Gene Symbol: Tnfrsf1a
Description: tumor necrosis factor receptor superfamily, member 1a
Alias: CD120a, FPF, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNF-alphaR1, TNFAR, TNFR60, TNFRI, TNFRp55, TNFalpha-R1, Tnfr-2, Tnfr1, p55, p55-R, tumor necrosis factor receptor superfamily member 1A, TNF receptor alpha chain, TNF-RI, TNF-alpha-R1, TNFR-I, p60, tumor necrosis factor receptor 1, tumor necrosis factor receptor type I
Species: mouse
Products:     Tnfrsf1a

Top Publications

  1. Simon A, Park H, Maddipati R, Lobito A, Bulua A, Jackson A, et al. Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome. Proc Natl Acad Sci U S A. 2010;107:9801-6 pubmed publisher
    TNF, acting through p55 tumor necrosis factor receptor 1 (TNFR1), contributes to the pathogenesis of many inflammatory diseases...
  2. Calzascia T, Pellegrini M, Hall H, Sabbagh L, Ono N, Elford A, et al. TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice. J Clin Invest. 2007;117:3833-45 pubmed
    ..Here, we show a role for TNF-alpha and its receptors, TNFR1 and TNFR2, specifically in antitumor immunity...
  3. Cowley S, Sedgwick J, Elkins K. Differential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growth. J Immunol. 2007;179:7709-19 pubmed
  4. Garrett W, Lord G, Punit S, Lugo Villarino G, Mazmanian S, Ito S, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007;131:33-45 pubmed
    ..These findings reveal a novel function for T-bet as a peacekeeper of host-commensal relationships and provide new perspectives on the pathophysiology of IBD. ..
  5. Vondenhoff M, Greuter M, Goverse G, Elewaut D, Dewint P, Ware C, et al. LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. J Immunol. 2009;182:5439-45 pubmed publisher
    ..Furthermore, the same signals may regulate lymphangiogenesis to the lymph node through induction of VEGF-C. ..
  6. Baracchi F, Opp M. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun. 2008;22:982-93 pubmed publisher
    ..and responses to sleep deprivation of mice lacking both the IL-1 beta receptor 1 and TNFalpha receptor 1 (IL-1R1/TNFR1 KO)...
  7. Verri W, Guerrero A, Fukada S, Valerio D, Cunha T, Xu D, et al. IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice. Proc Natl Acad Sci U S A. 2008;105:2723-8 pubmed publisher
    ..IL-33 induced hypernociception in IL-18(-/-) mice but not in TNFR1(-/-) or IFNgamma(-/-) mice...
  8. Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, et al. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014;513:90-4 pubmed publisher
    ..developed independently of the microbiota and of MyD88 signalling but was partly rescued by TNFR1 (also known as TNFRSF1A) deficiency...
  9. Pronk C, Veiby O, Bryder D, Jacobsen S. Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors. J Exp Med. 2011;208:1563-70 pubmed publisher
    ..These effects of TNF involve two distinct TNF receptors. ..

More Information


  1. Quinones M, Kalkonde Y, Estrada C, Jimenez F, Ramirez R, Mahimainathan L, et al. Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Mol Cell Neurosci. 2008;37:96-109 pubmed
    ..Collectively, our data suggests that transgenic murine models of MS are useful to dissect mechanisms of disease and that in these models, up-regulation of chemokines and their receptors may be key determinants in TID. ..
  2. Twu Y, Gold M, Teh H. TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells. Eur J Immunol. 2011;41:335-44 pubmed publisher
    ..Therefore, in activated TNFR2(-/-) CD8(+) T cells, TNFR1 functions as a survival receptor by utilizing high intracellular levels of TRAF2 to promote I?B? phosphorylation ..
  3. Krautler N, Kana V, Kranich J, Tian Y, Perera D, Lemm D, et al. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell. 2012;150:194-206 pubmed publisher
    ..The ubiquity of preFDC and their strategic location at blood vessels may explain the de novo generation of organized lymphoid tissue at sites of lymphocytic inflammation...
  4. Kumari S, Bonnet M, Ulvmar M, Wolk K, Karagianni N, Witte E, et al. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity. 2013;39:899-911 pubmed publisher mice with epidermis-specific inhibition of the transcription factor NF-?B was triggered by TNF receptor 1 (TNFR1)-dependent upregulation of interleukin-24 (IL-24) and activation of signal transducer and activator of ..
  5. Chen X, Wu X, Zhou Q, Howard O, Netea M, Oppenheim J. TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment. J Immunol. 2013;190:1076-84 pubmed publisher
    ..This effect of TNF was blocked by anti-TNFR2 Ab, but not by anti-TNFR1 Ab. Furthermore, TNF was not able to maintain Foxp3 expression by TNFR2-deficient Tregs...
  6. Lau K, Juchheim A, Cavaliere K, Philips S, Lauffenburger D, Haigis K. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-?-induced apoptosis and proliferation by MAPKs. Sci Signal. 2011;4:ra16 pubmed publisher
    ..This study lays a foundation for the use of systems-based approaches to understand how dysregulation of the cellular network state underlies complex diseases. ..
  7. Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, et al. Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature. 2009;460:1159-63 pubmed publisher
    ..we identify riboflavin kinase (RFK, formerly known as flavokinase) as a previously unrecognized TNF-receptor-1 (TNFR1)-binding protein that physically and functionally couples TNFR1 to NADPH oxidase...
  8. McComb S, Cheung H, Korneluk R, Wang S, Krishnan L, Sad S. cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death Differ. 2012;19:1791-801 pubmed publisher
    ..These results show that cIAPs have an important role in limiting programmed necrosis of macrophages, which facilitates effective control of a pathogen. ..
  9. Chee J, Angstetra E, Mariana L, Graham K, Carrington E, Bluethmann H, et al. TNF receptor 1 deficiency increases regulatory T cell function in nonobese diabetic mice. J Immunol. 2011;187:1702-12 pubmed publisher
    ..However, when administered late, TNF decreases diabetes incidence and delays onset. TNFR1-deficient NOD mice were fully protected from diabetes and only showed mild peri-insulitis...
  10. Yang Y, Wang H, Dou Y, Wang Y, Han G, Wang R, et al. Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response. Clin Exp Immunol. 2011;165:372-82 pubmed publisher
    ..These findings suggest that either TNF-R1 or TNF-R2 plays a pathogenic role in the pathology of colitis and TNF signalling via TNF-R1 or TNF-R2 alone is not sufficient for inducing mucosal damage. ..
  11. Tang W, Lu Y, Tian Q, Zhang Y, Guo F, Liu G, et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science. 2011;332:478-84 pubmed publisher
    ..They also suggest new potential therapeutic interventions for various TNF?-mediated pathologies and conditions, including rheumatoid arthritis. ..
  12. Kovalenko A, Kim J, Kang T, Rajput A, Bogdanov K, Dittrich Breiholz O, et al. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med. 2009;206:2161-77 pubmed publisher
  13. Marchetti S, Gamas P, Belhacene N, Grosso S, Pradelli L, Colosetti P, et al. The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice. EMBO J. 2009;28:2449-60 pubmed publisher
    ..Our data identify a new role for Lyn as a regulator of psoriasis through its cleavage by caspases. ..
  14. Kapas L, Bohnet S, Traynor T, Majde J, Szentirmai E, Magrath P, et al. Spontaneous and influenza virus-induced sleep are altered in TNF-alpha double-receptor deficient mice. J Appl Physiol (1985). 2008;105:1187-98 pubmed publisher
    ..Results reinforce the hypothesis that TNF-alpha is involved in physiological sleep regulation but plays a limited role in the acute-phase response induced by influenza virus. ..
  15. Dong J, Jimi E, Zeiss C, Hayden M, Ghosh S. Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease. Genes Dev. 2010;24:1709-17 pubmed publisher
    ..Remarkably, crossing this strain with mice lacking TNF receptor 1 (TNFR1) leads to a complete rescue of the hyperinflammatory phenotype...
  16. Kajino Sakamoto R, Omori E, Nighot P, Blikslager A, Matsumoto K, Ninomiya Tsuji J. TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium. J Immunol. 2010;185:4729-37 pubmed publisher
    ..Thus, TAK1 signaling regulates ROS through transcription factor NF-E2-related factor 2, which is important for intestinal epithelial integrity...
  17. Biragyn A, Coscia M, Nagashima K, Sanford M, Young H, Olkhanud P. Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2. J Leukoc Biol. 2008;83:998-1008 pubmed publisher
    ..TNF-alpha or its receptors suggest that this is a NF-kappaB- and TNF-alpha-dependent process that does not require TNFR1. We demonstrate that mDF2beta triggers a TNFR2-mediated signaling cascade of "self-destruction" through up-..
  18. Mizoguchi E, Hachiya Y, Kawada M, Nagatani K, Ogawa A, Sugimoto K, et al. TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality. Gastroenterology. 2008;134:470-80 pubmed publisher
    ..Following DSS administration, mice lacking both RAG and TNFR1 exhibited a high mortality (>80%) rate with an impaired CEC regeneration compared with RAG KO and RAG x TNFR2 ..
  19. Ermolaeva M, Michallet M, Papadopoulou N, Utermöhlen O, Kranidioti K, Kollias G, et al. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol. 2008;9:1037-46 pubmed publisher
    b>Tumor necrosis factor receptor 1 (TNFR1) and Toll-like receptors (TLRs) regulate immune and inflammatory responses. Here we show that the TNFR1-associated death domain protein (TRADD) is critical in TNFR1, TLR3 and TLR4 signaling...
  20. Varfolomeev E, Goncharov T, Fedorova A, Dynek J, Zobel K, Deshayes K, et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol Chem. 2008;283:24295-9 pubmed publisher
    ..c-IAP1 and c-IAP2 are recruited to tumor necrosis factor receptor 1 (TNFR1)-associated complexes where they can regulate receptor-mediated signaling...
  21. Müller Hermelink N, Braumüller H, Pichler B, Wieder T, Mailhammer R, Schaak K, et al. TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis. Cancer Cell. 2008;13:507-18 pubmed publisher
    ..Through combined TNFR1 signaling and IFN-gamma signaling, Tag-specific CD4+ T cells induce antiangiogenic chemokines and prevent alpha(v)..
  22. Woodfin A, Voisin M, Imhof B, Dejana E, Engelhardt B, Nourshargh S. Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood. 2009;113:6246-57 pubmed publisher
    ..Using a cell-transfer technique, transmigration responses of wild-type and TNF-alpha p55/p75 receptor-deficient leukocytes (TNFR(-/-)) through mouse cremasteric venules were quantified by fluorescence ..
  23. Chen C, Pedraza P, Hao S, Stier C, Ferreri N. TNFR1-deficient mice display altered blood pressure and renal responses to ANG II infusion. Am J Physiol Renal Physiol. 2010;299:F1141-50 pubmed publisher
    The hypothesis that TNF receptor 1-deficient (TNFR1(-/-)) mice display blood pressure (BP) and renal functional responses that differ from wild-type (WT) mice was tested in an angiotensin II (ANG II)-dependent model of hypertension...
  24. Heikenwalder M, Prinz M, Zeller N, Lang K, Junt T, Rossi S, et al. Overexpression of lymphotoxin in T cells induces fulminant thymic involution. Am J Pathol. 2008;172:1555-70 pubmed publisher
    ..and receptor-ablated mice show that involution was not due to a T cell-autonomous defect but was triggered by TNFR1 and LTbetaR signaling to radioresistant stromal cells...
  25. Takaesu G, Inagaki M, Takubo K, Mishina Y, Hess P, Dean G, et al. TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms. PLoS ONE. 2012;7:e51073 pubmed publisher
    ..We found that Tnfr1 deficiency restored the reconstitution activity of Tak1 deficient bone marrow cells for 6-18 weeks...
  26. Armaka M, Apostolaki M, Jacques P, Kontoyiannis D, Elewaut D, Kollias G. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med. 2008;205:331-7 pubmed publisher
    ..Bone marrow grafting experiments demonstrated that development of arthritis requires TNF receptor I (TNFRI) expression in the radiation-resistant compartment, which is also known to be a sufficient target of TNF in the ..
  27. Zindl C, Kim T, Zeng M, Archambault A, Grayson M, Choi K, et al. The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function. Immunity. 2009;30:408-20 pubmed publisher
  28. Muller S, Rihs S, Schneider J, Paredes B, Seibold I, Brunner T, et al. Soluble TNF-alpha but not transmembrane TNF-alpha sensitizes T cells for enhanced activation-induced cell death. Eur J Immunol. 2009;39:3171-80 pubmed publisher
  29. Patel J, Williams J, Muccigrosso M, Liu L, Sun T, Rubin J, et al. Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS. Acta Neuropathol. 2012;124:847-60 pubmed publisher
    ..Activated astrocytes and microglia express both TNFR1 and TNFR2 within the demyelinated CC...
  30. Kajino Sakamoto R, Inagaki M, Lippert E, Akira S, Robine S, Matsumoto K, et al. Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol. 2008;181:1143-52 pubmed
    ..We propose that aberration in TAK1 signaling might disrupt intestinal homeostasis and favor the development of inflammatory disease. ..
  31. Constantin C, Mair N, Sailer C, Andratsch M, Xu Z, Blumer M, et al. Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. J Neurosci. 2008;28:5072-81 pubmed publisher
    ..type 2 (TNFR2) gene attenuated heat hyperalgesia and prevented TRPV1 upregulation in tumor-bearing mice, whereas TNFR1 gene deletion played a minor role...
  32. Alexander J, Jacob A, Cunningham P, Hensley L, Quigg R. TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1. Neurochem Int. 2008;52:447-56 pubmed
    In this study, we demonstrate that mice deficient in TNFR1 (TNFR1(-/-)) were resistant to LPS-induced encephalopathy...
  33. He S, Liang Y, Shao F, Wang X. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A. 2011;108:20054-9 pubmed publisher
    ..Taken together, these data indicate that there are multiple upstream necrosis-initiating signaling pathways converging on the RIP3 during an innate immune response to viral and bacterial infections in mammals. ..
  34. Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya Tsuji J. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood. 2012;120:3846-57 pubmed publisher
    ..Our results show that endothelial TAK1 signaling is important for 2 biologic processes in angiogenesis: inhibiting TNF-dependent endothelial cell death and promoting TNF-independent angiogenic cell migration. ..
  35. Hamid T, Gu Y, Ortines R, Bhattacharya C, Wang G, Xuan Y, et al. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation. Circulation. 2009;119:1386-97 pubmed publisher
    ..HF was induced in wild-type (WT), TNFR1(-/-), and TNFR2(-/-) mice via coronary ligation...
  36. Etemadi N, Holien J, Chau D, Dewson G, Murphy J, Alexander W, et al. Lymphotoxin ? induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. FEBS J. 2013;280:5283-97 pubmed publisher
    Both of the TNF superfamily ligands, TNF and LT?, can bind and signal through TNFR1 and TNFR2, yet mice mutant for each have different phenotypes...
  37. Ramesh V, Nair D, Zhang S, Hakim F, Kaushal N, Kayali F, et al. Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-? pathway. J Neuroinflammation. 2012;9:91 pubmed publisher
  38. Dong J, Jimi E, Zhong H, Hayden M, Ghosh S. Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms. Genes Dev. 2008;22:1159-73 pubmed publisher
    ..Therefore, unphosphorylated nuclear NF-kappaB can affect expression of genes not normally regulated by NF-kappaB through epigenetic mechanisms. ..
  39. Bonnet M, Preukschat D, Welz P, Van Loo G, Ermolaeva M, Bloch W, et al. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity. 2011;35:572-82 pubmed publisher
    ..Collectively, our findings provide an in vivo experimental paradigm that regulation of necroptosis in keratinocytes is important for the maintenance of immune homeostasis and the prevention of chronic inflammation in the skin. ..
  40. Xiao Y, Li H, Zhang J, Volk A, Zhang S, Wei W, et al. TNF-?/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations. Blood. 2011;118:6057-67 pubmed publisher
    ..We found that complete inactivation of TNF-? signaling by deleting both of its receptors, 1 and 2 (Tnfr1(-/-)r2(-/-)), can prevent the death of 30% to 40% of Tak1(-/-) HSPCs and partially repress the bone marrow failure ..
  41. Van Hauwermeiren F, Armaka M, Karagianni N, Kranidioti K, Vandenbroucke R, Loges S, et al. Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest. 2013;123:2590-603 pubmed publisher
    ..Both the antitumor and inflammatory effects of TNF are mediated by the TNF receptor p55 (p55TNFR) (encoded by the Tnfrsf1a gene)...
  42. Hensellek S, Brell P, Schaible H, Bräuer R, Segond von Banchet G. The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci. 2007;36:381-91 pubmed
    ..This TNFalpha effect was abolished in mice DRG neurones when DRG cultures were obtained from tnfr1/2-/- and tnfr1-/-, but not from tnfr2-/- mice...
  43. Taoufik E, Petit E, Divoux D, Tseveleki V, Mengozzi M, Roberts M, et al. TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proc Natl Acad Sci U S A. 2008;105:6185-90 pubmed publisher
    ..receptor (TNFR)I mediates neuroprotection by comparing the gene expression profiles of lesioned cortex from WT and TNFRI KO mice after permanent middle cerebral artery occlusion...
  44. Murthy A, Defamie V, Smookler D, Di Grappa M, Horiuchi K, Federici M, et al. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J Clin Invest. 2010;120:2731-44 pubmed publisher
    ..We demonstrated that TNF signaling promoted hepatotoxicity, while excessive TNF receptor 1 (TNFR1) shedding in Timp3-/- mice was protective...
  45. Guma M, Stepniak D, Shaked H, Spehlmann M, Shenouda S, Cheroutre H, et al. Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011;208:1889-900 pubmed publisher
    ..Inflammation is driven by massive TNF production, which requires additional activation of p38 and extracellular-signal-regulated kinase mitogen-activated protein kinases (MAPKs). ..
  46. Haas T, Emmerich C, Gerlach B, Schmukle A, Cordier S, Rieser E, et al. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009;36:831-44 pubmed publisher
    ..Finally, we demonstrate that sustained stability of the TNF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-RSC. ..
  47. Lai C, Shao J, Behrmann A, Krchma K, Cheng S, Towler D. TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts. Endocrinology. 2012;153:3897-910 pubmed publisher
    ..Aortic myofibroblasts from TNFR1(-/-) mice expressed levels of Msx2 that were 5% that of wild-type and were not inducible by TNF...
  48. Popivanova B, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, et al. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest. 2008;118:560-70 pubmed publisher
    ..AOM and DSS increased TNF-alpha expression and the number of infiltrating leukocytes expressing its major receptor, p55 (TNF-Rp55), in the lamina propria and submucosal regions of the colon...
  49. Shibata H, Yoshioka Y, Ohkawa A, Abe Y, Nomura T, Mukai Y, et al. The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models. Cytokine. 2008;44:229-33 pubmed publisher critically involved in a wide variety of inflammatory pathologies, such as hepatitis, via the TNF receptor-1 (TNFR1)...
  50. Vladimer G, Weng D, Paquette S, Vanaja S, Rathinam V, Aune M, et al. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity. 2012;37:96-107 pubmed publisher
    ..These studies reveal a role for NLRP12 in host resistance against pathogens. Minimizing NLRP12 inflammasome activation may have been a central factor in evolution of the high virulence of Y. pestis. ..
  51. Su L, Nalle S, Shen L, Turner E, Singh G, Breskin L, et al. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 2013;145:407-15 pubmed publisher
    ..intestinal permeability, epithelial expression of claudin-2, the long isoform of MLCK, and TNFR2 (but not TNFR1) and phosphorylation of the myosin II light chain...
  52. Dillon C, Weinlich R, Rodriguez D, Cripps J, Quarato G, Gurung P, et al. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell. 2014;157:1189-202 pubmed publisher
    ..functions in vitro to limit caspase-8-dependent, TNFR-induced apoptosis, and animals lacking RIPK1, RIPK3, and TNFR1 survive to adulthood...