Gene Symbol: Tlk
Description: tousled-like kinase 2 (Arabidopsis)
Alias: 4933403M19Rik, PKU-alpha, PKUalpha, Tlk, serine/threonine-protein kinase tousled-like 2, protein kinase U-alpha
Species: mouse
Products:     Tlk

Top Publications

  1. Shalom S, Don J. Tlk, a novel evolutionarily conserved murine serine threonine kinase, encodes multiple testis transcripts. Mol Reprod Dev. 1999;52:392-405 pubmed
    ..The new murine gene was designated accordingly Tlk (Tousled like kinase). Tousled like kinase sequences have been reported to occur in C. elegans and in the human...
  2. Zhang S, Xing H, Muslin A. Nuclear localization of protein kinase U-alpha is regulated by 14-3-3. J Biol Chem. 1999;274:24865-72 pubmed
    ..The coding sequence of the human form (protein kinase Ualpha, PKUalpha) of this protein kinase was found in GenBank(TM) on the basis of sequence homology...
  3. Silljé H, Takahashi K, Tanaka K, Van Houwe G, Nigg E. Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. EMBO J. 1999;18:5691-702 pubmed
    ..Drug-induced inhibition of DNA replication causes a rapid loss of Tlk activity, indicating that Tlk function is tightly linked to ongoing DNA replication...