Gene Symbol: Tie1
Description: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Alias: D430008P04Rik, TIE, tie-1, tyrosine-protein kinase receptor Tie-1, tyrosine kinase receptor 1
Species: mouse
Products:     Tie1

Top Publications

  1. Korhonen J, Polvi A, Partanen J, Alitalo K. The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis. Oncogene. 1994;9:395-403 pubmed
    ..We have here analysed the expression of the endothelial receptor tyrosine kinase tie during the earliest stages of vascular development...
  2. Taichman D, Schachtner S, Li Y, Puri M, Bernstein A, Scott Baldwin H. A unique pattern of Tie1 expression in the developing murine lung. Exp Lung Res. 2003;29:113-22 pubmed
    ..Animals lacking the receptor tyrosine kinase Tie1 die of hemorrhage and pulmonary edema...
  3. Puri M, Bernstein A. Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis. Proc Natl Acad Sci U S A. 2003;100:12753-8 pubmed
    ..b>TIE1 (TIE) and TIE2 (TEK) are related receptor tyrosine kinases with an embryonic expression pattern in endothelial ..
  4. Chen Y, Hims M, Shetty R, Mull J, Liu L, Leyne M, et al. Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP. Mol Cell Biol. 2009;29:736-44 pubmed publisher
    ..For the first time, we demonstrate that IKAP is crucial for both vascular and neural development during embryogenesis and that protein function is conserved between mouse and human. ..
  5. Angel J, Richie E. Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4. Mol Carcinog. 2002;33:105-12 pubmed
    ..Chromosome 4 has been associated with susceptibility to hematopoietic tumor development in several mouse models, suggesting that one or more genes mapping to this chromosome are important in lymphomagenesis in general. ..
  6. Shalaby F, Rossant J, Yamaguchi T, Gertsenstein M, Wu X, Breitman M, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995;376:62-6 pubmed
    ..These results indicate that Flk-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo. ..
  7. Sato T, Tozawa Y, Deutsch U, Wolburg Buchholz K, Fujiwara Y, Gendron Maguire M, et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 1995;376:70-4 pubmed
    b>Tie-1 and Tie-2 define a new class of receptor tyrosine kinases that are specifically expressed in developing vascular endothelial cells...
  8. Patan S. TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc Res. 1998;56:1-21 pubmed
    As shown previously, TIE1 and TIE2 receptor tyrosine kinases are specifically expressed in endothelial cells during embryonic angiogenesis...
  9. Lindahl P, Hellstrom M, Kalén M, Karlsson L, Pekny M, Pekna M, et al. Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development. 1998;125:3313-22 pubmed

More Information


  1. Kuo C, Veselits M, Barton K, Lu M, Clendenin C, Leiden J. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev. 1997;11:2996-3006 pubmed
    ..Despite these defects, in situ hybridization demonstrated normal expression of platelet-derived growth factor B, Tie1, Tie2, transforming growth factor beta, and heparin-binding epidermal growth factor in the vasculature of the LKLF-/..
  2. Kawahara M, Wu Q, Kono T. Involvement of insulin-like growth factor 2 in angiogenic factor transcription in Bi-maternal mouse conceptuses. J Reprod Dev. 2010;56:79-85 pubmed
    ..quantitative gene expression analysis for representative angiogenic factors-Vegf, Flt1, Flt4, Flk1, Ang1, Ang2, Tie1, and Tie2-for 3 types of bi-maternal conceptuses containing genomes with non-growing (ng) and fully grown (fg) ..
  3. Lin Q, Lu J, Yanagisawa H, Webb R, Lyons G, Richardson J, et al. Requirement of the MADS-box transcription factor MEF2C for vascular development. Development. 1998;125:4565-74 pubmed
    ..These results reveal multiple roles for MEF2C in vascular development and suggest that MEF2-dependent target genes mediate endothelial cell organization and SMC differentiation. ..
  4. Torigata M, Yamakawa D, Takakura N. Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer. Cancer Med. 2017;6:1378-1388 pubmed publisher
    The Tie receptors 1 and 2 (Tie1/2) play crucial roles in embryonic angiogenesis. Recent studies suggest enhanced expression of Tie1 in several types of cancer and negative correlations between Tie1 levels and clinical outcome...
  5. Partanen J, Puri M, Schwartz L, Fischer K, Bernstein A, Rossant J. Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development. Development. 1996;122:3013-21 pubmed
    b>TIE is a receptor tyrosine kinase expressed in both mature endothelial cells and their precursors, as well as in some hematopoietic cells...
  6. D Amico G, Korhonen E, Anisimov A, Zarkada G, Holopainen T, Hägerling R, et al. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest. 2014;124:824-34 pubmed publisher
    The endothelial Tie1 receptor is ligand-less, but interacts with the Tie2 receptor for angiopoietins (Angpt). Angpt2 is expressed in tumor blood vessels, and its blockade inhibits tumor angiogenesis...
  7. Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F, et al. Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood. 2006;107:1357-65 pubmed
    ..Forced expression of KLF6 using a tet-inducible system enhanced the hematopoietic potential of wild-type EBs. Collectively, these findings implicate Klf6 in ES-cell differentiation and hematopoiesis. ..
  8. Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, et al. The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep. 2015;12:1761-73 pubmed publisher
    b>Tie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor...
  9. Korhonen J, Lahtinen I, Halmekyto M, Alhonen L, Janne J, Dumont D, et al. Endothelial-specific gene expression directed by the tie gene promoter in vivo. Blood. 1995;86:1828-35 pubmed
    The tie gene encodes a receptor tyrosine kinase that is expressed in the endothelium of blood vessels, particularly during embryonic development and angiogenesis in adults...
  10. Yuan H, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme V, et al. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB J. 2007;21:3171-83 pubmed
    A critical role for Tie1, an orphan endothelial receptor, in blood vessel morphogenesis has emerged from mutant mouse studies. Moreover, it was recently demonstrated that certain angiopoietin (Ang) family members can activate Tie1...
  11. Carmeliet P, Lampugnani M, Moons L, Breviario F, Compernolle V, Bono F, et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999;98:147-57 pubmed
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival. ..
  12. Shen B, Shang Z, Wang B, Zhang L, Zhou F, Li T, et al. Genetic dissection of tie pathway in mouse lymphatic maturation and valve development. Arterioscler Thromb Vasc Biol. 2014;34:1221-30 pubmed publisher
    ..the role of receptor tyrosine kinase with immunoglobulin-like and EGF (epidermal growth factor)-like domains 1 (Tie1) and Tie2 in lymphatic formation using genetically modified mouse models...
  13. Yano M, Iwama A, Nishio H, Suda J, Takada G, Suda T. Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells. Blood. 1997;89:4317-26 pubmed
    Two highly related receptor tyrosine kinases, TIE and TEK, comprise a family of endothelial cell-specific kinase...
  14. Gory Fauré S, Prandini M, Pointu H, Roullot V, Pignot Paintrand I, Vernet M, et al. Role of vascular endothelial-cadherin in vascular morphogenesis. Development. 1999;126:2093-102 pubmed
    ..These data indicate that VE-cadherin is dispensable for endothelial homophilic adhesion but is required for vascular morphogenesis. ..
  15. Chan B, Yuan H, Ananth Karumanchi S, Sukhatme V. Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochem Biophys Res Commun. 2008;371:475-9 pubmed publisher
    b>Tie-1 is an endothelial specific cell surface protein whose biology remains poorly understood...
  16. Huang X, Gao X, Diaz Trelles R, Ruiz Lozano P, Wang Z. Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180. Dev Biol. 2008;319:258-66 pubmed publisher
    ..Together, these data reveal for the first time that BAF180 is critical for coronary vessel formation. ..
  17. Zhang H, Lawson W, Polosukhin V, Pozzi A, Blackwell T, Litingtung Y, et al. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am J Pathol. 2007;171:1113-26 pubmed
    ..In addition, bleomycin-exposed Id1(-/-) mice showed increased lung collagen accumulation and fibrogenesis, suggesting that Id1 up-regulation in the lung may play a critical role in lung homeostasis. ..
  18. Hellstrom M, Gerhardt H, Kalén M, Li X, Eriksson U, Wolburg H, et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001;153:543-53 pubmed
  19. Katsuno T, Umeda K, Matsui T, Hata M, Tamura A, Itoh M, et al. Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell. 2008;19:2465-75 pubmed publisher
    ..In conclusion, ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development...
  20. Korhonen E, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, et al. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest. 2016;126:3495-510 pubmed publisher
    ..A limited understanding of ANG signaling mechanisms and the orphan receptor Tie1 has hindered development of ANG/Tie-targeted therapeutics...
  21. Trokovic N, Trokovic R, Mai P, Partanen J. Fgfr1 regulates patterning of the pharyngeal region. Genes Dev. 2003;17:141-53 pubmed
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration. ..
  22. Woo K, Qu X, Babaev V, Linton M, Guzman R, Fazio S, et al. Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner. J Clin Invest. 2011;121:1624-35 pubmed publisher
    ..Our initial studies confirmed that expression of the endothelial receptor tyrosine kinase Tie1 was evident at regions of atherogenic flow in mature animals...
  23. Li K, Blum Y, Verma A, Liu Z, Pramanik K, Leigh N, et al. A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. Blood. 2010;115:133-9 pubmed publisher
    ..natural AS transcript for tyrosine kinase containing immunoglobulin and epidermal growth factor homology domain-1 (tie-1), tie-1AS lncRNA in zebrafish, mouse, and humans...
  24. Cusella De Angelis M, Balconi G, Bernasconi S, Zanetta L, Boratto R, Galli D, et al. Skeletal myogenic progenitors in the endothelium of lung and yolk sac. Exp Cell Res. 2003;290:207-16 pubmed
    ..The number (or potency to generate skeletal muscle) of these vessels associated cells decreases rapidly with age and is very low in mature animals, possibly correlating with reduced regenerative capacity of adult mammalian tissues. ..
  25. Lee J, Yu Q, Shin J, Sebzda E, Bertozzi C, Chen M, et al. Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006;11:845-57 pubmed
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function. ..
  26. Qu X, Zhou B, Scott Baldwin H. Tie1 is required for lymphatic valve and collecting vessel development. Dev Biol. 2015;399:117-128 pubmed publisher
    b>Tie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium...
  27. Theurillat J, Hainfellner J, Maddalena A, Weissenberger J, Aguzzi A. Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice. Am J Pathol. 1999;154:581-90 pubmed
    ..Expression patterns of the endothelial angiogenic receptors flt-1, flk-1, tie-1, and tie-2 were similar to those described in human gliomas, but flt-1 was expressed also in neoplastic ..
  28. Puri M, Partanen J, Rossant J, Bernstein A. Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development. Development. 1999;126:4569-80 pubmed
    TEK (TIE2) and TIE (TIE1) are structurally related receptor tyrosine kinases expressed in endothelial cells and their precursors...
  29. Uyttendaele H, Ho J, Rossant J, Kitajewski J. Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A. 2001;98:5643-8 pubmed
    ..Expression of an activated form of Notch4 in embryonic vasculature leads to abnormal vessel structure and patterning, implicating the Notch pathway in phases of vascular development associated with vessel patterning and remodeling. ..
  30. Schorpp Kistner M, Wang Z, Angel P, Wagner E. JunB is essential for mammalian placentation. EMBO J. 1999;18:934-48 pubmed
    ..Therefore, JunB appears to be involved in multiple signaling pathways regulating genes involved in the establishment of a proper feto-maternal circulatory system. ..
  31. Iljin K, Dube A, Kontusaari S, Korhonen J, Lahtinen I, Oettgen P, et al. Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter. FASEB J. 1999;13:377-86 pubmed
    The Tie gene encodes an endothelial cell receptor tyrosine kinase necessary for normal vascular development. The Tie gene promoter targets expression of heterologous genes specifically to endothelial cells in transgenic mice...
  32. Visvader J, Fujiwara Y, Orkin S. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev. 1998;12:473-9 pubmed
    ..These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast. ..
  33. Puri M, Rossant J, Alitalo K, Bernstein A, Partanen J. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J. 1995;14:5884-91 pubmed
    ..We have analyzed the role of the endothelial cell-specific receptor tyrosine kinase TIE in the mouse vasculature...
  34. Rodewald H, Sato T. Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells. Oncogene. 1996;12:397-404 pubmed
    ..b>Tie 1-deficient mice carrying a targeted insertional mutation in germ line show defects in endothelial cell integrity ..
  35. Su D, Gudas L. Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol. 2008;36:624-41 pubmed publisher
    ..The Tie1 gene exhibited reduced expression in RA-treated F9 RARgamma-/- cells as compared to wild-type (WT) by microarray ..
  36. Frankel W, Yang Y, Mahaffey C, Beyer B, O Brien T. Szt2, a novel gene for seizure threshold in mice. Genes Brain Behav. 2009;8:568-76 pubmed publisher
    ..While the biological function of Szt2 remains unknown, its high conservation, unique structure and effect on seizure threshold suggest that it serves an important role in the central nervous system. ..
  37. Teilmann S, Christensen S. Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs. Cell Biol Int. 2005;29:340-6 pubmed
    ..cell survival depend on proper signalling through angiopoietin receptors such as the receptor tyrosine kinases Tie-1 and Tie-2...
  38. La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, et al. Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest. 2018;128:834-845 pubmed publisher
    The endothelial tyrosine kinase receptor Tie1 remains poorly characterized, largely owing to its orphan receptor status. Global Tie1 inactivation causes late embryonic lethality, thereby reflecting its importance during development...
  39. Licht A, Müller Holtkamp F, Flamme I, Breier G. Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development. Blood. 2006;107:584-90 pubmed
    ..Consistently, HIFdn transgenic embryos expressed reduced levels of the endothelial angiopoietin receptor, Tie-2, whereas other endothelial markers, such as PECAM-1, Tie-1, and VE-cadherin were not affected...
  40. Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M. Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A. 2005;102:1076-81 pubmed
    ..In contrast, Flk-1(1212F) homozygous mice were viable and fertile. These results suggest that the signaling via Y1173 of Flk-1 is essential for endothelial and hematopoietic development during embryogenesis. ..
  41. Loughna S, Sato T. A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis. Mol Cell. 2001;7:233-9 pubmed
    ..In this report, we show that the combinatorial function of angiopoietin-1 and the orphan receptor TIE1 is critical specifically for the development of the right-hand side venous system but is dispensable for the left-..
  42. Dumont D, Fong G, Puri M, Gradwohl G, Alitalo K, Breitman M. Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development. Dev Dyn. 1995;203:80-92 pubmed
    ..developmental expression profiles of three endothelial specific receptor tyrosine kinases (RTKs) flk-1, tek, tie, as well as vascular endothelial growth factor (VEGF), the flk-1 ligand...
  43. Mukhopadhyay P, Brock G, Webb C, Pisano M, Greene R. Strain-specific modifier genes governing craniofacial phenotypes. Birth Defects Res A Clin Mol Teratol. 2012;94:162-75 pubmed publisher
  44. D Amico G, Korhonen E, Waltari M, Saharinen P, Laakkonen P, Alitalo K. Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report. Arterioscler Thromb Vasc Biol. 2010;30:207-9 pubmed publisher
    Studies of Tie1 gene-targeted embryos have demonstrated loss of blood vessel integrity, but the relevance of Tie1 in lymphatic vasculature development is unknown...
  45. Yang W, Yang D, Na S, Sandusky G, Zhang Q, Zhao G. Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005;280:9330-5 pubmed
    ..This finding is consistent with the altered expression of vegf, flt1, kdr, and tie1 in the mutant embryos...
  46. Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida Araki K, et al. Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 2004;279:34741-9 pubmed
    ..These results suggest that Foxo1 is essential to the ability of endothelial cells to respond properly to a high dose of VEGF, thereby playing a critical role in normal vascular development. ..
  47. Loughna S, Hardman P, Landels E, Jussila L, Alitalo K, Woolf A. A molecular and genetic analysis of renalglomerular capillary development. Angiogenesis. 1997;1:84-101 pubmed
    ..In transgenic mice, Tie1/LacZ-expressing cells were identified in E11 renal mesenchyme when patent vessels were absent...
  48. Sato T, Qin Y, Kozak C, Audus K. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc Natl Acad Sci U S A. 1993;90:9355-8 pubmed
    ..and characterization of two structurally related putative receptor tyrosine kinases, encoded by distinct genes (tie-1 and tie-2) on mouse chromosome 4...
  49. Furtado M, Costa M, Pranoto E, Salimova E, Pinto A, Lam N, et al. Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circ Res. 2014;114:1422-34 pubmed publisher
  50. Yuan H, Suri C, Yancopoulos G, Woolf A. Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. J Am Soc Nephrol. 1999;10:1722-36 pubmed
    The Tie-2 receptor tyrosine kinase transduces embryonic endothelial differentiation, with Angiopoietin-1 (Ang-1) acting as a stimulatory ligand and Ang-2 postulated to be a naturally occurring inhibitor...
  51. Yamakawa D, Kidoya H, Sakimoto S, Jia W, Naito H, Takakura N. Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1. J Biol Chem. 2013;288:12469-77 pubmed publisher
    ..Moreover, based on the fact that Tie1 never forms heterodimers with Tie2 in the absence of Ang1 despite having high amino acid sequence homology with ..
  52. Yang J, Boerm M, McCarty M, Bucana C, Fidler I, Zhuang Y, et al. Mekk3 is essential for early embryonic cardiovascular development. Nat Genet. 2000;24:309-13 pubmed
    ..We conclude that Mekk3 is necessary for blood vessel development and may be a possible target for drugs that control angiogenesis. ..
  53. Rampon C, Bouillot S, Climescu Haulica A, Prandini M, Cand F, Vandenbrouck Y, et al. Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta. Physiol Genomics. 2008;34:193-204 pubmed publisher
    ..Specific genes emerging from the microarray screen support the biological modifications observed in PCDH12-deficient placentas. ..
  54. Koblizek T, Runting A, Stacker S, Wilks A, Risau W, Deutsch U. Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues. Eur J Biochem. 1997;244:774-9 pubmed
    ..lines, Tie2 could be induced to become tyrosine phosphorylated, and this activation was found to be independent of Tie1. Studying Tie2 receptor activity during angiogenesis in mouse development, the receptor was only weakly ..
  55. Regan C, Li W, Boucher D, Spatz S, Su M, Kuida K. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A. 2002;99:9248-53 pubmed
    ..Moreover, the inability of Erk5-deficient mice to form a complex vasculature suggests that Erk5 may play an important role in controlling angiogenesis. ..
  56. Yang X, Gong Y, Friesel R. Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS ONE. 2011;6:e18374 pubmed publisher
  57. Bi W, Drake C, Schwarz J. The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev Biol. 1999;211:255-67 pubmed
  58. Yamagishi H, Olson E, Srivastava D. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest. 2000;105:261-70 pubmed
    ..These results suggest that dHAND is required for vascular development and regulates angiogenesis, possibly through a VEGF signaling pathway. ..
  59. Fong G, Rossant J, Gertsenstein M, Breitman M. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995;376:66-70 pubmed
    ..We suggest that the Flt-1 signalling pathway may regulate normal endothelial cell-cell or cell-matrix interactions during vascular development. ..
  60. Downes M, Francois M, Ferguson C, Parton R, Koopman P. Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum Mol Genet. 2009;18:2839-50 pubmed publisher
    ..Together, our results indicate that vascular anomalies in HLT arise from defects in regulation of genes required for the acquisition of structural integrity during microvascular maturation. ..
  61. Wu C, Xu W, Kozak C, Desnick R. Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping. Mamm Genome. 1996;7:349-52 pubmed
    ..The availability of the mouse URO-decarboxylase should facilitate studies of the structure and organization of the mouse genomic sequence and the development of a mouse model of this inherited porphyria. ..
  62. van Nes J, de Graaff W, Lebrin F, Gerhard M, Beck F, Deschamps J. The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development. 2006;133:419-28 pubmed
    ..Cdx genes thus operate in a redundant way during placentogenesis, as they do during embryonic axial elongation and patterning, and independently from the previously reported early Cdx2-specific role in the trophectoderm at implantation...
  63. Kaipainen A, Korhonen J, Mustonen T, van Hinsbergh V, Fang G, Dumont D, et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci U S A. 1995;92:3566-70 pubmed
    ..Our results suggest that FLT4 is a marker for lymphatic vessels and some high endothelial venules in human adult tissues. They also support the theory on the venous origin of lymphatic vessels...
  64. Sleigh J, Gómez Martín A, Wei N, Bai G, Yang X, Schiavo G. Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis. Sci Rep. 2017;7:9216 pubmed publisher
    ..Our findings indicate that mutant GlyRS-mediated disruption of Nrp1/VEGF-A signalling is permissive to maturation and maintenance of the vasculature in CMT2D mice. ..
  65. Qiao L, Gu Q, Dai Y, Shen Z, Liu X, Qi R, et al. XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells. Tumour Biol. 2008;29:122-9 pubmed publisher
    ..A significant decrease in the expression of Tie-1, Ang-1, Ang-2 and c-Myc was observed. Our data suggest that XAF1 possesses a potential antiangiogenesis effect...
  66. Baumer S, Keller L, Holtmann A, Funke R, August B, Gamp A, et al. Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood. 2006;107:4754-62 pubmed
    VE-PTP, a receptor-type phosphotyrosine phosphatase, associates with the tyrosine kinase receptor Tie-2 and VE-cadherin and enhances the adhesive function of the latter...
  67. Gale N, Yancopoulos G. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev. 1999;13:1055-66 pubmed
  68. Iwama A, Hamaguchi I, Hashiyama M, Murayama Y, Yasunaga K, Suda T. Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells. Biochem Biophys Res Commun. 1993;195:301-9 pubmed
    ..of their full-length cDNA sequences revealed that they were mouse homologues of the endothelial cell RTK genes, TIE and TEK...
  69. Brindle N, Saharinen P, Alitalo K. Signaling and functions of angiopoietin-1 in vascular protection. Circ Res. 2006;98:1014-23 pubmed
    ..We also consider the data on Ang1 receptors and speculate on how to maximize therapeutic benefit by targeting the Tie receptors.
  70. Qu X, Tompkins K, Batts L, Puri M, Baldwin H, Baldwin S. Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice. Development. 2010;137:1285-95 pubmed publisher
    b>Tie1 is an endothelial receptor tyrosine kinase that is essential for development and maintenance of the vascular system; however, the role of Tie1 in development of the lymphatic vasculature is unknown...
  71. Ayadi A, Zheng H, Sobieszczuk P, Buchwalter G, Moerman P, Alitalo K, et al. Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1. EMBO J. 2001;20:5139-52 pubmed
    ..g. atherosclerosis), and here egr-1 dysfunction could possibly be associated with obstructions that ultimately affect the lymphatics. These results show that Net is involved in vascular biology and egr-1 regulation in vivo. ..
  72. Hart A, Melet F, Grossfeld P, Chien K, Jones C, Tunnacliffe A, et al. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity. 2000;13:167-77 pubmed
    ..leading to bleeding within the vascular plexus of the cerebral meninges and specific downregulation of Tek/Tie-2, the receptor for angiopoietin-1...