in the heart...
  15. Ding F, Zhang X, Li X, Zhang Y, Li B, Ding J. Mammalian target of rapamycin complex 2 signaling pathway regulates transient receptor potential cation channel 6 in podocytes. PLoS ONE. 2014;9:e112972 pubmed publisher
    Transient receptor potential cation channel 6 (TRPC6) is a nonselective cation channel, and abnormal expression and gain of function of TRPC6 are involved in the pathogenesis of hereditary and nonhereditary forms of renal disease...
  16. Hartmann J, Dragicevic E, Adelsberger H, Henning H, Sumser M, Abramowitz J, et al. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron. 2008;59:392-8 pubmed publisher
    ..Taken together, our results establish TRPC3 as a new type of postsynaptic channel that mediates mGluR-dependent synaptic transmission in cerebellar Purkinje cells and is crucial for motor coordination. ..
  17. Shengyou Y, Li Y. The effects of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII. J Renin Angiotensin Aldosterone Syst. 2015;16:1266-73 pubmed publisher
    the objective of this article is to evaluate the role of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII. mouse podocyte cell lines were cultured in vitro...
  18. Anderson M, Kim E, Hagmann H, Benzing T, Dryer S. Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol. Am J Physiol Cell Physiol. 2013;305:C276-89 pubmed publisher
    Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding podocin result in nephrotic syndromes...
  19. Kistler A, Singh G, Altintas M, Yu H, Fernandez I, Gu C, et al. Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease. J Biol Chem. 2013;288:36598-609 pubmed publisher
    Gain-of-function mutations in the calcium channel TRPC6 lead to autosomal dominant focal segmental glomerulosclerosis and podocyte expression of TRPC6 is increased in some acquired human glomerular diseases, particularly in membranous ..
  20. Albarrán L, Berna Erro A, Dionisio N, Redondo P, Lopez E, Lopez J, et al. TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets. Biochim Biophys Acta. 2014;1843:789-96 pubmed publisher
    ..Therefore, cytosolic-free Ca(2+) concentration is tightly regulated in this cell. TRPC6 is expressed in platelets, and an important role for this Ca(2+) channel in Ca(2+) homeostasis has been reported ..
  21. Li H, Huang J, Du W, Jia C, Yao H, Wang Y. TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity. J Neurochem. 2012;123:1010-8 pubmed publisher
    ..However, the mechanisms by which TRPC6 protects neurons are largely unknown...
  22. Perez Leighton C, Schmidt T, Abramowitz J, Birnbaumer L, Kofuji P. Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits. Eur J Neurosci. 2011;33:856-67 pubmed publisher
    ..retina have strongly implicated diacylglycerol-sensitive transient receptor potential channels containing TRPC3, TRPC6 and TRPC7 subunits in melanopsin-evoked depolarization...
  23. Shi J, Takahashi S, Jin X, Li Y, Ito Y, Mori Y, et al. Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293 cells. Br J Pharmacol. 2007;152:122-31 pubmed
    ..Here we report that this compound exerts non-specific inhibitory actions on the TRPC6 channel, a transient receptor potential (TRP) protein...
  24. Storch U, Forst A, Philipp M, Gudermann T, Mederos y Schnitzler M. Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. J Biol Chem. 2012;287:3530-40 pubmed publisher
    ..These findings suggest a novel regulatory mechanism relying on the expression of TRPC1 and the subsequent formation of heteromeric TRPC channel complexes with reduced calcium permeability, thereby fine-tuning neuronal migration. ..
  25. Lopez E, Berna Erro A, Salido G, Rosado J, Redondo P. FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6. Biochim Biophys Acta. 2015;1853:2684-96 pubmed publisher
    ..Diacylglycerol evokes NCCE through activating TRPC3 and TRPC6 in human platelets...
  26. Monet M, Francoeur N, Boulay G. Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. J Biol Chem. 2012;287:17672-81 pubmed publisher
    b>TRPC6 is a cation channel in the plasma membrane that plays a role in Ca(2+) entry after the stimulation of a G(q)-protein-coupled or tyrosine-kinase receptor...
  27. Dyachenko V, Husse B, Rueckschloss U, Isenberg G. Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels. Cell Calcium. 2009;45:38-54 pubmed publisher
    ..activated a nearly voltage-independent GsMTx-4-sensitive non-selective cation conductance Gns, antibodies against TRPC6 prevented Gns activation...
  28. Foller M, Kasinathan R, Koka S, Lang C, Shumilina E, Birnbaumer L, et al. TRPC6 contributes to the Ca(2+) leak of human erythrocytes. Cell Physiol Biochem. 2008;21:183-92 pubmed publisher
    ..RT-PCR revealed mRNA encoding the non-selective cation channel TRPC6 in erythroid progenitor cells...
  29. Buess M, Engler O, Hirsch H, Moroni C. Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6. Oncogene. 1999;18:1487-94 pubmed
    ..One transcript, expressed in the precursor but downregulated in the tumor cells, was cloned and identified as the murine calcium channel mtrp6.
  30. Kim E, Roshanravan H, Dryer S. Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015;1853:2610-20 pubmed publisher
    ..We have confirmed that overexpression of Sdc4 core protein increases surface abundance of TRPC6 channels in cultured podocytes, whereas Sdc4 knockdown has the opposite effect...
  31. Chung H, Kim G, Holewinski R, Venkatraman V, Zhu G, Bedja D, et al. Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2017;114:E10763-E10771 pubmed publisher
    ..coupled to hyperactivation of the nonselective cation channel, transient receptor potential canonical channel 6 (Trpc6), in isolated myocytes...
  32. Tang H, Yamamura A, Yamamura H, Song S, Fraidenburg D, Chen J, et al. Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016;310:L846-59 pubmed publisher
    ..Here, we report that CaSR functionally interacts with TRPC6 to regulate [Ca(2+)]cyt in PASMC...
  33. Chen W, Thielmann I, Gupta S, Subramanian H, Stegner D, van Kruchten R, et al. Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets. J Thromb Haemost. 2014;12:528-39 pubmed publisher
    ..We aimed to elucidate the role of Orai1 in diacylglycerol (DAG)-mediated ROCE. Trpc6(-/-) , Orai1(-/-) and Orai1(-/-) /Trpc6(-/-) mice were generated, and their platelets were analyzed...
  34. Alvarez Miguel I, Cidad P, Pérez García M, Lopez Lopez J. Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension. J Physiol. 2017;595:1497-1513 pubmed publisher
    Canonical transient receptor potential (TRPC)3 and TRPC6 channels of vascular smooth muscle cells (VSMCs) mediate stretch- or agonist-induced cationic fluxes, contributing to membrane potential and vascular tone...
  35. Shi J, Geshi N, Takahashi S, Kiyonaka S, Ichikawa J, Hu Y, et al. Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II. J Physiol. 2013;591:2851-66 pubmed publisher
    ..CaM)-dependent kinase II (CaMKII)-mediated regulation of the mouse transient receptor potential channel TRPC6 was explored by chimera, deletion and site-directed mutagenesis approaches...
  36. Alessandri Haber N, Dina O, Chen X, Levine J. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci. 2009;29:6217-28 pubmed publisher
    ..TRPC1 and TRPC6, two GsMTx-4-sensitive SACs, are expressed in dorsal root ganglion (DRG) neurons...
  37. Fan Q, Zhang H, Ding J, Liu S, Miao J, Xing Y, et al. R168H and V165X mutant podocin might induce different degrees of podocyte injury via different molecular mechanisms. Genes Cells. 2009;14:1079-90 pubmed publisher
    ..Podocyte injury caused by the normal localized podocin(V165X) was effectively inhibited by TRPC6 knockdown...
  38. Loga F, Domes K, Freichel M, Flockerzi V, Dietrich A, Birnbaumer L, et al. The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone. Cardiovasc Res. 2013;100:280-7 pubmed publisher
    ..this concept by investigating the role of cGMP/cGKI signalling on vascular tone and peripheral resistance using Trpc6(-/-), Trpc3(-/-), Trpc3(-/-)/6(-/-), Trpc1(-/-)/3(-/-)/6(-/-), and SM-specific cGKI(-/-) (sm-cGKI(-/-)) mice...
  39. Beis D, Schwarting R, Dietrich A. Evidence for a supportive role of classical transient receptor potential 6 (TRPC6) in the exploration behavior of mice. Physiol Behav. 2011;102:245-50 pubmed publisher
    ..To test the influence of TRPC6 activity on behavior, we developed a TRPC6-deficient (TRPC6(-/-)) mouse model in a BALB/c genetic background...
  40. Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, et al. TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Glia. 2017;65:1535-1549 pubmed publisher
    ..Targeted therapies to reduce TRPC3 channel activity in astrocytes might therefore be beneficial in traumatic brain injury. ..
  41. Yamaguchi N, Chakraborty A, Pasek D, Molkentin J, Meissner G. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. Am J Physiol Heart Circ Physiol. 2011;300:H2187-95 pubmed publisher
    ..5 hearts; rather increased Erk1/2 and p90RSK phosphorylation levels likely leading to reduced GSK-3? activity were found to precede development of cardiac hypertrophy in mice expressing dysfunctional ryanodine receptor ion channel. ..
  42. Kinoshita H, Kuwahara K, Nishida M, Jian Z, Rong X, Kiyonaka S, et al. Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Circ Res. 2010;106:1849-60 pubmed publisher
    ..In cardiac myocytes, ANP induced phosphorylation of TRPC6 at threonine 69, the PKG phosphorylation site, and significantly inhibited agonist-evoked NFAT activation and Ca(2+..
  43. Lutas A, Lahmann C, Soumillon M, Yellen G. The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons. elife. 2016;5: pubmed publisher
    ..Our findings suggest that disruption of NALCN could impair the basal ganglia circuit, which may underlie the severe motor deficits in humans carrying mutations in NALCN. ..
  44. Klaiber M, Dankworth B, Kruse M, Hartmann M, Nikolaev V, Yang R, et al. A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proc Natl Acad Sci U S A. 2011;108:18500-5 pubmed publisher
    ..The concomitant rise in [Ca(2+)](i) might increase the propensity to cardiac hypertrophy and arrhythmias. ..
  45. Nagy G, Botond G, Borhegyi Z, Plummer N, Freund T, Hájos N. DAG-sensitive and Ca(2+) permeable TRPC6 channels are expressed in dentate granule cells and interneurons in the hippocampal formation. Hippocampus. 2013;23:221-32 pubmed publisher
    ..In this study, we investigated the localization of TRPC6 channels in the adult hippocampal formation...
  46. Wang L, Jirka G, Rosenberg P, Buckley A, Gomez J, Fields T, et al. Gq signaling causes glomerular injury by activating TRPC6. J Clin Invest. 2015;125:1913-26 pubmed publisher
    ..have been linked to gain-of-function mutations in the gene encoding the transient receptor potential channel C6 (TRPC6)...
  47. Zhang Y, Qin W, Zhang L, Wu X, Du N, Hu Y, et al. MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis. Sci Rep. 2015;5:9401 pubmed publisher
    ..Further analysis identified TRPC6 as a target of miR-26a, and TRPC6 overexpression abolished the anti-apoptotic effect of miR-26a...
  48. Weber E, Han F, Tauseef M, Birnbaumer L, Mehta D, Muller W. TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response. J Exp Med. 2015;212:1883-99 pubmed publisher
    ..Transient receptor potential canonical 6 (TRPC6), a Ca(2+) channel expressed in endothelial cells, colocalizes with platelet/endothelial cell adhesion molecule-1 (..
  49. Nishioka K, Nishida M, Ariyoshi M, Jian Z, Saiki S, Hirano M, et al. Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel. Arterioscler Thromb Vasc Biol. 2011;31:2278-86 pubmed publisher
    ..Cilostazol specifically suppressed diacylglycerol-activated TRPC channels (TRPC3/TRPC6/TRPC7) through protein kinase A (PKA)-dependent phosphorylation of TRPC channels in HEK293 cells...
  50. Lutas A, Birnbaumer L, Yellen G. Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014;34:16336-47 pubmed publisher
  51. Ramanathan G, Gupta S, Thielmann I, Pleines I, Varga Szabo D, May F, et al. Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets. J Thromb Haemost. 2012;10:419-29 pubmed publisher
    ..To investigate the function of TRPC6 in platelet Ca(2+) signaling and activation, we analyzed platelets from mice deficient in TRPC6 using a wide range ..
  52. Suresh Babu S, Wójtowicz A, Freichel M, Birnbaumer L, Hecker M, Cattaruzza M. Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells. Sci Signal. 2012;5:ra91 pubmed publisher
    ..Thus, we have identified a stretch-induced signaling pathway in vascular cells that leads to the activation of zyxin, a cytoskeletal protein specifically involved in transducing mechanical stimuli. ..
  53. Chen W, Oberwinkler H, Werner F, Gaßner B, Nakagawa H, Feil R, et al. Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels. Arterioscler Thromb Vasc Biol. 2013;33:2121-9 pubmed publisher
    ..Conversely, direct activation of TRPC6 with hyperforin replicated the hyperpermeability responses to histamine...