Genomes and Genes
Gene Symbol: Tomm20
Description: translocase of outer mitochondrial membrane 20
Alias: 1810060K07Rik, BB284719, Gm19268, MAS20, MOM19, TOM20, mKIAA0016, mitochondrial import receptor subunit TOM20 homolog, mitochondrial 20 kDa outer membrane protein, outer mitochondrial membrane receptor Tom20, translocase of outer mitochondrial membrane 20 homolog
- Ott M, Norberg E, Walter K, Schreiner P, Kemper C, Rapaport D, et al. The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release. J Biol Chem. 2007;282:27633-9 pubmed..Here, we show that the protein translocase of the outer mitochondrial membrane is required for Bax insertion and cytochrome c release. ..
- Hikosaka K, Ikutani M, Shito M, Kazuma K, Gulshan M, Nagai Y, et al. Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes. J Biol Chem. 2014;289:14796-811 pubmed publisher..Our findings indicate the critical roles of Nmnat3 in maintenance of the NAD pool in mature erythrocytes and the physiological impacts at its absence in mice. ..
- Valentijn A, Metcalfe A, Kott J, Streuli C, Gilmore A. Spatial and temporal changes in Bax subcellular localization during anoikis. J Cell Biol. 2003;162:599-612 pubmed..Our data suggest that Bax regulation occurs at several levels, with formation of clusters a late event, and with critical changes determining cell fate occurring earlier. ..
- Kang B, Xia F, Pop R, Dohi T, Socolovsky M, Altieri D. Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. J Biol Chem. 2011;286:16758-67 pubmed publisher..shRNA knockdown of the mitochondrial import receptor Tom20 abolished mitochondrial import of survivin and sensitized tumor cells to apoptosis, whereas silencing of Tom70 had ..
- Zhu Y, Swanson B, Wang M, Hildeman D, Schaefer B, Liu X, et al. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A. 2004;101:7681-6 pubmed..Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 family members on mitochondria rather than by sequestration to the microtubules. ..
- Gomez Velazquez M, Badia Careaga C, Lechuga Vieco A, Nieto Arellano R, Tena J, Rollán I, et al. CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart. PLoS Genet. 2017;13:e1006985 pubmed publisher..Thus, CTCF mediates local regulatory interactions to coordinate transcriptional programs controlling transitions in morphology and function during heart development. ..
- Khacho M, Clark A, Svoboda D, Maclaurin J, Lagace D, Park D, et al. Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis. Hum Mol Genet. 2017;26:3327-3341 pubmed publisher..These data demonstrate that mitochondrial dysfunction, as observed in genetic mitochondrial and neurodegenerative diseases, underlies the decline of brain function and cognition due to impaired stem cell maintenance and neurogenesis. ..
- Kumar N, Srivillibhuthur M, Joshi S, Walton K, Zhou A, Faller W, et al. A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016;143:3711-3722 pubmed..Our study highlights the still unappreciated role of metabolic regulation during organogenesis, and suggests that it might contribute to neonatal gastrointestinal disorders. ..
- Doucet Beaupré H, Gilbert C, Profes M, Chabrat A, Pacelli C, Giguère N, et al. Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. Proc Natl Acad Sci U S A. 2016;113:E4387-96 pubmed publisher..These results reveal the key role of these transcription factors beyond the early developmental stages and provide mechanistic links between mitochondrial dysfunctions, ?-synuclein aggregation, and the survival of dopaminergic neurons. ..
- Chaffee B, Shang F, Chang M, Clement T, Eddy E, Wagner B, et al. Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly. Development. 2014;141:3388-98 pubmed publisher..These observations suggest that CDK1-dependent phosphorylations required for the initiation of nuclear membrane disassembly during mitosis are adapted for removal of nuclei during fiber cell differentiation. ..
- Korrodi Gregório L, Vieira S, Esteves S, Silva J, Freitas M, Brauns A, et al. TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. Biol Open. 2013;2:453-65 pubmed publisher..In essence TCTEX1D4/PPP1C complex appears to be involved in microtubule dynamics, sperm motility, acrosome reaction and in the regulation of the blood-testis barrier. ..
- Morishita H, Eguchi S, Kimura H, Sasaki J, Sakamaki Y, Robinson M, et al. Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem. 2013;288:11436-47 pubmed publisher..Taken together, these results suggest that clearance of lens organelles is independent of macroautophagy. These findings also clarify the physiological role of Atg5 and Pik3c3 in quality control and development of the lens, respectively...