Gene Symbol: Timm44
Description: translocase of inner mitochondrial membrane 44
Alias: 0710005E20Rik, D8Ertd118e, Mimt44, Tim44, mitochondrial import inner membrane translocase subunit TIM44, translocator of inner mitochondrial membrane 44, translocator of inner mitochondrial membrane 44; DNA segment, Chr 8, ERATO Doi 118, expressed
Ahting U, Floss T, Uez N, Schneider Lohmar I, Becker L, Kling E, et al
. Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim Biophys Acta. 2009;1787:371-6 pubmed publisher
..Haploinsufficiency of the Tim23 mutation underlines the critical role of the mitochondrial import machinery for maintaining mitochondrial function...
Wada J, Kanwar Y. Characterization of mammalian translocase of inner mitochondrial membrane (Tim44) isolated from diabetic newborn mouse kidney. Proc Natl Acad Sci U S A. 1998;95:144-9 pubmed
..homology with any known genes; however, at the amino acid level, it had 50% similarity and 29% identity with yeast Tim44. C-terminal FLAG epitope-tagged mTim44 fusion protein was transiently expressed in COS7 cells...
Bauer M, Gempel K, Reichert A, Rappold G, Lichtner P, Gerbitz K, et al
. Genetic and structural characterization of the human mitochondrial inner membrane translocase. J Mol Biol. 1999;289:69-82 pubmed
..cerevisiae, translocation of preproteins into the matrix requires the membrane proteins Tim23, Tim17 and Tim44, which drive translocation in cooperation with mtHsp70 and its co-chaperone Mge1p...
Wallner E, Wada J, Lin S, Pan X, Reddy J, Chugh S, et al
. Renal gene expression in embryonic and newborn diabetic mice. Exp Nephrol. 2002;10:130-8 pubmed
Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki S, Masuda K, et al
. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol. 2009;11:958-66 pubmed publisher
Ishihara T, Ban Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, et al
. Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015;35:211-23 pubmed publisher
..Thus, the dynamics of mtDNA nucleoids regulated by mitochondrial fission is required for neonatal cardiomyocyte development by promoting homogeneous distribution of active mitochondria throughout the cardiomyocytes. ..
Huang Y, Zhou J, Luo S, Wang Y, HE J, Luo P, et al
. Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44. Gut. 2018;67:307-319 pubmed publisher
..mass spectrometry and siRNA interference studies demonstrate that translocase of inner mitochondrial membrane 44 (TIM44)-superoxide dismutase 2 (SOD2) pathway inhibition is responsible for the excessive ROS, autophagy and apoptosis ..