Trpa1

Summary

Gene Symbol: Trpa1
Description: transient receptor potential cation channel, subfamily A, member 1
Alias: Anktm1, TRPA1b, transient receptor potential cation channel subfamily A member 1, ankyrin-like with transmembrane domains protein 1
Species: mouse
Products:     Trpa1

Top Publications

  1. Sawada Y, Hosokawa H, Hori A, Matsumura K, Kobayashi S. Cold sensitivity of recombinant TRPA1 channels. Brain Res. 2007;1160:39-46 pubmed
    TRPM8 and TRPA1, members of the transient receptor potential (TRP) channel family, are candidates for cooling-activated receptors...
  2. Fajardo O, Meseguer V, Belmonte C, Viana F. TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J Neurosci. 2008;28:7863-75 pubmed publisher
    ..The pharmacological response to TRPM8 and TRPA1 agonists and antagonists suggested that, unlike results observed in somatic tissues, TRPA1 is the major mediator ..
  3. Materazzi S, Nassini R, Andre E, Campi B, Amadesi S, Trevisani M, et al. Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2008;105:12045-50 pubmed publisher
    ..alpha,beta-unsaturated carbonyl group that has been proposed to gate the irritant transient receptor potential A1 (TRPA1) channel...
  4. Nagatomo K, Kubo Y. Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc Natl Acad Sci U S A. 2008;105:17373-8 pubmed publisher
    ..We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca(2+)(i) imaging and electrophysiological analyses...
  5. Bessac B, Sivula M, von Hehn C, Caceres A, ESCALERA J, Jordt S. Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 2009;23:1102-14 pubmed publisher
    ..These responses are mediated by transient receptor potential ankyrin 1 (TRPA1), an ion channel serving as a detector for reactive chemicals...
  6. Sisignano M, Park C, Angioni C, Zhang D, von Hehn C, Cobos E, et al. 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci. 2012;32:6364-72 pubmed publisher
    ..5,6-EET potently induced a calcium flux (100 nm) in cultured DRG neurons that was completely abolished when TRPA1 was deleted or inhibited...
  7. Del Camino D, Murphy S, Heiry M, Barrett L, Earley T, Cook C, et al. TRPA1 contributes to cold hypersensitivity. J Neurosci. 2010;30:15165-74 pubmed publisher
    b>TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial...
  8. Eberhardt M, Filipović M, Leffler A, de la Roche J, Kistner K, Fischer M, et al. Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies. J Biol Chem. 2012;287:28291-306 pubmed publisher
    ..The electrophilic structure of this cytotoxic ketoaldehyde suggests TRPA1, a receptor channel deeply involved in inflammatory and neuropathic pain, as a molecular target...
  9. Cattaruzza F, Spreadbury I, Miranda Morales M, Grady E, Vanner S, Bunnett N. Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice. Am J Physiol Gastrointest Liver Physiol. 2010;298:G81-91 pubmed publisher
    The excitatory ion channel transient receptor potential ankyrin-1 (TRPA1) is prominently expressed by primary afferent neurons and is a mediator of inflammatory pain. Inflammatory agents can directly activate [e.g...

More Information

Publications76

  1. Engel M, Leffler A, Niedermirtl F, Babes A, Zimmermann K, Filipović M, et al. TRPA1 and substance P mediate colitis in mice. Gastroenterology. 2011;141:1346-58 pubmed publisher
    ..2 different models, the involvement of the irritant receptor transient receptor potential of the ankyrin type-1 (TRPA1), and the effects of CGRP and substance P...
  2. Munns C, AlQatari M, Koltzenburg M. Many cold sensitive peripheral neurons of the mouse do not express TRPM8 or TRPA1. Cell Calcium. 2007;41:331-42 pubmed
    ..Members of the transient receptor potential family TRPM8 and TRPA1 are candidates for the principal transducers of cold stimuli...
  3. Trevisan G, Hoffmeister C, Rossato M, Oliveira S, Silva M, Silva C, et al. TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout. Free Radic Biol Med. 2014;72:200-9 pubmed publisher
    ..The transient potential receptor ankyrin 1 (TRPA1) is expressed by a subpopulation of peptidergic nociceptors and, via its activation by endogenous reactive oxygen ..
  4. Chen C, Broom D, Liu Y, de Nooij J, Li Z, Cen C, et al. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006;49:365-77 pubmed
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy. ..
  5. Bautista D, Jordt S, Nikai T, Tsuruda P, Read A, Poblete J, et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006;124:1269-82 pubmed
    b>TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic. TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) nociception, hearing, and inflammatory pain...
  6. Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, et al. TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol. 2011;7:701-11 pubmed publisher
    ..TRP) cation channels using reactive disulfides with different redox potentials reveals the capability of TRPA1 to sense O(2)...
  7. Chen J, Kang D, Xu J, Lake M, Hogan J, Sun C, et al. Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun. 2013;4:2501 pubmed publisher
    b>TRPA1 is an ion channel and has been proposed as a thermosensor across species...
  8. Moilanen L, Laavola M, Kukkonen M, Korhonen R, Leppänen T, Hogestatt E, et al. TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse. Sci Rep. 2012;2:380 pubmed publisher
    Transient receptor potential ankyrin 1 (TRPA1) is an ion channel involved in thermosensation and nociception. TRPA1 is activated by exogenous irritants and also by oxidants formed in inflammatory reactions...
  9. Caspani O, Zurborg S, Labuz D, Heppenstall P. The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain. PLoS ONE. 2009;4:e7383 pubmed publisher
    ..Recently the transient receptor potential (TRP) channels TRPM8 and TRPA1 have been identified and proposed to be molecular sensors for cold...
  10. Bang S, Kim K, Yoo S, Kim Y, Hwang S. Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation. Eur J Neurosci. 2007;26:2516-23 pubmed
    ..specifically activate those sensory neuronal TRP channels, and a well-known example is cinnamaldehyde for TRPA1. Here we show that human and mouse TRPA1 are activated by acetaldehyde, an intermediate substance of ethanol ..
  11. Schmidt M, Dubin A, Petrus M, Earley T, Patapoutian A. Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron. 2009;64:498-509 pubmed publisher
    Transient receptor potential A1 (TRPA1) ion channel senses a variety of noxious stimuli and is involved in nociception. Many TRPA1 agonists covalently modify the channel, which can lead to desensitization...
  12. Takahashi N, Mizuno Y, Kozai D, Yamamoto S, Kiyonaka S, Shibata T, et al. Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin). 2008;2:287-98 pubmed
    b>TRPA1 is a member of the transient receptor potential (TRP) cation channel family, and is predominantly expressed in nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia...
  13. Mishra S, Hoon M. Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. Mol Cell Neurosci. 2010;43:157-63 pubmed publisher
    ..Thus, our data demonstrate that TrpV1 neurons are selectively tuned nociceptors that mediate responses to thermal but not mechanical pain and insinuate a labeled line model for somatosensory coding. ..
  14. Tsubota Matsunami M, Noguchi Y, Okawa Y, Sekiguchi F, Kawabata A. Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3.2 and TRPA1 channels in mice. J Pharmacol Sci. 2012;119:293-6 pubmed
    ..2. AP18, a TRPA1 blocker, also prevented the NaHS-induced colonic pain and referred hyperalgesia...
  15. Talavera K, Gees M, Karashima Y, Meseguer V, Vanoirbeek J, Damann N, et al. Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci. 2009;12:1293-9 pubmed publisher
    ..In contrast with this view, we found that the chemosensory cation channel transient receptor potential A1 (TRPA1) is crucially involved in nicotine-induced irritation...
  16. Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, et al. Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest. 2008;118:4049-57 pubmed publisher
    ..we showed that alkaline pH activated transient receptor potential cation channel, subfamily A, member 1 (TRPA1) and that activation of this ion channel was involved in nociception...
  17. Xiao B, Dubin A, Bursulaya B, Viswanath V, Jegla T, Patapoutian A. Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci. 2008;28:9640-51 pubmed publisher
    b>TRPA1 is a member of the transient receptor potential (TRP) family of ion channels and is expressed in a subset of nociceptive neurons...
  18. Andre E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, et al. Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest. 2008;118:2574-82 pubmed publisher
    ..aldehydes present in CS, crotonaldehyde and acrolein, induce neurogenic inflammation by stimulating TRPA1, an excitatory ion channel coexpressed with TRPV1 on capsaicin-sensitive nociceptors...
  19. Trevisan G, Hoffmeister C, Rossato M, Oliveira S, Silva M, Ineu R, et al. Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents. Arthritis Rheum. 2013;65:2984-95 pubmed publisher
    ..The aim of this study was to evaluate the role of transient receptor potential ankyrin 1 (TRPA-1) and TRPA-1 stimulants, such as H2 O2 , in a rodent model of MSU-induced inflammation...
  20. Kwan K, Allchorne A, Vollrath M, Christensen A, Zhang D, Woolf C, et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006;50:277-89 pubmed
    b>TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has proposed roles in sensing sound, painful cold, and irritating ..
  21. Caceres A, Brackmann M, Elia M, Bessac B, Del Camino D, D Amours M, et al. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci U S A. 2009;106:9099-104 pubmed publisher
    ..b>TRPA1 is an irritant-sensing ion channel expressed in airway chemosensory nerves...
  22. Taylor Clark T, Kiros F, Carr M, McAlexander M. Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. Am J Respir Cell Mol Biol. 2009;40:756-62 pubmed publisher
    ..Recent studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1), an ion channel largely restricted to a subset of capsaicin-sensitive sensory nerves, functions as a transducer ..
  23. Wang Y, Chang R, Liman E. TRPA1 is a component of the nociceptive response to CO2. J Neurosci. 2010;30:12958-63 pubmed publisher
    ..Here we show that CO(2) specifically activates a subpopulation of trigeminal neurons that express TRPA1, a mustard oil- and cinnamaldehyde-sensitive channel, and that these responses are dependent on a functional TRPA1 ..
  24. Fernandes E, Russell F, Spina D, McDougall J, Graepel R, Gentry C, et al. A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor ?-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis. Arthritis Rheum. 2011;63:819-29 pubmed publisher
    To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in inflammatory hyperalgesia mediated by tumor necrosis factor ?(TNF?) and joint inflammation...
  25. Barabas M, Kossyreva E, Stucky C. TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons. PLoS ONE. 2012;7:e47988 pubmed publisher
    ..CGRP expression and IB4-binding are commonly used to define peptidergic and non-peptidergic subpopulations. TRPA1 is a polymodal, plasma membrane ion channel that contributes to mechanical and cold hypersensitivity during tissue ..
  26. Vriens J, Owsianik G, Hofmann T, Philipp S, Stab J, Chen X, et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron. 2011;70:482-94 pubmed publisher
    ..These experiments reveal an unanticipated role for TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat. ..
  27. Cho H, Callaghan B, Bron R, Bravo D, Furness J. Identification of enteroendocrine cells that express TRPA1 channels in the mouse intestine. Cell Tissue Res. 2014;356:77-82 pubmed publisher
    b>TRPA1 is an ion channel that detects specific chemicals in food and also transduces mechanical, cold and chemical stimulation...
  28. Andersson D, Gentry C, Alenmyr L, Killander D, Lewis S, Andersson A, et al. TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid ?(9)-tetrahydrocannabiorcol. Nat Commun. 2011;2:551 pubmed publisher
    b>TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for analgesics...
  29. Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, Facchinetti F, et al. Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. PLoS ONE. 2012;7:e42454 pubmed publisher
    The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism...
  30. Brierley S, Hughes P, Page A, Kwan K, Martin C, O Donnell T, et al. The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology. 2009;137:2084-2095.e3 pubmed publisher
    ..TRP ankyrin 1 (TRPA1) is implicated in inflammatory pain; it interacts with G-protein-coupled receptors, but little is known about its ..
  31. Wang L, Cvetkov T, Chance M, Moiseenkova Bell V. Identification of in vivo disulfide conformation of TRPA1 ion channel. J Biol Chem. 2012;287:6169-76 pubmed publisher
    b>TRPA1 (transient receptor potential ankyrin 1) is an ion channel expressed in the termini of sensory neurons and is activated in response to a broad array of noxious exogenous and endogenous thiol-reactive compounds, making it a crucial ..
  32. Fernandes E, Vong C, Quek S, Cheong J, Awal S, Gentry C, et al. Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B?-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. FASEB J. 2013;27:1664-73 pubmed publisher
    ..5 mg/kg, by 97%) and the TRP ankyrin 1 (TRPA1) antagonists TCS 5861528 (10 mg/kg; 82%) and HC-030031 (100 mg/kg; 76%)...
  33. DeBerry J, Schwartz E, Davis B. TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis. Pain. 2014;155:1280-7 pubmed publisher
    ..required for inflammatory visceral hyperalgesia: transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1). Injection of CYP (100 mg/kg, i.p...
  34. Andersson D, Gentry C, Bevan S. TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. PLoS ONE. 2012;7:e46917 pubmed publisher
    ..electrophysiology and behavioral measurements to show that the somatic pronociceptive actions of H(2)S require TRPA1. A H(2)S donor, NaHS, activated TRPA1 expressed in CHO cells and stimulated DRG neurons isolated from Trpa1(+/+) ..
  35. Kwan K, Glazer J, Corey D, Rice F, Stucky C. TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci. 2009;29:4808-19 pubmed publisher
    Transient receptor potential ankyrin 1 (TRPA1) is expressed by nociceptive neurons of the dorsal root ganglia (DRGs) and trigeminal ganglia, but its roles in cold and mechanotransduction are controversial...
  36. Macpherson L, Xiao B, Kwan K, Petrus M, Dubin A, Hwang S, et al. An ion channel essential for sensing chemical damage. J Neurosci. 2007;27:11412-5 pubmed
    ..Here we show that formaldehyde activates the ion channel TRPA1 and that TRPA1-deficient mice exhibit dramatically reduced formaldehyde-induced pain responses...
  37. Macpherson L, Dubin A, Evans M, Marr F, Schultz P, Cravatt B, et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature. 2007;445:541-5 pubmed
    The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and is expressed in nociceptive neurons...
  38. Nagatomo K, Ishii H, Yamamoto T, Nakajo K, Kubo Y. The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression. Biophys J. 2010;99:3609-18 pubmed publisher
    The transient receptor potential A1 channel (TRPA1) is activated by various compounds, including isothiocyanates, menthol, and cinnamaldehyde...
  39. de Oliveira C, Garami A, Lehto S, Pakai E, Tékus V, Pohoczky K, et al. Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci. 2014;34:4445-52 pubmed publisher
    The rodent transient receptor potential ankyrin-1 (TRPA1) channel has been hypothesized to serve as a temperature sensor for thermoregulation in the cold...
  40. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    ..GFR/Ret signaling, in turn, autoregulates expression of both GFRalpha1 and GFRalpha2 and promotes expression of TrpA1, MrgA1, MrgA3, and MrgB4, acquisition of normal neuronal size, axonal innervation of the epidermis, and postnatal ..
  41. Gu Q, Lin R. Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1. J Appl Physiol (1985). 2010;108:891-7 pubmed publisher
    ..Transient receptor potential A1 (TRPA1) is selectively expressed in a subpopulation of pulmonary C-fiber afferents and has been considered as a major ..
  42. Kerstein P, Del Camino D, Moran M, Stucky C. Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain. 2009;5:19 pubmed publisher
    b>TRPA1 has been implicated in both chemo- and mechanosensation. Recent work demonstrates that inhibiting TRPA1 function reduces mechanical hypersensitivity produced by inflammation...
  43. Lennertz R, Kossyreva E, Smith A, Stucky C. TRPA1 mediates mechanical sensitization in nociceptors during inflammation. PLoS ONE. 2012;7:e43597 pubmed publisher
    ..to intense mechanical stimuli were completely suppressed by acute incubation of the receptive terminals with the TRPA1 inhibitor, HC-030031...
  44. Karashima Y, Talavera K, Everaerts W, Janssens A, Kwan K, Vennekens R, et al. TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A. 2009;106:1273-8 pubmed publisher
    b>TRPA1 functions as an excitatory ionotropic receptor in sensory neurons...
  45. Okubo K, Matsumura M, Kawaishi Y, Aoki Y, Matsunami M, Okawa Y, et al. Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice. Br J Pharmacol. 2012;166:1738-43 pubmed publisher
    ..2 T-type calcium channels in rats. Given evidence for the activation of transient receptor potential ankyrin-1 (TRPA1) channels by H(2)S, we asked whether TRPA1 channels, in addition to Ca(v)3...
  46. Everaerts W, Gees M, Alpizar Y, Farre R, Leten C, Apetrei A, et al. The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr Biol. 2011;21:316-21 pubmed publisher
    ..The noxious effects of MO are currently ascribed to specific activation of the cation channel TRPA1 in nociceptive neurons...
  47. Madrid R, De La Pena E, Donovan Rodriguez T, Belmonte C, Viana F. Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels. J Neurosci. 2009;29:3120-31 pubmed publisher
    ..Similar behavioral effects of I(KD) blockade were observed in TRPA1(-/-) mice...
  48. Brierley S, Castro J, Harrington A, Hughes P, Page A, Rychkov G, et al. TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J Physiol. 2011;589:3575-93 pubmed publisher
    The mechanosensory role of TRPA1 and its contribution to mechanical hypersensitivity in sensory neurons remains enigmatic...
  49. Nagata K, Duggan A, Kumar G, Garcia Anoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci. 2005;25:4052-61 pubmed
    Mechanosensory channels of sensory cells mediate the sensations of hearing, touch, and some forms of pain. The TRPA1 (a member of the TRP family of ion channel proteins) channel is activated by pain-producing chemicals, and its ..
  50. Story G, Peier A, Reeve A, Eid S, Mosbacher J, Hricik T, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003;112:819-29 pubmed
    ..Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8...
  51. Jabba S, Goyal R, Sosa Pag n J, Moldenhauer H, Wu J, Kalmeta B, et al. Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. Neuron. 2014;82:1017-31 pubmed publisher
    ..Here we screened 12,000 random mutant clones of the cold-activated mouse TRPA1 ion channel with a heat stimulus...
  52. Cruz Orengo L, Dhaka A, Heuermann R, Young T, Montana M, Cavanaugh E, et al. Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain. 2008;4:30 pubmed publisher
    ..and allyl isothiocyanate (AITC), derivatives of cinnamon and mustard oil respectively, activate thermoTRP member TRPA1 via direct modification of channel cysteine residues...
  53. Viswanath V, Story G, Peier A, Petrus M, Lee V, Hwang S, et al. Opposite thermosensor in fruitfly and mouse. Nature. 2003;423:822-3 pubmed
  54. Ogawa H, Takahashi K, Miura S, Imagawa T, Saito S, Tominaga M, et al. H(2)S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation. Neuroscience. 2012;218:335-43 pubmed publisher
    ..Here we show that H(2)S activates mouse transient receptor potential ankyrin 1 (TRPA1) channels and elicits acute pain, using TRPA1-gene deficient mice (TRPA1(-/-)) and heterologous expression system...
  55. Nozawa K, Kawabata Shoda E, Doihara H, Kojima R, Okada H, Mochizuki S, et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A. 2009;106:3408-13 pubmed publisher
    ..Here, we demonstrate that the transient receptor potential (TRP) cation channel TRPA1, which is activated by pungent compounds or cold temperature, is highly expressed in EC cells...
  56. Poole D, Pelayo J, Cattaruzza F, Kuo Y, Gai G, Chiu J, et al. Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine. Gastroenterology. 2011;141:565-75, 575.e1-4 pubmed publisher
    ..the intestine is routinely exposed to irritant alimentary compounds and inflammatory mediators that activate TRPA1, there is no direct evidence for functional TRPA1 receptors on enteric neurons, and the effects of TRPA1 ..
  57. Graepel R, Fernandes E, Aubdool A, Andersson D, Bevan S, Brain S. 4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther. 2011;337:117-24 pubmed publisher
    This study explores the in vivo effects of the proposed transient receptor potential ankyrin 1 (TRPA1) agonist 4-oxo-2-nonenal (4-ONE)...
  58. Pozsgai G, Bodkin J, Graepel R, Bevan S, Andersson D, Brain S. Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo. Cardiovasc Res. 2010;87:760-8 pubmed publisher
    The aim of the study is to investigate transient receptor potential ankyrin 1 (TRPA1)-induced responses in the vasculature and on blood pressure and heart rate (HR), in response to TRPA1 agonists using wild-type (WT) and TRPA1 knockout (..
  59. Taylor Clark T, McAlexander M, Nassenstein C, Sheardown S, Wilson S, Thornton J, et al. Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol. 2008;586:3447-59 pubmed publisher
    ..One such alkenal, 4-hydroxynonenal (4HNE), activates TRPA1 in cultured sensory neurones...
  60. Salazar H, Llorente I, Jara Oseguera A, García Villegas R, Munari M, Gordon S, et al. A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci. 2008;11:255-61 pubmed publisher
    ..Although it is well known that TRPA1 channels are activated by pungent compounds found in garlic, onion, mustard and cinnamon extracts, activation of ..
  61. Akopian A, Ruparel N, Jeske N, Hargreaves K. Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol. 2007;583:175-93 pubmed
    ..The TRPA1 channel plays a key role in the processing of noxious information and can undergo functional desensitization by ..
  62. Bandell M, Story G, Hwang S, Viswanath V, Eid S, Petrus M, et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004;41:849-57 pubmed
    ..natural compounds present in cinnamon oil, wintergreen oil, clove oil, mustard oil, and ginger all activate TRPA1 (ANKTM1). Bradykinin, an inflammatory peptide acting through its G protein-coupled receptor, also activates TRPA1...
  63. Pozsgai G, Hajna Z, Bagoly T, Boros M, Kemeny A, Materazzi S, et al. The role of transient receptor potential ankyrin 1 (TRPA1) receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation. Eur J Pharmacol. 2012;689:56-64 pubmed publisher
    Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP)...
  64. Izzo A, Capasso R, Aviello G, Borrelli F, Romano B, Piscitelli F, et al. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol. 2012;166:1444-60 pubmed publisher
    ..that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1). Both endocannabinoids and TRPA1 may modulate gastrointestinal motility...
  65. Trevisan G, Materazzi S, Fusi C, Altomare A, Aldini G, Lodovici M, et al. Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade. Cancer Res. 2013;73:3120-31 pubmed publisher
    ..drugs that cause CIPN exert their effects by increasing oxidative stress, which activates the ion channel TRPA1 expressed by nociceptors...
  66. Elitt C, McIlwrath S, Lawson J, Malin S, Molliver D, Cornuet P, et al. Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. J Neurosci. 2006;26:8578-87 pubmed
    ..and increased the level of mRNA encoding GFRalpha3, TrkA, TRPV1, and the putative noxious cold-detecting channel TRPA1. Nearly all GFRalpha3-positive neurons expressed TRPV1 immunoreactivity, and most of these neurons were also ..
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    ..These responses were absent in neurons from mice lacking TRPA1, an ion channel of the transient receptor potential (TRP) gene family...