Tnfrsf4

Summary

Gene Symbol: Tnfrsf4
Description: tumor necrosis factor receptor superfamily, member 4
Alias: ACT35, CD134, Ly-70, Ox40, TXGP1L, Txgp1, tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, tax-transcriptionally activated glycoprotein 1
Species: mouse
Products:     Tnfrsf4

Top Publications

  1. Vu M, Xiao X, Gao W, Degauque N, Chen M, Kroemer A, et al. OX40 costimulation turns off Foxp3+ Tregs. Blood. 2007;110:2501-10 pubmed
    b>OX40 is a recently identified T-cell costimulatory molecule that belongs to the TNF/TNFR superfamily. OX40 can be expressed by both activated T effector cells and Foxp3(+) Tregs...
  2. So T, Croft M. Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells. J Immunol. 2007;179:1427-30 pubmed
    ..Here we show that OX40 (CD134) signaling inhibits TGF-beta-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 T ..
  3. Jember A, Zuberi R, Liu F, Croft M. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J Exp Med. 2001;193:387-92 pubmed
    ..In this report, we have investigated the role of the tumor necrosis factor receptor family member OX40 in allergic inflammation using OX40-deficient mice...
  4. Reis B, Rogoz A, Costa Pinto F, Taniuchi I, Mucida D. Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4? T cell immunity. Nat Immunol. 2013;14:271-80 pubmed publisher
    ..Our results demonstrate considerable plasticity in the CD4(+) T cell lineage that allows chronic exposure to luminal antigens without pathological inflammation. ..
  5. Sanchez P, Kedl R. An alternative signal 3: CD8? T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling. Vaccine. 2012;30:1154-61 pubmed publisher
    ..In contrast, antigen specific CD8(+) T cell responses are compromised in the absence of the TNF receptors CD27 and OX40. These data indicate that CD27/OX40 can serve the central function as signal 3 mediators, independent of IFN or IL-..
  6. Toennies H, Green J, Arch R. Expression of CD30 and Ox40 on T lymphocyte subsets is controlled by distinct regulatory mechanisms. J Leukoc Biol. 2004;75:350-7 pubmed
    ..Although some TNFR-related molecules are constitutively expressed, others, such as CD30 and Ox40, are induced upon activation of lymphocytes...
  7. Evans D, Prell R, Thalhofer C, Hurwitz A, Weinberg A. Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alphaCTLA-4. J Immunol. 2001;167:6804-11 pubmed
    ..Previously, we reported that OX40 engagement resulted in a 60-fold increase in the number of Ag-specific CD4(+) memory T cells that persisted 60 days ..
  8. Rogers P, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 2001;15:445-55 pubmed
    It is important to understand which molecules are essential for long-lived immunity. We show that OX40 (CD134) is required with CD28 for the survival of CD4 T cells following antigen-driven expansion...
  9. Hirschhorn Cymerman D, Rizzuto G, Merghoub T, Cohen A, Avogadri F, Lesokhin A, et al. OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis. J Exp Med. 2009;206:1103-16 pubmed publisher
    ..use of the alkylating agent cyclophosphamide (CTX) and an agonist antibody targeting the co-stimulatory receptor OX40 (OX86) provides potent antitumor immunity capable of regressing established, poorly immunogenic B16 melanoma tumors...

More Information

Publications63

  1. Bandyopadhyay S, Long M, Qui H, Hagymasi A, Slaiby A, Mihalyo M, et al. Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation. J Immunol. 2008;181:7728-37 pubmed
    ..Enforced dual costimulation through OX40 and 4-1BB redirected CD8 cells encountering soluble exogenous peptide to expand and differentiate into IFN-gamma ..
  2. Murata K, Nose M, Ndhlovu L, Sato T, Sugamura K, Ishii N. Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J Immunol. 2002;169:4628-36 pubmed
    The interaction between OX40 and OX40 ligand (OX40L) is suggested to provide T cells with an effective costimulatory signals during T cell-APC interaction...
  3. Redmond W, Gough M, Weinberg A. Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo. Eur J Immunol. 2009;39:2184-94 pubmed publisher
    ..Recent work has demonstrated that signaling through the OX40 (CD134) co-stimulatory receptor, a member of the TNFR super-family, can augment CD4 and CD8 T-cell expansion, ..
  4. Kim M, Gaspal F, Wiggett H, McConnell F, Gulbranson Judge A, Raykundalia C, et al. CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Immunity. 2003;18:643-54 pubmed
    ..cells, the CD4(+)CD3(-) cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand...
  5. Gaspal F, Bekiaris V, Kim M, Withers D, Bobat S, MacLennan I, et al. Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella. J Immunol. 2008;180:2824-9 pubmed
    CD30 and OX40 (CD134) are members of the TNFR superfamily expressed on activated CD4 T cells, and mice deficient in both these molecules harbor a striking defect in the capacity to mount CD4 T cell-dependent memory Ab responses...
  6. Song A, Tang X, Harms K, Croft M. OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen. J Immunol. 2005;175:3534-41 pubmed
    ..response to tumor-expressed Ag following adoptive T cell transfer, we show that CD8 effector cells deficient in OX40, a TNFR family member, could not mediate short-term tumor suppression. OX40 was required at two critical stages...
  7. Song J, So T, Cheng M, Tang X, Croft M. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity. 2005;22:621-31 pubmed
    ..Here, we show that Survivin is controlled in peripheral T cells by OX40 cosignaling via sustained PI3k and PKB activation...
  8. Marques R, Williams A, Eksmond U, Wullaert A, Killeen N, Pasparakis M, et al. Generalized immune activation as a direct result of activated CD4+ T cell killing. J Biol. 2009;8:93 pubmed publisher
    ..We therefore propose activated CD4(+) T cell killing as a common etiology for both immune deficiency and activation in HIV infection. ..
  9. Huddleston C, Weinberg A, Parker D. OX40 (CD134) engagement drives differentiation of CD4+ T cells to effector cells. Eur J Immunol. 2006;36:1093-103 pubmed
    ..Addition of an agonist antibody to OX40 (CD134), a costimulatory TNF receptor family member expressed on activated CD4+ T cells, enables the proliferating T ..
  10. Salek Ardakani S, Moutaftsi M, Crotty S, Sette A, Croft M. OX40 drives protective vaccinia virus-specific CD8 T cells. J Immunol. 2008;181:7969-76 pubmed
    ..We show that the TNFR molecule OX40 (CD134) controls primary VACV-specific CD8 T cell expansion and antiviral cytokine production and dictates development of ..
  11. So T, Soroosh P, Eun S, Altman A, Croft M. Antigen-independent signalosome of CARMA1, PKC?, and TNF receptor-associated factor 2 (TRAF2) determines NF-?B signaling in T cells. Proc Natl Acad Sci U S A. 2011;108:2903-8 pubmed publisher
    ..We now show that one TNFR family member, OX40 (CD134), after ligation by OX40L, assembles a unique complex that not only contains TRAF2, RIP, and IKK?/?/? but also ..
  12. Gaspal F, Kim M, McConnell F, Raykundalia C, Bekiaris V, Lane P. Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory. J Immunol. 2005;174:3891-6 pubmed
    Recently, we reported that a CD4(+)CD3(-)CD11c(-) accessory cell provided OX40-dependent survival signals to follicular T cells...
  13. Xu L, Yan J, Wang B, Liu P, Gong J, Wang C. [Effect of the costimulatory molecules OX40-OX40 ligand interaction on the expression of NFATc1 in leukocytes of apolipoprotein E-deficient mice]. Zhonghua Xin Xue Guan Bing Za Zhi. 2011;39:526-30 pubmed
    To investigate the effect of OX40/OX40L interaction on the nuclear factor of activated T cells c1 (NFATc1) in ApoE-/- mice...
  14. Pippig S, Pena Rossi C, Long J, Godfrey W, Fowell D, Reiner S, et al. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol. 1999;163:6520-9 pubmed
    b>CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes...
  15. Kopf M, Ruedl C, Schmitz N, Gallimore A, Lefrang K, Ecabert B, et al. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Immunity. 1999;11:699-708 pubmed
    b>OX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implicated in stimulation of T cells and T-dependent humoral responses...
  16. Kim M, Bekiaris V, McConnell F, Gaspal F, Raykundalia C, Lane P. OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors. J Immunol. 2005;174:1433-7 pubmed
    In this study we examined the role and regulation of OX40 signals during CD4 T cell priming on dendritic cells (DCs)...
  17. Calderhead D, Buhlmann J, van den Eertwegh A, Claassen E, Noelle R, Fell H. Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J Immunol. 1993;151:5261-71 pubmed
    A cDNA library was prepared from the murine Th cell line Th2 D.10 and used to clone the murine homologue of Ox40 by polymerase chain reaction...
  18. Redmond W, Gough M, Charbonneau B, Ratliff T, Weinberg A. Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. J Immunol. 2007;179:7244-53 pubmed
    Several members of the TNFR superfamily, including OX40 (CD134), 4-1BB (CD137), and CD27 provide critical costimulatory signals that promote T cell survival and differentiation in vivo...
  19. Boettler T, Moeckel F, Cheng Y, Heeg M, Salek Ardakani S, Crotty S, et al. OX40 facilitates control of a persistent virus infection. PLoS Pathog. 2012;8:e1002913 pubmed publisher
    ..Here, we show that the co-stimulatory molecule OX40 (CD134) is critically required in the context of persistent LCMV clone 13 infection...
  20. Humphreys I, Loewendorf A, De Trez C, Schneider K, Benedict C, Munks M, et al. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism. J Immunol. 2007;179:2195-202 pubmed
    ..The basis for this shift in CD8 T populations is unknown. In this study, we demonstrate that OX40, a TNFR superfamily member, specifically regulates the accumulation of CD8 T cells reactive with the persistent-..
  21. Klinger M, Kim J, Chmura S, Barczak A, Erle D, Killeen N. Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J Immunol. 2009;182:4581-9 pubmed publisher
    b>OX40 is a member of the TNF receptor family expressed on activated and regulatory T (Treg) cells...
  22. Stuber E, Neurath M, Calderhead D, Fell H, Strober W. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity. 1995;2:507-21 pubmed
    b>OX40 is a member of the TNF/NGF-receptor family expressed on activated T cells, whose ligand is found on activated T and B cells...
  23. Song A, Song J, Tang X, Croft M. Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol. 2007;37:1224-32 pubmed
    The relative contribution of OX40 (CD134) to priming of CD8 T cells in complex systems where CD4 and CD8 cells respond and cooperate together is not clear...
  24. Kim J, Klinger M, Benjamin J, Xiao Y, Erle D, Littman D, et al. Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS ONE. 2009;4:e6580 pubmed publisher
    ..The significance of TCR signaling in regulatory T (Treg) cells has not been systematically addressed. Using an Ox40-cre allele that is prominently expressed in Treg cells, and a conditional null allele of the gene encoding p56(Lck),..
  25. Gramaglia I, Jember A, Pippig S, Weinberg A, Killeen N, Croft M. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J Immunol. 2000;165:3043-50 pubmed
    The costimulatory receptor OX40 has recently been shown to be involved in primary CD4 responses to several defined Ags...
  26. Taraban V, Rowley T, O Brien L, Chan H, Haswell L, Green M, et al. Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol. 2002;32:3617-27 pubmed
    This study addresses the relative importance of CD134 (OX40) and CD137 (4-1BB) in the costimulation of CD4+ and CD8+ T cells under comparable conditions of antigenic stimulation...
  27. Carboni S, Aboul Enein F, Waltzinger C, Killeen N, Lassmann H, Pena Rossi C. CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis. J Neuroimmunol. 2003;145:1-11 pubmed
    We investigated the role of the CD134 (also named OX40) molecule in experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS)...
  28. Hendriks J, Xiao Y, Rossen J, Van Der Sluijs K, Sugamura K, Ishii N, et al. During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. J Immunol. 2005;175:1665-76 pubmed
    Independent studies have shown that CD27, 4-1BB, and OX40 can all promote survival of activated CD8+ T cells...
  29. Takeda I, Ine S, Killeen N, Ndhlovu L, Murata K, Satomi S, et al. Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J Immunol. 2004;172:3580-9 pubmed
    The OX40 (CD134) molecule is induced primarily during T cell activation and, as we show in this study, is also expressed on CD25+CD4+ regulatory T (Treg) cells...
  30. Qui H, Hagymasi A, Bandyopadhyay S, St Rose M, Ramanarasimhaiah R, Menoret A, et al. CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. J Immunol. 2011;187:3555-64 pubmed publisher
    ..We demonstrate that CD134 (OX40) costimulation programs naive self- and virus-reactive CD4 T cells to undergo in vivo differentiation into ..
  31. Mousavi S, Soroosh P, Takahashi T, Yoshikai Y, Shen H, Lefrancois L, et al. OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J Immunol. 2008;181:5990-6001 pubmed
    A T cell costimulatory molecule, OX40, contributes to T cell expansion, survival, and cytokine production...
  32. Al Shamkhani A, Birkeland M, Puklavec M, Brown M, James W, Barclay A. OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur J Immunol. 1996;26:1695-9 pubmed
    b>OX40, a member of the tumor necrosis factor (TNF) receptor/nerve growth factor (NGF) receptor superfamily was first identified as a marker of activated rat CD4+ cells with the MRC OX40 monoclonal antibody (mAb)...
  33. Song J, Salek Ardakani S, Rogers P, Cheng M, Van Parijs L, Croft M. The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol. 2004;5:150-8 pubmed
    ..Here we show that in the absence of OX40 costimulation, antigen-activated CD4+ cells are short-lived because the activity of protein kinase B (PKB; also ..
  34. Bansal Pakala P, Halteman B, Cheng M, Croft M. Costimulation of CD8 T cell responses by OX40. J Immunol. 2004;172:4821-5 pubmed
    ..Using OX40-deficient CD8 cells specific for a defined Ag, and agonist and antagonist OX40 reagents, we show that OX40/OX40 ..
  35. Lathrop S, Huddleston C, Dullforce P, Montfort M, Weinberg A, Parker D. A signal through OX40 (CD134) allows anergic, autoreactive T cells to acquire effector cell functions. J Immunol. 2004;172:6735-43 pubmed
    ..Provision of a costimulatory signal by coinjection of an agonist Ab to OX40 (CD134), a TNFR family member expressed on activated CD4 T cells, results in death of the mice within 12 days...
  36. van Wanrooij E, van Puijvelde G, de Vos P, Yagita H, Van Berkel T, Kuiper J. Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:204-10 pubmed
    ..b>Tnfrsf4 (OX40) and Tnfsf4 (OX40 ligand) are members of the tumor necrosis factor (TNF) and TNF receptor family and OX40/..
  37. Gough M, Ruby C, Redmond W, Dhungel B, Brown A, Weinberg A. OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor. Cancer Res. 2008;68:5206-15 pubmed publisher
    ..requires appropriate costimulatory signals, including ligation of the costimulatory molecule OX40 (TNFRSF4, CD134)...
  38. Xiao X, Gong W, Demirci G, Liu W, Spoerl S, Chu X, et al. New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J Immunol. 2012;188:892-901 pubmed publisher
    b>OX40 is a T cell costimulatory molecule that belongs to the TNFR superfamily. In the absence of immune activation, OX40 is selectively expressed by Foxp3(+) regulatory T cells (Tregs), but not by resting conventional T cells...
  39. Salek Ardakani S, Flynn R, Arens R, Yagita H, Smith G, Borst J, et al. The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice. J Clin Invest. 2011;121:296-307 pubmed publisher
    ..With strongly replicating (i.e., virulent) VACV, the TNFR family costimulatory receptors OX40 (also known as CD134) and CD27 were engaged and promoted the generation of high numbers of memory CD8+ T cells, which protected against ..
  40. Cuadros C, Dominguez A, Lollini P, Croft M, Mittler R, Borgstrom P, et al. Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice. Int J Cancer. 2005;116:934-43 pubmed
    ..Administration of multiple immunizations in combination with the costimulatory agonist anti-OX40 or anti-4-1BB MAb significantly enhanced the immune responses in these mice, resulting in complete tumor rejection ..
  41. Lee S, Rossi R, Lee S, Croft M, Kwon B, Mittler R, et al. CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent. J Immunol. 2007;179:2203-14 pubmed
    The TNFR superfamily members 4-1BB (CD137) and OX40 (CD134) are costimulatory molecules that potently boost CD8 and CD4 T cell responses...
  42. Niedbala W, Cai B, Liu H, Pitman N, Chang L, Liew F. Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A. 2007;104:15478-83 pubmed
    ..The induction of Tregs (NO-Tregs) is independent of cGMP but depends on p53, IL-2, and OX40. NO-Tregs produced IL-4 and IL-10, but not IL-2, IFNgamma, or TGFbeta...
  43. Xiao X, Kroemer A, Gao W, Ishii N, Demirci G, Li X. OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo. J Immunol. 2008;181:3193-201 pubmed
    b>OX40 is a member of the TNFR superfamily and has potent T cell costimulatory activities...
  44. Song J, So T, Croft M. Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol. 2008;180:7240-8 pubmed
    The costimulatory molecule OX40 (CD134) is required in many instances for effective T cell-mediated immunity, controlling proliferation, and survival of T cells after encountering specific Ag...
  45. Murata S, Ladle B, Kim P, Lutz E, Wolpoe M, Ivie S, et al. OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen. J Immunol. 2006;176:974-83 pubmed
    T cell costimulation via OX40 is known to increase CD4+ T cell expansion and effector function and enhances the development of T cell memory. OX40 costimulation can also prevent, and even reverse, CD4+ T cell anergy...
  46. Withers D, Jaensson E, Gaspal F, McConnell F, Eksteen B, Anderson G, et al. The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals. J Immunol. 2009;183:5079-84 pubmed publisher
    ..In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4(+) T cells are comprehensively depleted from the lamina propria...
  47. Soroosh P, Ine S, Sugamura K, Ishii N. OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity. J Immunol. 2006;176:5975-87 pubmed
    Signals through the OX40 costimulatory receptor on naive CD4 T cells are essential for full-fledged CD4 T cell activation and the generation of CD4 memory T cells...
  48. Yang J, Liu H, Diaz Meco M, Moscat J. NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo. EMBO J. 2010;29:3421-33 pubmed publisher
    ..These results establish NBR1 as a novel PB1 adapter in Th2 differentiation and asthma. ..
  49. Bekiaris V, Gaspal F, Kim M, Withers D, Sweet C, Anderson G, et al. Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge. Eur J Immunol. 2009;39:2120-5 pubmed publisher
    ..Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD8(+) effectors...
  50. So T, Choi H, Croft M. OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling. J Immunol. 2011;186:3547-55 pubmed publisher
    ..in activated or effector T cells are important, and these can be strongly influenced by signaling from OX40 (CD134), a member of the TNFR superfamily...
  51. Piconese S, Valzasina B, Colombo M. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med. 2008;205:825-39 pubmed publisher
    ..We show that T reg cells can be functionally inactivated by OX40 triggering. In tumors, the vast majority of CD4(+) T cells are Foxp3(+) and OX40(bright)...
  52. Piconese S, Pittoni P, Burocchi A, Gorzanelli A, Carè A, Tripodo C, et al. A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2. Eur J Immunol. 2010;40:2902-13 pubmed publisher
    b>OX40 stimulation is known to enhance activation of effector T cells and to inhibit induction and suppressive function of Treg...
  53. Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg A, Colombo M. Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood. 2005;105:2845-51 pubmed
    OX40 (CD134) is a member of the tumor necrosis factor (TNF) receptor family that is transiently expressed on T cells after T-cell receptor (TCR) ligation...
  54. Baum P, Gayle R, Ramsdell F, Srinivasan S, Sorensen R, Watson M, et al. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 1994;13:3992-4001 pubmed
    A ligand was cloned for murine OX40, a member of the TNF receptor family, using a T cell lymphoma cDNA library...