Trh

Summary

Gene Symbol: Trh
Description: thyrotropin releasing hormone
Alias: Pro-TRH, Trf, thyrotropin releasing hormone, TSH-releasing factor, pro-thyrotropin-releasing hormone, prothyroliberin, protirelin, thyrotropin-releasing factor
Species: mouse
Products:     Trh

Top Publications

  1. Hashida T, Yamada M, Hashimoto K, Shibusawa N, Monden T, Satoh T, et al. A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice. Endocrinology. 2002;143:2808-11 pubmed
    b>TRH has been reported to possess several neurophysiological actions in the brain...
  2. Chiamolera M, Wondisford F. Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology. 2009;150:1091-6 pubmed publisher
    ..Hypothalamic TSH-releasing hormone (TRH) stimulates TSH secretion from the anterior pituitary...
  3. Nikrodhanond A, Ortiga Carvalho T, Shibusawa N, Hashimoto K, Liao X, Refetoff S, et al. Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis. J Biol Chem. 2006;281:5000-7 pubmed
    Hypothalamic thyrotropin-releasing hormone (TRH) stimulates thyroid-stimulating hormone (TSH) secretion from the anterior pituitary. TSH then initiates thyroid hormone (TH) synthesis and release from the thyroid gland...
  4. Satoh T, Yamada M, Monden T, Iizuka M, Mori M. Cloning of the mouse hypothalamic preprothyrotropin-releasing hormone (TRH) cDNA and tissue distribution of its mRNA. Brain Res Mol Brain Res. 1992;14:131-5 pubmed
    A complementary DNA (cDNA) for mouse hypothalamic preprothyrotropin-releasing hormone (TRH) was isolated and characterized using three different combinations of the polymerase chain reaction (PCR)...
  5. Satoh T, Yamada M, Iwasaki T, Mori M. Negative regulation of the gene for the preprothyrotropin-releasing hormone from the mouse by thyroid hormone requires additional factors in conjunction with thyroid hormone receptors. J Biol Chem. 1996;271:27919-26 pubmed
    ..These results indicate that the negative regulation of murine ppTRH gene by T3 might be mediated by the cooperation of T3R monomers with unknown factor(s) interacting with the element downstream of the TSS. ..
  6. Yamada M, Saga Y, Shibusawa N, Hirato J, Murakami M, Iwasaki T, et al. Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene. Proc Natl Acad Sci U S A. 1997;94:10862-7 pubmed
    Thyrotropin-releasing hormone (TRH) is a brain hypothalamic hormone that regulates thyrotropin (TSH) secretion from the anterior pituitary and is ubiquitously distributed throughout the brain and other tissues including pancreas...
  7. Michaud J, Rosenquist T, May N, Fan C. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev. 1998;12:3264-75 pubmed
    ..Our results strongly indicate that SIM1 functions upstream to maintain Brn2 expression, which in turn directs the terminal differentiation of specific neuroendocrine lineages within the PVN/SON. ..
  8. Shibusawa N, Yamada M, Hirato J, Monden T, Satoh T, Mori M. Requirement of thyrotropin-releasing hormone for the postnatal functions of pituitary thyrotrophs: ontogeny study of congenital tertiary hypothyroidism in mice. Mol Endocrinol. 2000;14:137-46 pubmed
    We recently reported that TRH-deficient mice showed characteristic tertiary hypothyroidism. In the present study, we investigated how this tertiary hypothyroidism occurred particularly in pre- and postnatal stages...
  9. Nillni E, Xie W, Mulcahy L, Sanchez V, Wetsel W. Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. J Biol Chem. 2002;277:48587-95 pubmed
    ..The Cpe(fat) mutation leads to rapid degradation of the enzyme. To test whether pro-thyrotropin-releasing hormone (TRH) conversion to TRH involves CPE, processing was examined in the Cpe(fat/fat) mouse...

More Information

Publications62

  1. van der Zwaag B, Burbach J, Scharfe C, Oefner P, Brunner H, Padberg G, et al. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. Genomics. 2005;86:55-67 pubmed
  2. Zhang X, van den Pol A. Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions. J Neurosci. 2012;32:3032-43 pubmed publisher
    Thyrotropin-releasing hormone (TRH) increases activity and decreases food intake, body weight, and sleep, in part through hypothalamic actions. The mechanism of this action is unknown...
  3. Costa e Sousa R, Hollenberg A. Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis. Endocrinology. 2012;153:4128-35 pubmed publisher
    ..primary hypothyroidism leads to the up-regulation of the genes encoding many key players in the HPT axis, such as TRH, type 2 deiodinase (dio2), pyroglutamyl peptidase II (PPII), TRH receptor 1 (TRHR1), and the TSH ?- and ?-subunits...
  4. Michaud J, DeRossi C, May N, Holdener B, Fan C. ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mech Dev. 2000;90:253-61 pubmed
    ..Together, these results implicate ARNT2 as the in vivo dimerization partner of SIM1 in controlling the development of these neuroendocrine lineages. ..
  5. Fonseca T, Correa Medina M, Campos M, Wittmann G, Werneck de Castro J, Arrojo e Drigo R, et al. Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest. 2013;123:1492-500 pubmed publisher
    ..This allows plasma T4 to signal a negative feedback loop that inhibits production of thyrotropin-releasing hormone (TRH) in the mediobasal hypothalamus (MBH) and thyroid-stimulating hormone (TSH) in the pituitary...
  6. McKnight K, Hou J, Hoodless P. Foxh1 and Foxa2 are not required for formation of the midgut and hindgut definitive endoderm. Dev Biol. 2010;337:471-81 pubmed publisher
    ..This finding represents a significant insight into specification and regionalization of mouse definitive endoderm. ..
  7. de Gortari P, Romero F, Cisneros M, Joseph Bravo P. Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions. Neurochem Int. 2005;46:347-56 pubmed
    Released TRH is inactivated by an ectopeptidase, pyroglutamyl aminopeptidase II (PPII)...
  8. Yan R, Huang T, Xie Z, Xia G, Qian H, Zhao X, et al. Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons. Acta Biochim Biophys Sin (Shanghai). 2013;45:345-52 pubmed publisher
    ..Together, our results indicate that Lmx1b, a key transcription factor for the specification of 5-HT and dopaminergic transmitter phenotypes during embryogenesis, determines some peptide phenotypes in these neurons as well. ..
  9. Parmentier R, Kolbaev S, Klyuch B, Vandael D, Lin J, Selbach O, et al. Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone. J Neurosci. 2009;29:4471-83 pubmed publisher
    ..Thyrotropin-releasing hormone (TRH) promotes arousal and combats sleepiness associated with narcolepsy...
  10. Roller M, Camper S. Localization of the thyrotropin-releasing hormone gene, Trh, on mouse chromosome 6. Mamm Genome. 1995;6:443-4 pubmed
  11. Pérez Monter C, Martínez Armenta M, Miquelajauregui A, Furlan Magaril M, Varela Echavarria A, Recillas Targa F, et al. The Krüppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development. Mol Cell Endocrinol. 2011;333:127-33 pubmed publisher
    ..In the hypothalamus, neuronal thyrotropin-releasing hormone (TRH) populations control important physiological process, including energy homeostasis and autonomic function; however, ..
  12. Hernandez A, Martinez M, Fiering S, Galton V, St Germain D. Type 3 deiodinase is critical for the maturation and function of the thyroid axis. J Clin Invest. 2006;116:476-84 pubmed
    ..Peripheral tissues are also hypothyroid. Hypothalamic T3 content is decreased while thyrotropin-releasing hormone (TRH) expression is elevated...
  13. Chung S, Liao X, Di Cosmo C, van Sande J, Wang Z, Refetoff S, et al. Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Endocrinology. 2012;153:6145-54 pubmed publisher
    ..MCH1R-knockout (KO)] exhibit reduced circulating iodothyronine (T(4), free T(4), T(3), and rT(3)) levels and high TRH and TSH when compared with wild-type (WT) mice...
  14. Deli L, Wittmann G, Kallo I, Lechan R, Watanabe M, Liposits Z, et al. Type 1 cannabinoid receptor-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons. Endocrinology. 2009;150:98-103 pubmed publisher
    Hypophysiotropic TRH-synthesizing neurons of the hypothalamic paraventricular nucleus (PVN) have a critical role in the regulation of the energy homeostasis through control of the hypothalamic-pituitary-thyroid axis...
  15. Keith B, Adelman D, Simon M. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc Natl Acad Sci U S A. 2001;98:6692-7 pubmed
    ..5. These results demonstrate that Arnt and Arnt2 have both unique and overlapping essential functions in embryonic development. ..
  16. Yao S, BERGAN J, Lanjuin A, Dulac C. Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues. elife. 2017;6: pubmed publisher
    ..These results uncover the critical role of oxytocin signaling in a molecularly defined neuronal population in order to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis. ..
  17. Yamada M, Shibusawa N, Hashida T, Satoh T, Monden T, Prasad C, et al. Abundance of cyclo (His-Pro)-like immunoreactivity in the brain of TRH-deficient mice. Endocrinology. 1999;140:538-41 pubmed
    Cyclo(His-Pro) or CHP was initially discovered as a metabolite of thyrotropin-releasing hormone (TRH) resulting from the action of the enzyme Pyroglutamyl aminopeptidase...
  18. Thirunarayanan N, Nir E, Raaka B, Gershengorn M. Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice. Neuropsychopharmacology. 2013;38:950-6 pubmed publisher
    Thyrotropin-releasing hormone receptor type 2 (TRH-R2), not TRH-R1, has been proposed to mediate the CNS effects of TRH and its more effective analog taltirelin (TAL)...
  19. Groba C, Mayerl S, van Mullem A, Visser T, Darras V, Habenicht A, et al. Hypothyroidism compromises hypothalamic leptin signaling in mice. Mol Endocrinol. 2013;27:586-97 pubmed publisher
    ..studied the consequences of hypothyroidism on leptin production as well as leptin sensing in congenital hypothyroid TRH receptor 1 knockout (Trhr1 ko) mice and euthyroid control animals...
  20. Campbell J, Macosko E, Fenselau H, Pers T, Lyubetskaya A, Tenen D, et al. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017;20:484-496 pubmed publisher
    ..This resource will accelerate biological discovery by providing insights into molecular and cell type diversity from which function can be inferred. ..
  21. Kiss A, ADAMEOVA A, Kubovcakova L, Jamal B, Bacova Z, Zorad S, et al. Effect of immobilization on in vitro thyrotropin-releasing hormone release from brain septum in wild-type and corticotropin-releasing hormone knock-out mice. Ann N Y Acad Sci. 2004;1018:207-13 pubmed
    There is considerable evidence linking alcohol consumption, sedation, and thyrotropin-releasing hormone (TRH) in the brain septum...
  22. Kinoshita K, Watanabe Y, Asai H, Yamamura M, Matsuoka Y. Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area. Br J Pharmacol. 1995;116:3274-8 pubmed
    1. The mechanism of the anti-ataxic action of thyrotropin-releasing hormone (TRH) and its analogue. TA-0910, in the Rolling mouse Nagoya (RMN), an ataxic mutant mouse, has been investigated. 2. TRH (30 mg kg-1, i.p...
  23. Wang W, Lufkin T. The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus. Dev Biol. 2000;227:432-49 pubmed
    ..The involvement of Otp and Sim1 in specifying specific hypothalamic neurosecretory cell lineages is shown to operate via distinct signaling pathways that partially overlap with Brn2. ..
  24. Krashes M, Shah B, Madara J, Olson D, Strochlic D, Garfield A, et al. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014;507:238-42 pubmed publisher
    ..paraventricular nucleus, specifically from subsets of neurons expressing thyrotropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also known as ADCYAP1)...
  25. Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, et al. NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin ? gene: analysis of TRH knockout mice. PLoS ONE. 2012;7:e40437 pubmed publisher
    Thyrotropin-releasing hormone (TRH) is a major stimulator of thyrotropin-stimulating hormone (TSH) synthesis in the anterior pituitary, though precisely how TRH stimulates the TSH? gene remains unclear...
  26. McKnight K, Hou J, Hoodless P. Dynamic expression of thyrotropin-releasing hormone in the mouse definitive endoderm. Dev Dyn. 2007;236:2909-17 pubmed
    Thyrotropin-releasing hormone (TRH) is a well-characterized regulator of the hypothalamic-pituitary-thyroid endocrine axis. Here, we describe the expression of Trh during early embryonic development in the mouse...
  27. Katakami H, Kato Y, Inada M, Imura H. Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency. J Endocrinol Invest. 1984;7:231-3 pubmed
    ..levels, and low plasma thyrotropin concentrations, which were responsive to thyrotropin-releasing hormone (TRH)...
  28. Yamada M, Satoh T, Mori M. Mice lacking the thyrotropin-releasing hormone gene: what do they tell us?. Thyroid. 2003;13:1111-21 pubmed
    Thyrotropin-releasing hormone (TRH) is localized in the brain hypothalamus and stimulates the secretion and synthesis of pituitary thyrotropin (TSH)...
  29. Caqueret A, Boucher F, Michaud J. Laminar organization of the early developing anterior hypothalamus. Dev Biol. 2006;298:95-106 pubmed
    ..In addition, our analysis suggests that Sim1 function is required for the production or the survival of postmitotic neurons as well as for correct positioning of AH neurons...
  30. Martínez Armenta M, Díaz de León Guerrero S, Catalán A, Alvarez Arellano L, Uribe R, Subramaniam M, et al. TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development. Mol Cell Endocrinol. 2015;400:129-39 pubmed publisher
    ..The molecular mechanisms that regulate the differentiation of the hypothalamic thyrotropin-releasing hormone (TRH) phenotype are poorly understood...
  31. Goshu E, Jin H, Lovejoy J, Marion J, Michaud J, Fan C. Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. Mol Endocrinol. 2004;18:1251-62 pubmed
    ..PVN and supraoptic nuclei contain five major cell types: oxytocin-, vasopressin-, CRH-, somatostatin-, and TRH-secreting neurons. Sim1, Arnt2, and Otp genes are essential for terminal differentiation of these neurons...
  32. Guo F, Bakal K, Minokoshi Y, Hollenberg A. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology. 2004;145:2221-7 pubmed
    The regulation of TRH gene expression in the paraventricular nucleus of the hypothalamus (PVH) by leptin is critical for normal function of the thyroid axis in rodents and humans...
  33. Harder S, Lu X, Wang W, Buck F, Gershengorn M, Bruhn T. Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2). Endocrinology. 2001;142:1188-94 pubmed
    We cloned the mouse TRH receptor type 2 (mTRH-R2) gene, which is 92% identical with rat TRH-R2 and 50% identical with mTRH-R1 at the amino acid level, and identified an intron within the coding sequence that is not present in the TRH-R1 ..
  34. Sun Y, Bak B, Schoenmakers N, van Trotsenburg A, Oostdijk W, Voshol P, et al. Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nat Genet. 2012;44:1375-81 pubmed publisher
    ..and serum thyroid-stimulating hormone (TSH) concentrations, reduced pituitary thyrotropin-releasing hormone (TRH) receptor expression, decreased triiodothyronine concentrations and increased body mass...
  35. Cheung L, Okano H, Camper S. Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes. Mol Cell Endocrinol. 2017;439:213-223 pubmed publisher
    ..In addition, despite changes in pituitary hormone expression, hypothalamic-pituitary axes appear to be functional. Therefore, SOX21 variants may be a cause of non-endocrine short stature in humans. ..
  36. Acampora D, Postiglione M, Avantaggiato V, Di Bonito M, Vaccarino F, Michaud J, et al. Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene. Genes Dev. 1999;13:2787-800 pubmed
  37. Brod S, Bauer V. Ingested (oral) thyrotropin releasing factor (TRH) inhibits EAE. Cytokine. 2013;61:323-8 pubmed publisher
    ..We examined whether another protein, thyrotropin releasing factor (TRH), would have similar anti-inflammatory effects in EAE after oral administration...
  38. Naylor S, Carritt B, Boileau C, Beroud C, Alexander C, Allderdice P, et al. Report of the sixth international workshop on human chromosome 3 mapping 1995. Cytogenet Cell Genet. 1996;72:255-70 pubmed
  39. Decherf S, Seugnet I, Becker N, Demeneix B, Clerget Froidevaux M. Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription. Mol Cell Endocrinol. 2013;381:115-23 pubmed publisher
    ..studies, we analyzed RXR subtype effects in T3-dependent repression of hypothalamic thyrotropin-releasing hormone (Trh)...
  40. Chiappini F, Ramadoss P, Vella K, Cunha L, Ye F, Stuart R, et al. Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus. Mol Cell Endocrinol. 2013;365:84-94 pubmed publisher
    Thyrotropin-releasing hormone (TRH) in the paraventricular nucleus (PVN) of the hypothalamus is regulated by thyroid hormone (TH)...
  41. González J, Horjales Araujo E, Fugger L, Broberger C, Burdakov D. Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone. J Physiol. 2009;587:1179-86 pubmed publisher
    ..We explored whether the activity of orexin cells is modulated by thyrotropin-releasing hormone (TRH), an endogenous stimulant of wakefulness and locomotor activity whose mechanism of action is not fully understood...
  42. Ono H, Hoshino Y, Yasuo S, Watanabe M, Nakane Y, Murai A, et al. Involvement of thyrotropin in photoperiodic signal transduction in mice. Proc Natl Acad Sci U S A. 2008;105:18238-42 pubmed publisher
    ..Taken together, our findings suggest that melatonin-dependent regulation of thyroid hormone levels in the MBH appears to involve TSH in mammals...
  43. Backman M, Machon O, Van Den Bout C, Krauss S. Targeted disruption of mouse Dach1 results in postnatal lethality. Dev Dyn. 2003;226:139-44 pubmed
    ..Neural stem cells derived from mutant and wild-type newborn brains display similar growth kinetics when cultivated in vitro. ..
  44. Tomás Roca L, Corral San Miguel R, Aroca P, Puelles L, Marín F. Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features. Brain Struct Funct. 2016;221:815-38 pubmed publisher
    ..Additionally, our analysis identified an internal molecular organization of the migrated pontine nuclei that reflects a differential segmental origin of their neurons as assessed by Hox gene expression. ..
  45. Waniek A, Hartlage Rübsamen M, Höfling C, Kehlen A, Schilling S, Demuth H, et al. Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes. Biochim Biophys Acta. 2015;1852:146-55 pubmed publisher
    ..QC expression was initially described in the hypothalamus, where thyrotropin-releasing hormone (TRH) is one of its physiological substrates...
  46. Kouidhi S, Seugnet I, Decherf S, Guissouma H, Elgaaied A, Demeneix B, et al. Peroxisome proliferator-activated receptor-gamma (PPARgamma) modulates hypothalamic Trh regulation in vivo. Mol Cell Endocrinol. 2010;317:44-52 pubmed publisher
    ..To examine potential crosstalk between PPARgamma and TRbeta in the hypothalamus, thyrotropin-releasing hormone (Trh) regulation in the newborn mouse hypothalamus was followed...
  47. Guissouma H, Froidevaux M, Hassani Z, Demeneix B. In vivo siRNA delivery to the mouse hypothalamus confirms distinct roles of TR beta isoforms in regulating TRH transcription. Neurosci Lett. 2006;406:240-3 pubmed
    ..hormone receptor (TR) isoforms, TRbeta1 and TRbeta2, on T3-transcriptional repression of the hypothalamic gene, TRH. The cationic lipid based technique used, JetSI/DOPE, was previously shown to efficiently knock-down reporter gene ..
  48. Yamada M, Shibusawa N, Ishii S, Horiguchi K, Umezawa R, Hashimoto K, et al. Prolactin secretion in mice with thyrotropin-releasing hormone deficiency. Endocrinology. 2006;147:2591-6 pubmed
    The physiological roles of TRH in pituitary lactotrophs, particularly during lactation, remain unclear...
  49. García Moreno F, Pedraza M, Di Giovannantonio L, Di Salvio M, López Mascaraque L, Simeone A, et al. A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei. Nat Neurosci. 2010;13:680-9 pubmed publisher
    ..The diencephalic transcription factor OTP was necessary for this migratory behavior. ..
  50. Schonemann M, Ryan A, McEvilly R, O Connell S, Arias C, Kalla K, et al. Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev. 1995;9:3122-35 pubmed
  51. Dupré S, Guissouma H, Flamant F, Seugnet I, Scanlan T, Baxter J, et al. Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology. 2004;145:2337-45 pubmed
    ..a key regulatory role in the negative feedback effects of circulating TH levels on production of hypothalamic TRH and hypophyseal TSH. Both TRbeta-isoforms (TRbeta1 and TRbeta2) are expressed in the hypothalamus and pituitary...
  52. Horn S, Kersseboom S, Mayerl S, Muller J, Groba C, Trajkovic Arsic M, et al. Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8. Endocrinology. 2013;154:968-79 pubmed publisher
    ..differentiation in the cerebellum, cerebral cortex, and striatum but was ineffective in suppressing hypothalamic TRH expression. In contrast, TSH transcript levels in the pituitary were strongly down-regulated in response to tetrac...
  53. Kádár A, Sanchez E, Wittmann G, Singru P, Fuzesi T, Marsili A, et al. Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse. J Comp Neurol. 2010;518:3948-61 pubmed publisher
    Hypophysiotropic thyrotropin-releasing hormone (TRH) neurons, the central regulators of the hypothalamic-pituitary-thyroid axis, are located in the hypothalamic paraventricular nucleus (PVN) in a partly overlapping distribution with non-..