Trdn

Summary

Gene Symbol: Trdn
Description: triadin
Alias: 2310045H21Rik, EG432451, TDN, cardiac triadin
Species: mouse

Top Publications

  1. ncbi Triadin deletion induces impaired skeletal muscle function
    Sarah Oddoux
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble F 38000, France
    J Biol Chem 284:34918-29. 2009
  2. ncbi Molecular cloning and characterization of mouse cardiac triadin isoforms
    C S Hong
    Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong dong, Puk Gu, Kwangju 500 712, South Korea
    Gene 278:193-9. 2001
  3. ncbi Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+
    Jose M Eltit
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 285:38453-62. 2010
  4. ncbi Caveolin 3 is associated with the calcium release complex and is modified via in vivo triadin modification
    Stéphane Vassilopoulos
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble, France
    Biochemistry 49:6130-5. 2010
  5. ncbi SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart
    Ying Feng
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 16:528-38. 2009
  6. ncbi Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias
    Nagesh Chopra
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:7636-41. 2009
  7. ncbi Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture
    Janos Fodor
    Department of Physiology, University of Debrecen, P O Box 22, Hungary
    J Physiol 586:5803-18. 2008
  8. ncbi Altered stored calcium release in skeletal myotubes deficient of triadin and junctin
    Ying Wang
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 7260, United States
    Cell Calcium 45:29-37. 2009
  9. ncbi AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis
    Anna Buj-Bello
    Department of Neurobiology and Genetics, INSERM U596, CNRS UMR 7104, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch, France
    Hum Mol Genet 17:2132-43. 2008
  10. ncbi Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle
    Xiaohua Shen
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37864-74. 2007

Scientific Experts

  • U Kirchhefer
  • P Kirchhof
  • L Csernoch
  • Jocelyn Laporte
  • Stéphane Vassilopoulos
  • Sarah Oddoux
  • Isabelle Marty
  • Claudio F Perez
  • Paul D Allen
  • Ying Wang
  • Mathieu Rederstorff
  • Jose M Eltit
  • Julie Brocard
  • Isaac N Pessah
  • Julien Faure
  • Nagesh Chopra
  • Ying Feng
  • Peter Szentesi
  • Jose R Lopez
  • Anna Buj-Bello
  • Clara Franzini-Armstrong
  • Janos Fodor
  • Larry R Jones
  • Xiaohua Shen
  • Demetrios A Arvanitis
  • Sunghee Hong
  • C S Hong
  • Sandrine Arbogast
  • Alain Krol
  • Alain Lescure
  • Arnaud Ferry
  • Pascale Guicheney
  • Perrine Castets
  • Odile Dubourg
  • Alban Vignaud
  • Valérie Allamand
  • Maud Beuvin
  • Jeanne Laine
  • Ana Ferreiro
  • Séverine Groh
  • Marine Cacheux
  • Kevin P Campbell
  • Wei Feng
  • Bradley R Fruen
  • Isela T Padilla
  • Tadeusz F Molinski
  • Joel Lunardi
  • Benoit Giannesini
  • Jerry P Eu
  • David Bendahan
  • Josef Lazar
  • Xinghai Li
  • Edwin D Moore
  • Brandy Akin
  • Stuart Firestein
  • Roderick T Bronson
  • James L Manley
  • Tao Yang
  • Karine Pernet-Gallay
  • Annie Schweitzer
  • Sabine Huke
  • Gerhard Meissner
  • Parisa Asghari
  • Hongzhe Duan
  • Robert A Cattolica
  • William A Coetzee
  • Bjorn C Knollmann
  • Timothy R Fulton
  • Thinn Hlaing
  • Jacques Brocard
  • Matthew T Valley
  • Barbara E C Knollmann-Ritschel
  • Allison L Yang
  • Francoise Fougerousse
  • Beatrix Dienes
  • Patrice Denefle
  • Patrick Schultz
  • Muriel Durand
  • Gyula P Szigeti
  • Nadia Messaddeq
  • Danièle Spehner
  • Anne-Marie Douar
  • Marie Montus
  • Christine Kretz
  • Monika Sztretye
  • Jean Louis Mandel
  • Laszlo Szabo
  • Yannick Schwab
  • Christopher R Pierson
  • Anne Marie Douar

Detail Information

Publications16

  1. ncbi Triadin deletion induces impaired skeletal muscle function
    Sarah Oddoux
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble F 38000, France
    J Biol Chem 284:34918-29. 2009
    ..These results indicate that triadin alteration leads to the development of a myopathy, which could be studied using this new animal model...
  2. ncbi Molecular cloning and characterization of mouse cardiac triadin isoforms
    C S Hong
    Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong dong, Puk Gu, Kwangju 500 712, South Korea
    Gene 278:193-9. 2001
    ..In the present study, mouse cardiac triadin cDNAs have been identified by cDNA library screening and RT-PCR...
  3. ncbi Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+
    Jose M Eltit
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 285:38453-62. 2010
    ....
  4. ncbi Caveolin 3 is associated with the calcium release complex and is modified via in vivo triadin modification
    Stéphane Vassilopoulos
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble, France
    Biochemistry 49:6130-5. 2010
    ....
  5. ncbi SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart
    Ying Feng
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 16:528-38. 2009
    ..profiles in the SRp38(-/-) embryonic heart revealed a defect in processing of the pre-mRNA encoding cardiac triadin, a protein that functions in regulation of Ca(2+) release from the sarcoplasmic reticulum during excitation-..
  6. ncbi Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias
    Nagesh Chopra
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:7636-41. 2009
    ..Here, we identify the role of triadin using mice with ablation of the Trdn gene (Trdn(-/-))...
  7. ncbi Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture
    Janos Fodor
    Department of Physiology, University of Debrecen, P O Box 22, Hungary
    J Physiol 586:5803-18. 2008
    ..These results suggest that Trisk 95 negatively regulates RyR function by suppressing localized calcium release events and global calcium signals in cultured muscle cells...
  8. ncbi Altered stored calcium release in skeletal myotubes deficient of triadin and junctin
    Ying Wang
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 7260, United States
    Cell Calcium 45:29-37. 2009
    ..The results suggest that triadin has a role in facilitating KCl depolarization-induced Ca2+ release in contrast to junctin which has a role in maintaining sarcoplasmic reticulum Ca2+ store size in C2C12 myotubes...
  9. ncbi AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis
    Anna Buj-Bello
    Department of Neurobiology and Genetics, INSERM U596, CNRS UMR 7104, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch, France
    Hum Mol Genet 17:2132-43. 2008
    ..This study provides a proof-of-principle that local delivery of an AAV vector expressing myotubularin can improve the motor capacities of XLMTM muscle and represents a novel approach to study myotubularin function in skeletal muscle...
  10. ncbi Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle
    Xiaohua Shen
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37864-74. 2007
    ..Overall, our data support an indirect role for triadin in regulating myoplasmic Ca(2+) homeostasis and organizing the molecular complex of the triad but not in regulating skeletal-type excitation-contraction coupling...
  11. ncbi Triadin is a critical determinant of cellular Ca cycling and contractility in the heart
    Uwe Kirchhefer
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Munster, Germany
    Am J Physiol Heart Circ Physiol 293:H3165-74. 2007
    ..Thus the maintenance of triadin expression is essential for normal SR Ca cycling and contractile function...
  12. ncbi Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase
    Demetrios A Arvanitis
    Molecular Biology Division, Center for Basic Research, Foundation for Biomedical Research of the Academy of Athens, Athens, Greece
    Am J Physiol Heart Circ Physiol 293:H1581-9. 2007
    ..Collectively, our data suggest that HRC may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart...
  13. ncbi Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    J Mol Cell Cardiol 42:962-71. 2007
    ..An imbalance between prolonged intracellular calcium release and shortening of the ventricular action potential may contribute to genesis of arrhythmias in this model...
  14. ncbi Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein
    Sunghee Hong
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1727:188-96. 2005
    ..Collectively, our study provides comprehensive information about the structure and expression of the mammalian HRC gene, together with the comparative expression data of the related SR genes...
  15. ncbi Altered function in atrium of transgenic mice overexpressing triadin 1
    Uwe Kirchhefer
    Institut fur Pharmakologie und Toxikologie, Westfalische Wilhelms Universitat, 48149 Munster, Germany
    Am J Physiol Heart Circ Physiol 283:H1334-43. 2002
    ..of SR proteins and contractility in atria of 3-, 6-, and 18-wk-old transgenic mice overexpressing canine cardiac triadin 1 under control of the alpha-myosin heavy chain (MHC) promoter...
  16. ncbi Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy
    Mathieu Rederstorff
    Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, Strasbourg, France
    PLoS ONE 6:e23094. 2011
    ....