Tnfsf10

Summary

Gene Symbol: Tnfsf10
Description: tumor necrosis factor (ligand) superfamily, member 10
Alias: A330042I21Rik, AI448571, APO-2L, Ly81, TL2, Trail, TNF-related apoptosis inducing ligand, TNF-related apoptosis-inducing ligand, TRAIL/APO2L, tumor necrosis factor ligand superfamily member 10
Species: mouse

Top Publications

  1. pmc TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation
    Emmet E McGrath
    Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    J Leukoc Biol 90:855-65. 2011
  2. pmc Role of tumor necrosis factor-related apoptosis-inducing ligand in immune response to influenza virus infection in mice
    Eri Ishikawa
    Department of Immunology, Yokohama City University School of Medicine, Fukuura 3 9, Kanazawa Ku, Yokohama 236 0004, Japan
    J Virol 79:7658-63. 2005
  3. ncbi Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
    Erika Cretney
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, A Beckett Street, East Melbourne, 8006 Victoria, Australia
    J Immunol 168:1356-61. 2002
  4. pmc The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL
    Erik L Brincks
    Department of Urology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 187:4581-8. 2011
  5. doi Dual effects of TRAIL in suppression of autoimmunity: the inhibition of Th1 cells and the promotion of regulatory T cells
    Tokunori Ikeda
    Department of Immunogenetics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    J Immunol 185:5259-67. 2010
  6. pmc Systemic immunological tolerance to ocular antigens is mediated by TRAIL-expressing CD8+ T cells
    Thomas S Griffith
    Department of Urology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 186:791-8. 2011
  7. ncbi Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Pascal Schneider
    Department of Exploratory Sciences, Biogen, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 278:5444-54. 2003
  8. pmc Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 195:161-9. 2002
  9. ncbi Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    H Walczak
    Immunex Corporation, Seattle, Washington 98101, USA
    Nat Med 5:157-63. 1999
  10. pmc Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Tsung Chuan Ho
    Department of Medical Research, Mackay Memorial Hospital, Taipei 104, Taiwan
    J Biol Chem 286:35943-54. 2011

Scientific Experts

  • Kazuyoshi Takeda
  • Mark Smyth
  • Stella Bernardi
  • Christian M Capitini
  • N Rubio
  • Giorgio Zauli
  • Lisa M Sedger
  • Susanne Herold
  • Nicole M Haynes
  • K Hofmann
  • THOMAS GRIFFITH
  • M Melnick
  • Li xin Xie
  • Erika Cretney
  • Men Luh Yen
  • Erik L Brincks
  • Shi Jun Zheng
  • Youhai H Chen
  • Pascal Schneider
  • Prajwal Gurung
  • Hideo Yagita
  • Salah Eddine Lamhamedi-Cherradi
  • Yoshihiro Hayakawa
  • Ning Zhang
  • Kei Takahashi
  • Bimmi Shrestha
  • Tsung Chuan Ho
  • Valerie Kedinger
  • Mitsuhiro Iyori
  • Joo Young Kim
  • A Badmann
  • B A Di Bartolo
  • Maud Chasseraud
  • Emmet E McGrath
  • Victoria Watt
  • Xiumei Cao
  • Meenu R Pillai
  • Xiujie Yu
  • Nathalie M Droin
  • Jeffrey Chan
  • Hwei Fang Tsai
  • Suthakar Ganapathy
  • Tokunori Ikeda
  • Soojeong Kang
  • Mathieu Coureuil
  • Ping Ning Hsu
  • Il Kang Na
  • Yusuke Kitahara
  • Be Hang Lee
  • Giuseppina Cantarella
  • Kevin L Legge
  • Naiara Beraza
  • Kenta Moriwaki
  • Julieta Marino
  • Vanessa Montalvo
  • Kristin E Hubert
  • Joseph E Aslan
  • Thomas Kaufmann
  • Mami Nakahara
  • Gregory J Gores
  • SangKon Oh
  • Heather Zwaferink
  • Anne Grosse-Wilde
  • Y J Jeon
  • Alisan Kahraman
  • Jeremy B Swann
  • Michael A Reott
  • Jilian A Sacks
  • Florian Wiede
  • Mathilde Romagnoli
  • Olaf Hoffmann
  • Rebecca L Vanoosten
  • Gaël Roué
  • Markus Weckmann
  • D Berg
  • X Ren
  • Thomas A Ferguson
  • Tomiyasu Murata
  • Sara E Hamilton
  • Andreas Strasser
  • Nadia Corazza
  • Stephen P Schoenberger
  • Adam P Uldrich
  • Dale I Godfrey
  • Nadeen Zerafa
  • Edith M Janssen
  • Eri Ishikawa
  • Ali G Gharavi
  • Joan K Riley
  • Michael J Pinkoski

Detail Information

Publications99

  1. pmc TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation
    Emmet E McGrath
    Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    J Leukoc Biol 90:855-65. 2011
    ..We previously demonstrated that a death receptor ligand, TRAIL, accelerates neutrophil apoptosis in vitro...
  2. pmc Role of tumor necrosis factor-related apoptosis-inducing ligand in immune response to influenza virus infection in mice
    Eri Ishikawa
    Department of Immunology, Yokohama City University School of Medicine, Fukuura 3 9, Kanazawa Ku, Yokohama 236 0004, Japan
    J Virol 79:7658-63. 2005
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis of various tumor cells but not normal cells. However, various cytokines and virus infection differentially regulate TRAIL and TRAIL receptor expression...
  3. ncbi Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
    Erika Cretney
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, A Beckett Street, East Melbourne, 8006 Victoria, Australia
    J Immunol 168:1356-61. 2002
    We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate immune surveillance against tumor development...
  4. pmc The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL
    Erik L Brincks
    Department of Urology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 187:4581-8. 2011
    ..We recently reported that TRAIL is another means by which IAV-specific CD8 T cells can kill IAV-infected cells...
  5. doi Dual effects of TRAIL in suppression of autoimmunity: the inhibition of Th1 cells and the promotion of regulatory T cells
    Tokunori Ikeda
    Department of Immunogenetics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    J Immunol 185:5259-67. 2010
    b>TRAIL is known to play a pivotal role in the inhibition of autoimmune disease...
  6. pmc Systemic immunological tolerance to ocular antigens is mediated by TRAIL-expressing CD8+ T cells
    Thomas S Griffith
    Department of Urology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 186:791-8. 2011
    ..AC injection of Ag did not prime CD4(+) T cells and led to increased TRAIL expression by splenic CD8(+) T cells...
  7. ncbi Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Pascal Schneider
    Department of Exploratory Sciences, Biogen, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 278:5444-54. 2003
    ..mTNFRH1, -2 and -3, are most homologous to those of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors...
  8. pmc Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 195:161-9. 2002
    ..Here we show that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell-mediated and IFN-gamma-dependent tumor surveillance...
  9. ncbi Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    H Walczak
    Immunex Corporation, Seattle, Washington 98101, USA
    Nat Med 5:157-63. 1999
    To evaluate the utility of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a cancer therapeutic, we created leucine zipper (LZ) forms of human (hu) and murine (mu) TRAIL to promote and stabilize the formation of ..
  10. pmc Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Tsung Chuan Ho
    Department of Medical Research, Mackay Memorial Hospital, Taipei 104, Taiwan
    J Biol Chem 286:35943-54. 2011
    ..This macrophage-mediated tumor killing is prevented by blockage of TNF-related apoptosis-inducing ligand (TRAIL) following treatment with the soluble TRAIL receptor...
  11. doi TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner
    Jeffrey Chan
    Centre for Vascular Research, The University of New South Wales, Sydney NSW 2052, Australia
    Circ Res 106:1061-71. 2010
    Rationale: TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is well reported as an inducer of apoptosis in tumor models; however, its role and function in vivo in atherosclerosis and vascular injury has not been ..
  12. pmc Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage
    Naiara Beraza
    Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen 5205, Germany
    J Exp Med 206:1727-37. 2009
    ..resistant to Fas-mediated apoptosis but hypersensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as the result of a strong up-regulation of its receptor DR5 on hepatocytes...
  13. ncbi Reduced apoptosis and ameliorated listeriosis in TRAIL-null mice
    Shi Jun Zheng
    Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5652-8. 2004
    ..We report in this study that mice deficient in TRAIL were partially resistant to primary listeriosis, and blocking TRAIL with a soluble death receptor 5 markedly ..
  14. ncbi Identification and characterization of a new member of the TNF family that induces apoptosis
    S R Wiley
    Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Immunity 3:673-82. 1995
    ..This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity...
  15. pmc Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent
    Prajwal Gurung
    Department of Urology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 187:2148-54. 2011
    ..In contrast, CLP-treated Trail(-/-) and Dr5(-/-) mice were better able to control the secondary bacterial infection, and the Ag-specific CD8 T ..
  16. ncbi Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice
    Lisa M Sedger
    Department of Molecular Immunology, Immunex Corporation, Seattle, USA
    Eur J Immunol 32:2246-54. 2002
    To define the normal physiological role for the TRAIL/Apo2L in vivo, we generated TRAIL/Apo2L gene-targeted mice. These mice develop normally and show no defects in lymphoid or myeloid cell homeostasis or function...
  17. ncbi TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    Blood 105:2082-9. 2005
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a key effector molecule expressed by natural killer (NK) cells and has been shown to prevent tumor initiation, growth, and metastasis...
  18. pmc Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses
    Nathalie M Droin
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Mol Cell Biol 23:7638-47. 2003
    ..We demonstrate here that superantigen Staphylococcus enterotoxin B (SEB) induced a dramatic upregulation of FasL, TRAIL, and TNF mRNA expression and function in IEC from BALB/c and C57BL/6 mice...
  19. pmc CD8 T cells utilize TRAIL to control influenza virus infection
    Erik L Brincks
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 181:4918-25. 2008
    ..However, recent studies suggest that CD8(+) T cells can also utilize TRAIL to kill virally infected cells...
  20. pmc Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
    Immunity 30:56-66. 2009
    ..These observations identify caspase-8 and the BH3-only proteins Bid and Bim as potential therapeutic targets for treatment of inflammatory liver diseases...
  21. pmc TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice
    Victoria Watt
    Department of Cardiovascular Science, Medical School, University of Sheffield, Sheffield S10 2RX, UK
    Atherosclerosis 215:348-54. 2011
    b>TRAIL (tumour necrosis factor-related apoptosis inducing ligand) is most often reported to induce apoptosis in tumour cells. It is expressed in artery walls but its role and regulation in vascular pathologies is little studied...
  22. ncbi TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice
    Erika Cretney
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, Victoria, Australia
    Immunol Cell Biol 83:511-9. 2005
    Studies have suggested that endogenous TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L may suppress the induction of some autoimmune diseases in mice...
  23. doi TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation from monocyte/macrophage lineage precursor cells
    Men Luh Yen
    Department of Primary Care Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Immunol 45:2205-13. 2008
    ..Recent evidence indicates that the TNF-related apoptosis-inducing ligand (TRAIL) of the TNF ligand superfamily, which was initially thought to induce apoptosis in many transformed cell lines, ..
  24. ncbi IL-21 induces the functional maturation of murine NK cells
    Jason Brady
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 172:2048-58. 2004
    ..These developmental changes suggested that IL-21 functions to induce the terminal differentiation of mouse NK cells, resulting in heightened NK cell-mediated cytotoxicity and immune surveillance...
  25. pmc TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality
    Nadia Corazza
    Division of Immunopathology, Institute of Pathology, University of Bern, Bern, Switzerland
    J Clin Invest 116:2493-9. 2006
    TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family with potent apoptosis-inducing properties in tumor cells...
  26. pmc TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
    Anne Grosse-Wilde
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Invest 118:100-10. 2008
    b>TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in established tumor cell lines but not nontransformed cells...
  27. ncbi Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease
    Markus Weckmann
    Department of Paediatrics and Adolescent Medicine, Albert Ludwigs University Freiburg, 79106 Freiburg, Germany
    Nat Med 13:1308-15. 2007
    ..Here we characterize the development of allergic airway disease in TRAIL-deficient (Tnfsf10(-/-)) mice and in mice exposed to short interfering RNA targeting TRAIL...
  28. pmc TRAIL limits excessive host immune responses in bacterial meningitis
    Olaf Hoffmann
    Department of Neurology, Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Clin Invest 117:2004-13. 2007
    Apart from potential roles in anti-tumor surveillance, the TNF-related apoptosis-inducing ligand (TRAIL) has important regulatory functions in the host immune response...
  29. ncbi Cutting edge: TRAIL deficiency accelerates hematological malignancies
    Nadeen Zerafa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    J Immunol 175:5586-90. 2005
    ..In this study, we provide the first evaluation of spontaneous tumor formation over the life span of TRAIL-deficient mice. Interestingly, >25% of these mice do develop lymphoid malignancies after 500 days of life...
  30. ncbi Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Cell Immunol 214:194-200. 2001
    ..Here we show tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a critical role in the NK cell-..
  31. ncbi Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice
    Salah Eddine Lamhamedi-Cherradi
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nat Immunol 4:255-60. 2003
    b>TRAIL, the tumor necrosis factor-related apoptosis-inducing ligand, selectively induces apoptosis of tumor cells, but not most normal cells. Its role in normal, nontransformed tissues is not clear...
  32. pmc Critical roles of TRAIL in hepatic cell death and hepatic inflammation
    Shi Jun Zheng
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 113:58-64. 2004
    The TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis of tumor cells but not most normal cells. Its role in hepatic cell death and hepatic diseases is not clear...
  33. doi TRAIL and DR5 promote thyroid follicular cell apoptosis in iodine excess-induced experimental autoimmune thyroiditis in NOD mice
    Xiujie Yu
    Key Lab of Hormone and Institute of Endocrinology, Metabolic Disease Hospital, Tianjin Medical University of Tianjin, 127, Tianjin Medical University of Tianjin, 300070, Tianjin, China
    Biol Trace Elem Res 143:1064-76. 2011
    ..apoptosis signaling pathways, such as Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), have been shown to be active in thyroid cells and may be involved in destructive thyroiditis...
  34. pmc The plasticity of regulatory T cell function
    Meenu R Pillai
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 187:4987-97. 2011
    ..of IL-10 and IL-35 was compensated for by a concurrent increase in cathepsin E (Ctse) expression, enhanced TRAIL (Tnfsf10) expression, and soluble TRAIL release, rendering IL-10/IL-35 double-deficient T(regs) functionally dependent on ..
  35. pmc CD8+ T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons
    Bimmi Shrestha
    Departments of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 86:8937-48. 2012
    ..Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; also known as CD253) has been reported to inhibit infection with dengue virus, a closely related flavivirus, in ..
  36. pmc The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, Wenhua Xi Road 107, Jinan 250012, Shandong Province, China
    J Biol Chem 288:9396-407. 2013
    ..that the relative expression of MTDH correlated with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in breast cancer...
  37. pmc Graft-versus-host disease impairs vaccine responses through decreased CD4+ and CD8+ T cell proliferation and increased perforin-mediated CD8+ T cell apoptosis
    Christian M Capitini
    Blood and Marrow Transplant Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:1351-9. 2013
    ..Using Fas ligand-deficient or TRAIL-deficient DLI had no impact on apoptosis of HY-specific T cells...
  38. pmc Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage
    A Badmann
    Division of Immunopathology, Institute of Pathology, University of Bern, and Visceral and Transplantation Surgery, University Hospital, Bern, Switzerland
    Cell Death Dis 2:e171. 2011
    ..We recently identified TNF-related apoptosis-inducing ligand (TRAIL) and c-Jun kinase (JNK)-dependent activation of the pro-apoptotic Bcl-2 homolog Bim as an important apoptosis ..
  39. pmc TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation
    Men Luh Yen
    Department of General Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 7:e38048. 2012
    ..Recent evidence indicates that in addition to triggering apoptosis, the TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation...
  40. doi Functional roles of tumor necrosis factor-related apoptosis-inducing ligand-DR5 interaction in B16F10 cells by activating the nuclear factor-κB pathway to induce metastatic potential
    Kei Takahashi
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Cancer Sci 104:558-62. 2013
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been recognized as a promising target for cancer therapy because it can induce apoptotic cell death in tumor cells but not normal cells...
  41. pmc TRAIL-deficient mice exhibit delayed regression of retinal neovascularization
    Kristin E Hubert
    Department of Pediatrics, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Am J Pathol 175:2697-708. 2009
    While it is well established that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various cell types, the role of TRAIL in regulation of retinal neovascularization (NV) has not been described...
  42. pmc The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease
    Il Kang Na
    Department of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    J Clin Invest 120:343-56. 2010
    ..Donor alloreactive T cells used the cognate proteins FasL and TNF-related apoptosis-inducing ligand (TRAIL) (but not TNF or perforin) to mediate tGVHD, thereby damaging thymic stromal cells, cytoarchitecture, and function...
  43. ncbi Peritumoral administration of granulocyte colony-stimulating factor induces an apoptotic response on a murine mammary adenocarcinoma
    Julieta Marino
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    Cancer Biol Ther 8:1737-43. 2009
    ..Western blot analysis of tumor lysates showed that G-CSF treatment increased the amount of Fas-L, TRAIL and Bax proteins, whereas decreased the expression of procaspase 3 and Bcl-2...
  44. doi Interferon-induced TRAIL-independent cell death in DNase II-/- embryos
    Yusuke Kitahara
    Department of Medical Chemistry, Kyoto University Graduate School of Medicine, Yoshida Konoe, Kyoto, Japan
    Eur J Immunol 40:2590-8. 2010
    ..During this death process, a set of genes was strongly activated, one of which encoded TRAIL, a death ligand...
  45. pmc Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice
    Giuseppina Cantarella
    Department of Experimental and Clinical Pharmacology, University of Catania School of Medicine, Catania, Italy
    Neuropsychopharmacology 35:1302-14. 2010
    ..In this study, the function of the proapoptotic cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in SCI-induced damage was investigated in the mouse...
  46. pmc Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Exp Med 205:3065-77. 2008
    ..epithelial cell (AEC) apoptosis by the release of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in a murine model of influenza-induced pneumonia...
  47. doi Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling
    Kenta Moriwaki
    Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, Osaka, Japan
    Gastroenterology 137:188-98, 198.e1-2. 2009
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes apoptosis in cancer cells, but not normal cells, and is critically involved in tumor rejection through natural killer (NK) cell-mediated immune surveillance...
  48. pmc Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice
    Lisa M Sedger
    Institute for Biotechnology of Infectious Disease, and Department of Medical and Molecular Biosciences, University of Technology, Sydney
    Blood 115:3258-68. 2010
    To delineate the relative roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas ligand in lymphocyte biology and lymphoproliferative disease, we generated mice defective in both molecules. B6...
  49. doi Tumor necrosis factor-related apoptosis-inducing ligand and vascular calcification
    Maud Chasseraud
    French National Institute of Health and Medical Research INSERM, ERI 12 EA 4292 and University of Picardie Jules Verne, Amiens, France
    Ther Apher Dial 15:140-6. 2011
    ..Given that OPG can bind the pro-apoptotic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), we hypothesized that the TRAIL protein is involved in the formation of vascular calcification both in vitro and ..
  50. pmc Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor
    Suthakar Ganapathy
    Division of Radiation Biology, Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, Greehey Children s Cancer Research Institute, San Antonio, Texas, United States of America
    PLoS ONE 5:e15627. 2010
    ..We have recently shown that resveratrol can enhance the apoptosis-inducing potential of TRAIL in prostate cancer cells through multiple mechanisms in vitro...
  51. pmc Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis
    Valerie Kedinger
    Department of Cancer Biology, Institut Génétique de Biologie Moléculaire et Cellulaire IGBMC, France
    Mol Cancer 10:34. 2011
    Gene ablation studies have revealed that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL, Apo2L, TNFSF10) plays a crucial role in tumor surveillance, as TRAIL-deficient mice exhibit an increased sensitivity to different ..
  52. doi TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation
    Joo Young Kim
    Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Republic of Korea
    FEBS Lett 585:2144-50. 2011
    One major obstacle in the clinical application of TRAIL as a cancer therapeutic agent is the acquisition of TRAIL resistance. We found that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis...
  53. pmc The role of TRADD in TRAIL-induced apoptosis and signaling
    Xiumei Cao
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    FASEB J 25:1353-8. 2011
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily...
  54. doi Systemic delivery of TNF-related apoptosis-inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and prevents type 1 diabetes in nonobese diabetic mice
    Soojeong Kang
    Department of Pharmacology, Dong A University College of Medicine, Busan, South Korea
    Endocrinology 151:5638-46. 2010
    Recent studies have demonstrated that TNF-related apoptosis-inducing ligand (TRAIL) is a modulator of the immune response...
  55. pmc TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells
    Mitsuhiro Iyori
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 187:3087-95. 2011
    ..In this study, enhanced Ag presentation was observed in draining lymph nodes in TRAIL(-/-) and DR5(-/-) mice compared with that of wild-type mice...
  56. pmc Puma and Trail/Dr5 pathways control radiation-induced apoptosis in distinct populations of testicular progenitors
    Mathieu Coureuil
    Laboratory of Gametogenesis, Apoptosis and Genotoxicity, INSERM, U967 Institute of Cellular and Molecular Radiobiology, CEA, Univ Paris VII, Fontenay aux Roses, France
    PLoS ONE 5:e12134. 2010
    ..b>Trail-/- or Puma-/- spermatogonia display a reduced sensitivity to radiation-induced apoptosis...
  57. doi TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe ⁻/⁻ mice
    B A Di Bartolo
    Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia
    Diabetologia 54:3157-67. 2011
    TNF-related apoptosis-inducing ligand (TRAIL) is implicated in the regulation of diabetes and is reduced in patients with cardiovascular disease...
  58. doi CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors
    Nicole M Haynes
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Australia
    J Immunol 185:532-41. 2010
    ..In this study, using the first described C57BL/6 (B6) TRAIL-sensitive experimental tumor models, we have characterized the innate and adaptive immune components involved in ..
  59. ncbi The modular nature of apoptotic signaling proteins
    K Hofmann
    MEMOREC Stoffel GmbH, Koln, Germany
    Cell Mol Life Sci 55:1113-28. 1999
    ....
  60. ncbi TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursors
    Giorgio Zauli
    Department of Biomedicine, University of Trieste, Trieste, Italy
    J Cell Physiol 214:117-25. 2008
    Experimental evidences indicate that the TNF family member TNF-related apoptosis inducing ligand (TRAIL) might be involved in modulating osteoclastic differentiation...
  61. ncbi Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level
    Gaël Roué
    Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Immunol 178:1923-30. 2007
    ..MCL) cells to apoptosis, we have analyzed their sensitivity to the extrinsic apoptotic signal triggered by TRAIL. We show here that TRAIL can trigger apoptosis in a majority of MCL cell lines and primary cultures, irrespective ..
  62. ncbi TNF-dependent overexpression of CCL21 is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder
    Florian Wiede
    Interdisziplinäres Zentrum für Klinische Forschung der Universität Erlangen Nürnberg, Erlangen, Germany
    Eur J Immunol 37:351-7. 2007
    ..gld/gld and B6.gld/gld.TRAIL-/- mice. In contrast, a distinct consequence of TNF deficiency in B6...
  63. ncbi Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D
    Tomiyasu Murata
    Department of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468 8503, Japan
    J Biol Chem 281:22503-16. 2006
    ..genes, death receptor 5 (DR5), which is the receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), showed the highest level of induction...
  64. ncbi The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells
    Sara E Hamilton
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology, Minneapolis, Minnesota 55454, USA
    Nat Immunol 7:475-81. 2006
    ..The necessity for CD4 help was overcome, however, if the HP-memory CD8(+) T cells lacked expression of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand; also called Apo-2L)...
  65. pmc NKG2D function protects the host from tumor initiation
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Exp Med 202:583-8. 2005
    ..These findings suggest an important early role for the NKG2D in controlling and shaping tumor formation...
  66. ncbi TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF
    Giorgio Zauli
    Department of Normal Human Morphology, University of Trieste, Italy
    Blood 104:2044-50. 2004
    ..In this study, we have investigated the effect of TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, in osteoclastogenesis, by using human peripheral blood mononuclear ..
  67. pmc Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3
    Ali G Gharavi
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:2488-93. 2004
    ..These findings demonstrate a strong genetic influence on HIVAN and demonstrate a major renal disease susceptibility locus on mouse chromosome 3A1-3...
  68. ncbi Roles of tumor necrosis factor-related apoptosis-inducing ligand in corneal transplantation
    Lixin Xie
    Shandong Eye Institute and Hospital, Qingdao, China
    Transplantation 76:1556-9. 2003
    ..Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis of tumor cells without significant toxicity and inhibit autoimmune disease...
  69. pmc Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy
    Shulin Wang
    Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Department of Medicine, and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 100:15095-100. 2003
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exhibits specific tumoricidal activity and is under development for cancer therapy...
  70. ncbi Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer
    Naoko Seki
    Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    Cancer Res 63:207-13. 2003
    Recent reports have suggested that the death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may partially limit the formation of hepatic metastases of a variety of mouse tumors, and the major source of TRAIL in ..
  71. ncbi TRAIL: a mechanism of tumor surveillance in an immune privileged site
    Hae Ock Lee
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:4739-44. 2002
    b>TRAIL is a recently described member of the TNF superfamily. The ability of TRAIL to induce apoptosis in a large number of tumors has stimulated interest in TRAIL as a tumor therapeutic agent...
  72. pmc Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation
    Raid Kassis
    Laboratoire de la Rage, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Virol 78:6543-55. 2004
    ..demonstrate that the early induction of apoptosis in a model of lyssavirus-infected neuroblastoma cells involves a TRAIL-dependent pathway requiring the activation of caspase-8 but not of caspase-9 or caspase-10...
  73. ncbi Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha
    Lisa M Sedger
    Department of Molecular Immunology, Immunex, Seattle, WA 98101, USA
    J Immunol 169:6193-201. 2002
    ..Thus, TNF-alpha and lymphotoxin-alpha are required for loss of BM B lineage cells during respiratory infection with influenza virus...
  74. pmc TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help
    Jilian A Sacks
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 180:4570-6. 2008
    ..We investigated the role of the proapoptotic molecule TRAIL in this defect...
  75. pmc TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse
    Alisan Kahraman
    Miles and Shirley Fitterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Hepatology 47:1317-30. 2008
    The contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a death ligand expressed by cells of the innate immune system, to cholestatic liver injury has not been explored...
  76. doi Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling
    Y J Jeon
    School of Biological Science Bio Max Institute, Seoul National University, Seoul, Korea
    Oncogene 27:4344-52. 2008
    b>TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a potent inducer of apoptosis in tumor cells and holds a promise as a therapeutic agent against cancer...
  77. ncbi Activation of tumor-specific CD8+ T Cells after intratumoral Ad5-TRAIL/CpG oligodeoxynucleotide combination therapy
    Rebecca L Vanoosten
    Department of Urology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa 52242 1089, USA
    Cancer Res 67:11980-90. 2007
    ..These results collectively show that local treatment with Ad5-mTRAIL and CpG ODN can augment tumor antigen cross-presentation resulting in T-cell proliferation, enhanced CTL activity, and increased animal survival...
  78. ncbi Canonical nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL
    Mathilde Romagnoli
    INSERM, UMR 601, France
    Clin Cancer Res 13:6010-8. 2007
    ..In this study, we specifically address the role of NF-kappaB blockade in mediated antimyeloma activity using the IkappaB kinase-2 pharmacologic inhibitor, AS602868...
  79. pmc Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection
    Heather Zwaferink
    Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Dr Bohr Gasse 9 4, A1030 Vienna, Austria
    Infect Immun 76:1649-56. 2008
    ..that interferon-upregulated caspase activation or other interferon-inducible, death-associated proteins, including TRAIL, protein kinase R, and p53, were not necessary for cell death...
  80. ncbi Tumor necrosis factor-related, apoptosis-inducing ligand supports growth of mouse mastocytoma tumors by killing tumor-infiltrating macrophages
    Alessandro Strebel
    Institute for Medical Microbiology, University of Basel, Petersplatz 10, 4003 Basel, Switzerland
    Int J Cancer 100:627-34. 2002
    b>TRAIL antisense transfected mastocytoma cells (R56VTas) injected into syngeneic DBA/2 mice demonstrate significantly delayed tumor growth compared to mock transfected cells (R56VTMo)...
  81. pmc IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis
    SangKon Oh
    Vaccine Branch and Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1578, USA
    Proc Natl Acad Sci U S A 105:5201-6. 2008
    ..and defective secondary CD8+ T cell responses because of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis...
  82. ncbi Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes
    Salah Eddine Lamhamedi-Cherradi
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Diabetes 52:2274-8. 2003
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues are not clear...
  83. pmc Normal thymocyte negative selection in TRAIL-deficient mice
    Erika Cretney
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    J Exp Med 198:491-6. 2003
    ..A recent report suggested that TRAIL was a critical factor in this process, a result that does not fit well with previous studies that excluded a role ..
  84. ncbi Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice
    Qing Sheng Mi
    Autoimmunity Diabetes Group, The John P Robarts Research Institute, London, Ontario, Canada
    Diabetes 52:1967-75. 2003
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including pancreas and lymphocytes, and can induce apoptosis in various tumor cells but not in most normal cells...
  85. doi Expression of immunoregulatory molecules by thyrocytes protects nonobese diabetic-H2h4 mice from developing autoimmune thyroiditis
    Mami Nakahara
    Department of Medical Gene Technology, Divisions of ClinicalPharmaceutics, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Endocrinology 150:1545-51. 2009
    ..for the feasibility of this approach, the immunoregulatory molecules, TNF-related apoptosis-inducing ligand (TRAIL) and indoleamine 2, 3-dioxygenase, were expressed in the thyroid glands using adenovirus vector in nonobese ..
  86. ncbi Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California 90089 0641, USA
    Anat Rec 262:318-30. 2001
    ..The results of these experiments indicate that the TNF/TNF-R1 signal transduction pathway plays an important role in balancing cell proliferation and apoptosis during SMG duct and presumptive acini formation...
  87. ncbi Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells
    X Ren
    Institute for Immunobiology and Department of Immunology, Shanghai Medical College, Fudan University, Shanghai, China
    Cell Death Differ 14:2076-84. 2007
    ..In this report, tumor necrosis factor-related apoptosis inducing ligand (TRAIL)/death receptor 5 (DR5) was explored as one of the pivotal factors for the suppression and cytotoxicity induced by ..
  88. ncbi A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility
    Yian Wang
    Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 64:1647-54. 2004
    ..Furthermore, this model can be used in determining genetic modifiers that contribute to susceptibility or resistance to lung SCC development...
  89. ncbi Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL
    Thomas S Griffith
    Department of Urology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 178:2679-87. 2007
    ..induced by these treatments displayed a "helpless CTL" phenotype and suppress the immune response by producing TRAIL. Animals deficient in TRAIL were resistant to tolerance induction by apoptotic cells...
  90. doi No requirement for TRAIL in intrathymic negative selection
    Erika Cretney
    Cancer Immunology Program, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Int Immunol 20:267-76. 2008
    The contribution of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway to intrathymic negative selection is a controversial subject with two studies suggesting a key role for TRAIL, while others demonstrated ..
  91. ncbi Genomic structure and precise mapping of a thymic regulatory region on mouse chromosome 17 revealed by a c-myc transgene insertion
    A Lavenu
    Department of Immunology, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex, 75724, France
    Genomics 34:381-8. 1996
    ..Analysis of Tsil offers a unique opportunity to identify a regulatory region or a gene that might play an important role in T-cell maturation...
  92. pmc Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis
    Joseph E Aslan
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Cell 34:497-509. 2009
    b>TRAIL selectively kills diseased cells in vivo, spurring interest in this death ligand as a potential therapeutic. However, many cancer cells are resistant to TRAIL, suggesting the mechanism mediating TRAIL-induced apoptosis is complex...
  93. ncbi CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
    Edith M Janssen
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 434:88-93. 2005
    ..This death is mediated by tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)...
  94. pmc Constitutive pro-apoptotic molecules are differentially expressed in the fetal and adult mouse eye
    Vanessa Montalvo
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892 1857, USA
    Curr Eye Res 34:328-32. 2009
    ..To compare gene expression of pro-apoptotic molecules in the fetal and adult mouse eye. Materials and..
  95. ncbi Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L
    D Berg
    Department of Molecular Internal Medicine, Medical Clinic and Polyclinic II, University of Wuerzburg, Wuerzburg 97070, Germany
    Cell Death Differ 14:2021-34. 2007
    Variants of human TRAIL (hTRAIL) and human CD95L (hCD95L), encompassing the TNF homology domain (THD), interact with the corresponding receptors and stimulate CD95 and TRAILR2 signaling after cross-linking...
  96. pmc Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
    Jeremy B Swann
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 105:652-6. 2008
    ..Overall, these data not only confirm the key role that MyD88 plays in promoting tumor development but also demonstrate that inflammation-induced carcinogenesis and cancer immunoediting can indeed occur in the same mouse tumor model...
  97. ncbi TRAIL and KILLER are expressed and induce apoptosis in the murine preimplantation embryo
    Joan K Riley
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Reprod 71:871-7. 2004
    b>TRAIL (tumor necrosis factor [TNF]-related apoptosis-inducing ligand) and KILLER are a death-inducing ligand and receptor pair that belong to the TNF and TNF-receptor superfamilies, respectively...
  98. ncbi TRAIL expression is induced in both osteoblasts containing intracellular Staphylococcus aureus and uninfected osteoblasts in infected cultures
    Michael A Reott
    FEMS Microbiol Lett 278:185-92. 2008
    ..The present study examined the production of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) following S...
  99. pmc Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 105:10895-900. 2008
    ..In this article, we show that the death signal mediated by TNF-related apoptosis-inducing ligand (TRAIL) receptor 2/death receptor 5 (DR5) may be a key regulator of cholestatic liver injury...

Research Grants11

  1. The regulation of tumor immunity by NKT cells
    Mark Smyth; Fiscal Year: 2007
    ..This proposal focuses clearly on a pivotal immune control mechanism that will influence many current and future immunotherapies. ..
  2. TRAIL-expressing Recombinant Adenovirus Based Immunotherapy for RCC
    THOMAS GRIFFITH; Fiscal Year: 2009
    ..the development of a recombinant adenoviral vector encoding the human TNF-related apoptosis-inducing ligand (TRAIL; Ad5-TRAIL) cDNA...
  3. Recombinant Immunotherapy for Renal Cell Carcinoma
    THOMAS GRIFFITH; Fiscal Year: 2007
    Although many agents induce apoptosis, they are commonly associated with side effects that compromise health. TRAIL (TNF-related apoptosis-inducing ligand)/Apo-2L is generating excitement because it induces apoptosis in a wide range of ..
  4. TRAIL-expressing Recombinant Adenovirus Based Immunotherapy for RCC
    Thomas S Griffith; Fiscal Year: 2010
    ..the development of a recombinant adenoviral vector encoding the human TNF-related apoptosis-inducing ligand (TRAIL;Ad5-TRAIL) cDNA...