Genomes and Genes
Gene Symbol: Tnnc1
Description: troponin C, cardiac/slow skeletal
Alias: AI874626, TnC, cTnC, cTnI, tncc, troponin C, slow skeletal and cardiac muscles
- Tsika R, Schramm C, Simmer G, Fitzsimons D, Moss R, Ji J. Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype. J Biol Chem. 2008;283:36154-67 pubmed publisher..These novel in vivo data support a role for TEAD-1 in modulating slow muscle gene expression. ..
- MacGowan G, Evans C, Hu T, Debrah D, Mullet S, Chen H, et al. Troponin I protein kinase C phosphorylation sites and ventricular function. Cardiovasc Res. 2004;63:245-55 pubmedCardiac Troponin I (cTnI) phosphorylation by protein kinase C (PKC) results in a reduction of maximal actomyosin ATPase activity, an effect that is more marked at higher levels of calcium (Ca2+) and is likely to reduce active force ..
- Villani R, Hodgson S, Legrand J, Greaney J, Wong H, Pichol Thievend C, et al. Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development. 2017;144:1887-1895 pubmed publisher..Microarray expression studies identified WNT5A and TNC as potential downstream effectors of SOX18 that are important for epidermal WNT signalling...
- Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, Schwartz R, et al. A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature. 2009;460:287-91 pubmed publisher..We propose that WHSC1 functions together with developmental transcription factors to prevent the inappropriate transcription that can lead to various pathophysiologies. ..
- Misra C, Sachan N, McNally C, Koenig S, Nichols H, Guggilam A, et al. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012;8:e1002690 pubmed publisher..In summary, the Gata4 G295S mutation functions as a hypomorph in vivo and leads to defects in cardiomyocyte proliferation during embryogenesis, which may contribute to the development of congenital heart defects in humans. ..
- Scruggs S, Walker L, Lyu T, Geenen D, Solaro R, Buttrick P, et al. Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol. 2006;40:465-73 pubmed..with the decline in function was an increased phosphorylation of sarcomeric proteins including cardiac troponin I (cTnI)...
- Danalache B, Gutkowska J, Slusarz M, Berezowska I, Jankowski M. Oxytocin-Gly-Lys-Arg: a novel cardiomyogenic peptide. PLoS ONE. 2010;5:e13643 pubmed publisher..These results raise the possibility that C-terminally extended OT molecules stimulate CM differentiation and contribute to heart growth during fetal life. ..
- Mommersteeg M, Brown N, Prall O, de Gier de Vries C, Harvey R, Moorman A, et al. Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ Res. 2007;101:902-9 pubmed..In conclusion, our data suggest a cellular mechanism for pulmonary myocardium formation and highlight the key roles played by Pitx2c and Nkx2-5 in its formation and identity. ..
- Yamane A, Ohnuki Y, Saeki Y. Delayed embryonic development of mouse masseter muscle correlates with delayed MyoD family expression. J Dent Res. 2000;79:1933-6 pubmed..These results suggest that the delayed expression of the myoD family genes in the masseter correlates with delayed differentiation and maturation, probably due to the later functional requirements of the masseter than of the tongue. ..
- Kreutziger K, Piroddi N, McMichael J, Tesi C, Poggesi C, Regnier M. Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle. J Mol Cell Cardiol. 2011;50:165-74 pubmed publisher..and relaxation in cardiac muscle are regulated at the thin filament via Ca(2+) binding to cardiac troponin C (cTnC) and strong cross-bridge binding...
- Chen Z, Friedrich G, Soriano P. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 1994;8:2293-301 pubmed..Although transcription of a number of muscle-specific genes believed to be TEF-1 targets appears normal, the defect in cardiogenesis is likely attributable to diminished transcription of one or several cardiac-specific genes. ..
- Tachampa K, Kobayashi T, Wang H, Martin A, Biesiadecki B, Solaro R, et al. Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle. J Biol Chem. 2008;283:15114-21 pubmed publisherThe precise mechanism of cardiac troponin I (cTnI) proteolysis in myocardial stunning is not fully understood...
- Tasheva E, Ke A, Deng Y, Jun C, Takemoto L, Koester A, et al. Differentially expressed genes in the lens of mimecan-null mice. Mol Vis. 2004;10:403-16 pubmed..Our results provide insight into the function of mimecan in the lens and enable further characterization of molecular mechanisms by which this protein exerts its biological roles. ..
- Farah C, Reinach F. The troponin complex and regulation of muscle contraction. FASEB J. 1995;9:755-67 pubmed..In vertebrate skeletal and cardiac muscle the Ca(2+)-binding protein troponin C (TnC) is one subunit of the ternary troponin complex which, through its association with actin and tropomyosin on the ..
- Liang B, Chung F, Qu Y, Pavlov D, Gillis T, Tikunova S, et al. Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility. Physiol Genomics. 2008;33:257-66 pubmed publisherThe cardiac troponin C (cTnC) mutation, L29Q, has been found in a patient with familial hypertrophic cardiomyopathy...
- Sakakibara I, Santolini M, Ferry A, Hakim V, Maire P. Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype. PLoS Genet. 2014;10:e1004386 pubmed publisher..Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer. ..
- Sadayappan S, Finley N, Howarth J, Osinska H, Klevitsky R, Lorenz J, et al. Role of the acidic N' region of cardiac troponin I in regulating myocardial function. FASEB J. 2008;22:1246-57 pubmedCardiac troponin I (cTnI) phosphorylation modulates myocardial contractility and relaxation during beta-adrenergic stimulation...
- Ding J, Xu X, Yang D, Chu P, Dalton N, Ye Z, et al. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J. 2004;23:885-96 pubmed..These studies raise a new paradigm for the etiology of certain human heart diseases of genetic or environmental origin that may be triggered by dysfunction in RNA processing. ..
- Parmacek M, Leiden J. Structure and expression of the murine slow/cardiac troponin C gene. J Biol Chem. 1989;264:13217-25 pubmedCardiac troponin C (cTnC) is the calcium-binding subunit of the myofibrillar thin filament that regulates excitation-contraction coupling in cardiac muscle...
- Vikstrom K, Leinwand L. Contractile protein mutations and heart disease. Curr Opin Cell Biol. 1996;8:97-105 pubmed..Biochemical data from studies of mutant myosin suggest a dominant-negative mechanism for inheritance of this disease. The most likely primary defect is sarcomere dysfunction, which is followed by the major clinical symptoms. ..
- Hagiwara N, Ma B, Ly A. Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev Dyn. 2005;234:301-11 pubmed..Together with our earlier report, demonstrating early postnatal muscle defects in the Sox6 null-p100H mutant, the present results suggest that Sox6 likely plays an important role in muscle development...
- Parvatiyar M, Pinto J, Liang J, Potter J. Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C. J Biol Chem. 2010;285:27785-97 pubmed publisher..The main findings from this study were as follows: 1) cTnC mutants demonstrated distinct functional phenotypes reminiscent of bona fide HCM, RCM, and DCM mutations; 2) a ..
- Parmacek M, Bengur A, Vora A, Leiden J. The structure and regulation of expression of the murine fast skeletal troponin C gene. Identification of a developmentally regulated, muscle-specific transcriptional enhancer. J Biol Chem. 1990;265:15970-6 pubmed..160-amino acid sTnC protein shares 70% amino acid sequence identity with the slow/cardiac isoform of troponin C (cTnC). However, three areas of significant sequence divergence were identified...
- Jin J, Wang J, Zhang J. Expression of cDNAs encoding mouse cardiac troponin T isoforms: characterization of a large sample of independent clones. Gene. 1996;168:217-21 pubmed..Three novel alternative splicing acceptor sites in the 5'-untranslated portion of exon 2 have been identified with different frequencies. ..
- Du J, Liu J, Feng H, Hossain M, Gobara N, Zhang C, et al. Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI. Am J Physiol Heart Circ Physiol. 2008;294:H2604-13 pubmed publisherTransgenic mice were generated to express a restrictive cardiomyopathy (RCM) human cardiac troponin I (cTnI) R192H mutation in the heart (cTnI(193His) mice)...
- Yin X, Choudhury M, Bag J. Overexpression of sTnC polypeptide in muscle cells is controlled by its rapid degradation. FEBS Lett. 2002;517:45-9 pubmed..Analyses of the mRNA and polypeptide levels of several thin filament complements showed no effect of overexpression of the sTnC mRNA. ..
- Sumandea M, Vahebi S, SUMANDEA C, Garcia Cazarin M, Staidle J, Homsher E. Impact of cardiac troponin T N-terminal deletion and phosphorylation on myofilament function. Biochemistry. 2009;48:7722-31 pubmed publisher..with recombinant cTn engineered to contain modified cTnT (truncated, phosphorylated) in the presence of wild-type cTnI and cTnC...
- Heikinheimo M, Scandrett J, Wilson D. Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev Biol. 1994;164:361-73 pubmed..The temporal and spacial patterns of GATA-4 expression support a role for this factor in the regulation of cardiac differentiation, analogous to the established role of transcription factor GATA-1 in the regulation of hematopoiesis. ..
- Yamane A, Mayo M, Shuler C, Crowe D, Ohnuki Y, Dalrymple K, et al. Expression of myogenic regulatory factors during the development of mouse tongue striated muscle. Arch Oral Biol. 2000;45:71-8 pubmed
- Homsher E, Lee D, Morris C, Pavlov D, Tobacman L. Regulation of force and unloaded sliding speed in single thin filaments: effects of regulatory proteins and calcium. J Physiol. 2000;524 Pt 1:233-43 pubmed..native bovine cardiac tropomyosin (nTm), and either native bovine cardiac troponin (nTn), troponin containing a TnC mutant, CBMII, in which the sole regulatory site in cardiac TnC (site II) is inactivated (CBMII-Tn), or troponin ..