Gene Symbol: Timm23
Description: translocase of inner mitochondrial membrane 23
Alias: Tim23, mitochondrial import inner membrane translocase subunit Tim23, translocase of inner mitochondrial membrane 23 homolog
Cortes U, Tong W, Coyle D, Meyer Ficca M, Meyer R, Petrilli V, et al
. Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol. 2004;24:7163-78 pubmed
..In addition, these mice were susceptible to streptozotocin-induced diabetes and endotoxic shock. These data indicate that PARG(110) plays an important role in DNA damage responses and in pathological processes. ..
Karbowski M, Norris K, Cleland M, Jeong S, Youle R. Role of Bax and Bak in mitochondrial morphogenesis. Nature. 2006;443:658-62 pubmed
..Our results show that Bax and Bak regulate mitochondrial dynamics in healthy cells and indicate that Bcl-2 family members may also regulate apoptosis through organelle morphogenesis machineries. ..
Ahting U, Floss T, Uez N, Schneider Lohmar I, Becker L, Kling E, et al
. Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim Biophys Acta. 2009;1787:371-6 pubmed publisher
The Tim23 protein is the key component of the mitochondrial import machinery. It locates to the inner mitochondrial membrane and its own import is dependent on the DDP1/TIM13 complex...
Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler T, et al
. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol. 2009;186:805-16 pubmed publisher
..These findings clearly demonstrate the physiological importance of Drp1-mediated organelle division in mice. ..
Underhill D, Vogan K, Kibar Z, Morrison J, Rommens J, Gros P. Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation. Mamm Genome. 2000;11:633-8 pubmed
..This map includes genes that encode proteins involved in protein sorting and targeting (Tim23 and Copa), ion transport (Atp1a2, Atp1a4, and Girk3), transcription (Nhlh1), immune regulation (Cd48 and ..
Sun Y, Kuraishi T, Aoki F, Sakai S. Hormonal regulation of mitochondrial Tim23 gene expression in the mouse mammary gland. Mol Cell Endocrinol. 2001;172:177-84 pubmed
b>Tim23, a mitochondrial inner membrane protein, is essential for cell viability. Mouse Tim23 cDNA consisted of 1142 nucleotides plus poly(A) at the 3' end...
Kibar Z, Vogan K, Groulx N, Justice M, Underhill D, Gros P. Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet. 2001;28:251-5 pubmed
..Ltap is expressed broadly in the neuroectoderm throughout early neurogenesis and is altered in two independent Lp alleles, identifying this gene as a strong candidate for Lp. ..
Murdoch J, Doudney K, Paternotte C, Copp A, Stanier P. Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet. 2001;10:2593-601 pubmed
..Loss of Lpp1 function disrupts neurulation by permitting more extensive floor plate induction by Shh, thereby inhibiting midline bending of the neural plate during initiation of neurulation. ..
Engl G, Florian S, Tranebjærg L, Rapaport D. Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology. Hum Mol Genet. 2012;21:287-99 pubmed publisher
..Taken together, these results suggest that alterations in the levels of DDP1 can affect the morphology of mitochondria and thus shed new light on the pathogenic mechanisms of DDON. ..