Tor1aip2

Summary

Gene Symbol: Tor1aip2
Description: torsin A interacting protein 2
Alias: 1110020D10Rik, 15kDa, A130072J07, AA103493, AW060462, AW610675, C77739, Ifrg15, Lull1, torsin-1A-interacting protein 2, interferon alpha responsive protein, 15 kDa interferon-responsive protein, interferon alpha responsive gene, 15 kDa, interferon alpha responsive protein (15 kDa), lumenal domain like LAP1
Species: mouse
Products:     Tor1aip2

Top Publications

  1. Goodchild R, Dauer W. The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein. J Cell Biol. 2005;168:855-62 pubmed
    ..Furthermore, we identify a novel transmembrane protein, lumenal domain like LAP1 (LULL1), which also appears to interact with torsinA. Interestingly, LULL1 resides in the main ER...
  2. Goodchild R, Kim C, Dauer W. Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Neuron. 2005;48:923-32 pubmed
    ..These observations demonstrate that neurons have a unique requirement for nuclear envelope localized torsinA function and suggest that loss of this activity is a key molecular event in the pathogenesis of DYT1 dystonia...
  3. Akhter M, Kobayashi I, Kiyoshima T, Nagata K, Wada H, Ookuma Y, et al. In situ expression of 15 kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar. J Mol Histol. 2010;41:185-91 pubmed publisher
    ..0 to make a profile of the regulator genes for odontogenesis. Fifteen kDa interferon alpha responsive gene (Ifrg15) is one of several highly-expressed genes in the E12.0 mandible...
  4. Wu F, Ding B, Qi B, Shang M, Yang X, Liu Y, et al. Sequence analysis, expression patterns and transcriptional regulation of mouse Ifrg15 during preimplantation embryonic development. Gene. 2012;507:119-24 pubmed publisher
    b>Ifrg15 is a newly identified interferon alpha responsive gene and is implicated in a wide variety of physiological roles in mammals...
  5. Goodchild R, Buchwalter A, Naismith T, Holbrook K, Billion K, Dauer W, et al. Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum. J Cell Sci. 2015;128:2854-65 pubmed publisher
    ..The ER system contains two transmembrane proteins, LAP1 and LULL1 (also known as TOR1AIP1 and TOR1AIP2, respectively), that reversibly co-assemble with and activate torsinA...
  6. Yang Y, Wang J, Zhao C, Chen X, Chen L, Zhang J, et al. The interferon α-responsive gene, Ifrg15, plays vital roles during mouse early embryonic development. Cell Mol Life Sci. 2016;73:2969-84 pubmed publisher
    The interferon alpha-responsive gene (Ifrg15) mRNA is highly expressed in various stages during preimplantation mammalian embryo development. Unfortunately, few studies have investigated the effect of Ifrg15 in this process...
  7. Kim C, Perez A, Perkins G, Ellisman M, Dauer W. A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc Natl Acad Sci U S A. 2010;107:9861-6 pubmed publisher