Gene Symbol: Trim24
Description: tripartite motif-containing 24
Alias: A130082H20Rik, AI447469, D430004I05Rik, TIF1, TIF1-alpha, TIF1alpha, Tif1a, transcription intermediary factor 1-alpha, E3 ubiquitin-protein ligase Trim24, RING-type E3 ubiquitin transferase TIF1-alpha, transcriptional intermediary factor 1, alpha, tripartite motif-containing protein 24
Species: mouse
Products:     Trim24

Top Publications

  1. Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken M, et al. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. Oncogene. 1999;18:1209-17 pubmed
    ..Similar to TIF1alpha and TIF1beta, the structure of TIF1beta is characterized by multiple domains: RING finger, B boxes, Coiled coil, ..
  2. Remboutsika E, Lutz Y, Gansmuller A, Vonesch J, Losson R, Chambon P. The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J Cell Sci. 1999;112 ( Pt 11):1671-83 pubmed
    ..The putative transcriptional mediator TIF1alpha is a nuclear protein kinase that has been identified via its interaction with liganded nuclear receptors, ..
  3. Niederreither K, Remboutsika E, Gansmuller A, Losson R, Dolle P. Expression of the transcriptional intermediary factor TIF1alpha during mouse development and in the reproductive organs. Mech Dev. 1999;88:111-7 pubmed
    ..In situ hybridization was used to investigate the expression pattern of the putative nuclear receptor mediator TIF1alpha during mouse embryogenesis and adult life. TIF1alpha is ubiquitously expressed until midgestation. At 12...
  4. Khetchoumian K, Teletin M, Mark M, Lerouge T, Cerviño M, Oulad Abdelghani M, et al. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem. 2004;279:48329-41 pubmed
    ..Moreover, like TIF1alpha and TIF1beta, TIF1delta can homodimerize and contains a PXVXL motif necessary and sufficient for HP1 (..
  5. Le Douarin B, Zechel C, Garnier J, Lutz Y, Tora L, Pierrat P, et al. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J. 1995;14:2020-33 pubmed
    ..We have isolated a mouse nuclear protein, TIF1, which enhances RXR and RAR AF-2 in yeast and interacts in a ligand-dependent manner with several NRs in yeast and ..
  6. Le Douarin B, Nielsen A, Garnier J, Ichinose H, Jeanmougin F, Losson R, et al. A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996;15:6701-15 pubmed chromatin structure and function, as well as a protein structurally and functionally related to TIF1 (renamed TIF1 alpha), which was named TIF1 beta...
  7. Remboutsika E, Yamamoto K, Harbers M, Schmutz M. The bromodomain mediates transcriptional intermediary factor 1alpha -nucleosome interactions. J Biol Chem. 2002;277:50318-25 pubmed
    ..We used the nuclear receptor coregulator TIF1alpha, a protein kinase that associates tightly with euchromatin, to analyze the properties of the BrD in a ..
  8. Nielsen A, Ortiz J, You J, Oulad Abdelghani M, Khechumian R, Gansmuller A, et al. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 1999;18:6385-95 pubmed
    Mammalian TIF1alpha and TIF1beta (KAP-1/KRIP-1) are related transcriptional intermediary factors that possess intrinsic silencing activity...
  9. Allton K, Jain A, Herz H, Tsai W, Jung S, Qin J, et al. Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A. 2009;106:11612-6 pubmed publisher
    ..Mass spectrometry of TAP-purified p53-complexes from embryonic stem cells revealed Tripartite-motif protein 24 (Trim24), a previously unknown partner of p53...

More Information


  1. Laz E, Holloway M, Chen C, Waxman D. Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology. 2007;148:3327-37 pubmed protein (Tox)], 73-fold [tripartite motif-containing 24 (Trim24)/transcription initiation factor-1alpha (TIF1alpha)], and 125-fold [cut-like 2 (Cutl2)/cut homeobox 2 (Cux2)] higher than in adult males, depending on the strain ..
  2. Conforto T, Zhang Y, Sherman J, Waxman D. Impact of CUX2 on the female mouse liver transcriptome: activation of female-biased genes and repression of male-biased genes. Mol Cell Biol. 2012;32:4611-27 pubmed publisher
    ..highly female-specific genes that were positively regulated by CUX2, including A1bg, Cyp2b9, Cyp3a44, Tox, and Trim24. CUX2 expression and chromatin binding were high in immature male liver, where repression of adult male-biased ..
  3. Josset L, Belser J, Pantin Jackwood M, Chang J, Chang S, Belisle S, et al. Implication of inflammatory macrophages, nuclear receptors, and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation. J Virol. 2012;86:7192-206 pubmed publisher
    ..regulatory factors (IRFs) and increased NF-?B activation, as well as inhibition of the negative regulator TRIM24, (ii) early and persistent infiltration of immune cells, including inflammatory macrophages, and (iii) the absence ..
  4. Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, et al. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet. 1999;23:287-95 pubmed
    PML and Tif1a are fused to RARA and Braf, respectively, resulting in the production of PML-RARalpha and Tif1alpha-B-Raf (T18) oncoproteins...
  5. Herquel B, Ouararhni K, Khetchoumian K, Ignat M, Teletin M, Mark M, et al. Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2011;108:8212-7 pubmed publisher
    b>TRIM24 (TIF1?), TRIM28 (TIF1?), and TRIM33 (TIF1?) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors...
  6. Jain A, Barton M. Regulation of p53: TRIM24 enters the RING. Cell Cycle. 2009;8:3668-74 pubmed
    ..Depletion of TRIM24, formerly named TIF1alpha, in tumor-derived cells induces p53-dependent apoptosis...
  7. Miki T, Fleming T, Crescenzi M, Molloy C, Blam S, Reynolds S, et al. Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. Proc Natl Acad Sci U S A. 1991;88:5167-71 pubmed
    ..The high frequency at which clones were identified and the large sizes of some of the transforming cDNA inserts isolated suggest wide applicability of this mammalian expression cloning system for isolating cDNAs of biologic interest. ..
  8. Rafiee M, Girardot C, Sigismondo G, Krijgsveld J. Expanding the Circuitry of Pluripotency by Selective Isolation of Chromatin-Associated Proteins. Mol Cell. 2016;64:624-635 pubmed publisher
    ..b>Trim24, a previously unrecognized protein in the network, converges with OSN on multiple enhancers and suppresses the ..
  9. Kikuchi M, Okumura F, Tsukiyama T, Watanabe M, Miyajima N, Tanaka J, et al. TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. Biochim Biophys Acta. 2009;1793:1828-36 pubmed publisher
    ..In this study, we found that TRIM24/transcriptional intermediary factor 1alpha (TIF1alpha), which is known as a ligand-dependent nuclear receptor co-regulator, interacts with AR and enhances ..
  10. Tisserand J, Khetchoumian K, Thibault C, Dembele D, Chambon P, Losson R. Tripartite motif 24 (Trim24/Tif1?) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor ? (Rar?) inhibition. J Biol Chem. 2011;286:33369-79 pubmed publisher
    Recent genetic studies in mice have established that the nuclear receptor coregulator Trim24/Tif1? suppresses hepatocarcinogenesis by inhibiting retinoic acid receptor ? (Rara)-dependent transcription and cell proliferation...
  11. Khetchoumian K, Teletin M, Tisserand J, Herquel B, Ouararhni K, Losson R. Trim24 (Tif1 alpha): an essential 'brake' for retinoic acid-induced transcription to prevent liver cancer. Cell Cycle. 2008;7:3647-52 pubmed
    ..TRIM24 (formerly known as TIF1 alpha) was among the first co-regulators identified as interacting with RARs in a ligand-dependent fashion, and it was ..
  12. Ignat M, Teletin M, Tisserand J, Khetchoumian K, Dennefeld C, Chambon P, et al. Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha. Proc Natl Acad Sci U S A. 2008;105:2598-603 pubmed publisher
    ..Using genetic approaches, we demonstrate here that the transcriptional intermediary factor 1alpha (TIF1alpha), recently shown to function as a tumor suppressor in murine hepatocytes, also participates in a molecular ..
  13. Herquel B, Ouararhni K, Martianov I, Le Gras S, Ye T, Keime C, et al. Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA. Nat Struct Mol Biol. 2013;20:339-46 pubmed publisher
    b>Trim24 (Tif1?) and Trim33 (Tif1?) interact to form a co-repressor complex that suppresses murine hepatocellular carcinoma...
  14. Hsu S, Yang C, Sim K, Hentschel D, O LEARY E, Bonventre J. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J. 2001;20:2273-85 pubmed
    ..the PHD-bromodomain of co-repressors of Krüppel-associated box (KRAB)-mediated repression, KRIP-1(TIF1beta) and TIF1alpha, as well as the co-activator/adaptor p300/CBP...
  15. Mujtaba S, He Y, Zeng L, Farooq A, Carlson J, Ott M, et al. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell. 2002;9:575-86 pubmed
  16. Parlato R, Kreiner G, Erdmann G, Rieker C, Stotz S, Savenkova E, et al. Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci. 2008;28:12759-64 pubmed publisher
  17. Khetchoumian K, Teletin M, Tisserand J, Mark M, Herquel B, Ignat M, et al. Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet. 2007;39:1500-6 pubmed
    ..Here, we provide evidence that the ligand-dependent nuclear receptor co-regulator Trim24 (also known as Tif1alpha) functions in mice as a liver-specific tumor suppressor...
  18. Torres Padilla M, Zernicka Goetz M. Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J Cell Biol. 2006;174:329-38 pubmed
    ..Very little is known about the molecules involved in this process. We show that the transcription intermediary factor 1 alpha (TIF1alpha) is involved in modulating gene expression during the first wave of transcription ..
  19. Perez Lloret J, Okoye I, Guidi R, Kannan Y, Coomes S, Czieso S, et al. T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy. Proc Natl Acad Sci U S A. 2016;113:E568-76 pubmed publisher
    ..and identified that transcription intermediary factor 1 regulator-alpha (Tif1α)/tripartite motif-containing 24 (Trim24) was predicted to be active in house dust mite (HDM)- and helminth-elicited Il4(gfp+)αβ(+)CD4(+) TH2 cells ..