Trib1

Summary

Gene Symbol: Trib1
Description: tribbles homolog 1 (Drosophila)
Alias: A530090O15Rik, TRB-1, Trb1, tribbles homolog 1
Species: mouse

Top Publications

  1. pmc Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency
    Masahiro Yamamoto
    Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 204:2233-9. 2007
  2. ncbi TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
    Takahiro Naiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 282:24075-82. 2007
  3. ncbi Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
    Endre Kiss-Toth
    Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, United Kingdom
    J Biol Chem 279:42703-8. 2004
  4. doi Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages
    Takashi Satoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 495:524-8. 2013
  5. pmc Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells
    Emilie Dugast
    UMR1064, Institut National de la Sante et de la Recherche Medicale, Nantes 44000, France
    J Biol Chem 288:10051-60. 2013
  6. doi COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1
    Akihiro Yoshida
    Department of Tumor Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Blood 122:1750-60. 2013
  7. pmc Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York, USA
    J Clin Invest 120:4410-4. 2010
  8. pmc Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia
    Priya H Dedhia
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 116:1321-8. 2010
  9. doi Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development
    Minoru Takasato
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 373:648-52. 2008
  10. pmc Control of adipose tissue inflammation through TRB1
    Anke Ostertag
    1Emmy Noether and Marie Curie Research Group, Molecular Metabolic Control, DKFZ ZMBH Alliance, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Diabetes 59:1991-2000. 2010

Scientific Experts

  • Endre Kiss-Toth
  • Takashi Satoh
  • Masahiro Yamamoto
  • Shizuo Akira
  • Emilie Dugast
  • Akihiro Yoshida
  • Ralph Burkhardt
  • Priya H Dedhia
  • Osamu Takeuchi
  • Anke Ostertag
  • Minoru Takasato
  • Takahiro Naiki
  • Yoshichika Yoshioka
  • Jean Paul Soulillou
  • Noriko Yoneda-Kato
  • Eiichi Morii
  • Joanna Ashton-Chess
  • Jean Paul Judor
  • Jun ya Kato
  • Mélanie Chesneau
  • Richard Danger
  • Nobuyuki Takakura
  • Virginie Pichard
  • Louise Docherty
  • Ségolène Pettré
  • Sophie Brouard
  • Sophie Conchon
  • Naoki Takemura
  • Ikuko Nakamae
  • Katsuhiro Nakagawa
  • Hiroyasu Kidoya
  • Hisamichi Naito
  • Stephan Herzig
  • Sekar Kathiresan
  • Daniela Strzoda
  • Olga Shestova
  • Allan Jones
  • Karen Keeshan
  • Anja Reimann
  • Lanwei Xu
  • Megan Robblee
  • Mauricio Berriel Diaz
  • Warren S Pear
  • Candice Romany
  • Alexandros Vegiopoulos
  • Stephen C Blacklow
  • Jan L Breslow
  • William R Lagor
  • Stefan Kleinsorg
  • Andrew Birkeland
  • SACHA ULJON
  • Victor D Fedorov
  • Maria E Vega
  • Daniel J Rader
  • Meirav Zaks-Zilberman
  • Michael Levin
  • Sue Anne Toh
  • Maria Liebert
  • Xiaoyu Li
  • Adam J Rose
  • Naoko Oshima
  • Makoto Asashima
  • Hiroshi Kiyonari
  • Koji Okabayashi
  • Ryuichi Nishinakamura
  • Chiyoko Kobayashi
  • Tatsuya Saitoh
  • Shintaro Sato
  • Yoshiharu Matsuura
  • Himanshu Kumar
  • Satoshi Uematsu
  • Atsushi Miyajima
  • Eiko Saijou
  • Keisuke Sekine
  • Taro Kawai
  • Yuichiro Miyaoka
  • Toru Okamoto
  • Ken J Ishii
  • Kiyoshi Takeda

Detail Information

Publications10

  1. pmc Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency
    Masahiro Yamamoto
    Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 204:2233-9. 2007
    ..b>Trib1 is reportedly involved in the regulation of NF-kappaB and MAP kinases, as well as gene expression in vitro...
  2. ncbi TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
    Takahiro Naiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 282:24075-82. 2007
    ..Whereas all the three TRBs were expressed in 3T3-L1 preadipocytes, TRB2 and TRB3, but not TRB1, were immediately down-regulated by differentiation stimuli...
  3. ncbi Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
    Endre Kiss-Toth
    Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, United Kingdom
    J Biol Chem 279:42703-8. 2004
    ..These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK...
  4. doi Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages
    Takashi Satoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 495:524-8. 2013
    ..b>Trib1 is an adaptor protein involved in protein degradation by interacting with COP1 ubiquitin ligase...
  5. pmc Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells
    Emilie Dugast
    UMR1064, Institut National de la Sante et de la Recherche Medicale, Nantes 44000, France
    J Biol Chem 288:10051-60. 2013
    In a previous study, we identified TRIB1, a serine-threonine kinase-like molecule, as a biomarker of chronic antibody-mediated rejection of human kidneys when measured in peripheral blood mononuclear cells...
  6. doi COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1
    Akihiro Yoshida
    Department of Tumor Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Blood 122:1750-60. 2013
    ..In this process, mammalian homolog of Tribbles, Trib1, which contains a COP1-binding motif, is essential for down-regulation of C/EBPα expression...
  7. pmc Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York, USA
    J Clin Invest 120:4410-4. 2010
    ..This locus contains only one annotated gene, tribbles homolog 1 (TRIB1), which has not previously been implicated in lipoprotein metabolism...
  8. pmc Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia
    Priya H Dedhia
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 116:1321-8. 2010
    b>Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation...
  9. doi Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development
    Minoru Takasato
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 373:648-52. 2008
    ..However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development...
  10. pmc Control of adipose tissue inflammation through TRB1
    Anke Ostertag
    1Emmy Noether and Marie Curie Research Group, Molecular Metabolic Control, DKFZ ZMBH Alliance, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Diabetes 59:1991-2000. 2010
    ..Therefore, this study aimed to test the hypothesis that the TRB gene family fulfills broader functions in the integration of metabolic and inflammatory pathways in various tissues...