Traf3

Summary

Gene Symbol: Traf3
Description: TNF receptor-associated factor 3
Alias: AI528849, CAP-1, CD40bp, CRAF1, LAP1, T-BAM, amn, TNF receptor-associated factor 3, CD40 receptor-associated factor 1, RING-type E3 ubiquitin transferase TRAF3, TRAFAMN
Species: mouse
Products:     Traf3

Top Publications

  1. Zarnegar B, Wang Y, Mahoney D, Dempsey P, Cheung H, He J, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol. 2008;9:1371-8 pubmed publisher
    ..kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or cIAP2...
  2. Zarnegar B, Yamazaki S, He J, Cheng G. Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc Natl Acad Sci U S A. 2008;105:3503-8 pubmed publisher
    ..factor receptor-associated factors (TRAFs) have identified positive roles for TRAF2, TRAF5, and TRAF6, but not TRAF3, in canonical (p50-dependent) NF-kappaB activation...
  3. He J, Zarnegar B, Oganesyan G, Saha S, Yamazaki S, Doyle S, et al. Rescue of TRAF3-null mice by p100 NF-kappa B deficiency. J Exp Med. 2006;203:2413-8 pubmed
    ..25:280-288). We demonstrate that loss of tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) results in constitutive noncanonical NF-kappaB activity...
  4. Oganesyan G, Saha S, Guo B, He J, Shahangian A, Zarnegar B, et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature. 2006;439:208-11 pubmed
    ..Here we demonstrate that cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in type I IFN responses activated by several ..
  5. Chang J, Hu H, Jin J, Puebla Osorio N, Xiao Y, Gilbert B, et al. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med. 2014;211:137-51 pubmed publisher
    ..Here we identified TNF receptor-associated factor 3 (TRAF3) as a regulator of Treg cell function...
  6. Cheng G, Cleary A, Ye Z, Hong D, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995;267:1494-8 pubmed
    ..A yeast two-hybrid screen identified a gene, CRAF1, encoding a protein that interacts directly with the CD40 cytoplasmic tail through a region of similarity to the ..
  7. Tseng P, Matsuzawa A, Zhang W, Mino T, Vignali D, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010;11:70-5 pubmed publisher
    ..Here we show that TRAF3, a ubiquitin ligase that interacts with both MyD88 and TRIF, regulated the production of interferon and ..
  8. Xie P, Poovassery J, Stunz L, Smith S, Schultz M, Carlin L, et al. Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes. J Leukoc Biol. 2011;90:1149-57 pubmed publisher
    The key role of TRAF6 in TLR signaling pathways is well known. More recent evidence has implicated TRAF3 as another TRAF family member important to certain TLR responses of myeloid cells...
  9. He J, Saha S, Kang J, Zarnegar B, Cheng G. Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway. J Biol Chem. 2007;282:3688-94 pubmed
    ..Whereas TRAF2, 5, and 6 are activators of the canonical NF-kappaB signaling pathway, TRAF3 is an inhibitor of the noncanonical NF-kappaB pathway...

More Information

Publications62

  1. Saha S, Pietras E, He J, Kang J, Liu S, Oganesyan G, et al. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 2006;25:3257-63 pubmed
    ..Here, we demonstrate that TRAF3, like Cardif, is required for type I interferon production in response to intracellular double-stranded RNA...
  2. Qian Y, Qin J, Cui G, Naramura M, Snow E, Ware C, et al. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity. 2004;21:575-87 pubmed
    ..These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling. ..
  3. Xie P, Hostager B, Bishop G. Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes. J Exp Med. 2004;199:661-71 pubmed
    ..Among these, TRAF3 was the first identified to directly bind both receptors, yet its role remains a mystery...
  4. Xu Y, Cheng G, Baltimore D. Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity. 1996;5:407-15 pubmed
    b>TRAF3 was found as a protein that binds to the cytoplasmic tail of CD40 but is part of a family of proteins with common structure and activity...
  5. Xie P, Kraus Z, Stunz L, Liu Y, Bishop G. TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling. J Immunol. 2011;186:143-55 pubmed publisher
    ..However, the specific function of TRAF3 in T cells has remained unclear...
  6. Arch R, Thompson C. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol Cell Biol. 1998;18:558-65 pubmed
    ..While 4-1BB bound TRAF2 and TRAF1, Ox40 interacted with TRAF3 and TRAF2...
  7. Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng P, Keats J, Wang H, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008;9:1364-70 pubmed publisher
    The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative nuclear factor-kappaB (NF-kappaB) signaling in resting cells by targeting NF-kappaB-inducing kinase (NIK) for ubiquitin-dependent degradation, thus ..
  8. Matsuzawa A, Tseng P, Vallabhapurapu S, Luo J, Zhang W, Wang H, et al. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science. 2008;321:663-8 pubmed publisher
    ..a tumor necrosis factor receptor (TNFR) family member, forms a complex containing adaptor molecules TRAF2 and TRAF3, ubiquitin-conjugating enzyme Ubc13, cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2), IkappaB kinase ..
  9. Gardam S, Sierro F, Basten A, Mackay F, Brink R. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity. 2008;28:391-401 pubmed publisher
    Tumor necrosis factor receptor-associated factors 2 and 3 (TRAF2 and TRAF3) were shown to function in a cooperative and nonredundant manner to suppress nuclear factor-kappaB2 (NF-kappaB2) activation, gene expression, and survival in ..
  10. Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, et al. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med. 2010;207:2647-62 pubmed publisher
    ..In this study, we report that TRAF3 is a receptor proximal negative regulator of IL-17 receptor (IL-17R) signaling...
  11. Hacker H, Redecke V, Blagoev B, Kratchmarova I, Hsu L, Wang G, et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006;439:204-7 pubmed
    ..Using MyD88 as a prototypical adaptor, we identified TNF receptor-associated factor 3 (TRAF3) as a new component of TIR signalling complexes that is recruited along with TRAF6...
  12. Hostager B, Haxhinasto S, Rowland S, Bishop G. Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem. 2003;278:45382-90 pubmed
    ..We also find that TRAF2 participates in the degradation of TRAF3 associated with CD40 signaling, a role that may limit inhibitory actions of TRAF3...
  13. Xie P, Stunz L, Larison K, Yang B, Bishop G. Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity. 2007;27:253-67 pubmed
    Tumor necrosis factor receptor-associated factor 3 (TRAF3) is an adaptor protein that directly binds to a number of receptors of the tumor necrosis factor receptor (TNF-R) superfamily...
  14. Yi Z, Stunz L, Bishop G. TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells. J Exp Med. 2013;210:1079-86 pubmed publisher
    ..In this study, we show that TNF receptor associated factor 3 (TRAF3) plays a critical role in the transition between these two distinct signaling pathways and ..
  15. Jabara H, Laouini D, Tsitsikov E, Mizoguchi E, Bhan A, Castigli E, et al. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002;17:265-76 pubmed
    ..wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice...
  16. Zirlik A, Bavendiek U, Libby P, MacFarlane L, Gerdes N, Jagielska J, et al. TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells. Arterioscler Thromb Vasc Biol. 2007;27:1101-7 pubmed
    ..These results implicate endothelial TRAF-1, -2, -3, -5, and -6 in CD40 signaling in atherogenesis, identifying these molecules as potential targets for selective therapeutic intervention. ..
  17. Allen I, Wilson J, Schneider M, Lich J, Roberts R, Arthur J, et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-?B signaling. Immunity. 2012;36:742-54 pubmed publisher
    ..The noncanonical NF-?B pathway was regulated upon degradation of TRAF3 and activation of NIK...
  18. Guan K, Wei C, Zheng Z, Song T, Wu F, Zhang Y, et al. MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3. J Immunol. 2015;194:4880-90 pubmed publisher
  19. Zhou Y, He C, Yan D, Liu F, Liu H, Chen J, et al. The kinase CK1É› controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3. Nat Immunol. 2016;17:397-405 pubmed publisher
    The signaling adaptor TRAF3 is a highly versatile regulator of both innate immunity and adaptive immunity, but how its phosphorylation is regulated is still unknown...
  20. Hildebrand J, Luo Z, Manske M, Price Troska T, Ziesmer S, Lin W, et al. A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling. J Exp Med. 2010;207:2569-79 pubmed publisher
    ..This mutation encodes a His159Tyr substitution in the cytoplasmic tail of BAFF-R adjacent to the TRAF3 binding motif...
  21. Mambetsariev N, Lin W, Stunz L, Hanson B, Hildebrand J, Bishop G. Nuclear TRAF3 is a negative regulator of CREB in B cells. Proc Natl Acad Sci U S A. 2016;113:1032-7 pubmed publisher
    The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signaling through B-lymphocyte receptors, including CD40, BAFF receptor, and Toll-like receptors, and also plays a critical role inhibiting B-cell homoeostatic ..
  22. Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, et al. Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response. FASEB J. 2014;28:1756-68 pubmed publisher
    ..donovani and L. donovani + LPS costimulated macrophages. TRAF3, which was ubiquitinated (2...
  23. Jenkinson S, Williams J, Jeon H, Zhang J, Nitta T, Ohigashi I, et al. TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development. Proc Natl Acad Sci U S A. 2013;110:21107-12 pubmed publisher
    ..We therefore assessed the effect of selective deletion in TEC of TNF receptor-associated factor 3 (TRAF3), an inhibitor of nonclassical NF-?B signaling...
  24. Hoshino K, Sasaki I, Sugiyama T, Yano T, Yamazaki C, Yasui T, et al. Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells. J Immunol. 2010;184:3341-5 pubmed publisher
    ..Our results show that IKKalpha is a unique molecule involved in TLR7/9-MyD88-dependent type I IFN production through DC subset-specific mechanisms. ..
  25. Witherden A, Hafezparast M, Nicholson S, Ahmad Annuar A, Bermingham N, Arac D, et al. An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. Gene. 2002;283:71-82 pubmed
    ..We show a summary of 95 markers and 91 genomic clones that has enabled us to identify 18 transcripts including new genes and candidates for Loa which will help in future studies of gene context and regulation. ..
  26. Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q, et al. MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling. J Exp Med. 2010;207:2959-73 pubmed publisher
    ..c-Jun N-terminal kinase (JNK) and NF-?B activity by removing ubiquitin moieties from proteins, including TRAF2, TRAF3, and TRAF6. MCPIP1-deficient mice spontaneously developed fatal inflammatory syndrome...
  27. Zhou J, Wu R, High A, Slaughter C, Finkelstein D, Rehg J, et al. A20-binding inhibitor of NF-?B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein ? activation and protects from inflammatory disease. Proc Natl Acad Sci U S A. 2011;108:E998-1006 pubmed publisher
    ..Together, our data reveal ABIN1 as an essential anti-inflammatory component of TLR-signaling pathways that controls C/EBP? activity. ..
  28. Tanimura N, Saitoh S, Matsumoto F, Akashi Takamura S, Miyake K. Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochem Biophys Res Commun. 2008;368:94-9 pubmed publisher
    ..The internalized signaling complex consisting of TLR4 and TRAM colocalizes with TRAF3, a signaling molecule downstream of TRIF, in endosome/lysosome...
  29. Brown S, Richards C, Hanscom H, Feng S, Winkles J. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. Biochem J. 2003;371:395-403 pubmed
    ..These results indicate that Fn14 is a functional TWEAK receptor that can associate with four distinct TRAF family members and stimulate the NF-kappaB transcription factor signalling pathway. ..
  30. Daffis S, Suthar M, Szretter K, Gale M, Diamond M. Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog. 2009;5:e1000607 pubmed publisher
  31. Rothlin C, Ghosh S, Zuniga E, Oldstone M, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007;131:1124-36 pubmed
  32. Lin D, Zhang M, Zhang M, Ren Y, Jin J, Zhao Q, et al. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015;112:11324-9 pubmed publisher
    ..USP25 was associated with TRAF3 and TRAF6 after infection by RNA or DNA viruses and protected virus-induced proteasome-dependent or independent ..
  33. Jiang X, Deng K, Luo Y, Jiang D, Gao L, Zhang X, et al. Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy. Hypertension. 2015;66:356-67 pubmed publisher
    ..Here, we identified tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein in tumor necrosis factor-related signaling cascades, as a key regulator of cardiac ..
  34. Yao Z, Lei W, Duan R, Li Y, Luo L, Boyce B. RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors. J Biol Chem. 2017;292:10169-10179 pubmed publisher
    ..and release of active TGF? from the resorbed bone, coupled with RANKL-induced autophagolysosomal degradation of TRAF3, a known inhibitor of OC formation...
  35. Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
    ..Here we show that tumour necrosis factor receptor-associated factor 3 (TRAF3) is upregulated in mouse and human livers with hepatic steatosis...
  36. Gardam S, Turner V, Anderton H, Limaye S, Basten A, Koentgen F, et al. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood. 2011;117:4041-51 pubmed publisher
    ..signals are controlled by the homologous RING finger proteins cIAP1 and cIAP2, in collaboration with TRAF2 and TRAF3. There is also mounting evidence that all 4 of these signaling molecules can act as tumor suppressors in human B-..
  37. Rub A, Dey R, Jadhav M, Kamat R, Chakkaramakkil S, Majumdar S, et al. Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nat Immunol. 2009;10:273-80 pubmed publisher
    ..membrane cholesterol inhibited the assembly of an IL-12-inducing CD40 signalosome containing the adaptors TRAF2, TRAF3 and TRAF5 and the kinase Lyn and promoted the assembly of an IL-10-inducing CD40 signalosome containing the ..
  38. Gong J, Li Z, Guo S, Zhang X, Zhang P, Zhao G, et al. Neuron-Specific Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke. Hypertension. 2015;66:604-16 pubmed publisher
    ..Here, we report the versatile biological roles of tumor necrosis factor receptor-associated factor 3 (TRAF3) in ischemic stroke...
  39. Kuan A, Chamberlain W, Malkiel S, Lieu H, Factor S, Diamond B, et al. Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies. Immunogenetics. 1999;49:79-85 pubmed
    ..Future studies will determine whether the genetic factors identified in this study are also involved in susceptibility to rheumatic fever. ..
  40. Lin Y, Huang D, Chu C, Lin Y, Lin W. The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3. Sci Signal. 2013;6:ra71 pubmed publisher
    ..signaling at endosomes stimulates the production of type I interferons (IFNs) through a pathway that depends on TRAF3 and the kinase TBK1 (TANK-binding kinase-1)...
  41. Ohazama A, Courtney J, Sharpe P. Expression of TNF-receptor-associated factor genes in murine tooth development. Gene Expr Patterns. 2003;3:127-9 pubmed
    ..We carried out comparative in situ hybridization analysis of five Traf genes Traf1, Traf2, Traf3, Traf4 and Traf6 during murine odontogenesis from the formation of the epithelial thickening to the early bell ..
  42. Ha Y, Lee J. Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol. 2004;172:231-9 pubmed
    ..Molecular association studies further revealed that the TRAF3 association with p40(phox), a cytosolic subunit of NADPH oxidase and p85 (a subunit of PI3-K), may possibly be ..
  43. Gu H, Yu J, Dong D, Zhou Q, Wang J, Yang P. The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells. Toxicol Sci. 2015;144:186-96 pubmed publisher
    ..This study investigates the role of miR-322 and its putative target gene, TNF receptor-associated factor 3 (TRAF3), in high glucose-induced apoptosis...
  44. Kim S, Lee K, Chin C, Ng S, Pereira N, Xu S, et al. DOK3 is required for IFN-? production by enabling TRAF3/TBK1 complex formation and IRF3 activation. J Immunol. 2014;193:840-8 pubmed publisher
    ..DOK3 was also shown to bind TRAF3, and the binding of TRAF3 and TBK1 to DOK3 required the tyrosine-rich C-terminal domain of DOK3...
  45. Villanueva J, Malle E, Gardam S, Silveira P, Zammit N, Walters S, et al. TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. Eur J Immunol. 2015;45:1820-31 pubmed publisher
    ..These studies demonstrate a critical role for TRAF2 in the maintenance of peripheral CD8(+) CD44(hi) CD122(+) T-cell and NKT-cell homeostasis by modulating sensitivity to T-cell intrinsic growth factors such as IL-15. ..
  46. Liu S, Chen J, Cai X, Wu J, Chen X, Wu Y, et al. MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. elife. 2013;2:e00785 pubmed publisher
    ..DOI:http://dx.doi.org/10.7554/eLife.00785.001. ..
  47. Zhang P, Reichardt A, Liang H, Aliyari R, Cheng D, Wang Y, et al. Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5. Sci Signal. 2012;5:ra81 pubmed publisher
    ..of RIG-I (retinoic acid-inducible gene I), a component of a pattern recognition receptor that detects viruses, TRAF3 binds to the adaptor protein Cardif [caspase activation and recruitment domain (CARD) adaptor-inducing interferon-?..
  48. Edwards S, Desai A, Liu Y, Moore C, Xie P. Expression and function of a novel isoform of Sox5 in malignant B cells. Leuk Res. 2014;38:393-401 pubmed publisher
    Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas...
  49. Li P, Liu H, Zhang Y, Liao R, He K, Ruan X, et al. Endotoxin Tolerance Inhibits Degradation of Tumor Necrosis Factor Receptor-Associated Factor 3 by Suppressing Pellino 1 Expression and the K48 Ubiquitin Ligase Activity of Cellular Inhibitor of Apoptosis Protein 2. J Infect Dis. 2016;214:906-15 pubmed publisher
    ..regulates Toll-like receptor 4 signaling by regulating tumor necrosis factor receptor-associated factor 3 (TRAF3) degradation and is suppressed with the induction of endotoxin tolerance...
  50. Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, et al. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017;18:586-602 pubmed publisher
    ..Mechanistically, NDR1 interacts with TRAF3 and prevents its binding to IL-17R, which promotes the formation of an IL-17R-Act1-TRAF6 complex and downstream ..
  51. Xie P, Bishop G. Roles of TNF receptor-associated factor 3 in signaling to B lymphocytes by carboxyl-terminal activating regions 1 and 2 of the EBV-encoded oncoprotein latent membrane protein 1. J Immunol. 2004;173:5546-55 pubmed
    ..The present study further investigated how TRAF3 participates in LMP1 signaling...
  52. Zhong B, Liu X, Wang X, Liu X, Li H, Darnay B, et al. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Sci Signal. 2013;6:ra35 pubmed publisher
    ..signaling complex, and it associated with the adaptor proteins tumor necrosis factor receptor-associated factor 3 (TRAF3) and TRAF6 after stimulation of TLR4 with its ligand lipopolysaccharide (LPS)...
  53. Bishop G. TRAF3 as a powerful and multitalented regulator of lymphocyte functions. J Leukoc Biol. 2016;100:919-926 pubmed
    ..Cytoplasmic TNFR -associated factor 3 restrains nuclear factor-?B2 activation in both T and B cells. Clinical implications and future directions for the study of this context-dependent signaling regulator are discussed. ..