Gene Symbol: Tmem30a
Description: transmembrane protein 30A
Alias: 2010200I23Rik, AW540225, Cdc50a, D9Wsu20e, cell cycle control protein 50A, P4-ATPase flippase complex beta subunit TMEM30A
Xu Q, Yang G, Liu N, Xu P, Chen Y, Zhou Z, et al
. P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth. FEBS Lett. 2012;586:1803-12 pubmed publisher
..Inducing the loss of function of CDC50A in hippocampal neurons via RNA interference reduced neurite outgrowth, and the co-overexpression of CDC50A and ..
Zhang L, Yang Y, Li S, Zhang S, Zhu X, Tai Z, et al
. Loss of Tmem30a leads to photoreceptor degeneration. Sci Rep. 2017;7:9296 pubmed publisher
..Folding and transporting of P4-ATPases to their cellular destination requires the ? subunit TMEM30A proteins. However, the in vivo functions of Tmem30a remain unknown...
Folmer D, Mok K, de Wee S, Duijst S, Hiralall J, Seppen J, et al
. Cellular localization and biochemical analysis of mammalian CDC50A, a glycosylated ?-subunit for P4 ATPases. J Histochem Cytochem. 2012;60:205-18 pubmed publisher
..This study analyzed the tissue distribution and cellular localization of CDC50A, the most abundant and ubiquitously expressed CDC50 homologue in the mouse...
Kato U, Inadome H, Yamamoto M, Emoto K, Kobayashi T, Umeda M. Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. J Biol Chem. 2013;288:4922-34 pubmed publisher
..ovary (CHO) cells, at least eight members of P4-ATPases were identified, but only a single CDC50 family protein, CDC50A, was expressed. We demonstrated that CDC50A associated with and recruited P4-ATPase ATP8A1 to the plasma membrane...
Segawa K, Kurata S, Yanagihashi Y, Brummelkamp T, Matsuda F, Nagata S. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014;344:1164-8 pubmed publisher
..Using a haploid genetic screen in human cells, we found that ATP11C (adenosine triphosphatase type 11C) and CDC50A (cell division cycle protein 50A) are required for aminophospholipid translocation from the outer to the inner ..
Liu L, Zhang L, Zhang L, Yang F, Zhu X, Lu Z, et al
. Hepatic Tmem30a Deficiency Causes Intrahepatic Cholestasis by Impairing Expression and Localization of Bile Salt Transporters. Am J Pathol. 2017;187:2775-2787 pubmed publisher
..Transmembrane protein 30A (TMEM30A), a ?-subunit, is essential for the function of ATP8B1 and ATP11C...