Genomes and Genes
Gene Symbol: tPA
Description: plasminogen activator, tissue
Alias: AU020998, AW212668, D8Ertd2e, tPA, tissue-type plasminogen activator, t-plasminogen activator
Publications131 found, 100 shown here
- Characterization of the murine plasminogen/urokinase-type plasminogen-activator systemH R Lijnen
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Eur J Biochem 241:840-8. 1996..However, quantitative differences were observed both in the presence of cells and in plasma which may contribute to a reduced u-PA-mediated fibrinolytic activity in the murine systems...
- Tissue plasminogen activator as a modulator of neuronal survival and functionStella E Tsirka
Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794 8651, U S A
Biochem Soc Trans 30:222-5. 2002The tissue plasminogen activator (tPA)/plasmin proteolytic system has been implicated in both physiological and pathological processes in the mammalian brain. The physiological roles include facilitating neurite outgrowth and pathfinding...
- Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signalingMonica Fernandez-Monreal
CNRS UMR 6185, University of Caen, Centre Cyceron, Bd Henri Becquerel, BP 5229, 14074, Caen, France
J Biol Chem 279:50850-6. 2004Tissue-type plasminogen activator (tPA) has been involved in both physiological and pathological glutamatergic-dependent processes, such as synaptic plasticity, seizure, trauma, and stroke...
- Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient miceLeif R Lund
Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, Copenhagen, Denmark
EMBO J 25:2686-97. 2006Simultaneous ablation of the two known activators of plasminogen (Plg), urokinase-type (uPA) and the tissue-type (tPA), results in a substantial delay in skin wound healing...
- Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activationXiaohui Zhang
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Whitehead Biomedical Research Bldg, 615 Michael St, Suite 505J, Atlanta, GA 30322, USA
Am J Pathol 171:1281-90. 2007Tissue-type plasminogen activator (tPA) is a serine proteinase found in the intravascular space and the central nervous system...
- Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in miceJohn J Sheehan
Department of Pharmacological Sciences and Program in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, New York 11794 8651, USA
J Neurosci 27:1738-45. 2007..Finally, our results provide a mechanism that explains the resistance of plasminogen-deficient mice to excitotoxicity...
- Plasmin-mediated degradation of laminin gamma-1 is critical for ethanol-induced neurodegenerationAnna E Skrzypiec
Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom
Biol Psychiatry 66:785-94. 2009..Abrupt ethanol withdrawal (EW) may result in neuronal hyperexcitability leading to hallucinations, seizures, neurodegeneration, and sometimes death...
- Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related proteinYasuhiro Suzuki
Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan, Japan
Blood 114:3352-8. 2009..These findings indicate that t-PA deteriorates ICB via MMP-3 induction in endothelial cells, which is regulated through the LRP/nuclear factor-kappaB pathway...
- Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brainChen Zhang
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Cereb Blood Flow Metab 29:1946-54. 2009..cerebral ischemia indicate that besides its thrombolytic effect, treatment with tissue-type plasminogen activator (tPA) also induces an increase in matrix metalloproteinase-9 (MMP-9) activity in the ischemic tissue associated with the ..
- Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruptionYao Yao
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794 8651, USA
J Cell Sci 124:1486-95. 2011..increases the permeability of BBB in both wild-type mice and mice deficient for tissue plasminogen activator (tPA), which converts plasminogen into active plasmin, suggesting that plasmin-mediated truncation of MCP1 plays an ..
- Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptorsDavid Pineda
Cancer Research Programme, IMIM Hospital del Mar, C Dr Aiguader 88, 08003 Barcelona, Spain
Glia 60:526-40. 2012..Tissue plasminogen activator (tPA) is a serine protease which best-known function is fibrinolysis, but it is also involved in many other ..
- Tissue plasminogen activator and plasminogen activator inhibitor 1 contribute to sonic hedgehog-induced in vitro cerebral angiogenesisHua Teng
Department of Neurology, Henry Ford Hospital, Detroit, Michigan, United States of America
PLoS ONE 7:e33444. 2012..This was associated with increases in tissue plasminogen activator (tPA) activation and reduction of plasminogen activator inhibitor 1 (PAI-1)...
- tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathwayLing Lin
Division of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Pathol 177:1687-96. 2010..Here we define the intracellular signaling events by which tissue plasminogen activator (tPA) promotes renal interstitial fibroblast proliferation...
- An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cellsB A Hosler
Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
Mol Cell Biol 13:2919-28. 1993....
- Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesisS P Oh
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 97:2626-31. 2000..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...
- Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migrationChunzhang Cao
Department of Physiology and Surgery, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, 21201, USA
EMBO J 25:1860-70. 2006..on Mac-1 recognition of a binary complex consisting of fibrin within the provisional matrix and the protease tPA (tissue-type plasminogen activator)...
- The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1Taku Nagai
Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
J Neurosci 26:12374-83. 2006..Here we show that the tissue plasminogen activator (tPA)-plasmin system regulates nicotine-induced reward and dopamine release by activating protease activated receptor-1 (..
- Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in miceY Suzuki
Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
J Thromb Haemost 5:1732-9. 2007..Matrix metalloproteinases (MMPs), which can be activated through the plasminogen/plasmin system, may contribute to ICB after ischemic stroke...
- Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signalingKebin Hu
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Clin Invest 117:3821-32. 2007..Here we describe a signaling pathway that leads to this activation. Tissue-type plasminogen activator (tPA) promoted TGF-beta1-mediated alpha-SMA and type I collagen expression in rat kidney interstitial fibroblasts...
- Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancerOriol Roda
Cancer Research Programme, Municipal Institute of Medical Research, Barcelona, Spain
Gastroenterology 136:1379-90, e1-5. 2009Tissue plasminogen activator (tPA) exerts many different functions in addition to its role in fibrinolysis...
- Angiopoietins 3 and 4: diverging gene counterparts in mice and humansD M Valenzuela
Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Proc Natl Acad Sci U S A 96:1904-9. 1999..Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist...
- Male fertility and protein C inhibitor/plasminogen activator inhibitor-3 (PCI): localization of PCI in mouse testis and failure of single plasminogen activator knockout to restore spermatogenesis in PCI-deficient micePavel Uhrin
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
Fertil Steril 88:1049-57. 2007..To investigate the mechanisms responsible for the testicular abnormalities and infertility of previously generated male protein C inhibitor (PCI)-deficient mice...
- Physiological consequences of loss of plasminogen activator gene function in miceP Carmeliet
Whitehead Institute of Biomedical Research, Cambridge, Massachusetts 02142
Nature 368:419-24. 1994..Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival...
- A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant miceU Frey
Federal Institute for Neurobiology, Magdeburg, Germany
J Neurosci 16:2057-63. 1996..Most remarkably, t-PA-deficient mice exhibit a different form of long-lasting potentiation that is characterized by an NMDA receptor-dependent modification of GABA transmission in the CA1 region...
- Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activatorT H Bugge
Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 93:5899-904. 1996..in the urokinase-type plasminogen activator (uPA), urokinase receptor (uPAR), tissue-type plasminogen activator (tPA), and plasminogen permits a critical, genetic-based analysis of the physiological and pathological roles of the two ..
- An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampusS E Tsirka
Department of Pharmacology, University Medical Center at Stony Brook, New York 11794 8651, USA
J Neurosci 17:543-52. 1997Mice lacking the serine protease tissue plasminogen activator (tPA) are resistant to excitotoxin-mediated hippocampal neuronal degeneration. We have used genetic and cellular analyses to study the role of tPA in neuronal cell death...
- Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of lamininZ L Chen
Department of Pharmacology, University at Stony Brook, New York 11794 8651, USA
Cell 91:917-25. 1997..acids can provoke neuronal death in the hippocampus, and the extracellular proteases tissue plasminogen activator (tPA) and plasmin (ogen) have been implicated in this death...
- Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in miceN Nagai
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Center for Molecular and Vascular Biology, KU Leuven, Belgium
Circulation 99:2440-4. 1999..ischemic infarction (FCI) was studied in mice deficient in plasminogen (Plg-/-), in tissue or urokinase plasminogen activator (tPA-/- or uPA-/-), or in plasminogen activator inhibitor-1 or alpha2-antiplasmin (PAI-1(-/-) or alpha2-AP-/-).
- Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processesZ L Chen
Department of Pharmacology, University at Stony Brook, Stony Brook, New York 11794 8651, USA
J Neurosci 19:9813-20. 1999..These results indicate that excitotoxin-induced neuronal death and BBB breakdown are separable events in the hippocampus...
- Mouse carotid artery ligation induces platelet-leukocyte-dependent luminal fibrin, required for neointima developmentT Kawasaki
Center for Molecular and Vascular Biology, University of Leuven, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
Circ Res 88:159-66. 2001..Delayed coagulation then results in formation of a fibrin matrix, which is used by smooth muscle cells to migrate into the lumen...
- Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crushL B Siconolfi
Neuroscience Program and Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 21:4348-55. 2001..These proteases include the plasminogen activators (PAs), tissue PA (tPA) and urokinase PA (uPA), and their substrate, plasminogen...
- The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependentLaetitia Devy
Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
FASEB J 16:147-54. 2002..The single deficiency of tPA, uPA, or uPAR, as well as combined deficiencies of uPA and tPA, did not dramatically affect microvessel formation...
- Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activatorWeiquan Lu
Program in Molecular and Cellular Pharmacology and Department of Pharmacological Sciences, University Medical Center at Stony Brook, NY 11794 8651, USA
Development 129:2043-50. 2002..stroke) is promoted by an extracellular cascade involving the serine protease tissue plasminogen activator (tPA)...
- Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitisWeiquan Lu
Program in Pharmacology, Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, New York 11794 8651, USA
J Neurosci 22:10781-9. 2002..In the brains of MS patients, tissue plasminogen activator (tPA) mRNA and protein are upregulated, and changes in the levels of tPA correlate with progression of the disease...
- The hippocampal laminin matrix is dynamic and critical for neuronal survivalZu Lin Chen
Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York 10021, USA
Mol Biol Cell 14:2665-76. 2003..2) was posttranscriptional, because there was no effect on laminin mRNA expression; and 3) occurred in both tPA(-/-) and plasminogen(-/-) mice, indicating that increased plasmin activity was not responsible...
- Tissue plasminogen activator is a potent activator of PDGF-CCLinda Fredriksson
Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden
EMBO J 23:3793-802. 2004Tissue plasminogen activator (tPA) is a serine protease involved in the degradation of blood clots through the activation of plasminogen to plasmin...
- Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticityPetti T Pang
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
Science 306:487-91. 2004..Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is ..
- Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosisKarim Benchenane
INSERM Avenir tPA in the working brain, Universite de Caen, GIP Cyceron, Caen, France
Circulation 111:2241-9. 2005Accumulating evidence demonstrates a critical involvement of tissue-type plasminogen activator (tPA) in pathological and physiological brain conditions...
- Tissue-type plasminogen activator: a multifaceted modulator of neurotransmission and synaptic plasticityAndre L Samson
Australian Centre for Blood Diseases, Monash University, Level 6 Burnet Building, Alfred Medical Research and Education Precinct, 89 Commercial Road, Prahran 3181, Victoria, Australia
Neuron 50:673-8. 2006....
- Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemiaS R Lee
Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Neuroscience 150:50-7. 2007Knockout mice deficient in tissue plasminogen activator (tPA) are protected against hippocampal excitotoxicity...
- tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2Westley B Nolin
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794 8651, USA
Glia 56:177-89. 2008..we describe here a potentially synergistic therapeutic opportunity based on tissue plasminogen activator (tPA), an extracellular protease that converts plasminogen (plg) into the active protease plasmin...
- Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brainJie An
Institute of Pharmacology, Shandong University School of Medicine, Jinan, China
Blood 112:2787-94. 2008Tissue-type plasminogen activator (tPA) is found in the intravascular space and in the central nervous system. The low-density lipoprotein receptor-related protein (LRP) is expressed in neurons and in perivascular astrocytes...
- Tissue plasminogen activator promotes axonal outgrowth on CNS myelin after conditioned injuryKenneth Minor
Department of Biochemistry and Molecular Genetics, University of Colorado Denver, School of Medicine, Aurora, Colorado 8004, USA
J Neurochem 109:706-15. 2009..The following study suggests that the proteolytic enzyme tissue plasminogen activator (tPA) plays a major function in 'conditioning-injury induced' axon regeneration...
- Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient miceAnnika Jögi
Finsen Laboratory, Copenhagen University Hospital, Copenhagen Biocenter, Copenhagen, Denmark
PLoS ONE 5:e12746. 2010..the two plasminogen activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA)...
- Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in miceYongzhi Guo
Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
PLoS ONE 6:e24774. 2011..In this study, by using mice lacking genes for plasminogen, tissue-type plasminogen activator (tPA), and urokinase-type PA (uPA), we have investigated the functional roles of active plasmin in infection and sepsis...
- Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin depositionD J Pinsky
Columbia University College of Physicians and Surgeons, New York 10032, USA
J Clin Invest 102:919-28. 1998..in PAI-1 mRNA compared with normoxic controls; in contrast, transcripts for both tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) decreased under hypoxic conditions...
- Key role of tissue plasminogen activator in neurovascular couplingLaibaik Park
Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 105:1073-8. 2008..Here, we show that tissue plasminogen activator (tPA), a serine protease implicated in NMDA receptor signaling, is required for the flow increase evoked by ..
- Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activatorS E Tsirka
Department of Pharmacology, University Medical Center at Stony Brook, New York 11794 8651, USA
Nature 377:340-4. 1995..When neuronal activity is stimulated in the adult rat and mouse hippocampus, tissue plasminogen activator (tPA), a serine protease that converts inactive plasminogen to the active protease plasmin, is transcriptionally induced...
- Developmental expression of mouse stromelysin-3 mRNAO Lefebvre
Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM U184 ULP, Illkirch, C U de Strasbourg, France
Development 121:947-55. 1995....
- Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activatorK Yamamoto
Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Clin Invest 97:2440-51. 1996..Changes in tissue-type plasminogen activator gene expression do not appear to be essential for fibrin deposition/dissolution in this murine model of sepsis...
- A linkage map of mouse chromosome 8: further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19T A Howard
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
Genomics 10:207-13. 1991..5 cM-Junb/Ucp-10.5 cM-Mt-1-27.2 cM-Acta2-0.9 cM-Aprt. These data provide further definition of mouse chromosome 8 linkage relationships and the relationship between segments of this chromosome and human chromosomes 8, 16, and 19...
- Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1G Rao
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Oncogene 12:1165-72. 1996....
- Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse developmentA D Domashenko
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
Mol Reprod Dev 47:57-65. 1997....
- The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1K M Huttner
Joint Program in Neonatology, Children s Hospital, Boston, MA 02115, USA
FEBS Lett 413:45-9. 1997..These data indicate that mBD-1 is a close homolog of hBD-1, and suggest that analysis of its role in mouse host defense may provide significant insights into human epithelial innate immunity...
- Pemphigus vulgaris and pemphigus foliaceus antibodies are pathogenic in plasminogen activator knockout miceM G Mahoney
Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
J Invest Dermatol 113:22-5. 1999..These data definitively demonstrate that plasminogen activator is not necessary for pemphigus immunoglobulin G to induce acantholysis in the neonatal mouse model of pemphigus...
- Increased clearance explains lower plasma levels of tissue-type plasminogen activator by estradiol: evidence for potently enhanced mannose receptor expression in miceM Lansink
Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
Blood 94:1330-6. 1999....
- A murine model of myocardial microvascular thrombosisP D Christie
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Clin Invest 104:533-9. 1999..This study used mice with modifications of the thrombomodulin (TM) gene, the tissue-type plasminogen activator (tPA) gene, and the urokinase-type plasminogen activator (uPA) gene...
- Tissue plasminogen activator controls multiple forms of synaptic plasticity and memoryP Calabresi
Clinica Neurologica, Dip Neuroscienze, Universita di Tor Vergata, Via di Tor Vergata 135, Rome 00133, Italy
Eur J Neurosci 12:1002-12. 2000..These data indicate that t-PA plays a critical role in the formation of various forms of synaptic plasticity and memory...
- Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in miceT Kawasaki
Center for Molecular and Vascular Biology, University of Leuven, and Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
Blood 96:153-60. 2000..Hence, during acute thrombosis, fibrinolysis is efficiently prevented by plasma alpha(2)-AP, but also by vascular PAI-1, locally released into the circulation after endothelial injury...
- Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesisS Brodsky
Department of Medicine, State University of New York, Stony Brook, New York 11794 8152, USA
Am J Physiol Heart Circ Physiol 281:H1784-92. 2001..the necessary and sufficient components of the PA system [PAI-1, urokinase-type PA (uPA), or tissue-type PA (tPA), and plasminogen (Plg)] for angiogenesis, we examined angiogenic competence of vascular explant cultures obtained ..
- The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine releaseTaku Nagai
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
Proc Natl Acad Sci U S A 101:3650-5. 2004Tissue plasminogen activator (tPA) is a serine protease that catalyzes the conversion of plasminogen (plg) to plasmin, which in turn functions to degrade extracellular matrix proteins in the central nervous system...
- Plasminogen activator expression correlates with genetic differences in vascular remodelingVyacheslav A Korshunov
Center for Cardiovascular Research, Aab Institute of Biomedical Sciences and Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
J Vasc Res 41:481-90. 2004..In summary, flow-induced IMT of the carotid is genetically determined and correlates with t-PA and u-PA expression in 2 inbred mouse strains...
- The urokinase/urokinase receptor system mediates the IgG immune complex-induced inflammation in lungNelli Shushakova
Department of Nephrology, Medical School Hannover, Hannover, Germany
J Immunol 175:4060-8. 2005..The findings indicate an important link between the uPA/uPAR system and the two main components involved in the IC inflammation, namely, complement and FcgammaRs...
- The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammationAndrew D Cook
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, 3010, Victoria, Australia
Thromb Haemost 95:659-67. 2006..Peritoneal inflammation in t-PA-/- mice represents a useful model to study the progression of intra-abdominal adhesions during surgery and clinical peritonitis...
- Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activatorJianxue Li
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:7847-52. 2006..increase in mRNA expression and protein concentration in the nr cerebellum of tissue plasminogen activator (tPA), a gene closely linked to the mapped but as-yet-uncloned nr locus...
- PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPAHongtao Wang
Division of Gastroenterology and Nutrition, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
FEBS Lett 581:3098-104. 2007..This change correlated with increased tissue-type plasminogen activator (tPA) activity, and increased matrix metalloproteinase-9 (MMP-9), but not MMP-2 activity...
- The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brainChen Zhang
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Pathol 174:586-94. 2009..Tissue-type plasminogen activator (tPA) is a serine proteinase that is found in the intravascular space and the CNS...
- Local protease signaling contributes to neural tube closure in the mouse embryoEric Camerer
Cardiovasular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA
Dev Cell 18:25-38. 2010..Together, our results suggest a role for protease-activated receptor signaling in neural tube closure and identify a local protease network that may trigger Par2 signaling and monitor and regulate epithelial integrity in this context...
- Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA-/-) miceKonstantinos Pothakos
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11733, USA
Brain Res 1326:135-42. 2010Tissue Plasminogen Activator (tPA) is a serine protease expressed in different areas of the mammalian brain. It has been used clinically to dissolve clots and shown to have a role in neurodegeneration...
- Tissue plasminogen activator prevents white matter damage following strokeFernando Correa
Institut National de la Sante et de la Recherche Medicale INSERM, INSERM U919, Caen Cedex, F 14074 France
J Exp Med 208:1229-42. 2011Tissue plasminogen activator (tPA) is the only available treatment for acute stroke. In addition to its vascular fibrinolytic action, tPA exerts various effects within the brain, ranging from synaptic plasticity to control of cell fate...
- Involvement of tissue plasminogen activator "tPA" in ethanol-induced locomotor sensitization and conditioned-place preferenceAmine Bahi
Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
Behav Brain Res 226:250-8. 2012..In our previous studies we have shown that the serine protease tissue plasminogen activator (tPA) is involved in the rewarding properties of morphine and amphetamine...
- Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin systemNoreen Bukhari
Department of Pharmacological Sciences, Stony Brook University, New York, NY 11794 8651, USA
J Neurosci 31:14931-43. 2011..We report that the clearance of the core protein by the tissue plasminogen activator (tPA)/plasmin proteolytic system partially contributes to ChABC-promoted plasticity...
- Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforationsYue Shen
Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
PLoS ONE 7:e51303. 2012..to plasmin is performed by two plasminogen activators (PAs), urokinase-type PA (uPA) and tissue-type PA (tPA)...
- Tissue plasminogen activator arrests Alzheimer's disease pathogenesisShin Bi Oh
Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea
Neurobiol Aging 35:511-9. 2014..This study was aimed to determine whether endogenous tissue plasminogen activator (tPA) modulates the pathogenic process of AD...
- Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activatorEloïse Lemarchand
From the INSERM UMR S U919 serine proteases and pathophysiology of the neurovascular unit SP2U Université Caen Basse Normandie, GIP Cyceron, Caen, France E L, M G, S M D L, H V, Y R, A M, D V, C A, M R Service d Hématologie CHU Caen, France Y R and Délégation Recherche Clinique et Innovation DRCI, CHU de Caen, Caen, France M R
Stroke 46:1641-50. 2015Tissue-type plasminogen activator (tPA) is the only acute treatment for ischemic stroke. Unfortunately, the benefit of tPA-driven thrombolysis is not systematic, and understanding the reasons for this is mandatory...
- Hepatocyte growth factor acts as a mitogen and chemoattractant for postnatal subventricular zone-olfactory bulb neurogenesisTsu Wei Wang
Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
Mol Cell Neurosci 48:38-50. 2011..These results suggest that HGF influences multiple steps in postnatal forebrain neurogenesis. HGF is a mitogen for SVZ neural progenitors, and regulates their differentiation and olfactory bulb migration...
- Rapid physical mapping of cloned DNA on banded mouse chromosomes by fluorescence in situ hybridizationA L Boyle
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06510
Genomics 12:106-15. 1992..Clones hybridizing to each murine chromosome have been identified, thus providing a panel of marker probes to assist in chromosome identification...
- Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNAJ Huarte
Institute of Histology and Embryology, University of Geneva Medical School, Switzerland
Genes Dev 1:1201-11. 1987....
- Chromosomal assignment of three novel mouse genes expressed in testicular cellsL Lemaire
Institut fur Genetik, Heinrich Heine Universitat, Dusseldorf, Federal Republic of Germany
Genomics 21:409-14. 1994....
- Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesisT L Timme
Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030
Endocrinology 134:1039-45. 1994....
- Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathwaysY Y Huang
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, USA
Proc Natl Acad Sci U S A 93:8699-704. 1996..These results provide genetic evidence that t-PA is a downstream effector gene important for L-LTP and show that modest impairment of L-LTP in CA1 and CA3 does not result in hippocampus-dependent behavioral phenotypes...
- Expression of hepatocyte growth factor/scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory systemD P Thewke
Neuroscience Program and Department of Biochemistry Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 16:6933-44. 1996..system and compared with the expression of a known activator of HGF/SF, tissue-type plasminogen activator (tPA)...
- Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formationP Carmeliet
Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
Nat Genet 17:439-44. 1997....
- Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesisM Melnick
Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
Dev Dyn 211:11-25. 1998..plasminogen, plasminogen activators [urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA)], and Cdk4 in developing palates; 2) on embryonic day 14 (E14), which is a critical day for palatal growth, B10...
- Increased sensitivity to cocaine, and over-responding during cocaine self-administration in tPA knockout miceT L Ripley
Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Brain Res 826:117-27. 1999Tissue plasminogen activator, tPA, is induced in the brain by electrical activity leading to synaptic remodeling. It is also induced in the prefrontal cortex (PFC) by acute cocaine...
- Neuronal migration is retarded in mice lacking the tissue plasminogen activator geneN W Seeds
Department of Biochemistry, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 96:14118-23. 1999..In the developing cerebellum, granule neurons turn on the gene for tissue plasminogen activator (tPA) as they begin their migration into the cerebellar molecular layer...
- Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiationM Zhuo
Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 20:542-9. 2000..Both LRP and several of its ligands, including tissue plasminogen activator (tPA), apolipoprotein E/lipoproteins, alpha(2)-macroglobulin, and the beta-amyloid precursor protein, have been ..
- Urokinase mediates fibrinolysis in the pulmonary microvasculatureK Bdeir
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Blood 96:1820-6. 2000..In contrast, uPA(-/-) and tissue-type plasminogen activator tPA(-/-) mice, but not uPAR(-/-) mice, showed a marked impairment in pulmonary fibrinolysis throughout the experimental ..
- Evidence for impairment of behavioural inhibition in performance of operant tasks in tPA-/- miceT L Ripley
Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
Behav Brain Res 125:215-27. 2001We have previously shown that mice that lack the serine protease, tissue plasminogen activator (tPA), show over-responding on the active lever during time-out periods in an I.V. cocaine self-administration task...
- Permissive proteolytic activity for visual cortical plasticityNobuko Mataga
Laboratory for Neuronal Circuit Development, Institute of Physical and Chemical Research RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
Proc Natl Acad Sci U S A 99:7717-21. 2002The serine protease, tissue-type plasminogen activator (tPA) is a key regulator of extracellular proteolytic cascades...
- Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptorsRobert Pawlak
Laboratory of Neurobiology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:443-8. 2005..Here we show that tissue-plasminogen activator (tPA), a protease implicated in neuronal plasticity and seizures, is induced in the limbic system by chronic ethanol ..
- The role of tissue plasminogen activator in methamphetamine-related reward and sensitizationTaku Nagai
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
J Neurochem 92:660-7. 2005In the central nervous system, tissue plasminogen activator (tPA) plays a role in synaptic plasticity and remodeling...
- Phospholipase D1-promoted release of tissue plasminogen activator facilitates neurite outgrowthYan Zhang
Program in Molecular and Cellular Pharmacology, Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, New York 11794, USA
J Neurosci 25:1797-805. 2005..Seizure susceptibility is modulated by the enzyme tissue plasminogen activator (tPA), the normal physiological role of which includes promotion of synaptic reorganization in the mossy fiber pathway ..
- Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activatorAlexander de Giorgio-Miller
Department of Medicine, University College London, Rayne Institute, London, UK
Am J Pathol 167:721-32. 2005..Collagen accumulation was significantly increased in the presence of inhibitor and in tPA-deficient, but not uPA-deficient, fibroblasts compared with controls...
- Role of tissue-plasminogen activator (t-PA) in a mouse model of neonatal white matter lesions: interaction with plasmin inhibitors and anti-inflammatory drugsP Leroux
INSERM Avenir Dr V Laudenbach, Mécanismes et Traitement des Troubles du Développement Cérébral, School of Medicine and Pharmacy, Rouen University, 22 Boulevard Gambetta, 76183 Rouen, France
Neuroscience 146:670-8. 2007..Conversely, a t-PA-dependent inflammatory process occurred with high-dose ibotenic acid. Potential strategies for PVL in preterm neonates may include fibrinolytic monitoring for prevention and anti-inflammatory agents for treatment...
- c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cellsYongZhong Hou
Department of Physiology, Kinki University School of Medicine, Ohnohigashi 377 2, Osakasayama, Osaka 589 8511, Japan
Cardiovasc Res 75:186-94. 2007..The purpose of this study was to investigate whether c-Myc regulates expression of urokinase plasminogen activator (uPA) on hypoxia-induced vascular smooth muscle cells (VSMCs)...
- SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesisNesrine El-Bizri
Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
Development 135:2981-91. 2008..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
- Plasminogen activators are involved in the degradation of bone by osteoclastsVincent Everts
Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit, Research Institute MOVE, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Bone 43:915-20. 2008..Yet, several findings suggest that the two types of plasminogen activators (PA), the tissue- and urokinase-type PA (tPA and uPA, respectively) are also involved in this process...
- The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferiJoppe W R Hovius
Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
PLoS Pathog 5:e1000447. 2009..B. burgdorferi numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity) and PAI-1 (high fibrinolytic activity) knock-out mice compared to WT controls...
- Neuroserpin protects neurons from ischemia-induced plasmin-mediated cell death independently of tissue-type plasminogen activator inhibitionJialing Wu
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael St, Suite 505J, Atlanta, GA 30322, USA
Am J Pathol 177:2576-84. 2010The serine proteinase tissue-type plasminogen activator (tPA) and the serine proteinase inhibitor neuroserpin are both expressed in areas of the brain with the highest vulnerability to hypoxia/ischemia...
- A synthetic peptide derived from staphylokinase enhances plasminogen activation by tissue-type plasminogen activatorK Okada
Department of Physiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan
J Thromb Haemost 9:997-1006. 2011..A synthetic nonadecapeptide (SP; GPYLMVNVTGVDGKGNELL) previously enhanced the activation of plasminogen by the SAK/plasmin complex...
- The Mechanism of IVIG Action in PemphigusZhi Liu; Fiscal Year: 2006..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..