Trdn

Summary

Gene Symbol: Trdn
Description: triadin
Alias: 2310045H21Rik, EG432451, TDN, cardiac triadin
Species: mouse

Top Publications

  1. pmc Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias
    Nagesh Chopra
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:7636-41. 2009
  2. pmc Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+
    Jose M Eltit
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 285:38453-62. 2010
  3. ncbi Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle
    Xiaohua Shen
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37864-74. 2007
  4. pmc Caveolin 3 is associated with the calcium release complex and is modified via in vivo triadin modification
    Stéphane Vassilopoulos
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble, France
    Biochemistry 49:6130-5. 2010
  5. pmc Triadin deletion induces impaired skeletal muscle function
    Sarah Oddoux
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble F 38000, France
    J Biol Chem 284:34918-29. 2009
  6. pmc Altered stored calcium release in skeletal myotubes deficient of triadin and junctin
    Ying Wang
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 7260, United States
    Cell Calcium 45:29-37. 2009
  7. ncbi Molecular cloning and characterization of mouse cardiac triadin isoforms
    C S Hong
    Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong dong, Puk Gu, Kwangju 500 712, South Korea
    Gene 278:193-9. 2001
  8. pmc Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture
    Janos Fodor
    Department of Physiology, University of Debrecen, P O Box 22, Hungary
    J Physiol 586:5803-18. 2008
  9. pmc Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis
    Simona Boncompagni
    DNI Department of Neuroscience and Imaging, CeSI Center for Research on Ageing, University of G d Annunzio, Chieti, Italy
    PLoS ONE 7:e39962. 2012
  10. doi Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes
    Dana Kucerova
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Munster, Germany
    Am J Physiol Heart Circ Physiol 302:H2008-17. 2012

Scientific Experts

  • U Kirchhefer
  • Simona Boncompagni
  • P Kirchhof
  • L Csernoch
  • Jocelyn Laporte
  • Isabelle Marty
  • Paul D Allen
  • Julien Faure
  • Stéphane Vassilopoulos
  • Julie Brocard
  • Sarah Oddoux
  • Claudio F Perez
  • Ying Wang
  • Nathalie Roux-Buisson
  • Dana Kucerova
  • Wen Feng Cai
  • Pascale Guicheney
  • Marine Cacheux
  • Mathieu Rederstorff
  • Joel Lunardi
  • Jose M Eltit
  • Evangelia G Kranias
  • Isaac N Pessah
  • Nagesh Chopra
  • Ying Feng
  • Peter Szentesi
  • Jose R Lopez
  • Clara Franzini-Armstrong
  • Larry R Jones
  • Anna Buj-Bello
  • Janos Fodor
  • Xiaohua Shen
  • Demetrios A Arvanitis
  • Sunghee Hong
  • Vincent Probst
  • Pauline Trémeaux
  • Alain Lacampagne
  • Stela Florea
  • Alexander Heinick
  • Florence Kyndt
  • Isabelle Denjoy
  • Herve Le Marec
  • Joachim Neumann
  • Chi Kueng Lam
  • Peter Boknik
  • Frank U Müller
  • Vincent Lucet
  • Tracy Pritchard
  • Xiaoyang Zhou
  • Qunying Yuan
  • Jeremy Fauconnier
  • Stephan E Lehnart
  • Pierre F Ray
  • Philippe Durand
  • Marek Mát'us
  • Hideo A Baba
  • C S Hong
  • Antoine Leenhardt
  • Elodie Santoni
  • Peidong Han
  • Nicole Monnier
  • Wilhelm Schmitz
  • Philippe Mabo
  • Larissa Fabritz
  • Anne Fourest-Lieuvin
  • Perrine Castets
  • Valérie Allamand
  • Maud Beuvin
  • Sandrine Arbogast
  • Odile Dubourg
  • Ana Ferreiro
  • Alban Vignaud
  • Alain Krol
  • Alain Lescure
  • Jeanne Laine
  • Arnaud Ferry
  • Kevin P Campbell
  • Séverine Groh
  • Wei Feng
  • Tadeusz F Molinski
  • Isela T Padilla
  • Bradley R Fruen
  • Gerhard Meissner
  • Benoit Giannesini
  • Brandy Akin
  • David Bendahan
  • Barbara E C Knollmann-Ritschel
  • Karine Pernet-Gallay
  • Parisa Asghari
  • Stuart Firestein

Detail Information

Publications20

  1. pmc Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias
    Nagesh Chopra
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:7636-41. 2009
    ..Here, we identify the role of triadin using mice with ablation of the Trdn gene (Trdn(-/-))...
  2. pmc Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+
    Jose M Eltit
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 285:38453-62. 2010
    ....
  3. ncbi Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle
    Xiaohua Shen
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37864-74. 2007
    ..Overall, our data support an indirect role for triadin in regulating myoplasmic Ca(2+) homeostasis and organizing the molecular complex of the triad but not in regulating skeletal-type excitation-contraction coupling...
  4. pmc Caveolin 3 is associated with the calcium release complex and is modified via in vivo triadin modification
    Stéphane Vassilopoulos
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble, France
    Biochemistry 49:6130-5. 2010
    ....
  5. pmc Triadin deletion induces impaired skeletal muscle function
    Sarah Oddoux
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble F 38000, France
    J Biol Chem 284:34918-29. 2009
    ..These results indicate that triadin alteration leads to the development of a myopathy, which could be studied using this new animal model...
  6. pmc Altered stored calcium release in skeletal myotubes deficient of triadin and junctin
    Ying Wang
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 7260, United States
    Cell Calcium 45:29-37. 2009
    ..The results suggest that triadin has a role in facilitating KCl depolarization-induced Ca2+ release in contrast to junctin which has a role in maintaining sarcoplasmic reticulum Ca2+ store size in C2C12 myotubes...
  7. ncbi Molecular cloning and characterization of mouse cardiac triadin isoforms
    C S Hong
    Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong dong, Puk Gu, Kwangju 500 712, South Korea
    Gene 278:193-9. 2001
    ..In the present study, mouse cardiac triadin cDNAs have been identified by cDNA library screening and RT-PCR...
  8. pmc Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture
    Janos Fodor
    Department of Physiology, University of Debrecen, P O Box 22, Hungary
    J Physiol 586:5803-18. 2008
    ..These results suggest that Trisk 95 negatively regulates RyR function by suppressing localized calcium release events and global calcium signals in cultured muscle cells...
  9. pmc Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis
    Simona Boncompagni
    DNI Department of Neuroscience and Imaging, CeSI Center for Research on Ageing, University of G d Annunzio, Chieti, Italy
    PLoS ONE 7:e39962. 2012
    Triadin (Tdn) and Junctin (Jct) are structurally related transmembrane proteins thought to be key mediators of structural and functional interactions between calsequestrin (CASQ) and ryanodine receptor (RyRs) at the junctional ..
  10. doi Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes
    Dana Kucerova
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Munster, Germany
    Am J Physiol Heart Circ Physiol 302:H2008-17. 2012
    ..Thus the TRN-to-CSQ ratio is a critical modulator of the SR Ca(2+) signaling...
  11. pmc Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human
    Nathalie Roux-Buisson
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble, France
    Hum Mol Genet 21:2759-67. 2012
    ..Mutations in the triadin (TRDN) and in the junctin (ASPH) genes were searched in a cohort of 97 CPVT patients...
  12. pmc Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion
    Wen Feng Cai
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    Cardiovasc Res 94:333-41. 2012
    ..However, the significance of such decreases is currently unknown. Here, we addressed the functional role of these accessory proteins in the heart's responses to ischaemia/reperfusion (I/R) injury...
  13. pmc Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy
    Mathieu Rederstorff
    Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, Strasbourg, France
    PLoS ONE 6:e23094. 2011
    ....
  14. ncbi Altered function in atrium of transgenic mice overexpressing triadin 1
    Uwe Kirchhefer
    Institut fur Pharmakologie und Toxikologie, Westfalische Wilhelms Universitat, 48149 Munster, Germany
    Am J Physiol Heart Circ Physiol 283:H1334-43. 2002
    ..of SR proteins and contractility in atria of 3-, 6-, and 18-wk-old transgenic mice overexpressing canine cardiac triadin 1 under control of the alpha-myosin heavy chain (MHC) promoter...
  15. ncbi Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein
    Sunghee Hong
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1727:188-96. 2005
    ..Collectively, our study provides comprehensive information about the structure and expression of the mammalian HRC gene, together with the comparative expression data of the related SR genes...
  16. ncbi Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    J Mol Cell Cardiol 42:962-71. 2007
    ..An imbalance between prolonged intracellular calcium release and shortening of the ventricular action potential may contribute to genesis of arrhythmias in this model...
  17. pmc SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart
    Ying Feng
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 16:528-38. 2009
    ..profiles in the SRp38(-/-) embryonic heart revealed a defect in processing of the pre-mRNA encoding cardiac triadin, a protein that functions in regulation of Ca(2+) release from the sarcoplasmic reticulum during excitation-..
  18. ncbi Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase
    Demetrios A Arvanitis
    Molecular Biology Division, Center for Basic Research, Foundation for Biomedical Research of the Academy of Athens, Athens, Greece
    Am J Physiol Heart Circ Physiol 293:H1581-9. 2007
    ..Collectively, our data suggest that HRC may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart...
  19. ncbi Triadin is a critical determinant of cellular Ca cycling and contractility in the heart
    Uwe Kirchhefer
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Munster, Germany
    Am J Physiol Heart Circ Physiol 293:H3165-74. 2007
    ..Thus the maintenance of triadin expression is essential for normal SR Ca cycling and contractile function...
  20. pmc AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis
    Anna Buj-Bello
    Department of Neurobiology and Genetics, INSERM U596, CNRS UMR 7104, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch, France
    Hum Mol Genet 17:2132-43. 2008
    ..This study provides a proof-of-principle that local delivery of an AAV vector expressing myotubularin can improve the motor capacities of XLMTM muscle and represents a novel approach to study myotubularin function in skeletal muscle...