Gene Symbol: Trip10
Description: thyroid hormone receptor interactor 10
Alias: AI646975, Cip4, cdc42-interacting protein 4, Cdc42 interacting protein-4, TR-interacting protein 10, TRIP-10, thyroid receptor-interacting protein 10
Species: mouse
Products:     Trip10

Top Publications

  1. Chang L, Adams R, Saltiel A. The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Proc Natl Acad Sci U S A. 2002;99:12835-40 pubmed
    ..We report here the identification of the TC10-interacting protein CIP4/2 (Cdc42-interacting protein 4/2) as an effector in this pathway...
  2. Lodhi I, Chiang S, Chang L, Vollenweider D, Watson R, Inoue M, et al. Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab. 2007;5:59-72 pubmed
    ..Using the TC10-interacting protein CIP4 as bait in a yeast two-hybrid screen, we cloned a RasGAP and VPS9 domain-containing protein, Gapex-5/RME-6...
  3. Feng Y, Hartig S, Bechill J, Blanchard E, Caudell E, Corey S. The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis. J Biol Chem. 2010;285:4348-54 pubmed publisher
    The newly described F-BAR (Fer/CIP4 and Bin, amphiphysin, Rvs) family of proteins includes Cdc42-interacting protein-4 (CIP4), formin-binding protein-17 (FBP-17) and transactivator of cytoskeletal assembly-1 (Toca-1), and drives membrane ..
  4. Wang L, Rudert W, Grishin A, Dombrosky Ferlan P, Sullivan K, Deng X, et al. Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms. Biochem Biophys Res Commun. 2002;293:1426-30 pubmed
    ..Reported as Felic ( es-related, with homology to Ezrin, Lyn interactor with Cdc42), it is related to the CIP4 (Cdc42 Interacting Protein-4) gene...
  5. Chen Y, Aardema J, Kale S, Whichard Z, Awomolo A, Blanchard E, et al. Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling. Blood. 2013;122:1695-706 pubmed publisher
    ..b>Cdc42 interacting protein 4 (CIP4) is an F-BAR protein that localizes to membrane phospholipids through its BAR domain and ..
  6. Zhang X, Liu Y, Shao R, Li W. Cdc42-interacting protein 4 silencing relieves pulmonary fibrosis in STZ-induced diabetic mice via the Wnt/GSK-3?/?-catenin pathway. Exp Cell Res. 2017;359:284-290 pubmed publisher
    Cdc42-interacting protein-4 (CIP4) has been reported to be closely associated with diabetic nephropathy in rat. However, little is known about the correlation between CIP4 and diabetic pulmonary fibrosis (PF) in mice...
  7. Yin X, Warner D, Roberts E, Pisano M, Greene R. Identification of novel CBP interacting proteins in embryonic orofacial tissue. Biochem Biophys Res Commun. 2005;329:1010-7 pubmed
    ..The identification of these proteins as novel CBP-binding partners allows exploration of new mechanisms by which CBP regulates and integrates diverse cell signaling pathways. ..
  8. Hsu C, Leu Y, Tseng M, Lee K, Kuo T, Yen J, et al. Functional characterization of Trip10 in cancer cell growth and survival. J Biomed Sci. 2011;18:12 pubmed publisher
    The Cdc42-interacting protein-4, Trip10 (also known as CIP4), is a multi-domain adaptor protein involved in diverse cellular processes, which functions in a tissue-specific and cell lineage-specific manner...
  9. Saengsawang W, Taylor K, Lumbard D, Mitok K, Price A, Pietila L, et al. CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils. J Cell Sci. 2013;126:2411-23 pubmed publisher
    Cdc42-interacting protein 4 (CIP4), a member of the F-BAR family of proteins, plays important roles in a variety of cellular events by regulating both membrane and actin dynamics...

More Information


  1. Craig A, Greer P. Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol. 2002;22:6363-74 pubmed
    ..Further studies with mast cells derived from fps/fes-deficient mice will be required to provide insight into the role of Fps/Fes in mast cell activation. ..
  2. Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, Takenawa T. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol. 2006;172:269-79 pubmed
    The conserved FER-CIP4 homology (FCH) domain is found in the pombe Cdc15 homology (PCH) protein family members, including formin-binding protein 17 (FBP17). However, the amino acid sequence homology extends beyond the FCH domain...
  3. Archila S, King M, Carlson G, Rice N. The cytoskeletal organizing protein Cdc42-interacting protein 4 associates with phosphorylase kinase in skeletal muscle. Biochem Biophys Res Commun. 2006;345:1592-9 pubmed
    ..residues 1060-1237), we identified eight independent, yet overlapping, constructs of cdc42-interacting protein 4 (CIP4)...
  4. Koduru S, Kumar L, Massaad M, Ramesh N, Le Bras S, Ozcan E, et al. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010;107:16252-6 pubmed publisher
    The F-BAR domain containing protein CIP4 (Cdc42 interacting protein 4) interacts with Cdc42 and WASP/N-WASP and is thought to participate in the assembly of filamentous actin...
  5. Saengsawang W, Mitok K, Viesselmann C, Pietila L, Lumbard D, Corey S, et al. The F-BAR protein CIP4 inhibits neurite formation by producing lamellipodial protrusions. Curr Biol. 2012;22:494-501 pubmed publisher
    ..F-BAR proteins function in sensing and inducing membrane curvature. Cdc42-interacting protein 4 (CIP4), a member of the F-BAR family, regulates endocytosis in a variety of cell types...
  6. Koshkina N, Yang G, Kleinerman E. Inhibition of Cdc42-interacting protein 4 (CIP4) impairs osteosarcoma tumor progression. Curr Cancer Drug Targets. 2013;13:48-56 pubmed
    ..In the current study, we investigated the role of scaffolding protein Cdc42-interacting protein 4 (CIP4) in OS...