Tpm1

Summary

Gene Symbol: Tpm1
Description: tropomyosin 1, alpha
Alias: AA986836, AI854628, TM2, Tm3, Tmpa, Tpm-1, alpha-TM, alpha tropomyosin, alpha-tropomyosin, tropomyosin alpha-1 chain, tropomyosin-1
Species: mouse

Top Publications

  1. ncbi Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1
    M Schleef
    Developmental Biology Unit, University of Bielefeld, Federal Republic of Germany
    Genomics 17:519-21. 1993
  2. ncbi N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1
    Shantaram Bharadwaj
    Departments of General Surgery and Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 279:14039-48. 2004
  3. ncbi ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain
    N Nakagawa
    Department of Structural Molecular Biology, Osaka University, Japan
    Biochem Biophys Res Commun 272:505-12. 2000
  4. pmc Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L
    Sumeyye Yar
    Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 288:16235-46. 2013
  5. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
  6. pmc RBM4 promotes pancreas cell differentiation and insulin expression
    Jung Chun Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Cell Biol 33:319-27. 2013
  7. pmc Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation
    Benjamin R Nixon
    Department of Physiology and Cell Biology and The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States
    Arch Biochem Biophys 535:30-8. 2013
  8. pmc Tropomyosin dephosphorylation results in compensated cardiac hypertrophy
    Emily M Schulz
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 287:44478-89. 2012
  9. pmc Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network
    Shan Shan Zhang
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:13576-81. 2011
  10. ncbi Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics
    Robert D Gaffin
    Cardiovascular Research Institute and Department of Systems Biology and Translational Medicine, College of Medicine, Texas A and M University System Health Science Center, TX 77843 1114, USA
    Am J Physiol Heart Circ Physiol 291:H552-63. 2006

Research Grants

  1. ANALYSIS OF FUNCTIONAL ROLE OF TROPOMYOSIN IN HEART
    Mariappan Muthuchamy; Fiscal Year: 2002
  2. Mechanobiology of Cardiomyocytes
    Mariappan Muthuchamy; Fiscal Year: 2006
  3. Regulatory Mechanisms in Lymphatic Muscle Contraction
    Mariappan Muthuchamy; Fiscal Year: 2007
  4. Molecular Mechanisms of Lymphatic Muscle Contraction
    Mariappan Muthuchamy; Fiscal Year: 2009

Scientific Experts

  • Mariappan Muthuchamy
  • J R Patel
  • L Clayton
  • K Yamazaki
  • K L Vikstrom
  • David F Wieczorek
  • R John Solaro
  • Sudarsan Rajan
  • Robert D Gaffin
  • Galina Schevzov
  • Paul Delgado-Olguín
  • Beata M Wolska
  • Ganapathy Jagatheesan
  • Natalia Petrashevskaya
  • Grace M Arteaga
  • Sumeyye Yar
  • Benjamin R Nixon
  • Jung Chun Lin
  • Raisa Klevitsky
  • Jeffrey Robbins
  • Emily M Schulz
  • Benoit G Bruneau
  • Nabeel J Al Moamen
  • Chehade N Karam
  • Shan Shan Zhang
  • Natasha A Karp
  • Rethinasamy Prabhakar
  • Xiaoli Liu
  • Cuc T T Bach
  • Pieter P de Tombe
  • Chad M Warren
  • Geraldine M O'Neill
  • Peter W Gunning
  • Jian Fu Chen
  • Jeffery D Molkentin
  • Stephen B Liggett
  • Susan Vahebi
  • Edna C Hardeman
  • Josephine E Joya
  • Jim J C Lin
  • Brooke K McMichael
  • Laura L Issa
  • Rashid Nassar
  • David C Zawieja
  • James C Sacchettini
  • Angela Jeanes
  • Kuppan Gokulan
  • Greg P Boivin
  • Arnold Schwartz
  • Timothy E Hewett
  • J G Seidman
  • Shantaram Bharadwaj
  • Eileen M Burkart
  • Natalia Gromak
  • Henning Wittenburg
  • Beatrice Scellini
  • Yu Ting Yan
  • Brandon J Biesiadecki
  • Paul M L Janssen
  • Wen Kou Hsieh
  • Nicoletta Piroddi
  • Vadim Gaponenko
  • Jonathan P Davis
  • Chiara Tesi
  • Pey Jey Peng
  • Minae Kobayashi
  • Michelle M Monasky
  • Bin Liu
  • Woan Yuh Tarn
  • Robert T Davis
  • Shamim A K Chowdhury
  • Mark T Ziolo
  • Corrado Poggesi
  • Tomoyoshi Kobayashi
  • Chun Hao Su
  • Ozgur Ogut
  • Yu Huang
  • W Yang
  • Patti L Engel
  • M A Corbett
  • Gilbert Newman
  • Richard N Correll
  • Christine E Seidman
  • Danos Christodoulou
  • Hajer N Sheikh
  • Jo El J Schultz
  • Marco S Lofrano-Alves
  • Xue Li
  • Alexander Tarakhovsky
  • Robin M Shaw

Detail Information

Publications52

  1. ncbi Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1
    M Schleef
    Developmental Biology Unit, University of Bielefeld, Federal Republic of Germany
    Genomics 17:519-21. 1993
    ..5-kb of Tpm-1. The same restriction patterns were observed, proving the identity of the mapped and the cloned gene. The identity was supported by sequencing the 3' end of the gene...
  2. ncbi N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1
    Shantaram Bharadwaj
    Departments of General Surgery and Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 279:14039-48. 2004
    ..Our studies provide in vivo functional evidence that the N terminus is a critical determinant of TM1 functions, which in turn determines the organization of stress fibers...
  3. ncbi ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain
    N Nakagawa
    Department of Structural Molecular Biology, Osaka University, Japan
    Biochem Biophys Res Commun 272:505-12. 2000
    ....
  4. pmc Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L
    Sumeyye Yar
    Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 288:16235-46. 2013
    ..Thus, our results provide insight into the link between flexibility of TM and its function in ejecting hearts...
  5. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
    ..Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses...
  6. pmc RBM4 promotes pancreas cell differentiation and insulin expression
    Jung Chun Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Cell Biol 33:319-27. 2013
    ..These results suggest that RBM4 may have role in promoting pancreas cell differentiation and endocrine function, essentially via alternative splicing regulation...
  7. pmc Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation
    Benjamin R Nixon
    Department of Physiology and Cell Biology and The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States
    Arch Biochem Biophys 535:30-8. 2013
    ..This supports a role for Tm as a key protein in the regulation of muscle relaxation dynamics...
  8. pmc Tropomyosin dephosphorylation results in compensated cardiac hypertrophy
    Emily M Schulz
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 287:44478-89. 2012
    ..Collectively, these results suggest that modification of the Tm phosphorylation status in the heart, depending upon the cardiac state/condition, may modulate the development of cardiac hypertrophy...
  9. pmc Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network
    Shan Shan Zhang
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:13576-81. 2011
    ..Irx3 directly represses Cx43 transcription and indirectly activates Cx40 transcription. Our results reveal a critical role for Irx3 in the precise regulation of intercellular gap junction coupling and impulse propagation in the heart...
  10. ncbi Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics
    Robert D Gaffin
    Cardiovascular Research Institute and Department of Systems Biology and Translational Medicine, College of Medicine, Texas A and M University System Health Science Center, TX 77843 1114, USA
    Am J Physiol Heart Circ Physiol 291:H552-63. 2006
    ....
  11. ncbi MusTRD can regulate postnatal fiber-specific expression
    Laura L Issa
    Muscle Development Unit, Children s Medical Research Institute, Wentworthville, NSW 2145, Australia
    Dev Biol 293:104-15. 2006
    ..These data are consistent with our initial predictions for hMusTRD1alpha1 and suggest that slow fiber genes contain a specific common regulatory element that can be targeted by MusTRD proteins...
  12. ncbi Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis
    Angela Jeanes
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Reproduction 130:509-16. 2005
    ..Collagen type-I, inhibinbetaA, caldesmon 1 and tropomyosin 1 were found to be expressed by early-stage PM cells...
  13. pmc Specific features of neuronal size and shape are regulated by tropomyosin isoforms
    Galina Schevzov
    Oncology Research Unit, The Children s Hospital at Westmead, Westmead NSW 2145, Australia
    Mol Biol Cell 16:3425-37. 2005
    ..expression on neuronal morphogenesis, embryonic cortical neurons from transgenic mice expressing the isoforms Tm3 and Tm5NM1, under the control of the beta-actin promoter, were cultured in vitro...
  14. ncbi cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform
    Rashid Nassar
    Department of Pediatrics, Duke University, Durham, NC, USA
    Am J Physiol Heart Circ Physiol 288:H1147-56. 2005
    ....
  15. pmc Charged residue alterations in the inner-core domain and carboxy-terminus of alpha-tropomyosin differentially affect mouse cardiac muscle contractility
    Robert D Gaffin
    Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, 336 Reynolds Medical Building, College Station, TX 77843 1114, USA
    J Physiol 561:777-91. 2004
    ..These data demonstrate that changing charged residues at either the inner-core domain or the carboxyl end of TM alters sarcomeric performance differently, suggesting that the function of TM is compartmentalized along its length...
  16. pmc Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility
    Robert D Gaffin
    Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    J Physiol 556:531-43. 2004
    ..Our results provide the first evidence that charge changes at the carboxy-terminal of alpha-TM alter the functional characteristics of the heart at both the whole organ and myofilament levels...
  17. ncbi Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts
    Brooke K McMichael
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Bone 39:694-705. 2006
    ..This compartmentalization of tropomyosins to specific actin structures within osteoclasts is likely to play a critical role in determining the dynamic properties of the actin cytoskeleton and thus osteoclast activity...
  18. ncbi p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity
    Susan Vahebi
    Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Ave, Chicago, IL 60612 7342, USA
    Circ Res 100:408-15. 2007
    ..These data are the first to indicate that chronic activation of p38alpha MAPK directly depresses sarcomeric function in association with decreased phosphorylation of alpha-tropomyosin...
  19. pmc Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation
    Chehade N Karam
    Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Ave M C 901, Chicago, IL 60612 7342, USA
    J Muscle Res Cell Motil 31:315-22. 2011
    Tropomyosin-kappa (TPM1-κ) is a newly discovered tropomyosin (TM) isoform that is exclusively expressed in the human heart and generated by an alternative splicing of the α-TM gene...
  20. pmc Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure
    Nabeel J Al Moamen
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 50:137-46. 2011
    ..Thus, in the TM180 cardiomyopathy model, loss of AE3 had no apparent anti-hypertrophic effect and led to more rapid decompensation and heart failure...
  21. pmc Optimising experimental design for high-throughput phenotyping in mice: a case study
    Natasha A Karp
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Mamm Genome 21:467-76. 2010
    ..Consequently, in confirmatory studies, a power analysis along with the 3Rs can provide justification to increase the number of mice used...
  22. pmc Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction
    Cuc T T Bach
    Oncology Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales 2145, Australia
    Mol Cell Biol 29:1506-14. 2009
    ..Thus, we propose that Tm5NM1 can regulate the feedback loop between focal adhesion disassembly and focal complex formation at the leading edge that is required for productive and directed cell movement...
  23. pmc Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice
    Xiaoli Liu
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Circulation 119:261-8. 2009
    ..Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation...
  24. pmc Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:2111-6. 2008
    ..Together, our studies demonstrate essential roles for Dicer in cardiac contraction and indicate that miRNAs play critical roles in normal cardiac function and under pathological conditions...
  25. ncbi Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity
    Sudarsan Rajan
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, Cincinnati, OH 45267 0524, USA
    Circ Res 101:205-14. 2007
    ..As such, this is the first mouse model in which a mutation in a sarcomeric thin filament protein, specifically TM, leads to DCM...
  26. ncbi Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis
    Ganapathy Jagatheesan
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Am J Physiol Heart Circ Physiol 293:H949-58. 2007
    ..These results demonstrate that alterations in calcium response by modification of contractile proteins can prevent the pathological and physiological effects of this disease...
  27. ncbi Divergent regulation of the sarcomere and the cytoskeleton
    Galina Schevzov
    Oncology Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales 2145, Australia
    J Biol Chem 283:275-83. 2008
    ..Comprehensive analyses of tissues from transgenic and knock-out mouse lines that overexpress the cytoskeletal Tms, Tm3 and Tm5NM1, and a comparison with sarcomeric Tms provide evidence for this...
  28. pmc The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing
    Natalia Gromak
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    EMBO J 22:6356-64. 2003
    ..This suggests a novel mechanism for PTB-mediated splicing repression involving recruitment of raver1 as a potent splicing co-repressor...
  29. ncbi Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively
    R Klocke
    Developmental Biology Unit W7, University of Bielefeld, Germany
    Genomics 41:290-2. 1997
    ..Potential relations of both loci to disease genes are discussed...
  30. ncbi Contractile protein mutations and heart disease
    K L Vikstrom
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
    Curr Opin Cell Biol 8:97-105. 1996
    Mutations in several muscle structural proteins (the myosin heavy chain, alpha tropomyosin, cardiac troponin T and myosin binding protein C) result in a genetically dominant heart disease, hypertrophic cardiomyopathy...
  31. ncbi Anti-oncogenic effects of tropomyosin: isoform specificity and importance of protein coding sequences
    R H Braverman
    Laboratory of Cellular Oncology, NCI, Bethesda, Maryland 20892, USA
    Oncogene 13:537-45. 1996
    ..specificity in cellular transformation, cDNAs that consist of coding sequences of TM1 (product of beta gene) and TM2 (product of alpha gene), but lacking untranslated regions (UTRs), have been expressed separately in DT (v-Ki-ras ..
  32. ncbi Molecular diversity of myofibrillar proteins: gene regulation and functional significance
    S Schiaffino
    Department of Biomedical Sciences, University of Padova, Padua, Italy
    Physiol Rev 76:371-423. 1996
    ..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
  33. ncbi Assignment of the human skeletal muscle alpha-tropomyosin gene (TPM1) to band 15q22 by fluorescence in situ hybridization
    H Eyre
    Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, North Adelaide, Australia
    Cytogenet Cell Genet 69:15-7. 1995
    A sequence-tagged site (STS) was developed for the human skeletal muscle alpha-tropomyosin gene (TPM1) and used to isolate a genomic clone, lambda TPM1.1, containing part of the TPM1 gene...
  34. pmc Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryos
    M Muthuchamy
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    Mol Cell Biol 13:3311-23. 1993
    ..Our results show for the first time that the alpha- and beta-TM striated muscle transcripts are present in the earliest functional stages of the heart, and these TM isoforms are identical to those present throughout cardiac development...
  35. ncbi Chromosome mapping of nine tropomyosin-related sequences in mice
    M Gariboldi
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Mamm Genome 6:273-7. 1995
    ....
  36. ncbi Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse
    M Schleef
    University of Bielefeld, Developmental Biology Unit, Germany
    Neuromuscul Disord 4:205-17. 1994
    ..A cDNA derived from the 1100 nucleotide parvalbumin transcript was cloned and the sequence for the as yet unknown 3' extended trailer, generated by alternative polyadenylation, was determined...
  37. pmc Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2
    K Takenaga
    Division of Chemotherapy and Biochemistry, Chiba Cancer Center Research Institute, Japan
    Mol Cell Biol 8:5561-5. 1988
    ..284 amino acids and was closely related to the rat smooth and skeletal muscle alpha-TMs and the human fibroblast TM3. The amino acid sequence of TM2 showed a nearly complete match with that of human fibroblast TM3 except for the ..
  38. ncbi Coordinate induction of fibronectin, fibronectin receptor, tropomyosin, and actin genes in serum-stimulated fibroblasts
    R P Ryseck
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Exp Cell Res 180:537-45. 1989
    ....
  39. ncbi Targeted ablation of the murine alpha-tropomyosin gene
    E M Blanchard
    Howard Hughes Medical Institute, Boston, Mass, USA
    Circ Res 81:1005-10. 1997
    ..These findings imply that in heterozygotes there is a regulatory mechanism that maintains the level of myofibrillar tropomyosin despite the reduction in alpha-tropomyosin mRNA...
  40. ncbi Molecular and physiological effects of alpha-tropomyosin ablation in the mouse
    P Rethinasamy
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinatti Medical Center, OH 45267 0524, USA
    Circ Res 82:116-23. 1998
    ..The present study suggests that translational regulation plays a major role in the control of TM expression...
  41. ncbi Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9
    K Yamazaki
    Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Genomics 46:528-9. 1997
  42. ncbi A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation
    Rethinasamy Prabhakar
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Mol Cell Biochem 251:33-42. 2003
    ..This study demonstrates that mutations within tropomyosin can be severely disruptive of sarcomeric function, triggering a hypertrophic response coupled with a cascade of alterations in gene expression...
  43. ncbi Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy
    Eileen M Burkart
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Avenue, MC 901, Room E 202 MSB, Chicago, IL 606127342, USA
    J Mol Cell Cardiol 35:1285-93. 2003
    ..Although levels of phosphorylation at protein kinase C-dependent sites were the same in TG and NTG myofilaments, our data indicate that the effects of phosphorylation were more depressive in TG hearts...
  44. ncbi Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice
    Henning Wittenburg
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 8:67-77. 2002
    ..According to standard nomenclature, the gallstone QTL on chromosome 9 is named Lith5...
  45. pmc Impaired motor coordination in mice that lack punc
    W Yang
    Department of Human Genetics, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112, USA
    Mol Cell Biol 21:6031-43. 2001
    ..Compared with control littermates, however, homozygous mutants had significantly reduced retention times on the Rotarod, suggesting a role for Bergmann glia-expressed Punc in the cerebellar control of motor coordination...
  46. ncbi PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin
    J R Patel
    Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Am J Physiol Heart Circ Physiol 280:H2732-9. 2001
    ..These results show that PKA-mediated phosphorylation of myofibrillar proteins significantly alters the static and dynamic mechanical properties of myocardium, and these effects occur regardless of the type of Tm expressed...
  47. ncbi A mutation in alpha-tropomyosin(slow) affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy
    M A Corbett
    Muscle Development Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, New South Wales 2145, Australia
    Hum Mol Genet 10:317-28. 2001
    ..We suggest that the clinical phenotype is precipitated by a failure of the hypertrophy to persist and therefore compensate for muscle weakness...
  48. ncbi Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction
    M Muthuchamy
    Department of Molecular Genetics, Division of Cardiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
    Circ Res 85:47-56. 1999
    ..Thus, the FHC alpha-TM transgenic mouse can serve as a model system for the examination of pathological and physiological alterations imparted through aberrant TM isoforms...
  49. ncbi p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium
    L K Kochilas
    Division of Pediatric Cardiology, Children s Hospital of Philadelphia, Pennsylvania, USA
    Pediatr Res 45:635-42. 1999
    ..This result and further structural analysis suggests that the myocardial defect of Splotch embryos is associated with precocious cardiomyocyte differentiation...
  50. ncbi Tissue-specific expression and mapping of the Cox7ah gene in mouse
    S A Jaradat
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Genomics 49:363-70. 1998
    ..1. As a result, all three COX heart isoform genes in mouse group to chromosome 7. Interestingly, mapping of the mouse Cox7al to chromosome 9 suggests a new syntenic region between the mouse and the human genomes...
  51. ncbi Tropomyosin in preimplantation mouse development: identification, expression, and organization during cell division and polarization
    L Clayton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, United Kingdom
    Exp Cell Res 238:450-64. 1998
    ..We conclude that the early mouse conceptus contains a unique and specific set of tropomyosins which respond to polarizing signals...
  52. pmc Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun
    P M Chevray
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 89:5789-93. 1992
    ..Our results illustrate the range of protein interaction cloning for discovering proteins that bind to a given target polypeptide...

Research Grants9

  1. ANALYSIS OF FUNCTIONAL ROLE OF TROPOMYOSIN IN HEART
    Mariappan Muthuchamy; Fiscal Year: 2002
    ..Cardiovascular studies using transgenic mouse model will provide explicit information on the heart function during both normal and diseased states. ..
  2. Mechanobiology of Cardiomyocytes
    Mariappan Muthuchamy; Fiscal Year: 2006
    ..This will provide novel insight into transduction mechanisms of myocytes. ..
  3. Regulatory Mechanisms in Lymphatic Muscle Contraction
    Mariappan Muthuchamy; Fiscal Year: 2007
    ..End of Abstract) ..
  4. Molecular Mechanisms of Lymphatic Muscle Contraction
    Mariappan Muthuchamy; Fiscal Year: 2009
    ..The contractile mechanisms of lymphatics have not been known before and will significantly advance our understanding of the basis for the lymphatic vessel function. ..