Tlr2

Summary

Gene Symbol: Tlr2
Description: toll-like receptor 2
Alias: Ly105, toll-like receptor 2
Species: mouse
Products:     Tlr2

Top Publications

  1. Beckett E, Phipps S, Starkey M, Horvat J, Beagley K, Foster P, et al. TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life. PLoS ONE. 2012;7:e39460 pubmed publisher
    ..We investigated the role of TLR2 and 4 in the induction of immune responses to Chlamydia muridarum respiratory infection, in neonatal wild-type (Wt) ..
  2. Oldenburg M, Krüger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, et al. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science. 2012;337:1111-5 pubmed publisher
    ..Thus, our results reveal both a natural TLR13 ligand and specific mechanisms of antibiotic resistance as potent bacterial immune evasion strategy, avoiding recognition via TLR13. ..
  3. Shirey K, Lai W, Scott A, Lipsky M, Mistry P, Pletneva L, et al. The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature. 2013;497:498-502 pubmed publisher
    ..CD14 and TLR2 are also required for Eritoran-mediated protection, and CD14 directly binds Eritoran and inhibits ligand binding to ..
  4. Haag L, Fischer A, Otto B, Plickert R, Kuhl A, Göbel U, et al. Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10-/- mice via Toll-like-receptor-2 and -4 signaling. PLoS ONE. 2012;7:e40761 pubmed publisher
    ..jejuni infection mimicking severe episodes of human campylobacteriosis and are thus well suited to further dissect mechanisms underlying Campylobacter infections in vivo. ..
  5. Matsumoto C, Oda T, Yokoyama S, Tominari T, Hirata M, Miyaura C, et al. Toll-like receptor 2 heterodimers, TLR2/6 and TLR2/1 induce prostaglandin E production by osteoblasts, osteoclast formation and inflammatory periodontitis. Biochem Biophys Res Commun. 2012;428:110-5 pubmed publisher
    b>TLR2 forms heterodimers with TLR1 and TLR6, and regulates host defense mechanisms against pathogens. We examined the role of TLR2 heterodimer signaling in osteoclast formation and inflammatory periodontitis...
  6. Lee G, Chang Y, Wu J, Wu M, Wu K, Yet S, et al. TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production. Arterioscler Thromb Vasc Biol. 2012;32:2751-60 pubmed publisher
    ..Gene deletion experiments implicate a role for toll-like receptor 2 (TLR2) in atherogenesis. However, the underlying mechanisms remain unclear...
  7. de Almeida L, Macedo G, Marinho F, Gomes M, Corsetti P, Silva A, et al. Toll-like receptor 6 plays an important role in host innate resistance to Brucella abortus infection in mice. Infect Immun. 2013;81:1654-62 pubmed publisher
    ..abortus. An in vitro luciferase assay indicated that TLR6 cooperates with TLR2 to sense Brucella and further activates NF-?B signaling...
  8. Ma Y, Zhang X, Bao H, Mi S, Cai W, Yan H, et al. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS ONE. 2012;7:e40763 pubmed publisher
    ..Two weeks later, the mice were treated with TLR2 or TLR4 neutralizing antibody...
  9. Nadatani Y, Watanabe T, Tanigawa T, Ohkawa F, Takeda S, Higashimori A, et al. High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products. PLoS ONE. 2013;8:e80130 pubmed publisher
    ..We also investigated which receptor among TLR2, TLR4, or RAGE mediates HMGB1's effects on ulcer healing...
  10. Jeon S, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, et al. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog. 2012;8:e1002714 pubmed publisher
    ..breve-induced development of IL-10-producing T cells. CD103(+) DCs from Il10(-/-), Tlr2(-/-), and Myd88(-/-) mice showed defective B. breve-induced Tr1 cell development. B...

Detail Information

Publications62

  1. Beckett E, Phipps S, Starkey M, Horvat J, Beagley K, Foster P, et al. TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life. PLoS ONE. 2012;7:e39460 pubmed publisher
    ..We investigated the role of TLR2 and 4 in the induction of immune responses to Chlamydia muridarum respiratory infection, in neonatal wild-type (Wt) ..
  2. Oldenburg M, Krüger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, et al. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science. 2012;337:1111-5 pubmed publisher
    ..Thus, our results reveal both a natural TLR13 ligand and specific mechanisms of antibiotic resistance as potent bacterial immune evasion strategy, avoiding recognition via TLR13. ..
  3. Shirey K, Lai W, Scott A, Lipsky M, Mistry P, Pletneva L, et al. The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature. 2013;497:498-502 pubmed publisher
    ..CD14 and TLR2 are also required for Eritoran-mediated protection, and CD14 directly binds Eritoran and inhibits ligand binding to ..
  4. Haag L, Fischer A, Otto B, Plickert R, Kuhl A, Göbel U, et al. Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10-/- mice via Toll-like-receptor-2 and -4 signaling. PLoS ONE. 2012;7:e40761 pubmed publisher
    ..jejuni infection mimicking severe episodes of human campylobacteriosis and are thus well suited to further dissect mechanisms underlying Campylobacter infections in vivo. ..
  5. Matsumoto C, Oda T, Yokoyama S, Tominari T, Hirata M, Miyaura C, et al. Toll-like receptor 2 heterodimers, TLR2/6 and TLR2/1 induce prostaglandin E production by osteoblasts, osteoclast formation and inflammatory periodontitis. Biochem Biophys Res Commun. 2012;428:110-5 pubmed publisher
    b>TLR2 forms heterodimers with TLR1 and TLR6, and regulates host defense mechanisms against pathogens. We examined the role of TLR2 heterodimer signaling in osteoclast formation and inflammatory periodontitis...
  6. Lee G, Chang Y, Wu J, Wu M, Wu K, Yet S, et al. TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production. Arterioscler Thromb Vasc Biol. 2012;32:2751-60 pubmed publisher
    ..Gene deletion experiments implicate a role for toll-like receptor 2 (TLR2) in atherogenesis. However, the underlying mechanisms remain unclear...
  7. de Almeida L, Macedo G, Marinho F, Gomes M, Corsetti P, Silva A, et al. Toll-like receptor 6 plays an important role in host innate resistance to Brucella abortus infection in mice. Infect Immun. 2013;81:1654-62 pubmed publisher
    ..abortus. An in vitro luciferase assay indicated that TLR6 cooperates with TLR2 to sense Brucella and further activates NF-?B signaling...
  8. Ma Y, Zhang X, Bao H, Mi S, Cai W, Yan H, et al. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS ONE. 2012;7:e40763 pubmed publisher
    ..Two weeks later, the mice were treated with TLR2 or TLR4 neutralizing antibody...
  9. Nadatani Y, Watanabe T, Tanigawa T, Ohkawa F, Takeda S, Higashimori A, et al. High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products. PLoS ONE. 2013;8:e80130 pubmed publisher
    ..We also investigated which receptor among TLR2, TLR4, or RAGE mediates HMGB1's effects on ulcer healing...
  10. Jeon S, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, et al. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog. 2012;8:e1002714 pubmed publisher
    ..breve-induced development of IL-10-producing T cells. CD103(+) DCs from Il10(-/-), Tlr2(-/-), and Myd88(-/-) mice showed defective B. breve-induced Tr1 cell development. B...
  11. Saeed A, Duffort S, Ivanov D, Wang H, Laird J, Salomon R, et al. The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages. PLoS ONE. 2014;9:e106421 pubmed publisher
    ..We found that CEP specifically synergizes with low-dose TLR2-agonists (but not agonists for other TLRs) to induce production of inflammatory cytokines...
  12. Mudaliar H, Pollock C, Komala M, Chadban S, Wu H, Panchapakesan U. The role of Toll-like receptor proteins (TLR) 2 and 4 in mediating inflammation in proximal tubules. Am J Physiol Renal Physiol. 2013;305:F143-54 pubmed publisher
    ..b>TLR2 and 4 are present in proximal tubular cells and are activated by endogenous ligands upregulated in diabetic ..
  13. Cruz Guilloty F, Saeed A, Duffort S, Cano M, Ebrahimi K, Ballmick A, et al. T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. PLoS ONE. 2014;9:e88201 pubmed publisher
    ..Finally, T cell immunosuppressive therapy inhibited CEP-mediated pathology. These data indicate that T cells and M1 macrophages activated by oxidative damage cooperate in AMD pathogenesis. ..
  14. Lin H, Yan J, Wang Z, Hua F, Yu J, Sun W, et al. Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice. Hepatology. 2013;57:171-82 pubmed publisher
    ..Targeting of Toll-like receptor (TLR) 2 attenuates tumor metastases; we hypothesized that blocking TLR2 might also play a crucial role in reducing hepatocarcinogenesis...
  15. Tye H, Kennedy C, Najdovska M, McLeod L, MCCORMACK W, Hughes N, et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell. 2012;22:466-78 pubmed publisher
    ..Genetic and therapeutic targeting of TLR2 inhibited gastric tumorigenesis, but not inflammation, characterized by reduced proliferation and increased ..
  16. Aleyas A, Han Y, Patil A, Kim S, Kim K, Eo S. Impaired cross-presentation of CD8?+ CD11c+ dendritic cells by Japanese encephalitis virus in a TLR2/MyD88 signal pathway-dependent manner. Eur J Immunol. 2012;42:2655-66 pubmed publisher
    ..Finally, this study provides evidence that TLR2-MyD88 and p38 MAPK signal pathway might be involved in JEV-mediated inhibition of cross-presentation of soluble and ..
  17. Mercier B, Ventre E, Fogeron M, Debaud A, Tomkowiak M, Marvel J, et al. NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells. PLoS ONE. 2012;7:e42170 pubmed publisher
    ..Recently, we and others have demonstrated that TLR2 can additionally function as a costimulatory receptor on CD8 T cells...
  18. Gaddis D, Maynard C, Weaver C, Michalek S, Katz J. Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-? T cell response to Porphyromonas gingivalis. J Leukoc Biol. 2013;93:21-31 pubmed publisher
    ..g. into the circulation. As IL-10 and TLR2 are pivotal molecules in the immune response that P.g...
  19. Yuan Z, Panchal D, Syed M, Mehta H, Joo M, Hadid W, et al. Induction of cyclooxygenase-2 signaling by Stomatococcus mucilaginosus highlights the pathogenic potential of an oral commensal. J Immunol. 2013;191:3810-7 pubmed publisher
    ..Presence of TLR2 was necessary for induction of COX-2 and production of PGE? by S. mucilaginosus...
  20. He X, Nair A, Mekasha S, Alroy J, O Connell C, Ingalls R. Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation. PLoS ONE. 2011;6:e20846 pubmed publisher
    ..Data from the female mouse model of genital tract chlamydia infection suggests a requirement for TLR2-dependent signaling in the induction of inflammation and oviduct pathology...
  21. Miggin S, Palsson McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, et al. NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A. 2007;104:3372-7 pubmed
    ..However, we found that Mal was cleaved by caspase-1 and that inhibition of caspase-1 activity blocked TLR2- and TLR4-mediated NF-kappaB and p38 MAP kinase activation but not IL-1 or TLR7 signaling, which are Mal ..
  22. Boivin A, Pineau I, Barrette B, Filali M, Vallières N, Rivest S, et al. Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci. 2007;27:12565-76 pubmed
    ..In addition, significantly fewer macrophages were recruited and/or activated in the sciatic nerve distal stump of TLR2-, TLR4-, and MyD88-deficient mice compared with wild-type littermates, whereas WD, axonal regeneration, and ..
  23. Abplanalp A, Morris I, Parida B, Teale J, Berton M. TLR-dependent control of Francisella tularensis infection and host inflammatory responses. PLoS ONE. 2009;4:e7920 pubmed publisher
    ..Recent studies have implicated TLR2 as a critical element in the host protective response to F...
  24. Knapp S, Wieland C, Van T Veer C, Takeuchi O, Akira S, Florquin S, et al. Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J Immunol. 2004;172:3132-8 pubmed
    Toll-like receptors (TLR) are crucial pattern recognition receptors in innate immunity. The importance of TLR2 in host defense against Gram-positive bacteria has been suggested by the fact that this receptor recognizes major Gram-positive ..
  25. Derbigny W, Kerr M, Johnson R. Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines. J Immunol. 2005;175:6065-75 pubmed
    ..RT-PCR assays detected mRNA for TLR2 (TLRs 1 and 6), TLR3, and TLR5. No mRNA was detected for TLRs 4, 7, 8, and 9...
  26. Frasnelli M, Tarussio D, Chobaz Péclat V, Busso N, So A. TLR2 modulates inflammation in zymosan-induced arthritis in mice. Arthritis Res Ther. 2005;7:R370-9 pubmed
    ..in murine zymosan-induced arthritis (ZIA) in the light of recent data on the roles of Toll-like receptor 2 (TLR2) and Dectin-1 in the activation of monocyte/macrophages by zymosan...
  27. Balloy V, Si Tahar M, Takeuchi O, Philippe B, Nahori M, Tanguy M, et al. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Infect Immun. 2005;73:5420-5 pubmed
    ..fumigatus infection. In the current study, we looked for the involvement of Toll-like receptor 2 (TLR2) in the recognition of A...
  28. Vabulas R, Braedel S, Hilf N, Singh Jasuja H, Herter S, Ahmad Nejad P, et al. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J Biol Chem. 2002;277:20847-53 pubmed
    ..different Toll-like receptors (TLRs) and with bone marrow-derived dendritic cells from mice lacking functional TLR2 and/or TLR4 molecules...
  29. Morr M, Takeuchi O, Akira S, Simon M, Muhlradt P. Differential recognition of structural details of bacterial lipopeptides by toll-like receptors. Eur J Immunol. 2002;32:3337-47 pubmed
    ..two long-chain fatty acids in their lipid moiety, in that lipopeptides with three fatty acids were recognized by TLR2, whereas those with two long-chain fatty acids and lipoteichoic acid required the additional cooperation with TLR6; ..
  30. Li Y, Li H, Zhang Y, Sun X, Hanley G, Lesage G, et al. Toll-like receptor 2 is required for opioids-induced neuronal apoptosis. Biochem Biophys Res Commun. 2010;391:426-30 pubmed publisher
    Toll-like receptor 2 (TLR2), a key immune receptor in the TLR family, is widely expressed in various systems, including the immune and nervous systems and plays a critical role in controlling innate and adaptive immune responses...
  31. Cario E, Gerken G, Podolsky D. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology. 2007;132:1359-74 pubmed
    ..The aim of this study was to determine the functional relevance of TLR2 to control tight junction (TJ)-associated intestinal epithelial barrier integrity to balance mucosal homeostasis ..
  32. Heimesaat M, Fischer A, Siegmund B, Kupz A, Niebergall J, Fuchs D, et al. Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS ONE. 2007;2:e662 pubmed
    ..microflora during colitis is limited, we performed a global survey of the colon flora of C57BL/10 wild-type (wt), TLR2(-/-), TLR4(-/-), and TLR2/4(-/-) mice treated for seven days with 3.5% dextrane-sulfate-sodium (DSS)...
  33. Da Costa C, Wantia N, Kirschning C, Busch D, Rodriguez N, Wagner H, et al. Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Eur J Immunol. 2004;34:2874-84 pubmed
    ..In conclusion, HSP60 from C. pneumoniae triggers inflammatory responses in vivo that differ from responses induced by endotoxin or CpG oligonucleotides and are dependent on TLR2 and 4.
  34. Santos Sierra S, Deshmukh S, Kalnitski J, Küenzi P, Wymann M, Golenbock D, et al. Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J. 2009;28:2018-27 pubmed publisher
    ..b>TLR2-dependent signalling is currently believed to essentially require both adaptor proteins MyD88 (myeloid ..
  35. Salminen A, Vuolteenaho R, Paananen R, Ojaniemi M, Hallman M. Surfactant protein A modulates the lipopolysaccharide-induced inflammatory response related to preterm birth. Cytokine. 2011;56:442-9 pubmed publisher
    ..We conclude that SP-A modulates the levels of intrauterine inflammatory mediators involved in preterm birth and may contribute to inflammatory processes related to spontaneous preterm labor. ..
  36. Abdollahi Roodsaz S, Joosten L, Koenders M, Devesa I, Roelofs M, Radstake T, et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest. 2008;118:205-16 pubmed
    ..Here, we show that TLR2 and TLR4, but not TLR9, are involved in the pathogenesis of autoimmune arthritis and play distinct roles in the ..
  37. Schulte D, Yilmaz A, Shimada K, Fishbein M, Lowe E, Chen S, et al. Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease. J Immunol. 2009;183:5311-8 pubmed publisher
    ..These studies are consistent with the interpretation that macrophages and DCs may collaborate with T cells in the pathological mechanisms of coronary arteritis. ..
  38. Quigley M, Martinez J, Huang X, Yang Y. A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood. 2009;113:2256-64 pubmed publisher
    ..In this study, we showed that direct TLR2-myeloid differentiating factor 88 (MyD88) signaling in CD8 T cells was also required for their efficient clonal ..
  39. Fan J, Li Y, Vodovotz Y, Billiar T, Wilson M. Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2006;290:L738-L746 pubmed
    ..PMN) in alveolar macrophage (AMphi) priming, specifically, the role in mediating Toll-like receptor (TLR)4 and TLR2 cross talk in AMphi...
  40. Coban C, Ishii K, Kawai T, Hemmi H, Sato S, Uematsu S, et al. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med. 2005;201:19-25 pubmed
    ..Such responses were severely impaired in TLR9-/- and myeloid differentiation factor 88 (MyD88)-/-, but not in TLR2, TLR4, TLR7, or Toll/interleukin 1 receptor domain-containing adaptor-inducing interferon beta-/- mice...
  41. Shi X, Zekki H, Zhang J. The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response. Glia. 2011;59:231-41 pubmed publisher
    ..We sought to determine whether peripheral nerve injury could induce the expression of TLR2 on the site of injury-damaged nerves and/or in the central nervous system and to investigate whether TLR2 is ..
  42. Nahori M, Fournié Amazouz E, Que Gewirth N, Balloy V, Chignard M, Raetz C, et al. Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells. J Immunol. 2005;175:6022-31 pubmed
    ..This bacterium possesses an unusual LPS that has been shown to use TLR2 instead of TLR4 for signaling in human cells. The structure of its lipid A was recently deciphered...
  43. Kenny E, Talbot S, Gong M, Golenbock D, Bryant C, O Neill L. MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3. J Immunol. 2009;183:3642-51 pubmed publisher
    ..adaptor-like (Mal, or TIRAP) in TLR4 signaling has been demonstrated, there is limited information on its role in TLR2 signaling...
  44. Vanhoutte F, Breuilh L, Fontaine J, Zouain C, Mallevaey T, Vasseur V, et al. Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology. Microbes Infect. 2007;9:1606-13 pubmed
    ..That Schistosoma mansoni eggs activate myeloid DCs through TLR2 and TLR3 has been shown by us and others, but the consequences of this combined activation are still unknown...
  45. Fikrig E, Narasimhan S, Neelakanta G, Pal U, Chen M, Flavell R. Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks. J Infect Dis. 2009;200:1331-40 pubmed publisher
  46. Letiembre M, Echchannaoui H, Bachmann P, Ferracin F, Nieto C, Espinosa M, et al. Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytes. Infect Immun. 2005;73:8397-401 pubmed
    ..and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2-/-) polymorphonuclear leukocytes (PMN)...
  47. Banaiee N, Kincaid E, Buchwald U, Jacobs W, Ernst J. Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol. 2006;176:3019-27 pubmed
    ..tuberculosis 19-kDa lipoprotein inhibits induction of selected IFN-gamma-responsive genes through a TLR2-dependent pathway, whereas peptidoglycan inhibits responses to IFN-gamma by a TLR2-independent pathway...
  48. Favre J, Musette P, Douin Echinard V, Laude K, Henry J, Arnal J, et al. Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2007;27:1064-71 pubmed
    ..adhesion is a critical event in endothelial injury induced by ischemia/reperfusion (I/R), we assessed whether TLR2 were involved in I/R-induced coronary endothelial injury...
  49. Reiling N, Holscher C, Fehrenbach A, Kröger S, Kirschning C, Goyert S, et al. Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol. 2002;169:3480-4 pubmed
    ..tuberculosis infection has remained unexplored in vivo. To address this issue, we infected mice defective in CD14, TLR2, or TLR4 with M. tuberculosis by aerosol...
  50. Viriyakosol S, Matthias M, Swancutt M, Kirkland T, Vinetz J. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 2006;74:887-95 pubmed
    ..Peritoneal macrophages from CD14-/- and TLR2-/- mice exhibited no defect in cytokine responses to Leptospira compared to controls...
  51. Suliman H, Welty Wolf K, Carraway M, Schwartz D, Hollingsworth J, Piantadosi C. Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. FASEB J. 2005;19:1531-3 pubmed
    ..In wild-type (Wt) mice injected with heat-inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR-dependent increases in transcript levels for tumor necrosis factor (TNF-alpha), ..
  52. Copin R, De Baetselier P, Carlier Y, Letesson J, Muraille E. MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection. J Immunol. 2007;178:5182-91 pubmed
    ..Taken together, our results provide new insight into how immune responses fight Brucella infection. ..
  53. Tang S, Arumugam T, Xu X, Cheng A, Mughal M, Jo D, et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A. 2007;104:13798-803 pubmed
    ..We now report that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-gamma stimulation and energy deprivation...
  54. Joosten L, Koenders M, Smeets R, Heuvelmans Jacobs M, Helsen M, Takeda K, et al. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J Immunol. 2003;171:6145-53 pubmed
    ..Since agonists of the Toll-like pathway are abundantly involved in both septic and rheumatoid arthritis, targeting of MyD88 may be a novel therapy in inflammatory joint diseases. ..
  55. Nozaki N, Shishido T, Takeishi Y, Kubota I. Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice. Circulation. 2004;110:2869-74 pubmed
    ..05). These findings suggest that TLR-2 may play a role in the regulation of inflammatory and apoptotic mediators in the heart after Dox administration. ..
  56. Wang Q, McLoughlin R, Cobb B, Charrel Dennis M, Zaleski K, Golenbock D, et al. A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J Exp Med. 2006;203:2853-63 pubmed
    ..Synergy between the innate and adaptive responses was also shown when TLR2-/- mice exhibited impaired intraabdominal abscess formation in response to B. fragilis...
  57. Dennehy K, Ferwerda G, Faro Trindade I, Pyz E, Willment J, Taylor P, et al. Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol. 2008;38:500-6 pubmed publisher
    ..fungal beta-glucan receptor, Dectin-1, which collaborates through an undefined mechanism with Toll-like receptor 2 (TLR2) to induce optimal cytokine responses in macrophages...
  58. Zhang M, Gao Y, Du X, Zhang D, Ji M, Wu G. Toll-like receptor (TLR) 2 and TLR4 deficiencies exert differential in vivo effects against Schistosoma japonicum. Parasite Immunol. 2011;33:199-209 pubmed publisher
    Little is known about the functions of Toll-like receptor 2 (TLR2) and TLR4 in innate/acquired responses to Schistosoma japonicum. Through in vivo study, the contributions of TLR2 and TLR4 to host immune responses during S...
  59. Roux A, Ray A, Pawlik A, Medjahed H, Etienne G, Rottman M, et al. Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants. Cell Microbiol. 2011;13:692-704 pubmed publisher
    ..In conclusion, R morphotype in M. abscessus is associated with increased synthesis/exposure at the cell surface of lipoproteins, these changes profoundly modifying the innate immune response through TLR-2-dependent mechanisms...
  60. Obonyo M, Sabet M, Cole S, Ebmeyer J, Uematsu S, Akira S, et al. Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. Infect Immun. 2007;75:2408-14 pubmed
    ..pylori infection, bone marrow-derived macrophages from mice deficient in TLR2, TLR4, TLR9, and MyD88 were infected with H. pylori SS1 and SD4 for 24 or 48 h...
  61. Imanishi T, Hara H, Suzuki S, Suzuki N, Akira S, Saito T. Cutting edge: TLR2 directly triggers Th1 effector functions. J Immunol. 2007;178:6715-9 pubmed
    ..In mouse Th1 cells the stimulation by TLR2 but not by other TLRs directly induced IFN-gamma production, cell proliferation, and cell survival without TCR ..
  62. Netea M, Sutmuller R, Hermann C, Van der Graaf C, Van der Meer J, van Krieken J, et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol. 2004;172:3712-8 pubmed
    Toll-like receptor (TLR) 2 and TLR4 play a pivotal role in recognition of Candida albicans. We demonstrate that TLR2(-/-) mice are more resistant to disseminated Candida infection, and this is associated with increased chemotaxis and ..