Gene Symbol: Trdn
Description: triadin
Alias: 2310045H21Rik, EG432451, TDN, triadin, cardiac triadin
Species: mouse
Products:     Trdn

Top Publications

  1. Eltit J, Feng W, Lopez J, Padilla I, Pessah I, Molinski T, et al. Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+. J Biol Chem. 2010;285:38453-62 pubmed publisher
    ..To understand this mechanism, we study here how triadin alters [Ca(2+)](rest), Ca(2+) release, and Ca(2+) entry pathways using a combination of Ca(2+) microelectrodes, ..
  2. Feng Y, Valley M, Lazar J, Yang A, Bronson R, Firestein S, et al. SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Dev Cell. 2009;16:528-38 pubmed publisher
    ..profiles in the SRp38(-/-) embryonic heart revealed a defect in processing of the pre-mRNA encoding cardiac triadin, a protein that functions in regulation of Ca(2+) release from the sarcoplasmic reticulum during excitation-..
  3. Fodor J, Gönczi M, Sztretye M, Dienes B, Oláh T, Szabo L, et al. Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture. J Physiol. 2008;586:5803-18 pubmed publisher
    The 95 kDa triadin (Trisk 95), an integral protein of the sarcoplasmic reticular membrane in skeletal muscle, interacts with both the ryanodine receptor (RyR) and calsequestrin...
  4. Shen X, Franzini Armstrong C, Lopez J, Jones L, Kobayashi Y, Wang Y, et al. Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle. J Biol Chem. 2007;282:37864-74 pubmed
    To unmask the role of triadin in skeletal muscle we engineered pan-triadin-null mice by removing the first exon of the triadin gene. This resulted in a total lack of triadin expression in both skeletal and cardiac muscle...
  5. Wang Y, Li X, Duan H, Fulton T, Eu J, Meissner G. Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. Cell Calcium. 2009;45:29-37 pubmed publisher
    b>Triadin and junctin are integral sarcoplasmic reticulum membrane proteins that form a macromolecular complex with the skeletal muscle ryanodine receptor (RyR1) but their roles in skeletal muscle calcium homeostasis remain incompletely ..
  6. Roux Buisson N, Cacheux M, Fourest Lieuvin A, Fauconnier J, Brocard J, Denjoy I, et al. Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Hum Mol Genet. 2012;21:2759-67 pubmed publisher
    ..Based on a candidate gene approach, we focused our investigations on triadin and junctin, two proteins that link RyR2 and CSQ2...
  7. Oddoux S, Brocard J, Schweitzer A, Szentesi P, Giannesini B, Brocard J, et al. Triadin deletion induces impaired skeletal muscle function. J Biol Chem. 2009;284:34918-29 pubmed publisher
    b>Triadin is a multiple proteins family, some isoforms being involved in muscle excitation-contraction coupling, and some having still unknown functions...
  8. Chopra N, Yang T, Asghari P, Moore E, Huke S, Akin B, et al. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009;106:7636-41 pubmed publisher
    ..Although studies suggest that the jSR protein triadin anchors cardiac calsequestrin (Casq2) to RyR2, its contribution to E-C coupling remains unclear...
  9. Arvanitis D, Vafiadaki E, Fan G, Mitton B, Gregory K, Del Monte F, et al. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. Am J Physiol Heart Circ Physiol. 2007;293:H1581-9 pubmed
    ..The histidine-rich Ca-binding protein (HRC) is an SR component that binds to triadin and may affect Ca release through the ryanodine receptor...

More Information


  1. Hong C, Ji J, Kim J, Jung D, Kim D. Molecular cloning and characterization of mouse cardiac triadin isoforms. Gene. 2001;278:193-9 pubmed
    ..In the present study, mouse cardiac triadin cDNAs have been identified by cDNA library screening and RT-PCR...
  2. Kirchhefer U, Klimas J, Baba H, Buchwalow I, Fabritz L, Hüls M, et al. Triadin is a critical determinant of cellular Ca cycling and contractility in the heart. Am J Physiol Heart Circ Physiol. 2007;293:H3165-74 pubmed
    b>Triadin is involved in the regulation of cardiac excitation-contraction coupling...
  3. Osseni A, Sébastien M, Sarrault O, Baudet M, Coute Y, Faure J, et al. Triadin and CLIMP-63 form a link between triads and microtubules in muscle cells. J Cell Sci. 2016;129:3744-3755 pubmed
    ..We have shown previously that triadin, a member of this complex, has shaping properties on reticulum membrane and is indirectly involved in a link ..
  4. Rossi D, Bencini C, Maritati M, Benini F, Lorenzini S, Pierantozzi E, et al. Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulum. Biochem J. 2014;458:407-17 pubmed publisher
    ..of a large multiprotein complex containing the RyR (ryanodine receptor) and additional proteins, including triadin and calsequestrin...
  5. Kucerova D, Baba H, Boknik P, Fabritz L, Heinick A, Mát uš M, et al. Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2012;302:H2008-17 pubmed publisher
    Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplasmic ..
  6. Rani S, Park C, Sreenivasaiah P, Kim D. Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum. Mol Cells. 2016;39:149-55 pubmed publisher
    ..CSQ) and histidine-rich Ca(2+) binding protein (HRC) are known to bind the charged luminal region of triadin (TRN) and thus directly or indirectly regulate ryanodine receptor 2 (RyR2) activity...
  7. Zhang L, Salgado Somoza A, Vausort M, Leszek P, Devaux Y. A heart-enriched antisense long non-coding RNA regulates the balance between cardiac and skeletal muscle triadin. Biochim Biophys Acta Mol Cell Res. 2018;1865:247-258 pubmed publisher
    ..lncRNA which we arbitrarily named TRDN-AS due to its localisation in the antisense position of the gene encoding triadin (TRDN)...
  8. Boncompagni S, Thomas M, Lopez J, Allen P, Yuan Q, Kranias E, et al. Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. PLoS ONE. 2012;7:e39962 pubmed publisher
    b>Triadin (Tdn) and Junctin (Jct) are structurally related transmembrane proteins thought to be key mediators of structural and functional interactions between calsequestrin (CASQ) and ryanodine receptor (RyRs) at the junctional ..
  9. Kirchhefer U, Baba H, Kobayashi Y, Jones L, Schmitz W, Neumann J. Altered function in atrium of transgenic mice overexpressing triadin 1. Am J Physiol Heart Circ Physiol. 2002;283:H1334-43 pubmed
    ..of SR proteins and contractility in atria of 3-, 6-, and 18-wk-old transgenic mice overexpressing canine cardiac triadin 1 under control of the alpha-myosin heavy chain (MHC) promoter...
  10. Rederstorff M, Castets P, Arbogast S, Laine J, Vassilopoulos S, Beuvin M, et al. Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS ONE. 2011;6:e23094 pubmed publisher
  11. Cai W, Pritchard T, Florea S, Lam C, Han P, Zhou X, et al. Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovasc Res. 2012;94:333-41 pubmed publisher
    Junctin and triadin are calsequestrin-binding proteins that regulate sarcoplasmic reticulum (SR) Ca(2+) release by interacting with the ryanodine receptor...
  12. Denegri M, Avelino Cruz J, Boncompagni S, De Simone S, Auricchio A, Villani L, et al. Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias. Circ Res. 2012;110:663-8 pubmed publisher
    ..The decrease of CASQ2 is associated with a reduction in the levels of Triadin (TrD) and Junctin (JnC), two proteins that form, with CASQ2 and RyR2, a macromolecular complex devoted to control ..
  13. Singh V, Rubinstein J, Arvanitis D, Ren X, Gao X, Haghighi K, et al. Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein. J Am Heart Assoc. 2013;2:e000460 pubmed publisher
    ..The underlying mechanisms involved diminished interaction of Ala96 HRC with triadin, affecting ryanodine receptor (RyR) stability...
  14. Buj Bello A, Fougerousse F, Schwab Y, Messaddeq N, Spehner D, Pierson C, et al. AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis. Hum Mol Genet. 2008;17:2132-43 pubmed publisher
    ..This study provides a proof-of-principle that local delivery of an AAV vector expressing myotubularin can improve the motor capacities of XLMTM muscle and represents a novel approach to study myotubularin function in skeletal muscle. ..
  15. Vassilopoulos S, Oddoux S, Groh S, Cacheux M, Faure J, Brocard J, et al. Caveolin 3 is associated with the calcium release complex and is modified via in vivo triadin modification. Biochemistry. 2010;49:6130-5 pubmed publisher
    The triadin isoforms Trisk 95 and Trisk 51 are both components of the skeletal muscle calcium release complex...
  16. Payne S, Burney M, McCue K, Popal N, Davidson S, Anderson R, et al. A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. Dev Biol. 2015;405:82-95 pubmed publisher
    ..This work therefore reveals the importance of CHD7 in the cardiogenic mesoderm for multiple processes during cardiovascular development. ..
  17. Kirchhof P, Klimas J, Fabritz L, Zwiener M, Jones L, Schäfers M, et al. Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin. J Mol Cell Cardiol. 2007;42:962-71 pubmed
    ..These proteins regulate sarcoplasmic Ca(2+) release in close conjunction with two accessory proteins, triadin and junctin. Based on data from cardiomyocytes, we hypothesized that enhanced triadin expression could cause VT...
  18. Hong S, Kim T, Choi I, Woo J, Oh J, Park W, et al. Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein. Biochim Biophys Acta. 2005;1727:188-96 pubmed
    ..Collectively, our study provides comprehensive information about the structure and expression of the mammalian HRC gene, together with the comparative expression data of the related SR genes. ..