Gene Symbol: Tmbim1
Description: transmembrane BAX inhibitor motif containing 1
Alias: 2310061B02Rik, AA960455, AU024746, C78899, RECS1, Tmbib1, mKIAA4161, protein lifeguard 3, responsive to centrifugal force and shear stress gene 1 protein, transmembrane BAX inhibitor motif-containing protein 1
Species: mouse
Products:     Tmbim1

Top Publications

  1. Zhao H, Ito A, Sakai N, Matsuzawa Y, Yamashita S, Nojima H. RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation. Circ J. 2006;70:615-24 pubmed
    b>RECS1 is a mechanical stress responsive gene and RECS1 knockout (KO) mice (older than 14 months) are prone to cystic medial degeneration (CMD)...
  2. Zhao G, Zhang P, Gong J, Zhang X, Wang P, Yin M, et al. Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. Nat Med. 2017;23:742-752 pubmed publisher
    ..Here we report that transmembrane BAX inhibitor motif-containing 1 (TMBIM1) is an effective suppressor of steatohepatitis and a previously unknown regulator of the multivesicular body (MVB)-..
  3. Yoshisue H, Suzuki K, Kawabata A, Ohya T, Zhao H, Sakurada K, et al. Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library. Atherosclerosis. 2002;162:323-34 pubmed
  4. Zhao H, Ito A, Kimura S, Yabuta N, Sakai N, Ikawa M, et al. RECS1 deficiency in mice induces susceptibility to cystic medial degeneration. Genes Genet Syst. 2006;81:41-50 pubmed
    b>RECS1 is a novel shear stress-responsive gene that encodes a protein putatively forming seven-span transmembrane domains...