Gene Symbol: Tnfsf14
Description: tumor necrosis factor (ligand) superfamily, member 14
Alias: HVEM-L, HVEML, LIGHT, LTg, Ly113, Tnlg1d, tumor necrosis factor ligand superfamily member 14, tumor necrosis factor ligand 1d
Species: mouse
Products:     Tnfsf14

Top Publications

  1. Summers DeLuca L, McCarthy D, Cosovic B, Ward L, Lo C, Scheu S, et al. Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. J Exp Med. 2007;204:1071-81 pubmed
    ..In the absence of LTalphabeta or CD40L on Ag-specific T cells, DC dysfunction could be rescued in vivo via CD40 or LTbetaR stimulation, respectively, suggesting that these two pathways cooperate for optimal DC conditioning. ..
  2. Soroosh P, Doherty T, So T, Mehta A, Khorram N, Norris P, et al. Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations. J Exp Med. 2011;208:797-809 pubmed publisher
    ..decoy lymphotoxin ? receptor (LT-?R)-Fc, which can block tumor necrosis factor (TNF)-related ligands LIGHT (TNFSF14) and LT-?? binding to the herpesvirus entry mediator (HVEM) and the LT-?R, inhibited the accumulation of memory ..
  3. Wang J, Lo J, Foster A, Yu P, Chen H, Wang Y, et al. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest. 2001;108:1771-80 pubmed
    ..LIGHT, a newly discovered TNF superfamily member (TNFSF14), is expressed on activated T cells and immature dendritic cells...
  4. Shi G, Luo H, Wan X, Salcedo T, Zhang J, Wu J. Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood. 2002;100:3279-86 pubmed
    b>LIGHT is a tumor necrosis factor (TNF) family member and is expressed on activated T cells. Its known receptors are TR2 and LTbetaR on the cell surface, and TR6/DcR3 in solution...
  5. Ehlers S, Holscher C, Scheu S, Tertilt C, Hehlgans T, Suwinski J, et al. The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes. J Immunol. 2003;170:5210-8 pubmed
    ..Since LIGHT-KO mice proved to be equally resistant to M...
  6. Lo J, Wang Y, Tumanov A, Bamji M, Yao Z, Reardon C, et al. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science. 2007;316:285-8 pubmed
    ..We identified lymphotoxin (LT) and LIGHT, tumor necrosis factor cytokine family members that are primarily expressed on lymphocytes, as critical regulators ..
  7. Randall L, Amante F, Zhou Y, Stanley A, Haque A, Rivera F, et al. Cutting edge: selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA. J Immunol. 2008;181:7458-62 pubmed
    ..In this study we report a role for LIGHT-lymphotoxin beta Receptor (LTbetaR) signaling in the development of ECM and control of parasite growth...
  8. Misawa K, Nosaka T, Kojima T, Hirai M, Kitamura T. Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily. Cytogenet Cell Genet. 2000;89:89-91 pubmed
    A member of the tumor necrosis factor (TNF) superfamily, human TNFSF14 (hTNFSF14)/HVEM-L (herpes virus entry mediator ligand) was isolated as a cellular ligand for HVEM/TR2 and human lymphotoxin beta receptor (LTbetaR)...
  9. Sedy J, Gavrieli M, Potter K, Hurchla M, Lindsley R, Hildner K, et al. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol. 2005;6:90-8 pubmed
    ..BTLA bound the most membrane-distal cysteine-rich domain of HVEM, distinct from regions where the ligands LIGHT and lymphotoxin-alpha bound HVEM...

More Information


  1. Shaikh R, Santee S, Granger S, Butrovich K, Cheung T, Kronenberg M, et al. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. J Immunol. 2001;167:6330-7 pubmed
    b>LIGHT, a member of the TNF family of cytokines (homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for herpesvirus entry mediator, a receptor expressed on T cells), is induced on activated T ..
  2. Steinberg M, Turovskaya O, Shaikh R, Kim G, McCole D, Pfeffer K, et al. A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 2008;205:1463-76 pubmed publisher
    The interaction between the tumor necrosis factor (TNF) family member LIGHT and the TNF family receptor herpes virus entry mediator (HVEM) co-stimulates T cells and promotes inflammation...
  3. McCarthy D, Chiu S, Gao Y, Summers DeLuca L, Gommerman J. BAFF induces a hyper-IgA syndrome in the intestinal lamina propria concomitant with IgA deposition in the kidney independent of LIGHT. Cell Immunol. 2006;241:85-94 pubmed
    ..b>LIGHT has been previously shown to mediate a similar phenotype via signaling through the lymphotoxin-beta receptor (..
  4. Wimmer N, Huber B, Barabas N, Röhrl J, Pfeffer K, Hehlgans T. Lymphotoxin ? receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands. J Immunol. 2012;188:3426-33 pubmed publisher
  5. Anders R, Subudhi S, Wang J, Pfeffer K, Fu Y. Contribution of the lymphotoxin beta receptor to liver regeneration. J Immunol. 2005;175:1295-300 pubmed
    ..exhibits inducible expression, competes with herpesvirus glycoprotein D for herpesvirus entry mediator on T cells (LIGHT), signaling through the lymphotoxin receptor (LTbetaR) expressed on mature hepatocytes induces massive ..
  6. De Trez C, Schneider K, Potter K, Droin N, Fulton J, Norris P, et al. The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells. J Immunol. 2008;180:238-48 pubmed
    ..These results indicate the HVEM-BTLA pathway provides an inhibitory checkpoint for DC homeostasis in lymphoid tissue. Together, the LTbetaR and HVEM-BTLA pathways form an integrated signaling network regulating DC homeostasis. ..
  7. Wang Y, Koroleva E, Kruglov A, Kuprash D, Nedospasov S, Fu Y, et al. Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection. Immunity. 2010;32:403-13 pubmed publisher
    ..These results support a model wherein LT from RORgammat(+) cells orchestrates the innate immune response against mucosal microbial infection. ..
  8. Tamada K, Shimozaki K, Chapoval A, Zhu G, Sica G, Flies D, et al. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med. 2000;6:283-9 pubmed
    b>LIGHT was recently described as a member of the tumor necrosis factor (TNF) 'superfamily'. We have isolated a mouse homolog of human LIGHT and investigated its immunoregulatory functions in vitro and in vivo...
  9. Scheu S, Alferink J, Pötzel T, Barchet W, Kalinke U, Pfeffer K. Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis. J Exp Med. 2002;195:1613-24 pubmed
    The recently described tumor necrosis factor (TNF) family member LIGHT (herpes virus entry mediator [HVEM]-L/TNFSF14), a ligand for the lymphotoxin (LT)beta receptor, HVEM, and DcR3, was inactivated in the mouse...
  10. Petreaca M, Do D, Dhall S, McLelland D, Serafino A, Lyubovitsky J, et al. Deletion of a tumor necrosis superfamily gene in mice leads to impaired healing that mimics chronic wounds in humans. Wound Repair Regen. 2012;20:353-66 pubmed publisher
    ..Here we show that deletion of tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT) leads to impaired wounds in mice that have the characteristics of nonchronic and chronic ulcers...
  11. Xu G, Liu D, Okwor I, Wang Y, Korner H, Kung S, et al. LIGHT Is critical for IL-12 production by dendritic cells, optimal CD4+ Th1 cell response, and resistance to Leishmania major. J Immunol. 2007;179:6901-9 pubmed
    Although studies indicate LIGHT (lymphotoxin (LT)-like, exhibits inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) enhances inflammation and T cell-..
  12. Anand S, Wang P, Yoshimura K, Choi I, Hilliard A, Chen Y, et al. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. J Clin Invest. 2006;116:1045-51 pubmed
    b>LIGHT is an important costimulatory molecule for T cell immunity. Recent studies have further implicated its role in innate immunity and inflammatory diseases, but its cellular and molecular mechanisms remain elusive...
  13. Yu P, Lee Y, Liu W, Chin R, Wang J, Wang Y, et al. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol. 2004;5:141-9 pubmed
    ..The tumor-necrosis factor superfamily member LIGHT (also known as TNFSF-14) is a ligand of stromal cell-expressed lymphotoxin-beta receptor and T cell-expressed ..
  14. Fan Z, Yu P, Wang Y, Wang Y, Fu M, Liu W, et al. NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. Blood. 2006;107:1342-51 pubmed
    ..We now demonstrate that the TNF superfamily member, LIGHT, known as TNFSF14 and a T-cell costimulatory molecule, is a critical ligand for the activation of NK cells...
  15. Wang Y, Subudhi S, Anders R, Lo J, Sun Y, Blink S, et al. The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest. 2005;115:711-7 pubmed
    ..Taken together, our data revealed an unexpected regulatory role of HVEM in T cell-mediated immune responses and autoimmune diseases. ..
  16. Sedgmen B, Dawicki W, Gommerman J, Pfeffer K, Watts T. LIGHT is dispensable for CD4+ and CD8+ T cell and antibody responses to influenza A virus in mice. Int Immunol. 2006;18:797-806 pubmed
    The tumor necrosis factor family ligands, LIGHT (lymphotoxin like, exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), 4-1BBL and CD70, are found in the same gene cluster ..
  17. Lin P, Zhang J, Wang Q, Lu Y, Wang X, Xiong Z, et al. [Interaction between member LIGHT of TNF superfamily and SOCS3, which respond to induce the differentiation and maturation of dendritic cell]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007;38:644-8 pubmed
    To detect the relation between the member LIGHT of TNF superfamily and the suppressor of cytokine signaling 3 (SOCS3), and to investigate the effect of SOCS3 on dendritic cell (DC) maturation induced by LIGHT...
  18. Herro R, da Silva Antunes R, Aguilera A, Tamada K, Croft M. Tumor necrosis factor superfamily 14 (LIGHT) controls thymic stromal lymphopoietin to drive pulmonary fibrosis. J Allergy Clin Immunol. 2015;136:757-68 pubmed publisher
    ..We asked whether tumor necrosis factor superfamily protein 14 (TNFSF14) (aka LIGHT) controls TSLP production to initiate fibrosis...
  19. Van Praet J, Donovan E, Vanassche I, Drennan M, Windels F, Dendooven A, et al. Commensal microbiota influence systemic autoimmune responses. EMBO J. 2015;34:466-74 pubmed publisher
    ..Together, these data indicate that neonatal colonization of gut microbiota influences generalized autoimmunity in adult life. ..
  20. Maña P, Linares D, Silva D, Fordham S, Scheu S, Pfeffer K, et al. LIGHT (TNFSF14/CD258) is a decisive factor for recovery from experimental autoimmune encephalomyelitis. J Immunol. 2013;191:154-63 pubmed publisher
    The TNF superfamily ligand LIGHT (lymphotoxin-like, exhibits inducible expression and competes with HSV glycoprotein D for herpesvirus entry mediator [HVEM], a receptor expressed by T lymphocytes) has been shown to play a role in T cell ..
  21. Matsumoto M. Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J Med Invest. 1999;46:141-50 pubmed
  22. Zou G, Hu W, Wu W. TNF family molecule LIGHT regulates chemokine CCL27 expression on mouse embryonic stem cell-derived dendritic cells through NF-kappaB activation. Cell Signal. 2007;19:87-92 pubmed
    Cytokine LIGHT is a type II transmembrane protein belonging to the TNF family that was originally identified as a weak inducer of apoptosis...
  23. del Rio M, Fernández Renedo C, Scheu S, Pfeffer K, Shintani Y, Kronenberg M, et al. Therapeutic blockade of LIGHT interaction with herpesvirus entry mediator and lymphotoxin β receptor attenuates in vivo cytotoxic allogeneic responses. Transplantation. 2014;98:1165-74 pubmed publisher
    ..We postulated that antagonizing the interaction of LIGHT expression on activated T cells with its receptors, herpesvirus entry mediator and lymphotoxin β receptor, may ..
  24. Jia L, Zhang W, Zhang H, Li T, Wang Y, Qin Y, et al. Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. J Pathol. 2015;236:373-83 pubmed publisher
    ..Taken together, our results demonstrated that mechanical stress-induced ER stress promotes SMCs apoptosis, inflammation and degeneration, providing insight into TAAD formation and progression. ..
  25. Sandberg W, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad F, et al. Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis. Circ Res. 2009;104:60-8 pubmed publisher
    ..We have previously reported that the tumor necrosis factor superfamily member LIGHT could be involved in atherogenesis through its ability to promote vascular inflammation...
  26. Sun Y, Brown N, Ruddy M, Miller M, Lee Y, Wang Y, et al. B and T lymphocyte attenuator tempers early infection immunity. J Immunol. 2009;183:1946-51 pubmed publisher
    ..Both HVEM(-/-) and BTLA(-/-), but not LIGHT(-/-), mice are more resistant to listeriosis compared with wild-type mice, and blockade of the BTLA pathway ..
  27. Liu J, Schmidt C, Zhao F, Okragly A, Glasebrook A, Fox N, et al. LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function. Int Immunol. 2003;15:861-70 pubmed
    b>LIGHT, a newly identified member of the tumor necrosis factor (TNF) family, is expressed on activated T lymphocytes...
  28. Shi Y, Wu W, Chai Q, Li Q, Hou Y, Xia H, et al. LT?R controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat Commun. 2016;7:12369 pubmed publisher
    ..Finally, we show that LT?R is required for T-cell regeneration on irradiation-induced thymic injury. Together, these results uncover a cellular and molecular pathway that governs thymic EC differentiation for HPC homing. ..
  29. Brown G, Lee E, El Hayek J, Kintner K, Luck C. IL-12-independent LIGHT signaling enhances MHC class II disparate CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease. J Immunol. 2005;174:4688-95 pubmed
    Inhibition of LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)/herpes simplex virus entry mediator (HVEM) and LIGHT/lymphotoxin beta receptor (LT beta R) interactions decreases mortality in MHC class I ..
  30. Andrés Blasco I, Vinue A, Herrero Cervera A, Martinez Hervas S, Núñez L, Piqueras L, et al. Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin ?-Receptor pathway. Thromb Haemost. 2016;116:379-93 pubmed publisher
    ..The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin ?-Receptor(LT?-R) pathway, which is involved in T-cell and macrophage activation, was diminished in ..
  31. Kim H, Jeong C, Choi H, Kawada T, Yu R. LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM. FEBS Lett. 2011;585:579-84 pubmed publisher
    ..LIGHT/TNFSF14, a member of the TNF superfamily, plays a role in the development of various inflammatory diseases...
  32. Bhattacharyya S, Deb J, Patra A, Thuy Pham D, Chen W, Vaeth M, et al. NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med. 2011;208:823-39 pubmed publisher
    ..By affecting CD22, Rcan1, CnA, and NFATc1/?A expression, NFATc1 controls the Ca(2+)-dependent Cn-NFAT signaling network and, thereby, the fate of splenic B cells upon BCR stimulation. ..
  33. Chen W, Lv X, Liu C, Chen R, Liu J, Dai H, et al. Hematopoietic stem/progenitor cell differentiation towards myeloid lineage is modulated by LIGHT/LIGHT receptor signaling. J Cell Physiol. 2018;233:1095-1103 pubmed publisher
    ..LT-related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells (LIGHT) is a member of the tumor necrosis factor (TNF) superfamily...
  34. Aebischer J, Cassina P, Otsmane B, Moumen A, Seilhean D, Meininger V, et al. IFN? triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1. Cell Death Differ. 2011;18:754-68 pubmed publisher
    ..we describe a motoneuron-selective death pathway triggered by activation of lymphotoxin-? receptor (LT-?R) by LIGHT, and operating by a novel signaling scheme...
  35. Okwor I, Xu G, Tang H, Liang Y, Fu Y, Uzonna J. Deficiency of CD40 Reveals an Important Role for LIGHT in Anti-Leishmania Immunity. J Immunol. 2015;195:194-202 pubmed publisher
    We previously showed that LIGHT and its receptor herpes virus entry mediator (HVEM) are important for development of optimal CD4(+) Th1 cell immunity and resistance to primary Leishmania major infection in mice...
  36. Ge Y, Waldemer R, Nalluri R, Nuzzi P, Chen J. RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation. PLoS ONE. 2013;8:e68068 pubmed publisher
  37. Powolny Budnicka I, Riemann M, Tänzer S, Schmid R, Hehlgans T, Weih F. RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in ?? T cells. Immunity. 2011;34:364-74 pubmed publisher
    ..Thus, RelA and RelB within different thymocyte subpopulations cooperate in the regulation of IL-17 production by ?? T cells and contribute to the host's ability to fight bacterial infections. ..
  38. Krause P, Zahner S, Kim G, Shaikh R, Steinberg M, Kronenberg M. The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice. Gastroenterology. 2014;146:1752-62.e4 pubmed publisher
    ..Expression of the tumor necrosis factor (TNF) superfamily member 14 (TNFSF14, also known as LIGHT [homologous to lymphotoxins, exhibits inducible expression, and competes with HSV ..
  39. Banks T, Rickert S, Benedict C, Ma L, Ko M, Meier J, et al. A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. J Immunol. 2005;174:7217-25 pubmed
  40. Pouyanfard S, Bamdad T, Parsania M, Hashemi H, Mohammadi M. Impact of timing strategy of LIGHT, a new TNF superfamily on immune platform induced by HSV-1 gB DNA vaccine. Cytokine. 2010;50:99-103 pubmed publisher
    Although the role of various cytokines on stimulating the immune responses is characterized well, the importance of LIGHT, a member of TNF superfamily, is less clear...
  41. Ye Q, Fraser C, Gao W, Wang L, Busfield S, Wang C, et al. Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J Exp Med. 2002;195:795-800 pubmed
    LIGHT (TNFSF14), a tumor necrosis factor superfamily member expressed by activated T cells, binds to herpes virus entry mediator (HVEM) which is constitutively expressed by T cells and costimulates T cell activation in a CD28-independent ..
  42. del Rio M, Fernández Renedo C, Chaloin O, Scheu S, Pfeffer K, Shintani Y, et al. Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells. MAbs. 2016;8:478-90 pubmed publisher
    ..Mouse LIGHT (TNFSF14) is a type II transmembrane protein with a C-terminus extracellular TNF homology domain (THD) that assembles in ..
  43. Johansson Percival A, Li Z, Lakhiani D, He B, Wang X, Hamzah J, et al. Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity. Cell Rep. 2015;13:2687-98 pubmed publisher
    ..Here, we have developed a strategy for normalization by specific intratumoral delivery of LIGHT/TNFSF14. Importantly, normalization occurs by induced expression of contractile markers in intratumoral pericytes, which ..
  44. Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, et al. Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J Immunol. 2011;186:5047-57 pubmed publisher
    ..Thus, the LT?R signal exhibits a novel and unique function in promoting RANK activity for mTEC organization, indicating a link between thymic organogenesis mediated by multiple cytokine signals and the control of autoimmunity. ..
  45. Washburn M, Kovalev G, Koroleva E, Fu Y, Su L. LIGHT induces distinct signals to clear an AAV-expressed persistent antigen in the mouse liver and to induce liver inflammation. PLoS ONE. 2010;5:e10585 pubmed publisher
    ..We showed that expressing LIGHT with an adenovirus vector (Ad) in mice with established AAV in the liver led to clearance of the AAV...
  46. Doherty T, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho J, et al. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med. 2011;17:596-603 pubmed publisher
    ..Here we show that the tumor necrosis factor (TNF) family member LIGHT is expressed on lung inflammatory cells after allergen exposure...
  47. Daller B, Müsch W, Röhrl J, Tumanov A, Nedospasov S, Männel D, et al. Lymphotoxin-? receptor activation by lymphotoxin-?(1)?(2) and LIGHT promotes tumor growth in an NF?B-dependent manner. Int J Cancer. 2011;128:1363-70 pubmed publisher
    ..In our study, we demonstrate that both functional ligands of the LT?R, namely LT?(1) ?(2) and LIGHT, are involved in the activation of LT?R in solid fibrosarcomas...
  48. Qiao G, Qin J, Kunda N, Calata J, Mahmud D, Gann P, et al. LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases. Cancer Res. 2017;77:1880-1891 pubmed publisher
    ..We reported that the immunostimulatory cytokine LIGHT (TNFSF14) in the microenvironment of colon cancer metastases associates with improved patient survival, and here we ..
  49. Hardbower D, Asim M, Luis P, Singh K, Barry D, Yang C, et al. Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Proc Natl Acad Sci U S A. 2017;114:E751-E760 pubmed publisher
    ..Thus, ODC in macrophages tempers antimicrobial, M1 macrophage responses during bacterial infections through histone modifications and altered euchromatin formation, leading to the persistence and pathogenesis of these organisms. ..
  50. Wolf M, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, et al. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell. 2014;26:549-64 pubmed publisher
    ..NKT cells primarily cause steatosis via secreted LIGHT, while CD8(+) and NKT cells cooperatively induce liver damage...
  51. Stanley A, de Labastida Rivera F, Haque A, Sheel M, Zhou Y, Amante F, et al. Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection. PLoS Pathog. 2011;7:e1002279 pubmed publisher
    LIGHT (TNFSF14) is a member of the TNF superfamily involved in inflammation and defence against infection. LIGHT signals via two cell-bound receptors; herpes virus entry mediator (HVEM) and lymphotoxin-beta receptor (LT?R)...
  52. Schaer C, Hiltbrunner S, Ernst B, Mueller C, Kurrer M, Kopf M, et al. HVEM signalling promotes colitis. PLoS ONE. 2011;6:e18495 pubmed publisher
    ..These data show that HVEM stimulatory signals promote experimental colitis driven by innate or adaptive immune cells. ..
  53. Zheng Q, Cao Z, Hu X, Li G, Dong S, Xu G, et al. LIGHT/IFN-? triggers ? cells apoptosis via NF-?B/Bcl2-dependent mitochondrial pathway. J Cell Mol Med. 2016;20:1861-71 pubmed publisher
    b>LIGHT recruits and activates naive T cells in the islets at the onset of diabetes. IFN-? secreted by activated T lymphocytes is involved in beta cell apoptosis...
  54. Musicki K, Briscoe H, Britton W, Saunders B. LIGHT contributes to early but not late control of Mycobacterium tuberculosis infection. Int Immunol. 2010;22:353-8 pubmed publisher
    The TNF superfamily member, LIGHT, contributes to optimal T-cell activation in vitro through co-stimulation of dendritic cell cytokine production; however, its role in T-cell-mediated control of intracellular bacterial infections is ..
  55. Otsmane B, Moumen A, Aebischer J, Coque E, Sar C, Sunyach C, et al. Somatic and axonal LIGHT signaling elicit degenerative and regenerative responses in motoneurons, respectively. EMBO Rep. 2014;15:540-7 pubmed publisher
    ..Here, we show that the TNF family member LIGHT, known to act as a death-triggering factor in motoneurons through LT-?R, can also promote axon outgrowth and ..
  56. Dhall S, Do D, Garcia M, Wijesinghe D, Brandon A, Kim J, et al. A novel model of chronic wounds: importance of redox imbalance and biofilm-forming bacteria for establishment of chronicity. PLoS ONE. 2014;9:e109848 pubmed publisher
    ..Furthermore, the model can lead to the understanding of other fundamental mechanisms of chronic wound development that can potentially lead to novel therapies. ..
  57. Waldemer Streyer R, Chen J. Myocyte-derived Tnfsf14 is a survival factor necessary for myoblast differentiation and skeletal muscle regeneration. Cell Death Dis. 2015;6:e2026 pubmed publisher
    ..Here we identify the cytokine tumor necrosis factor superfamily member 14 (Tnfsf14) as a positive regulator of myoblast differentiation in culture and muscle regeneration in vivo...
  58. Chen L, Sun Y, Xu S, Fu X, Zhou Z, Lu C, et al. [Role of LIGHT signal pathway in Chlamydia muridarum urogenital infection in mice]. Wei Sheng Wu Xue Bao. 2015;55:492-500 pubmed
    ..the role of lymphotoxin-like inducible protein that competes with glycoprotein D for herpesvirus entry on T cells (LIGHT) in the development of protective immunity and pathology during Chlamydia Muridarum urogenital infection in mice...
  59. Herro R, Antunes R, Aguilera A, Tamada K, Croft M. The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis. J Invest Dermatol. 2015;135:2109-2118 pubmed publisher
    ..Factors that might promote these features are of interest for clinical therapy. We previously reported that LIGHT, a TNF superfamily molecule, mediated collagen deposition in the lungs in response to allergen...
  60. Vallabhapurapu S, Powolny Budnicka I, Riemann M, Schmid R, Paxian S, Pfeffer K, et al. Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells. Eur J Immunol. 2008;38:3508-19 pubmed publisher
    ..In contrast to previous reports, however, we show that LT signaling is dispensable for thymic NKT-cell development but is essential for their colonization of peripheral organs such as liver. ..
  61. Liu C, Ding H, Zhu W, Jiang S, Xu J, Zou G. LIGHT regulates the adipogenic differentiation of mesenchymal stem cells. J Cell Biochem. 2013;114:346-53 pubmed publisher
    b>LIGHT is a cytokine belonging to the TNF family. This cytokine has been extensively defined in its role on T-cell regulation and dendritic cell maturation. It also exhibits the role in liver regeneration...
  62. Kosuge H, Suzuki J, Kakuta T, Haraguchi G, Koga N, Futamatsu H, et al. Attenuation of graft arterial disease by manipulation of the LIGHT pathway. Arterioscler Thromb Vasc Biol. 2004;24:1409-15 pubmed
    The tumor necrosis factor (TNF) superfamily member LIGHT, which binds herpes virus entry mediator (HVEM) and lymphotoxin beta receptor (LTbetaR), plays important roles in regulating the immune response...
  63. Collette Y, Gilles A, Pontarotti P, Olive D. A co-evolution perspective of the TNFSF and TNFRSF families in the immune system. Trends Immunol. 2003;24:387-94 pubmed
    ..Unexpectedly, TNFSF subfamilies form monophyletic groups with shared functions, including TNFRSF usage. Finally, the mechanisms of (co-)evolution of TNFSF and TNFRSF are discussed. ..
  64. Wang J, Fu Y. LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)-mediated thymocyte deletion is dependent on the interaction between TCR and MHC/self-peptide. J Immunol. 2003;170:3986-93 pubmed
    Negative selection serves as a major mechanism to maintain self-tolerance. We previously reported that LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor), a TNF family member, plays an important role in ..
  65. Jungbeck M, Daller B, Federhofer J, Wege A, Wimmer N, Männel D, et al. Neutralization of LIGHT ameliorates acute dextran sodium sulphate-induced intestinal inflammation. Immunology. 2009;128:451-8 pubmed publisher
    ..inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T cells (LIGHT; TNFSF14) induced severe intestinal inflammation, suggesting a specific role of LIGHT-mediated signalling to the ..
  66. Togbe D, de Sousa P, Fauconnier M, Boissay V, Fick L, Scheu S, et al. Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS ONE. 2008;3:e2608 pubmed publisher
    ..An essential contribution of LIGHT, another LTbetaR ligand, could be excluded, as LIGHT deficient mice rapidly succumbed to ECM...
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    Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin beta receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of ..