Trib1

Summary

Gene Symbol: Trib1
Description: tribbles homolog 1 (Drosophila)
Alias: A530090O15Rik, TRB-1, Trb1, tribbles homolog 1
Species: mouse

Top Publications

  1. ncbi Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
    Endre Kiss-Toth
    Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, United Kingdom
    J Biol Chem 279:42703-8. 2004
  2. ncbi TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
    Takahiro Naiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 282:24075-82. 2007
  3. ncbi Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency
    Masahiro Yamamoto
    Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 204:2233-9. 2007
  4. ncbi Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development
    Minoru Takasato
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 373:648-52. 2008
  5. ncbi Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia
    Priya H Dedhia
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 116:1321-8. 2010
  6. ncbi Control of adipose tissue inflammation through TRB1
    Anke Ostertag
    1Emmy Noether and Marie Curie Research Group, Molecular Metabolic Control, DKFZ ZMBH Alliance, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Diabetes 59:1991-2000. 2010
  7. ncbi Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York, USA
    J Clin Invest 120:4410-4. 2010

Scientific Experts

  • Endre Kiss-Toth
  • Masahiro Yamamoto
  • Shizuo Akira
  • Takashi Satoh
  • Ralph Burkhardt
  • Anke Ostertag
  • Priya H Dedhia
  • Minoru Takasato
  • Takahiro Naiki
  • Stephan Herzig
  • Olga Shestova
  • Allan Jones
  • Anja Reimann
  • Megan Robblee
  • Mauricio Berriel Diaz
  • Candice Romany
  • SACHA ULJON
  • Victor D Fedorov
  • Meirav Zaks-Zilberman
  • Maria Liebert
  • Xiaoyu Li
  • Daniela Strzoda
  • Alexandros Vegiopoulos
  • William R Lagor
  • Stefan Kleinsorg
  • Andrew Birkeland
  • Daniel J Rader
  • Sekar Kathiresan
  • Stephen C Blacklow
  • Maria E Vega
  • Sue Anne Toh
  • Adam J Rose
  • Karen Keeshan
  • Lanwei Xu
  • Warren S Pear
  • Jan L Breslow
  • Michael Levin
  • Naoko Oshima
  • Makoto Asashima
  • Koji Okabayashi
  • Ryuichi Nishinakamura
  • Hiroshi Kiyonari
  • Chiyoko Kobayashi
  • Yoshiharu Matsuura
  • Atsushi Miyajima
  • Toru Okamoto
  • Ken J Ishii
  • Osamu Takeuchi
  • Tatsuya Saitoh
  • Himanshu Kumar
  • Satoshi Uematsu
  • Eiko Saijou
  • Yuichiro Miyaoka
  • Shintaro Sato
  • Keisuke Sekine
  • Taro Kawai
  • Kiyoshi Takeda

Detail Information

Publications7

  1. ncbi Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
    Endre Kiss-Toth
    Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, United Kingdom
    J Biol Chem 279:42703-8. 2004
    ..These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK...
  2. ncbi TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
    Takahiro Naiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 282:24075-82. 2007
    ..Whereas all the three TRBs were expressed in 3T3-L1 preadipocytes, TRB2 and TRB3, but not TRB1, were immediately down-regulated by differentiation stimuli...
  3. ncbi Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency
    Masahiro Yamamoto
    Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 204:2233-9. 2007
    ..b>Trib1 is reportedly involved in the regulation of NF-kappaB and MAP kinases, as well as gene expression in vitro...
  4. ncbi Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development
    Minoru Takasato
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 373:648-52. 2008
    ..However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development...
  5. ncbi Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia
    Priya H Dedhia
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 116:1321-8. 2010
    b>Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation...
  6. ncbi Control of adipose tissue inflammation through TRB1
    Anke Ostertag
    1Emmy Noether and Marie Curie Research Group, Molecular Metabolic Control, DKFZ ZMBH Alliance, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Diabetes 59:1991-2000. 2010
    ..Therefore, this study aimed to test the hypothesis that the TRB gene family fulfills broader functions in the integration of metabolic and inflammatory pathways in various tissues...
  7. ncbi Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York, USA
    J Clin Invest 120:4410-4. 2010
    ..This locus contains only one annotated gene, tribbles homolog 1 (TRIB1), which has not previously been implicated in lipoprotein metabolism...