Gene Symbol: Tnfrsf1b
Description: tumor necrosis factor receptor superfamily, member 1b
Alias: CD120b, TNF-R-II, TNF-R2, TNF-R75, TNF-alphaR2, TNFBR, TNFR80, TNFRII, TNFalpha-R2, Tnfr-1, Tnfr2, p75, tumor necrosis factor receptor superfamily member 1B, TNF receptor beta chain, TNF-RII, TNFR-II, p75 TNFR, p80 TNF-alpha receptor, tumor necrosis factor receptor 2, tumor necrosis factor receptor type II
Species: mouse
Products:     Tnfrsf1b

Top Publications

  1. Knight B, Yeoh G, Husk K, Ly T, Abraham L, Yu C, et al. Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J Exp Med. 2000;192:1809-18 pubmed
    ..The TNF inflammatory pathway may be a target for therapeutic intervention during the early stages of liver carcinogenesis. ..
  2. Doi T, Marino M, Takahashi T, Yoshida T, Sakakura T, Old L, et al. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proc Natl Acad Sci U S A. 1999;96:2994-9 pubmed
    ..Thus, the RelA-mediated antiapoptotic signal that protects normal cells from TNF injury in vitro can be shown to be operative in vivo. ..
  3. Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, De Jong Y, Ooi C, et al. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology. 2002;122:134-44 pubmed
    ..TNF) induces multiple effects including cell proliferation and death by ligation with TNF receptor type II (TNFR2). We studied the role of TNFR2 in chronic inflammation-induced colonic epithelial alteration...
  4. Hamid T, Gu Y, Ortines R, Bhattacharya C, Wang G, Xuan Y, et al. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation. Circulation. 2009;119:1386-97 pubmed publisher
    ..HF was induced in wild-type (WT), TNFR1(-/-), and TNFR2(-/-) mice via coronary ligation...
  5. Veroni C, Gabriele L, Canini I, Castiello L, Coccia E, Remoli M, et al. Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways. Mol Cell Neurosci. 2010;45:234-44 pubmed publisher
    ..We found that microglia upregulate TNFR2 mRNA and protein and shed large amounts of soluble TNFR2, but not TNFR1, in response to pro-inflammatory stimuli ..
  6. Vielhauer V, Stavrakis G, Mayadas T. Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J Clin Invest. 2005;115:1199-209 pubmed
    ..and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. TNFR1-deficient mice subjected to immune complex-mediated glomerulonephritis developed less proteinuria and ..
  7. Suresh M, Singh A, Fischer C. Role of tumor necrosis factor receptors in regulating CD8 T-cell responses during acute lymphocytic choriomeningitis virus infection. J Virol. 2005;79:202-13 pubmed
    ..responses to lymphocytic choriomeningitis virus (LCMV) with wild-type, p55R-deficient (p55(-/-)), p75R-deficient (p75(-/-)), and p55R- and p75R-deficient (DKO) mice...
  8. Higuchi Y, McTiernan C, Frye C, McGowan B, Chan T, Feldman A. Tumor necrosis factor receptors 1 and 2 differentially regulate survival, cardiac dysfunction, and remodeling in transgenic mice with tumor necrosis factor-alpha-induced cardiomyopathy. Circulation. 2004;109:1892-7 pubmed
    ..Although both TNF receptor 1 (TNFR1) and 2 (TNFR2) are present in the heart, comparatively little is known about the role of TNFR2...
  9. Li B, Vincent A, Cates J, Brantley Sieders D, Polk D, Young P. Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res. 2009;69:338-48 pubmed publisher
    ..Our studies suggest that TNFalpha constitutes a tumor microenvironment signal that biases recruited monocytes toward a proangiogenic/provasculogenic myeloid/endothelial phenotype. ..

More Information


  1. Bruggeman L, Drawz P, Kahoud N, Lin K, Barisoni L, Nelson P. TNFR2 interposes the proliferative and NF-?B-mediated inflammatory response by podocytes to TNF-?. Lab Invest. 2011;91:413-25 pubmed publisher
    The development of proliferative podocytopathies has been linked to ligation of tumor necrosis factor receptor 2 (TNFR2) expressed on the renal parenchyma; however, the TNFR2-positive cells within the kidney responsible for podocyte ..
  2. He S, Liang Y, Shao F, Wang X. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A. 2011;108:20054-9 pubmed publisher
    ..Taken together, these data indicate that there are multiple upstream necrosis-initiating signaling pathways converging on the RIP3 during an innate immune response to viral and bacterial infections in mammals. ..
  3. Kim E, Priatel J, Teh S, Teh H. TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo. J Immunol. 2006;176:1026-35 pubmed
    ..We demonstrate using the MHC class I-restricted 2C TCR and MHC class II-restricted AND TCR transgenic systems that TNFR2 regulates the threshold for clonal expansion of CD4 and CD8 T cell subsets in response to cognate Ag...
  4. Chen X, Subleski J, Kopf H, Howard O, Männel D, Oppenheim J. Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells. J Immunol. 2008;180:6467-71 pubmed
    b>TNFR2 is predominantly expressed by a subset of human and mouse CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs)...
  5. Kim E, Teh H. TNF type 2 receptor (p75) lowers the threshold of T cell activation. J Immunol. 2001;167:6812-20 pubmed
    ..Here the role of TNFR2 (p75) as a putative costimulatory receptor for T cell activation was examined...
  6. Xiao Y, Li H, Zhang J, Volk A, Zhang S, Wei W, et al. TNF-?/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations. Blood. 2011;118:6057-67 pubmed publisher
    ..Tak1 mediates a critical survival signal, which protects against both TNF-?/Fas-RIP-1-dependent necroptosis and TNF-?/Fas-independent apoptosis in HSPCs. ..
  7. Pasparakis M, Kousteni S, Peschon J, Kollias G. Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. Cell Immunol. 2000;201:33-41 pubmed
  8. Sasi S, Yan X, Enderling H, Park D, Gilbert H, Curry C, et al. Breaking the 'harmony' of TNF-? signaling for cancer treatment. Oncogene. 2012;31:4117-27 pubmed publisher
    Tumor necrosis factor-alpha (TNF-?) binds to two distinct receptors, TNFR1/p55 and TNFR2/p75...
  9. Chen M, Mudge C, Klumpp D. Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis. Am J Physiol Renal Physiol. 2006;291:F741-9 pubmed
    ..In urothelial cultures, only siRNAs targeting TNFR1, but not TNFR2, blocked TNF-induced apoptosis, indicating a primary role for TNFR1...
  10. Lai C, Shao J, Behrmann A, Krchma K, Cheng S, Towler D. TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts. Endocrinology. 2012;153:3897-910 pubmed publisher
    ..By contrast, TNF-inducible Msx2 expression was not reduced in TNFR2(-/-) cells...
  11. Jacobs M, Brown N, Allie N, Chetty K, Ryffel B. Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity. Pathobiology. 2000;68:68-75 pubmed
    ..Therefore, anti-mycobacterial immunity is largely dependent on TNF signalling via the TNF-R1, while activation of TNF-R2 plays a minor role...
  12. Guma M, Stepniak D, Shaked H, Spehlmann M, Shenouda S, Cheroutre H, et al. Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011;208:1889-900 pubmed publisher
    ..Inflammation is driven by massive TNF production, which requires additional activation of p38 and extracellular-signal-regulated kinase mitogen-activated protein kinases (MAPKs). ..
  13. Carballo E, Lai W, Blackshear P. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood. 2000;95:1891-9 pubmed
    ..TTP appears to be a physiological regulator of GM-CSF mRNA deadenylation and stability. (Blood. 2000;95:1891-1899) ..
  14. Fontaine V, Mohand Said S, Hanoteau N, Fuchs C, Pfizenmaier K, Eisel U. Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci. 2002;22:RC216 pubmed
    ..Selective inhibition of TNF-R1 function may represent a new approach to reduce ischemia-induced neuronal damage, being potentially superior to strategies aimed at suppression of TNF activity in general. ..
  15. Yap G, Scharton Kersten T, Charest H, Sher A. Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo. J Immunol. 1998;160:1340-5 pubmed host defense to the intracellular parasite, Toxoplasma gondii, was investigated in mice lacking both the p55 and p75 receptors for this cytokine. Upon i.p...
  16. Eugster H, Frei K, Bachmann R, Bluethmann H, Lassmann H, Fontana A. Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1. Eur J Immunol. 1999;29:626-32 pubmed
    The individual role of tumor necrosis factor receptor 1 (TNFR1) and TNFR2 signaling in experimental autoimmune encephalomeylitis (EAE) was investigated using mice lacking TNFR1 (TNFR1-/-), TNFR2 (TNFR2-/-) as well as double receptor (..
  17. Monden Y, Kubota T, Inoue T, Tsutsumi T, Kawano S, Ide T, et al. Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2007;293:H743-53 pubmed
    ..TNF-alpha initiates its biological effects by binding two distinct receptors: R1 (p55) and R2 (p75)...
  18. Arnott C, Scott K, Moore R, Robinson S, Thompson R, Balkwill F. Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. Oncogene. 2004;23:1902-10 pubmed
    ..further insight into TNF-alpha signalling during skin tumour formation, mice deficient in TNFR1 (TNFR1-/- mice) or TNFR2 (TNFR2-/- mice) were subjected to chemical carcinogenesis...
  19. Yamada Y, Webber E, Kirillova I, Peschon J, Fausto N. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Hepatology. 1998;28:959-70 pubmed
    ..Inhibition of AP-1 and C/EBP binding and in the expression of c-jun and c-myc mRNA in the first 4 hours after PH, as well as the apparent lack of Fos in AP-1 complexes, had no effect on the timing or extent of DNA replication. ..
  20. Goukassian D, Qin G, Dolan C, Murayama T, Silver M, Curry C, et al. Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation. 2007;115:752-62 pubmed
    ..Little is known about the role of TNF-alpha receptors (TNFR1/p55 and TNFR2/p75) in angiogenic signaling...
  21. Brown G, Thiele D. Enhancement of MHC class I-stimulated alloresponses by TNF/TNF receptor (TNFR)1 interactions and of MHC class II-stimulated alloresponses by TNF/TNFR2 interactions. Eur J Immunol. 2000;30:2900-7 pubmed disease. The present studies were designed to evaluate whether TNF/TNF receptor (TNFR)1 and TNF/TNFR2 interactions were involved in the generation of allospecific T cell responses...
  22. Kassiotis G, Kollias G. Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination. J Exp Med. 2001;193:427-34 pubmed
    ..Thus, blocking the function of the p55 TNFR in autoimmune demyelination may inhibit the noxious proinflammatory activities of TNF without compromising its immunosuppressive properties. ..
  23. Zhao X, Mohaupt M, Jiang J, Liu S, Li B, Qin Z. Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis. Cancer Res. 2007;67:4443-50 pubmed
    ..Although most of its functions are attributed to TNF receptor 1 (TNFR1), the independent role of TNFR2 is still largely unknown...
  24. Steinhoff U, Brinkmann V, Klemm U, Aichele P, Seiler P, Brandt U, et al. Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells. Immunity. 1999;11:349-58 pubmed
    ..This report demonstrates that CD8 T cells with defined antigen specificity cause intestinal inflammation, emphasizing a link between infection and autoimmune disease. ..
  25. Stoelcker B, Hehlgans T, Weigl K, Bluethmann H, Grau G, Männel D. Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. Infect Immun. 2002;70:5857-9 pubmed
    Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue ..
  26. Hill G, Teshima T, Rebel V, Krijanovski O, Cooke K, Brinson Y, et al. The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. J Immunol. 2000;164:656-63 pubmed
    ..We have studied this question by comparing normal mice with those lacking the p55 (p55 TNFR-/-) or p75 (p75 TNFR-/-) TNF-alpha receptors as donors in well-defined bone marrow transplant (BMT) models...
  27. Calzascia T, Pellegrini M, Hall H, Sabbagh L, Ono N, Elford A, et al. TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice. J Clin Invest. 2007;117:3833-45 pubmed
    ..Here, we show a role for TNF-alpha and its receptors, TNFR1 and TNFR2, specifically in antitumor immunity...
  28. Peschon J, Torrance D, Stocking K, Glaccum M, Otten C, Willis C, et al. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol. 1998;160:943-52 pubmed
    ..cytokine TNF are mediated by two structurally related, but functionally distinct, receptors, p55 and p75, that are coexpressed on most cell types...
  29. Kim E, Teh H. Critical role of TNF receptor type-2 (p75) as a costimulator for IL-2 induction and T cell survival: a functional link to CD28. J Immunol. 2004;173:4500-9 pubmed
    ..In this study the role of p75 as a T cell costimulatory molecule in controlling cell fate during TCR/CD28-mediated stimulation was examined...
  30. Ortiz L, Lasky J, Lungarella G, Cavarra E, Martorana P, Banks W, et al. Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice. Am J Respir Cell Mol Biol. 1999;20:825-33 pubmed
    We have investigated a potential role for tumor necrosis factor (TNF)-alpha and its two receptors (p55 and p75) in lung injury. We used several varieties of mice exposed endotracheally to two fibrogenic agents, silica (0...
  31. Chen X, Bäumel M, Männel D, Howard O, Oppenheim J. Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. J Immunol. 2007;179:154-61 pubmed
    ..states, mouse peripheral CD4(+)CD25(+) T regulatory cells (Tregs) expressed remarkably higher surface levels of TNFR2 than CD4(+)CD25(-) T effector cells (Teffs)...
  32. Deckert Schlüter M, Bluethmann H, Rang A, Hof H, Schluter D. Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J Immunol. 1998;160:3427-36 pubmed
    ..its biologic activity through two distinct receptors, TNF receptor type 1 (TNFR1, p55) and TNF receptor type 2 (TNFR2, p75)...
  33. Kontoyiannis D, Pasparakis M, Pizarro T, Cominelli F, Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity. 1999;10:387-98 pubmed
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies. ..
  34. Mukhopadhyay A, Suttles J, Stout R, Aggarwal B. Genetic deletion of the tumor necrosis factor receptor p60 or p80 abrogates ligand-mediated activation of nuclear factor-kappa B and of mitogen-activated protein kinases in macrophages. J Biol Chem. 2001;276:31906-12 pubmed
    ..These effects are mediated through two different receptors, TNFR1 and TNFR2 (also called p60 and p80, respectively), with p60 receptor being expressed on all cell types and p80 receptor only ..
  35. Chen X, Wu X, Zhou Q, Howard O, Netea M, Oppenheim J. TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment. J Immunol. 2013;190:1076-84 pubmed publisher
    ..In this study, we found that the proportion of Tregs in mouse strains deficient in TNFR2 or its ligands was reduced in the thymus and peripheral lymphoid tissues, suggesting a potential role of TNFR2 in ..
  36. Lau K, Juchheim A, Cavaliere K, Philips S, Lauffenburger D, Haigis K. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-?-induced apoptosis and proliferation by MAPKs. Sci Signal. 2011;4:ra16 pubmed publisher
    ..This study lays a foundation for the use of systems-based approaches to understand how dysregulation of the cellular network state underlies complex diseases. ..
  37. Lacerda L, Somers S, Opie L, Lecour S. Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway. Cardiovasc Res. 2009;84:201-8 pubmed publisher
    ..05), whereas hearts from TNF(-/-) or TNFR2(-/-) failed to be postconditioned. TNF-PostC reduced IS by 37% (P < 0...
  38. Twu Y, Gold M, Teh H. TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells. Eur J Immunol. 2011;41:335-44 pubmed publisher
    ..We have shown that TNFR2 regulates T-cell activation by lowering the activation threshold and providing costimulatory signaling...
  39. Sacca R, Cuff C, Lesslauer W, Ruddle N. Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling. J Immunol. 1998;160:485-91 pubmed
    ..Secreted LT alpha3 can bind to two cell surface receptors, TNFR1 and TNFR2, while the membrane-bound heterotrimer LT alpha1beta2 has been shown to interact with a distinct receptor, LT ..
  40. McComb S, Cheung H, Korneluk R, Wang S, Krishnan L, Sad S. cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death Differ. 2012;19:1791-801 pubmed publisher
    ..These results show that cIAPs have an important role in limiting programmed necrosis of macrophages, which facilitates effective control of a pathogen. ..
  41. Luo D, Luo Y, He Y, Zhang H, Zhang R, Li X, et al. Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol. 2006;169:1886-98 pubmed
    We have previously shown that tumor necrosis factor (TNF) acts via its two receptors TNFR1 and TNFR2 to elicit distinct signaling pathways in vascular endothelial cells (ECs)...
  42. Hoffmann U, Bergler T, Rihm M, Pace C, Kruger B, Rümmele P, et al. Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection. Am J Transplant. 2009;9:675-86 pubmed publisher
    An important role of TNF interacting with TNFR2 has been shown in different models of ischemic, nephrotoxic and immune-mediated renal injury...
  43. Caulin C, Ware C, Magin T, Oshima R. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol. 2000;149:17-22 pubmed macrophages and T lymphocytes that acts through two distinct receptors, TNFR1 (60 kD, CD120a) and TNFR2 (80 kD, CD120b), to affect cellular proliferation, differentiation, survival, and cell death...
  44. Yang Y, Wang H, Dou Y, Wang Y, Han G, Wang R, et al. Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response. Clin Exp Immunol. 2011;165:372-82 pubmed publisher
    ..These findings suggest that either TNF-R1 or TNF-R2 plays a pathogenic role in the pathology of colitis and TNF signalling via TNF-R1 or TNF-R2 alone is not sufficient for inducing mucosal damage. ..
  45. Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel U. Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B path. J Biol Chem. 2004;279:32869-81 pubmed
    ..TNFR) exhibit antagonistic functions during neurodegenerative processes in vivo with TNFR1 aggravating and TNFR2 reducing neuronal cell loss, respectively...
  46. Turner S, La Gruta N, Stambas J, Diaz G, Doherty P. Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells. Proc Natl Acad Sci U S A. 2004;101:3545-50 pubmed
    ..Freshly isolated CD8(+)D(b)NP(366)(+) and CD8(+)D(b)PA(224)(+) T cells from influenza-infected TNFR2(-/-) mice produce higher levels of IFN-gamma and TNF-alpha after in vitro stimulation with peptide, although the ..
  47. Richter M, Topham D. The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection. J Immunol. 2007;179:5054-63 pubmed
    ..We propose that TNFR-II and the VLA-1 synergize to protect effector CD8 T cells in the infected airways from apoptosis during the acute infection. ..
  48. Suvannavejh G, Lee H, Padilla J, Dal Canto M, Barrett T, Miller S. Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis. Cell Immunol. 2000;205:24-33 pubmed
    ..of autoreactive effector cells, we assessed the roles of the p55 (TNFR1/Tnfrsf1a/CD120a) and p75 (TNFR2/Tnfrsf1b/CD120b) TNF receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE)...
  49. Woodfin A, Voisin M, Imhof B, Dejana E, Engelhardt B, Nourshargh S. Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood. 2009;113:6246-57 pubmed publisher
    ..Using a cell-transfer technique, transmigration responses of wild-type and TNF-alpha p55/p75 receptor-deficient leukocytes (TNFR(-/-)) through mouse cremasteric venules were quantified by fluorescence ..
  50. Meng Y, Beckett M, Liang H, Mauceri H, Van Rooijen N, Cohen K, et al. Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy. Cancer Res. 2010;70:1534-43 pubmed publisher
    ..Our findings offer a mechanistic basis to target macrophage populations generally or TNFalpha-induced macrophage VEGF specifically as tractable strategies to improve the efficacy of radiotherapy. ..
  51. Kurrelmeyer K, Michael L, Baumgarten G, Taffet G, Peschon J, Sivasubramanian N, et al. Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci U S A. 2000;97:5456-61 pubmed
    ..TTC) staining in wild-type (both TNF receptors present) and mice lacking either the type 1 (TNFR1), type 2 (TNFR2), or both TNF receptors (TNFR1/TNFR2)...
  52. Biragyn A, Coscia M, Nagashima K, Sanford M, Young H, Olkhanud P. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol. 2008;83:998-1008 pubmed publisher
    ..We demonstrate that mDF2beta triggers a TNFR2-mediated signaling cascade of "self-destruction" through up-regulation of membrane-bound TNF-alpha and TNFR2...
  53. Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G, et al. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol. 1998;153:801-13 pubmed