Tnfsf10

Summary

Gene Symbol: Tnfsf10
Description: tumor necrosis factor (ligand) superfamily, member 10
Alias: A330042I21Rik, AI448571, APO-2L, Ly81, TL2, Tnlg6a, Trail, tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, TRAIL/APO2L, tumor necrosis factor ligand 6a
Species: mouse
Products:     Tnfsf10

Top Publications

  1. Di Bartolo B, Cartland S, Harith H, Bobryshev Y, Schoppet M, Kavurma M. TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL. PLoS ONE. 2013;8:e74211 pubmed publisher
    ..TNF-related apoptosis-inducing ligand (TRAIL) is a second ligand for OPG, and although its effect in vascular calcification in vitro is controversial, its role ..
  2. Brincks E, Katewa A, Kucaba T, Griffith T, Legge K. CD8 T cells utilize TRAIL to control influenza virus infection. J Immunol. 2008;181:4918-25 pubmed
    ..However, recent studies suggest that CD8(+) T cells can also utilize TRAIL to kill virally infected cells...
  3. McGrath E, Marriott H, Lawrie A, Francis S, Sabroe I, Renshaw S, et al. TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation. J Leukoc Biol. 2011;90:855-65 pubmed publisher
    ..We previously demonstrated that a death receptor ligand, TRAIL, accelerates neutrophil apoptosis in vitro...
  4. Cretney E, McQualter J, Kayagaki N, Yagita H, Bernard C, Grewal I, et al. TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice. Immunol Cell Biol. 2005;83:511-9 pubmed
    Studies have suggested that endogenous TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L may suppress the induction of some autoimmune diseases in mice...
  5. Grosse Wilde A, Voloshanenko O, Bailey S, Longton G, Schaefer U, Csernok A, et al. TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest. 2008;118:100-10 pubmed
    b>TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in established tumor cell lines but not nontransformed cells...
  6. Lamhamedi Cherradi S, Zheng S, Maguschak K, Peschon J, Chen Y. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Nat Immunol. 2003;4:255-60 pubmed
    b>TRAIL, the tumor necrosis factor-related apoptosis-inducing ligand, selectively induces apoptosis of tumor cells, but not most normal cells. Its role in normal, nontransformed tissues is not clear...
  7. Unsinger J, Kazama H, McDonough J, Griffith T, Hotchkiss R, Ferguson T. Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol. 2010;184:6766-72 pubmed publisher
    ..Surprisingly, when TRAIL null mice were examined, we found that these animals had significant apoptosis but retained their DTH responses...
  8. Weckmann M, Collison A, Simpson J, Kopp M, Wark P, Smyth M, et al. Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease. Nat Med. 2007;13:1308-15 pubmed
    ..Here we characterize the development of allergic airway disease in TRAIL-deficient (Tnfsf10(-/-)) mice and in mice exposed to short interfering RNA targeting TRAIL...
  9. Takeda K, Cretney E, Hayakawa Y, Ota T, Akiba H, Ogasawara K, et al. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood. 2005;105:2082-9 pubmed
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a key effector molecule expressed by natural killer (NK) cells and has been shown to prevent tumor initiation, growth, and metastasis...

More Information

Publications62

  1. Kaufmann T, Jost P, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S, et al. Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity. 2009;30:56-66 pubmed publisher
    ..These observations identify caspase-8 and the BH3-only proteins Bid and Bim as potential therapeutic targets for treatment of inflammatory liver diseases. ..
  2. Zheng S, Wang P, Tsabary G, Chen Y. Critical roles of TRAIL in hepatic cell death and hepatic inflammation. J Clin Invest. 2004;113:58-64 pubmed
    The TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis of tumor cells but not most normal cells. Its role in hepatic cell death and hepatic diseases is not clear...
  3. Hayakawa Y, Screpanti V, Yagita H, Grandien A, Ljunggren H, Smyth M, et al. NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy. J Immunol. 2004;172:123-9 pubmed
    ..are rapidly eliminated by NK cells in vivo via a pathway dependent on the TNF-related apoptosis-inducing ligand (TRAIL)...
  4. Chan J, Prado Lourenco L, Khachigian L, Bennett M, Di Bartolo B, Kavurma M. TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner. Circ Res. 2010;106:1061-71 pubmed publisher
    b>TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is well reported as an inducer of apoptosis in tumor models; however, its role and function in vivo in atherosclerosis and vascular injury has not been established...
  5. Sedger L, Glaccum M, Schuh J, Kanaly S, Williamson E, Kayagaki N, et al. Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice. Eur J Immunol. 2002;32:2246-54 pubmed
    To define the normal physiological role for the TRAIL/Apo2L in vivo, we generated TRAIL/Apo2L gene-targeted mice. These mice develop normally and show no defects in lymphoid or myeloid cell homeostasis or function...
  6. Griffith T, Brincks E, Gurung P, Kucaba T, Ferguson T. Systemic immunological tolerance to ocular antigens is mediated by TRAIL-expressing CD8+ T cells. J Immunol. 2011;186:791-8 pubmed publisher
    ..AC injection of Ag did not prime CD4(+) T cells and led to increased TRAIL expression by splenic CD8(+) T cells...
  7. Cretney E, Takeda K, Yagita H, Glaccum M, Peschon J, Smyth M. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol. 2002;168:1356-61 pubmed
    We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate immune surveillance against tumor development...
  8. Wiley S, Schooley K, Smolak P, Din W, Huang C, Nicholl J, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995;3:673-82 pubmed
    ..This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity...
  9. Schneider P, Olson D, Tardivel A, Browning B, Lugovskoy A, Gong D, et al. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem. 2003;278:5444-54 pubmed
    ..mTNFRH1, -2 and -3, are most homologous to those of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors...
  10. Takeda K, Smyth M, Cretney E, Hayakawa Y, Kayagaki N, Yagita H, et al. Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med. 2002;195:161-9 pubmed
    ..Here we show that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell-mediated and IFN-gamma-dependent tumor surveillance...
  11. Corazza N, Jakob S, Schaer C, Frese S, Keogh A, Stroka D, et al. TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. J Clin Invest. 2006;116:2493-9 pubmed
    TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family with potent apoptosis-inducing properties in tumor cells...
  12. Ho T, Chen S, Shih S, Chang S, Yang S, Hsieh J, et al. Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem. 2011;286:35943-54 pubmed publisher
    ..This macrophage-mediated tumor killing is prevented by blockage of TNF-related apoptosis-inducing ligand (TRAIL) following treatment with the soluble TRAIL receptor...
  13. Beraza N, Malato Y, Sander L, Al Masaoudi M, Freimuth J, Riethmacher D, et al. Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage. J Exp Med. 2009;206:1727-37 pubmed publisher
    ..resistant to Fas-mediated apoptosis but hypersensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as the result of a strong up-regulation of its receptor DR5 on hepatocytes...
  14. Ikeda T, Hirata S, Fukushima S, Matsunaga Y, Ito T, Uchino M, et al. Dual effects of TRAIL in suppression of autoimmunity: the inhibition of Th1 cells and the promotion of regulatory T cells. J Immunol. 2010;185:5259-67 pubmed publisher
    b>TRAIL is known to play a pivotal role in the inhibition of autoimmune disease...
  15. Hoffmann O, Priller J, Prozorovski T, Schulze Topphoff U, Baeva N, Lunemann J, et al. TRAIL limits excessive host immune responses in bacterial meningitis. J Clin Invest. 2007;117:2004-13 pubmed
    Apart from potential roles in anti-tumor surveillance, the TNF-related apoptosis-inducing ligand (TRAIL) has important regulatory functions in the host immune response...
  16. Zheng S, Jiang J, Shen H, Chen Y. Reduced apoptosis and ameliorated listeriosis in TRAIL-null mice. J Immunol. 2004;173:5652-8 pubmed
    ..We report in this study that mice deficient in TRAIL were partially resistant to primary listeriosis, and blocking TRAIL with a soluble death receptor 5 markedly ..
  17. Droin N, Pinkoski M, Dejardin E, Green D. Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses. Mol Cell Biol. 2003;23:7638-47 pubmed
    ..We demonstrate here that superantigen Staphylococcus enterotoxin B (SEB) induced a dramatic upregulation of FasL, TRAIL, and TNF mRNA expression and function in IEC from BALB/c and C57BL/6 mice...
  18. Brady J, Hayakawa Y, Smyth M, Nutt S. IL-21 induces the functional maturation of murine NK cells. J Immunol. 2004;172:2048-58 pubmed
    ..These developmental changes suggested that IL-21 functions to induce the terminal differentiation of mouse NK cells, resulting in heightened NK cell-mediated cytotoxicity and immune surveillance. ..
  19. Walczak H, Miller R, Ariail K, Gliniak B, Griffith T, Kubin M, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999;5:157-63 pubmed
    To evaluate the utility of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a cancer therapeutic, we created leucine zipper (LZ) forms of human (hu) and murine (mu) TRAIL to promote and stabilize the formation of ..
  20. Ishikawa E, Nakazawa M, Yoshinari M, Minami M. Role of tumor necrosis factor-related apoptosis-inducing ligand in immune response to influenza virus infection in mice. J Virol. 2005;79:7658-63 pubmed
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis of various tumor cells but not normal cells. However, various cytokines and virus infection differentially regulate TRAIL and TRAIL receptor expression...
  21. Yen M, Tsai H, Wu Y, Hwa H, Lee B, Hsu P. TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation from monocyte/macrophage lineage precursor cells. Mol Immunol. 2008;45:2205-13 pubmed publisher
    ..Recent evidence indicates that the TNF-related apoptosis-inducing ligand (TRAIL) of the TNF ligand superfamily, which was initially thought to induce apoptosis in many transformed cell lines, ..
  22. Takeda K, Smyth M, Cretney E, Hayakawa Y, Yamaguchi N, Yagita H, et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol. 2001;214:194-200 pubmed
    ..Here we show tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is a type II membrane protein belonging to the TNF family and plays a critical role in the NK cell-..
  23. Hameed A, Arnold N, Chamberlain J, Pickworth J, Paiva C, Dawson S, et al. Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension. J Exp Med. 2012;209:1919-35 pubmed publisher
    ..We have previously reported tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) immunoreactivity within pulmonary vascular lesions from patients with idiopathic PAH and animal models...
  24. Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, et al. Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease. Proc Natl Acad Sci U S A. 2008;105:10895-900 pubmed publisher
    ..In this article, we show that the death signal mediated by TNF-related apoptosis-inducing ligand (TRAIL) receptor 2/death receptor 5 (DR5) may be a key regulator of cholestatic liver injury...
  25. Lamhamedi Cherradi S, Zheng S, Tisch R, Chen Y. Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes. 2003;52:2274-8 pubmed
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues are not clear...
  26. Hirata S, Matsuyoshi H, Fukuma D, Kurisaki A, Uemura Y, Nishimura Y, et al. Involvement of regulatory T cells in the experimental autoimmune encephalomyelitis-preventive effect of dendritic cells expressing myelin oligodendrocyte glycoprotein plus TRAIL. J Immunol. 2007;178:918-25 pubmed
    ..cells (ES-DC) presenting MOG peptide in the context of MHC class II molecules and simultaneously expressing TRAIL (ES-DC-TRAIL/MOG)...
  27. Di Bartolo B, Chan J, Bennett M, Cartland S, Bao S, Tuch B, et al. TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe ?/? mice. Diabetologia. 2011;54:3157-67 pubmed publisher
    ..the development of atherosclerosis and diabetes in Apoe (-/-), Trail (also known as Tnfsf10)( -/- ) Apoe ..
  28. Watt V, Chamberlain J, Steiner T, Francis S, Crossman D. TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis. 2011;215:348-54 pubmed publisher
    b>TRAIL (tumour necrosis factor-related apoptosis inducing ligand) is most often reported to induce apoptosis in tumour cells. It is expressed in artery walls but its role and regulation in vascular pathologies is little studied...
  29. Gurung P, Rai D, Condotta S, Babcock J, Badovinac V, Griffith T. Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent. J Immunol. 2011;187:2148-54 pubmed publisher
    ..In contrast, CLP-treated Trail(-/-) and Dr5(-/-) mice were better able to control the secondary bacterial infection, and the Ag-specific CD8 T ..
  30. Brincks E, Gurung P, Langlois R, Hemann E, Legge K, Griffith T. The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J Immunol. 2011;187:4581-8 pubmed publisher
    ..We recently reported that TRAIL is another means by which IAV-specific CD8 T cells can kill IAV-infected cells...
  31. Zauli G, Rimondi E, Nicolin V, Melloni E, Celeghini C, Secchiero P. TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF. Blood. 2004;104:2044-50 pubmed
    ..In this study, we have investigated the effect of TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, in osteoclastogenesis, by using human peripheral blood mononuclear ..
  32. Zerafa N, Westwood J, Cretney E, Mitchell S, Waring P, Iezzi M, et al. Cutting edge: TRAIL deficiency accelerates hematological malignancies. J Immunol. 2005;175:5586-90 pubmed
    ..In this study, we provide the first evaluation of spontaneous tumor formation over the life span of TRAIL-deficient mice. Interestingly, >25% of these mice do develop lymphoid malignancies after 500 days of life...
  33. Girkin J, Hatchwell L, Collison A, Starkey M, Hansbro P, Yagita H, et al. TRAIL signaling is proinflammatory and proviral in a murine model of rhinovirus 1B infection. Am J Physiol Lung Cell Mol Physiol. 2017;312:L89-L99 pubmed publisher
    ..Naïve wild-type and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-deficient (Tnfsf10-/-) BALB/c mice were infected intranasally with RV1B...
  34. Cardile V, Musumeci G, Sicurezza E, Caggia S, Rusu M, Leonardi R, et al. Expression of TRAIL and its receptors DR5 and DcR2 in orthodontic tooth movement. Histol Histopathol. 2013;28:933-40 pubmed publisher
    b>TRAIL is a transmembrane protein that induces apoptosis in various tissues including alveolar bone. Its in vitro expression can be activated by several methods, such as RANKL administration and cell scraping...
  35. Sambandam Y, Baird K, Stroebel M, Kowal E, Balasubramanian S, Reddy S. Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation. Sci Rep. 2016;6:25143 pubmed publisher
    ..Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been shown to increase osteoclastogenesis...
  36. Takeda K, Nakayama M, Sakaki M, Hayakawa Y, Imawari M, Ogasawara K, et al. IFN-? production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukoc Biol. 2011;90:777-85 pubmed publisher
    ..Our results demonstrate that IFN-? production from lung resident NK cells is a key response in the natural resistance to the experimental lung metastasis of NK cell-resistant tumor cells. ..
  37. Sokulsky L, Collison A, Nightingale S, Fevre A, Percival E, Starkey M, et al. TRAIL deficiency and PP2A activation with salmeterol ameliorates egg allergen-driven eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2016;311:G998-G1008 pubmed publisher
    ..Wild-type and TRAIL-deficient (Tnfsf10-/-) mice were administered subcutaneous ovalbumin (OVA) followed by oral OVA challenges...
  38. Yano T, Ohira M, Nakano R, Tanaka Y, Ohdan H. Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice. PLoS ONE. 2017;12:e0186997 pubmed publisher
    Liver-resident natural killer (NK) cells express TNF-related apoptosis-inducing ligand (TRAIL), a critical molecule for NK cell-mediated tumor cell killing...
  39. Kim J, Lee J, Kim D, Koo G, Yu J, Kim Y. TRADD is critical for resistance to TRAIL-induced cell death through NF-?B activation. FEBS Lett. 2011;585:2144-50 pubmed publisher
    One major obstacle in the clinical application of TRAIL as a cancer therapeutic agent is the acquisition of TRAIL resistance. We found that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis...
  40. Gurung P, Kucaba T, Schoenberger S, Ferguson T, Griffith T. TRAIL-expressing CD8+ T cells mediate tolerance following soluble peptide-induced peripheral T cell deletion. J Leukoc Biol. 2010;88:1217-25 pubmed publisher
    ..T cell deletion by soluble OVA???????, B6 mice were unresponsive to challenge after CFA/OVA immunization, and Trail?/? or Dr5?/? mice were immune, although all strains displayed similar OT-II peripheral deletion...
  41. Kahraman A, Barreyro F, Bronk S, Werneburg N, Mott J, Akazawa Y, et al. TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse. Hepatology. 2008;47:1317-30 pubmed publisher
    The contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a death ligand expressed by cells of the innate immune system, to cholestatic liver injury has not been explored...
  42. Cao X, Pobezinskaya Y, Morgan M, Liu Z. The role of TRADD in TRAIL-induced apoptosis and signaling. FASEB J. 2011;25:1353-8 pubmed publisher
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily...
  43. Liabeuf S, Barreto D, Barreto F, Chasseraud M, Brazier M, Choukroun G, et al. The circulating soluble TRAIL is a negative marker for inflammation inversely associated with the mortality risk in chronic kidney disease patients. Nephrol Dial Transplant. 2010;25:2596-602 pubmed publisher
    ..In vitro and preclinical evidence suggests that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) might be involved in both the atherosclerosis pathway and modulation of the inflammatory response...
  44. Oh S, Perera L, Terabe M, Ni L, Waldmann T, Berzofsky J. IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis. Proc Natl Acad Sci U S A. 2008;105:5201-6 pubmed publisher
    ..and defective secondary CD8+ T cell responses because of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis...
  45. Gharavi A, Ahmad T, Wong R, Hooshyar R, Vaughn J, Oller S, et al. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci U S A. 2004;101:2488-93 pubmed
    ..These findings demonstrate a strong genetic influence on HIVAN and demonstrate a major renal disease susceptibility locus on mouse chromosome 3A1-3. ..
  46. Kang S, Park E, Joe Y, Seo E, Park M, Seo S, et al. Systemic delivery of TNF-related apoptosis-inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and prevents type 1 diabetes in nonobese diabetic mice. Endocrinology. 2010;151:5638-46 pubmed publisher
    Recent studies have demonstrated that TNF-related apoptosis-inducing ligand (TRAIL) is a modulator of the immune response...
  47. Steinwede K, Henken S, Bohling J, Maus R, Ueberberg B, Brumshagen C, et al. TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice. J Exp Med. 2012;209:1937-52 pubmed publisher
    ..Here, we examined the role of the TNF superfamily member TNF-related apoptosis-inducing ligand (TRAIL) in S...
  48. Reott M, Ritchie Miller S, Anguita J, Hudson M. TRAIL expression is induced in both osteoblasts containing intracellular Staphylococcus aureus and uninfected osteoblasts in infected cultures. FEMS Microbiol Lett. 2008;278:185-92 pubmed
    ..The present study examined the production of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) following S...
  49. Afshar Sterle S, Zotos D, Bernard N, Scherger A, Rödling L, Alsop A, et al. Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med. 2014;20:283-90 pubmed publisher
    ..Thus, malignant transformation of mature B cells requires mutations that impair intrinsic differentiation processes and permit escape from T cell-mediated tumor surveillance. ..
  50. Janssen E, Droin N, Lemmens E, Pinkoski M, Bensinger S, Ehst B, et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature. 2005;434:88-93 pubmed
    ..This death is mediated by tumour-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)...
  51. Sedger L, Hou S, Osvath S, Glaccum M, Peschon J, Van Rooijen N, et al. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. J Immunol. 2002;169:6193-201 pubmed
    ..Thus, TNF-alpha and lymphotoxin-alpha are required for loss of BM B lineage cells during respiratory infection with influenza virus. ..
  52. Hofmann K. The modular nature of apoptotic signaling proteins. Cell Mol Life Sci. 1999;55:1113-28 pubmed
  53. Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, et al. Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. Gastroenterology. 2009;137:188-98, 198.e1-2 pubmed publisher
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes apoptosis in cancer cells, but not normal cells, and is critically involved in tumor rejection through natural killer (NK) cell-mediated immune surveillance...