Timp1

Summary

Gene Symbol: Timp1
Description: tissue inhibitor of metalloproteinase 1
Alias: Clgi, EPA, TIMP-1, TPA-S1, Timp, metalloproteinase inhibitor 1, TPA-induced protein, collagenase inhibitor 16C8 fibroblast, erythroid-potentiating activity, tissue inhibitor of metalloproteinases 1
Species: mouse
Products:     Timp1

Top Publications

  1. Althoff G, Wolfer D, Timmesfeld N, Kanzler B, Schrewe H, Pagenstecher A. Long-term expression of tissue-inhibitor of matrix metalloproteinase-1 in the murine central nervous system does not alter the morphological and behavioral phenotype but alleviates the course of experimental allergic encephalomyelitis. Am J Pathol. 2010;177:840-53 pubmed publisher
    ..In the central nervous system (CNS), TIMPs 2, 3, and 4 are constitutively expressed at high levels, whereas TIMP1 can be induced by various stimuli...
  2. Misra S, Shergill U, Yang B, Janardhanan R, Misra K. Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency. J Vasc Interv Radiol. 2010;21:1255-61 pubmed publisher
    ..and its receptors (VEGFR-1, -2); matrix metalloproteinase-2 (MMP-2), -9 (MMP-9); tissue inhibitor of metalloproteinase-1, -2 (TIMP-1, -2); and a disintegrin and metalloproteinase thrombospondin-1 (ADAMTS-1) at the venous stenosis.
  3. Moore C, Milner R, Nishiyama A, Frausto R, Serwanski D, Pagarigan R, et al. Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination. J Neurosci. 2011;31:6247-54 pubmed publisher
    Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an extracellular protein and endogenous regulator of matrix metalloproteinases (MMPs) secreted by astrocytes in response to CNS myelin injury...
  4. Ardi V, Van Den Steen P, Opdenakker G, Schweighofer B, Deryugina E, Quigley J. Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway. J Biol Chem. 2009;284:25854-66 pubmed publisher
    ..activity of the generated MMP-9 enzyme were critically dependent on the tissue inhibitor of metalloproteinase (TIMP)-free status of the zymogen...
  5. De Vries M, Niessen H, Lowik C, Hamming J, Jukema J, Quax P. Plaque rupture complications in murine atherosclerotic vein grafts can be prevented by TIMP-1 overexpression. PLoS ONE. 2012;7:e47134 pubmed publisher
    ..and plaque rupture, we hypothesized that this model can be validated by overexpression of the MMP inhibitor TIMP-1...
  6. Fujimoto M, Takagi Y, Aoki T, Hayase M, Marumo T, Gomi M, et al. Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia. J Cereb Blood Flow Metab. 2008;28:1674-85 pubmed publisher
    ..and MMP-9, and the TIMPs family after 30 mins of middle cerebral artery occlusion, and elucidated the function of TIMP-1 and TIMP-2 in focal ischemia, using TIMP-1(-/-) and TIMP-2(-/-) mice...
  7. Lee M, Yoon B, Osiewicz K, Preston M, Bundy B, van Heeckeren A, et al. Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect Immun. 2005;73:661-5 pubmed
    Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections...
  8. Crocker S, Whitmire J, Frausto R, Chertboonmuang P, Soloway P, Whitton J, et al. Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. Am J Pathol. 2006;169:2104-16 pubmed
    ..In experimental autoimmune encephalomyelitis (EAE), TIMP-1 gene expression is induced in astrocytes surrounding inflammatory lesions in the CNS...
  9. Ould Yahoui A, Tremblay E, Sbai O, Ferhat L, Bernard A, Charrat E, et al. A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons. PLoS ONE. 2009;4:e8289 pubmed publisher
    Tissue inhibitor of metalloproteinases-1 (TIMP-1) displays pleiotropic activities, both dependent and independent of its inhibitory activity on matrix metalloproteinases (MMPs)...
  10. Fata J, Leco K, Moorehead R, Martin D, Khokha R. Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development. Dev Biol. 1999;211:238-54 pubmed
    ..We have delineated the spatiotemporal expression of all Timps (Timp-1 to Timp-4) during discrete phases of murine mammary development...

Detail Information

Publications100

  1. Althoff G, Wolfer D, Timmesfeld N, Kanzler B, Schrewe H, Pagenstecher A. Long-term expression of tissue-inhibitor of matrix metalloproteinase-1 in the murine central nervous system does not alter the morphological and behavioral phenotype but alleviates the course of experimental allergic encephalomyelitis. Am J Pathol. 2010;177:840-53 pubmed publisher
    ..In the central nervous system (CNS), TIMPs 2, 3, and 4 are constitutively expressed at high levels, whereas TIMP1 can be induced by various stimuli...
  2. Misra S, Shergill U, Yang B, Janardhanan R, Misra K. Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency. J Vasc Interv Radiol. 2010;21:1255-61 pubmed publisher
    ..and its receptors (VEGFR-1, -2); matrix metalloproteinase-2 (MMP-2), -9 (MMP-9); tissue inhibitor of metalloproteinase-1, -2 (TIMP-1, -2); and a disintegrin and metalloproteinase thrombospondin-1 (ADAMTS-1) at the venous stenosis.
  3. Moore C, Milner R, Nishiyama A, Frausto R, Serwanski D, Pagarigan R, et al. Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination. J Neurosci. 2011;31:6247-54 pubmed publisher
    Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an extracellular protein and endogenous regulator of matrix metalloproteinases (MMPs) secreted by astrocytes in response to CNS myelin injury...
  4. Ardi V, Van Den Steen P, Opdenakker G, Schweighofer B, Deryugina E, Quigley J. Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway. J Biol Chem. 2009;284:25854-66 pubmed publisher
    ..activity of the generated MMP-9 enzyme were critically dependent on the tissue inhibitor of metalloproteinase (TIMP)-free status of the zymogen...
  5. De Vries M, Niessen H, Lowik C, Hamming J, Jukema J, Quax P. Plaque rupture complications in murine atherosclerotic vein grafts can be prevented by TIMP-1 overexpression. PLoS ONE. 2012;7:e47134 pubmed publisher
    ..and plaque rupture, we hypothesized that this model can be validated by overexpression of the MMP inhibitor TIMP-1...
  6. Fujimoto M, Takagi Y, Aoki T, Hayase M, Marumo T, Gomi M, et al. Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia. J Cereb Blood Flow Metab. 2008;28:1674-85 pubmed publisher
    ..and MMP-9, and the TIMPs family after 30 mins of middle cerebral artery occlusion, and elucidated the function of TIMP-1 and TIMP-2 in focal ischemia, using TIMP-1(-/-) and TIMP-2(-/-) mice...
  7. Lee M, Yoon B, Osiewicz K, Preston M, Bundy B, van Heeckeren A, et al. Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect Immun. 2005;73:661-5 pubmed
    Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections...
  8. Crocker S, Whitmire J, Frausto R, Chertboonmuang P, Soloway P, Whitton J, et al. Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. Am J Pathol. 2006;169:2104-16 pubmed
    ..In experimental autoimmune encephalomyelitis (EAE), TIMP-1 gene expression is induced in astrocytes surrounding inflammatory lesions in the CNS...
  9. Ould Yahoui A, Tremblay E, Sbai O, Ferhat L, Bernard A, Charrat E, et al. A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons. PLoS ONE. 2009;4:e8289 pubmed publisher
    Tissue inhibitor of metalloproteinases-1 (TIMP-1) displays pleiotropic activities, both dependent and independent of its inhibitory activity on matrix metalloproteinases (MMPs)...
  10. Fata J, Leco K, Moorehead R, Martin D, Khokha R. Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development. Dev Biol. 1999;211:238-54 pubmed
    ..We have delineated the spatiotemporal expression of all Timps (Timp-1 to Timp-4) during discrete phases of murine mammary development...
  11. Chaillan F, Rivera S, Marchetti E, Jourquin J, Werb Z, Soloway P, et al. Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice. Behav Brain Res. 2006;173:191-8 pubmed
    Tissue inhibitor of metalloproteinases (TIMP-1) is one of the four-member family (TIMPs-1-4) of multifunctional proteins that inhibit matrix metalloproteinases (MMPs)...
  12. Sbai O, Ferhat L, Bernard A, Gueye Y, Ould Yahoui A, Thiolloy S, et al. Vesicular trafficking and secretion of matrix metalloproteinases-2, -9 and tissue inhibitor of metalloproteinases-1 in neuronal cells. Mol Cell Neurosci. 2008;39:549-68 pubmed publisher
    ..Nothing is known about MMP/TIMP trafficking and secretion in neuronal cells...
  13. Ogier C, Creidy R, Boucraut J, Soloway P, Khrestchatisky M, Rivera S. Astrocyte reactivity to Fas activation is attenuated in TIMP-1 deficient mice, an in vitro study. BMC Neurosci. 2005;6:68 pubmed
    Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a multifunctional secreted protein with pleiotropic actions, including the inhibition of matrix metalloproteinases (MMPs), cell death/survival and growth promoting activities...
  14. Martin D, Fowlkes J, Babic B, Khokha R. Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1. J Cell Biol. 1999;146:881-92 pubmed
    ..Using a double transgenic murine hepatic tumor model, we demonstrate that tissue inhibitor of metalloproteinase 1 (TIMP-1) blocks liver hyperplasia during tumor development, despite TAg-mediated reactivation of IGF-II...
  15. Jourquin J, Tremblay E, Bernard A, Charton G, Chaillan F, Marchetti E, et al. Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory. Eur J Neurosci. 2005;22:2569-78 pubmed
    The tissue inhibitor of metalloproteinases-1 (TIMP-1) belongs to a family of multifunctional proteins that inhibit matrix metalloproteinases (MMPs), but also regulate cell growth, proliferation, migration and apoptosis in non-nervous ..
  16. Martin D, Ruther U, Sanchez Sweatman O, Orr F, Khokha R. Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice. Oncogene. 1996;13:569-76 pubmed
    ..To investigate whether the TIMP-1 expressed in a host tissue suppresses cancer in vivo and to identify the affected stages, we developed transgenic ..
  17. Mohammed F, Pennington C, Kassiri Z, Rubin J, Soloway P, Ruther U, et al. Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology. 2005;41:857-67 pubmed
    ..We have previously demonstrated that TIMP-1 inhibits preneoplastic hepatocyte proliferation by attenuating growth factor bioavailability...
  18. Soloway P, Alexander C, Werb Z, Jaenisch R. Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. Oncogene. 1996;13:2307-14 pubmed
    b>Timp-1 has been implicated as a suppressor of tumor metastasis...
  19. Nothnick W, Soloway P, Curry T. Pattern of messenger ribonucleic acid expression of tissue inhibitors of metalloproteinases (TIMPs) during testicular maturation in male mice lacking a functional TIMP-1 gene. Biol Reprod. 1998;59:364-70 pubmed
    ..Tissue inhibitor of metalloproteinase (TIMP)-1 regulates ECM turnover and has been reported to stimulate Leydig cell steroidogenesis...
  20. Rouis M, Adamy C, Duverger N, Lesnik P, Horellou P, Moreau M, et al. Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipoprotein E-deficient mice. Circulation. 1999;100:533-40 pubmed
    ..the impact of adenovirus-mediated elevation in the circulating levels of human tissue inhibitor of MMP (TIMP-1) in atherosclerosis-susceptible apolipoprotein E-deficient (apoE(-/-)) mice...
  21. Kheradmand F, Rishi K, Werb Z. Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. J Cell Sci. 2002;115:839-48 pubmed
    ..MT1-MMP is, in turn, necessary for activation of MMP-2, a mesenchymal enzyme that is required for normal lung morphogenesis. ..
  22. Nothnick W, Soloway P, Curry T. Assessment of the role of tissue inhibitor of metalloproteinase-1 (TIMP-1) during the periovulatory period in female mice lacking a functional TIMP-1 gene. Biol Reprod. 1997;56:1181-8 pubmed
    Tissue inhibitor of metalloproteinase (TIMP)-1 is a multifunctional peptide that has been implicated in the ovulatory process...
  23. Welser Alves J, Crocker S, Milner R. A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli. J Neuroinflammation. 2011;8:61 pubmed publisher
    ..As such, it is important to define the TIMP expression profile in these cells, as well as the mechanisms of regulation by neuroinflammatory stimuli...
  24. Sager H, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, et al. Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015;132:1880-90 pubmed publisher
    ..The presented insight into post-MI bone marrow activation identifies a mechanistic target for muting inflammation in the ischemically damaged heart. ..
  25. Schelter F, Halbgewachs B, Bäumler P, Neu C, Gorlach A, Schrötzlmair F, et al. Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1?. Clin Exp Metastasis. 2011;28:91-9 pubmed publisher
    ..of this network, for instance caused by elevated host levels of tissue inhibitor of metalloproteinases-1 (TIMP-1), have been shown to increase the susceptibility of target organs to scattered metastasis by inducing the ..
  26. Paul S, Sharma A, Mahapatra P, Bhattacharya P, Reiter R, Swarnakar S. Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis. J Pineal Res. 2008;44:439-49 pubmed publisher
    ..varying degrees of severity were examined for expression of MMPs and tissue inhibitors of metalloproteinase (TIMP)-1. In addition, endometriosis was generated in mice and endometriotic tissues were tested for MMP-9 activity...
  27. Aoki T, Kataoka H, Moriwaki T, Nozaki K, Hashimoto N. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Stroke. 2007;38:2337-45 pubmed
    ..Tissue inhibitor of matrix metalloproteinase (TIMP) regulates the ECM degradation in vascular walls by inhibiting the activity of matrix metalloproteinases (MMPs)...
  28. Roten L, Nemoto S, Simsic J, Coker M, Rao V, Baicu S, et al. Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. J Mol Cell Cardiol. 2000;32:109-20 pubmed
    ..One of the better characterized TIMPs, TIMP-1, has been shown to bind to active MMPs and to regulate the MMP activational process...
  29. Behrendtsen O, Werb Z. Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos. Dev Dyn. 1997;208:255-65 pubmed
    ..blastocysts, we found that inhibitors of metalloproteinases, specifically, tissue inhibitor of metalloproteinases (TIMP)-1 and a peptide hydroxamic acid stimulated outgrowth and differentiation of PE from ICMs cultured on fibronectin, ..
  30. Di Gregoli K, George S, Jackson C, Newby A, Johnson J. Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte/macrophage invasion. Cardiovasc Res. 2016;109:318-30 pubmed publisher
    ..We therefore investigated the impact of TIMP-1 and TIMP-2 knockout on atherosclerotic plaque burden and composition in apolipoprotein E-knockout (Apoe(-/-)) ..
  31. Fowell A, Collins J, Duncombe D, Pickering J, Rosenberg W, Benyon R. Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation. Biochem Biophys Res Commun. 2011;407:277-82 pubmed publisher
    ..of liver fibrosis through the secretion of fibrillar collagens and the tissue inhibitors of metalloproteinase (TIMP)-1 and -2...
  32. Johnson M, Housey G, Kirschmeier P, Weinstein I. Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C. Mol Cell Biol. 1987;7:2821-9 pubmed
    ..6 X 10(3) that exhibits homology with sequences representing a protein with human erythroid-potentiating activity and protease inhibitory activity. ..
  33. Nothnick W. Tissue inhibitor of metalloproteinase-1 (TIMP-1) deficient mice display reduced serum progesterone levels during corpus luteum development. Endocrinology. 2003;144:5-8 pubmed
    b>TIMP-1 is a multifunctional protein that is abundantly expressed within the ovary during the period of early corpus luteum formation. TIMP-1 has been suggested to play a role in progesterone production, but reports are conflicting...
  34. Song M, Song Z, Barve S, Zhang J, Chen T, Liu M, et al. Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis. J Pharmacol Exp Ther. 2008;325:409-16 pubmed publisher
    ..The protective mechanism seems to be independent of oxidative stress. Our data provide further evidence that TM might be a potential therapy for hepatic fibrosis. ..
  35. Joronen K, Salminen H, Glumoff V, Savontaus M, Vuorio E. Temporospatial expression of tissue inhibitors of matrix metalloproteinases-1, -2 and -3 during development, growth and aging of the mouse skeleton. Histochem Cell Biol. 2000;114:157-65 pubmed
    ..To better understand the roles of TIMP-1, -2 and -3, we have studied their mRNA levels in several different mouse tissues with special emphasis on the ..
  36. Ryu J, Vicencio A, Yeager M, Kashgarian M, Haddad G, Eickelberg O. Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Thromb Haemost. 2005;94:175-83 pubmed
    ..pattern of matrix metalloproteases (MMP) and their inhibitors, the tissue inhibitors of metalloproteases (TIMP), in human and mouse lung development...
  37. Rosahl T, Spillane D, Missler M, Herz J, Selig D, Wolff J, et al. Essential functions of synapsins I and II in synaptic vesicle regulation. Nature. 1995;375:488-93 pubmed
  38. Smith L, Wagner T, Huizar I, Schnapp L. uPARAP expression during murine lung development. Gene Expr Patterns. 2008;8:486-93 pubmed publisher
    ..Finally, we compared lung development between wild-type and uPARAP(-/-) mice, and found no significant histologic differences, indicating the presence of alternative collagen degradation pathways during murine lung development. ..
  39. Vaillant B, Chiaramonte M, Cheever A, Soloway P, Wynn T. Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases. J Immunol. 2001;167:7017-26 pubmed
    ..matrix metalloproteases (MMP) -2, -3, -9, -12, and -13 and their inhibitors, tissue inhibitor of metalloproteases (TIMP) -1, -2, and -3, in the livers of infected mice and correlated their expression profiles with fibrosis and type 2 ..
  40. Wang J, Gao Y, Ma M, Li M, Zou D, Yang J, et al. Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice. Cell Biochem Biophys. 2013;67:537-46 pubmed publisher
    ..whether miR-21 was involved in diabetic nephropathy and to explore the relationship between miR-21 and MMP9/TIMP1 expression in diabetic nephropathy...
  41. Hall M, Young D, Waters J, Rowan A, Chantry A, Edwards D, et al. The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. J Biol Chem. 2003;278:10304-13 pubmed
    ..The reciprocal effect of TGF-beta on the expression of Timp-1 and MMP-1 supports its role in matrix anabolism, yet the mechanisms by which TGF-beta induces Timp-1 and ..
  42. Perugorria M, Murphy L, Fullard N, Chakraborty J, Vyrla D, Wilson C, et al. Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice. Hepatology. 2013;57:1238-49 pubmed publisher
    ..HSCs were unable to increase expression of fibrogenic genes IL-1? and tissue inhibitor of metalloproteinase 1 (TIMP-1), with the latter being the result of defective stimulation of TIMP-1 promoter activity by TLRs...
  43. Harslund J, Nielsen O, Brunner N, Offenberg H. Gender-dependent physiological implications of combined PAI-1 and TIMP-1 gene deficiency characterized in a mouse model. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1630-9 pubmed
    ..inhibitors plasminogen activator inhibitor type 1 (PAI-1) and tissue inhibitor of metalloproteinase type 1 (TIMP-1) are two distinct proteins with separate molecular pathways...
  44. Li S, Guo J, Wu J, Sun Z, Han M, Shan S, et al. miR-17 targets tissue inhibitor of metalloproteinase 1 and 2 to modulate cardiac matrix remodeling. FASEB J. 2013;27:4254-65 pubmed publisher
    ..miR-17 targeted the 3'-UTR of TIMP2 and the protein coding region of TIMP1. The miR-17 mimic decreased TIMP2 (P<0.01) and TIMP1 (P<0...
  45. Kim Y, Remacle A, Chernov A, Liu H, Shubayev I, Lai C, et al. The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration. PLoS ONE. 2012;7:e33664 pubmed publisher
    ..of the data, we determined that an endogenous, specific MMP-9 inhibitor [tissue inhibitor of metalloproteinases (TIMP)-1] was a top up-regulated gene in the injured nerve...
  46. Ridnour L, Dhanapal S, Hoos M, Wilson J, Lee J, Cheng R, et al. Nitric oxide-mediated regulation of ?-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem. 2012;123:736-49 pubmed publisher
    ..Regulation of MMP-9 and its endogenous inhibitor tissue inhibitor of metalloproteinase (TIMP)-1 by nitric oxide (NO) has been shown...
  47. Fjære E, Andersen C, Myrmel L, Petersen R, Hansen J, Tastesen H, et al. Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice. PLoS ONE. 2015;10:e0132910 pubmed publisher
    ..or absence of TIMP-1 affected the development of diet-induced glucose intolerance and hepatic steatosis using the Timp1 null mice...
  48. Kobuch J, Cui H, Grünwald B, Saftig P, Knolle P, Krüger A. TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice. Haematologica. 2015;100:1005-13 pubmed publisher
    ..We previously found that elevated systemic levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) induce an increase of neutrophils in the liver, which in turn strongly promotes liver metastasis...
  49. Crocker S, Frausto R, Whitmire J, Benning N, Milner R, Whitton J. Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1. Am J Pathol. 2007;171:1762-73 pubmed
    ..We show herein that TIMP-1 expression is induced in the myocardium by CVB3 infection...
  50. Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, et al. Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities. PLoS ONE. 2014;9:e103839 pubmed publisher
    Tissue inhibitor of metalloproteinases-1 (TIMP-1) regulates the extracellular matrix turnover by inhibiting the proteolytic activity of matrix metalloproteinases (MMPs)...
  51. Kopitz C, Gerg M, Gansbacher B, Krüger A. Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver. Hum Gene Ther. 2008;19:1039-49 pubmed publisher
    ..In the clinic, elevated expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) is often associated with increased aggressiveness of cancer...
  52. Grant S, Chapman V. Detailed genetic mapping of the A-raf proto-oncogene on the mouse X chromosome. Oncogene. 1991;6:397-402 pubmed
    ..We find that A-raf co-localizes with two other active genes, tissue inhibitor of metalloproteinases (Timp) and synapsin (Syn-1), 4.0 +/- 2...
  53. Bednarek N, Clément Y, Lelievre V, Olivier P, Loron G, Garnotel R, et al. Ontogeny of MMPs and TIMPs in the murine neocortex. Pediatr Res. 2009;65:296-300 pubmed publisher
    ..Here, our objective was to obtain comprehensive and comparative data on the ontogeny of MMP-2, MMP-9, TIMP-1, and TIMP-2 in the neocortex of male and female mice belonging to various strains, from embryonic life to ..
  54. Zhang X, Hoang E, Nothnick W. Estrogen-induced uterine abnormalities in TIMP-1 deficient mice are associated with elevated plasmin activity and reduced expression of the novel uterine plasmin protease inhibitor serpinb7. Mol Reprod Dev. 2009;76:160-72 pubmed publisher
    Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a multifunctional protein capable of regulating a variety of biological processes in a wide array of tissue and cell types...
  55. Guo L, Luo X, Xie H, Zhou H, Yuan L, Wang M, et al. Tissue inhibitor of matrix metalloproteinase-1 suppresses apoptosis of mouse bone marrow stromal cell line MBA-1. Calcif Tissue Int. 2006;78:285-92 pubmed
    We investigated the action of tissue inhibitor of metalloproteinase-1 (TIMP-1) on apoptosis and differentiation of mouse bone marrow stromal cell line MBA-1...
  56. Flenniken A, Campbell C, Williams B. Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. Matrix Suppl. 1992;1:275-80 pubmed
    We have identified elements in the 5' region of the murine tissue inhibitor of metalloproteinase (TIMP) gene which control the response to serum, phorbol esters and transforming growth factor beta (TGF-beta) in cell culture...
  57. Ye Q, van Amerongen M, Sandham J, Bank R, van Luyn M, Harmsen M. Site-specific tissue inhibitor of metalloproteinase-1 governs the matrix metalloproteinases-dependent degradation of crosslinked collagen scaffolds and is correlated with interleukin-10. J Tissue Eng Regen Med. 2011;5:264-74 pubmed publisher
    ..Interestingly, the major MMP inhibitor TIMP-1 was solely observed in subcutaneous implants, which is why MMP-13 and MMP-2 are not able to degrade the collagen ..
  58. Ikenaka Y, Yoshiji H, Kuriyama S, Yoshii J, Noguchi R, Tsujinoue H, et al. Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1 transgenic mouse model. Int J Cancer. 2003;105:340-6 pubmed
    The tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) has been recognized as a multifunctional protein...
  59. Foronjy R, Imai K, Shiomi T, Mercer B, Sklepkiewicz P, Thankachen J, et al. The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. Am J Pathol. 2010;177:598-607 pubmed publisher
    ..In contrast, SFRP1 activated ERK and up-regulated MMP1 and MMP9 without altering TIMP1 production when expressed in human lung epithelial cells...
  60. Zhang Y, Chen X, Wu D, Zhang X, Lu Y, Shi S, et al. Expression of tissue inhibitor of matrix metalloproteinase-1 in aging of transgenic mouse liver. Chin Med J (Engl). 2006;119:504-9 pubmed
    Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) is related to the aging of many organs, but few data are available on the change of TIMP-1 in liver aging...
  61. Merciris D, Schiltz C, Legoupil N, Marty Morieux C, De Vernejoul M, Geoffroy V. Over-expression of TIMP-1 in osteoblasts increases the anabolic response to PTH. Bone. 2007;40:75-83 pubmed
    ..We had shown previously that mice over-expressing TIMP-1 (tissue inhibitor of MMPs) specifically in osteoblasts display an increase in bone mineral density and bone mass ..
  62. Vannella K, Barron L, Borthwick L, Kindrachuk K, Narasimhan P, Hart K, et al. Incomplete deletion of IL-4R? by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. PLoS Pathog. 2014;10:e1004372 pubmed publisher
  63. Jackson H, Hojilla C, Weiss A, Sanchez O, Wood G, Khokha R. Timp3 deficient mice show resistance to developing breast cancer. PLoS ONE. 2015;10:e0120107 pubmed publisher
    ..Together our data is the first to identify a tumor promoting role of endogenous Timp3 in vivo, the spatial and temporal windows of this effect, and its dependence on Tnfr1. ..
  64. Coulombe B, Ponton A, Kerbel R, Skup D. Structure and function of murine TIMP gene. Matrix Suppl. 1992;1:269-74 pubmed
    Specific inhibitors of metalloproteinases, such as TIMP, are potential regulators of tissue integrity...
  65. Derry J, Barnard P. Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes. Genomics. 1992;12:632-8 pubmed
    ..the neuron-specific phosphoprotein synapsin I (SYN1), the glycoprotein tissue inhibitor of metalloproteinases (TIMP), the proto-oncogene A-raf-1 (ARAF1), and properdin (PFC), a positive regulator of the alternative pathway of human ..
  66. Yoshiba N, Yoshiba K, Hosoya A, Saito M, Yokoi T, Okiji T, et al. Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development. Cell Tissue Res. 2007;330:133-45 pubmed
    ..In this study, we analyzed and compared the distribution patterns of TIMP-2 and periostin during mouse mandible development...
  67. Zhou J, Stohlman S, Atkinson R, Hinton D, Marten N. Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection. J Virol. 2002;76:7374-84 pubmed
    ..increased levels of MMP-3 and MMP-12 mRNAs as well as that of tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) compared to sublethal infection...
  68. Disteche C, Zacksenhaus E, Adler D, Bressler S, Keitz B, Chapman V. Mapping and expression of the ubiquitin-activating enzyme E1 (Ube1) gene in the mouse. Mamm Genome. 1992;3:156-61 pubmed
    ..the Ube1 gene in interspecific backcrosses between Mus spretus and C57BL/6 shows that the Ube1 locus maps close to Timp, in a conserved region of the mouse and human X Chrs that include Otc, Cybb, Syn1, Timp, and Araf...
  69. Derry J, Lan N, Shih J, Barnard E, Barnard P. Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 1989;17:8403 pubmed
  70. Kadri Z, Maouche Chretien L, Rooke H, Orkin S, Romeo P, Mayeux P, et al. Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol. 2005;25:7412-22 pubmed
    ..In erythroid cells, expression of the tissue inhibitor of matrix metalloproteinase (TIMP-1) is strictly dependent on erythropoietin...
  71. Cocuzzi E, Walther S, Rajan S, Denhardt D. Expression and purification of mouse TIMP-1 from E. coli. FEBS Lett. 1992;307:375-8 pubmed
    ..We have expressed a cDNA clone of mouse TIMP-1 as a 22-kDa protein with 12 cysteine residues in E...
  72. Meier H, Bullinger J, Deten A, Marx G, Rabald S, Zimmer H, et al. Tissue inhibitor of matrix metalloproteinase-1 in norepinephrine-induced remodeling of the mouse heart. Cell Physiol Biochem. 2007;20:825-36 pubmed
    ..Varying concentrations, time and the addition of a neutralizing TIMP-1 antibody were evaluated...
  73. Gewert D, Coulombe B, Castelino M, Skup D, Williams B. Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse. EMBO J. 1987;6:651-7 pubmed
    A genomic clone encompassing the entire coding region of a murine gene homologous to human erythroid potentiating activity/tissue inhibitor of metalloproteinase (EPA/TIMP) was isolated and sequenced...
  74. Osawa Y, Hoshi M, Yasuda I, Saibara T, Moriwaki H, Kozawa O. Tumor necrosis factor-? promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells. PLoS ONE. 2013;8:e65251 pubmed publisher
    ..Tissue inhibitor of metalloproteinase (TIMP)-1 plays a crucial role in the pathogenesis of liver fibrosis...
  75. Böhmer R, Neuhaus B, Bühren S, Zhang D, Stehling M, Böck B, et al. Regulation of developmental lymphangiogenesis by Syk(+) leukocytes. Dev Cell. 2010;18:437-49 pubmed publisher
    ..This mechanism does not involve circulating endothelial progenitor cells and demonstrates the potential of hematopoietic cells to control developmental lymphangiogenesis. ..
  76. Kim B, Abdel Rahman M, Wang T, Pouly S, Mahmoud A, Cebulla C. Retinal MMP-12, MMP-13, TIMP-1, and TIMP-2 expression in murine experimental retinal detachment. Invest Ophthalmol Vis Sci. 2014;55:2031-40 pubmed publisher
    ..Gene expression of Mmp-12 and Mmp-13, and Timp-1 was strongly upregulated at all time points in RD compared with controls...
  77. Stetler Stevenson W. Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. J Clin Invest. 1999;103:1237-41 pubmed
  78. Zhou H, Zhang X, Nothnick W. Disruption of the TIMP-1 gene product is associated with accelerated endometrial gland formation during early postnatal uterine development. Biol Reprod. 2004;71:534-9 pubmed
    ..The objective of the present study was to examine the role of tissue inhibitor of metalloproteinase-1 (TIMP-1), a regulator of tissue remodeling events, during postnatal uterine development and to assess the phenotypic ..
  79. Harslund J, Frees D, Leifsson P, Offenberg H, Rømer M, Brunner N, et al. The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice. Pathog Dis. 2013;68:96-104 pubmed publisher
    ..In addition, double-gene knockout mice did not differ from wild-type mice in white blood cell, granulocyte and leucocyte counts, while single-gene genotypes differed in these phenotypes. ..
  80. Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, et al. Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury. Am J Pathol. 2014;184:3001-12 pubmed publisher
    ..We conclude that hepatocytes and bile ducts or ductules are important sources of ductular reaction and that the intrahepatic biliary system undergoes remarkable remodeling in response to chronic liver injury. ..
  81. Zanotti L, Angioni R, Calì B, Soldani C, Ploia C, Moalli F, et al. Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1. Leukemia. 2016;30:1143-54 pubmed publisher
    ..The proteomic analysis of the MSC secretome identified the tissue inhibitor of metalloproteinase-1 (TIMP-1) as a potential effector molecule responsible for the anti-angiogenic properties of MSC...
  82. Campbell C, Flenniken A, Skup D, Williams B. Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene. J Biol Chem. 1991;266:7199-206 pubmed
    Tissue inhibitor of metalloproteinase (TIMP) is one of a family of metalloproteinase inhibitors and a major interstitial inhibitor of collagenase...
  83. Jiang P, Chen C, Liu X, Pleasure D, Liu Y, Deng W. Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion. Cell Rep. 2016;15:1303-15 pubmed publisher
    ..We further identified TIMP-1 as a selectively upregulated component secreted from immature hiPSC-Astros...
  84. Nishino K, Yamanouchi K, Naito K, Tojo H. Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry. Dev Growth Differ. 2002;44:35-43 pubmed
    ..cells migrating into male gonads, and inhibited expression of the tissue inhibitor of metalloproteinases (TIMP)-3 gene, which is the endogenous inhibitor of matrix metalloproteinases (MMP)...
  85. English J, Kassiri Z, Koskivirta I, Atkinson S, Di Grappa M, Soloway P, et al. Individual Timp deficiencies differentially impact pro-MMP-2 activation. J Biol Chem. 2006;281:10337-46 pubmed
    ..through the formation of a trimolecular complex comprised of MT1-MMP/tissue inhibitor of metalloproteinase-2 (TIMP-2)/pro-MMP-2...
  86. Chapman V, Stephenson D, Mullins L, Keitz B, Disteche C, Orkin S. Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice. Genomics. 1991;9:309-13 pubmed
    ..A gene order of centromere, DXWas70, Cybb/Gf-1, Otc, Timp was established for the mouse X chromosome, which is in agreement with the map position observed on the human X ..
  87. Nakashima A, Tamura M. Regulation of matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1 gene expression by WNT3A and bone morphogenetic protein-2 in osteoblastic differentiation. Front Biosci. 2006;11:1667-78 pubmed
    ..In contrast, TIMP-1 mRNA expression was suppressed by BMP-2 in Wnt3a-C2C12 cells but not in Wnt5a-C2C12 cells...
  88. Li L, Chin L, Shupliakov O, Brodin L, Sihra T, Hvalby O, et al. Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. Proc Natl Acad Sci U S A. 1995;92:9235-9 pubmed
    ..These results provide strong support for the hypothesis that synapsin I plays a key role in the regulation of nerve terminal function in mature synapses. ..
  89. Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia. 2011;54:1468-79 pubmed publisher
    ..We therefore sought to define the role of TIMP1 in adipogenesis and to elucidate whether upregulation of TIMP1 in obesity has direct effects on adipocyte ..
  90. Ikonomidis J, Gibson W, Butler J, McClister D, Sweterlitsch S, Thompson R, et al. Effects of deletion of the tissue inhibitor of matrix metalloproteinases-1 gene on the progression of murine thoracic aortic aneurysms. Circulation. 2004;110:II268-73 pubmed
    ..We hypothesized that removal of the primary endogenous aortic MMP inhibitor (TIMP) through TIMP-1 gene deletion will increase TAA progression...
  91. Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B. Biglycan and decorin differentially regulate signaling in the fetal membranes. Matrix Biol. 2014;35:266-75 pubmed publisher
  92. Blavier L, DeClerck Y. Tissue inhibitor of metalloproteinases-2 is expressed in the interstitial matrix in adult mouse organs and during embryonic development. Mol Biol Cell. 1997;8:1513-27 pubmed
    Tissue inhibitor of metalloproteinases-2 (TIMP-2) is a member of a family of inhibitors of matrix-degrading metalloproteinases...
  93. Cameron S, Ture S, Mickelsen D, Chakrabarti E, Modjeski K, McNitt S, et al. Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion. Circulation. 2015;132:47-58 pubmed publisher
    ..Platelet ERK5 may be a target for acute therapeutic intervention in the thrombotic and inflammatory post-MI environment. ..
  94. Eskandari M, Vijungco J, Flores A, Borensztajn J, Shively V, Pearce W. Enhanced abdominal aortic aneurysm in TIMP-1-deficient mice. J Surg Res. 2005;123:289-93 pubmed
    ..The aim of this study was to show that, in an elastase-induced murine model of aneurysm formation, TIMP-1 has a protective effect...