Ticam2

Summary

Gene Symbol: Ticam2
Description: toll-like receptor adaptor molecule 2
Alias: B430113A10, TICAM-2, TRAM, Tirp, Trif, TIR domain-containing adapter molecule 2, TIR domain-containing adapter protein, TRIF-related adapter molecule TRAM, TRIF-related adaptor molecule, Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2, toll/interleukin-1 receptor domain-containing protein
Species: mouse
Products:     Ticam2

Top Publications

  1. McAleer J, Rossi R, Vella A. Lipopolysaccharide potentiates effector T cell accumulation into nonlymphoid tissues through TRIF. J Immunol. 2009;182:5322-30 pubmed publisher
    ..survival and Th1 differentiation by stimulating MyD88 and Toll/IL-1R domain-containing adaptor-inducing IFN-beta (TRIF) signaling pathways...
  2. Zhang Z, Kim T, Bao M, Facchinetti V, Jung S, Ghaffari A, et al. DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity. 2011;34:866-78 pubmed publisher
    ..identification of a viral sensor, consisting of RNA helicases DDX1, DDX21, and DHX36, and the adaptor molecule TRIF, by isolation and sequencing of poly I:C-binding proteins in myeloid dendritic cells (mDCs)...
  3. Fitzgerald K, Rowe D, Barnes B, Caffrey D, Visintin A, Latz E, et al. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003;198:1043-55 pubmed
    Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM) is the fourth TIR domain-containing adaptor protein to be described that participates in Toll receptor signaling...
  4. Cai S, Batra S, Shen L, Wakamatsu N, Jeyaseelan S. Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. J Immunol. 2009;183:6629-38 pubmed publisher
    Klebsiella pneumoniae causes extensive lung damage. TLR signaling involves adaptors TRIF and MyD88. However, the relative contribution of TRIF and MyD88 signaling in host defense against pulmonary K...
  5. Sacre S, Lundberg A, Andreakos E, Taylor C, Feldmann M, Foxwell B. Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling. J Immunol. 2007;178:2148-54 pubmed
    ..One of these adaptors, Toll-IL-1R domain-containing adaptor inducing IFN-beta-related adaptor molecule (TRAM), has been shown to be essential for TLR4 signaling in TRAM(-/-) mice and cell lines...
  6. Rowe D, McGettrick A, Latz E, Monks B, Gay N, Yamamoto M, et al. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A. 2006;103:6299-304 pubmed
    b>TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively in the TLR4 pathway...
  7. Bin L, Xu L, Shu H. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003;278:24526-32 pubmed
    ..In this report, we identified a novel TIR domain-containing adapter protein designated as TIRP. Co-immunoprecipitation experiments suggest that TIRP is associated with IL-1 receptors...
  8. Sotolongo J, España C, Echeverry A, Siefker D, Altman N, Zaias J, et al. Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity. J Exp Med. 2011;208:2705-16 pubmed publisher
    ..myeloid differentiation factor 88 (MyD88) and toll/interleukin 1 receptor domain-containing adapter inducing IFN-? (TRIF), is required for protection against Gram-negative bacteria...
  9. Choi Y, Im E, Pothoulakis C, Rhee S. TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. J Biol Chem. 2010;285:21382-90 pubmed publisher
    ..Here we show that the TIR domain containing adaptor-inducing interferon-beta (TRIF), an adaptor molecule mediating TLR3 signaling and MyD88-independent signaling of TLR4, plays an inhibitory role in ..

More Information

Publications85

  1. Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem. 2003;278:49751-62 pubmed
    ..TICAM-1/TRIF was identified as an adapter that facilitates activation of IRF-3 followed by expression of interferon (IFN)-beta ..
  2. Biswas S, Bist P, Dhillon M, Kajiji T, del Fresno C, Yamamoto M, et al. Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance. J Immunol. 2007;179:4083-92 pubmed
    ..We investigated the role of the TRIF/IFN-beta pathway in TLR4-induced endotoxin tolerance...
  3. Kagan J, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. 2008;9:361-8 pubmed publisher
    Toll-like receptor 4 (TLR4) induces two distinct signaling pathways controlled by the TIRAP-MyD88 and TRAM-TRIF pairs of adaptor proteins, which elicit the production of proinflammatory cytokines and type I interferons, respectively...
  4. McGettrick A, Brint E, Palsson McDermott E, Rowe D, Golenbock D, Gay N, et al. Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A. 2006;103:9196-201 pubmed
    ..Mal), Toll/IL-1R domain-containing adapter inducing IFN-beta (Trif), and Trif-related adapter molecule (TRAM). Here we show that TRAM is transiently phosphorylated by PKCepsilon on serine-16 in an LPS-dependent manner...
  5. Yang Q, Lu F, Zhou Y, Wang L, Zhong Q, Lin S, et al. HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling. J Cereb Blood Flow Metab. 2011;31:593-605 pubmed publisher
    ..model with Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-? knockout mice (TRIF(-/-)) and evaluated the activity and expression of TRIF pathway-related kinases...
  6. Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003;4:1144-50 pubmed
    ..Here we have identified a fourth TIR domain-containing adaptor, TRIF-related adaptor molecule (TRAM), and analyzed its physiological function by gene targeting...
  7. Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol. 2004;5:503-7 pubmed
    ..innate immune responses through Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88 and Trif. Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by ..
  8. Tanimura N, Saitoh S, Matsumoto F, Akashi Takamura S, Miyake K. Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochem Biophys Res Commun. 2008;368:94-9 pubmed publisher
    ..In contrast, TRIF/TICAM-1 and TRAM/TICAM-2 are essential for both...
  9. Janssen E, Ozcan E, Liadaki K, Jabara H, Manis J, Ullas S, et al. TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol. 2014;192:2651-8 pubmed publisher
    ..adaptor molecules MyD88 and Toll/IL-IR domain-containing adapter-inducing IFN-? (TRIF)-related adaptor molecule (TRAM), which recruits TRIF...
  10. Arpaia N, Godec J, Lau L, Sivick K, McLaughlin L, Jones M, et al. TLR signaling is required for Salmonella typhimurium virulence. Cell. 2011;144:675-88 pubmed publisher
    ..Our results indicate that S. typhimurium requires cues from the innate immune system to regulate virulence genes necessary for intracellular survival, growth, and systemic infection. ..
  11. Donnelly S, O Neill S, Stack C, Robinson M, Turnbull L, Whitchurch C, et al. Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3. J Biol Chem. 2010;285:3383-92 pubmed publisher
    ..The proteases specifically block the MyD88-independent TRIF-dependent signaling pathway of Toll-like receptor (TLR)4 and TLR3...
  12. Takizawa H, Fritsch K, Kovtonyuk L, Saito Y, Yakkala C, Jacobs K, et al. Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness. Cell Stem Cell. 2017;21:225-240.e5 pubmed publisher
    ..This process is mediated via TLR4-TRIF-ROS-p38, but not MyD88 signaling, and can be inhibited pharmacologically without preventing emergency ..
  13. Sato N, Takahashi N, Suda K, Nakamura M, Yamaki M, Ninomiya T, et al. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha. J Exp Med. 2004;200:601-11 pubmed
    ..Toll-IL-1 receptor domain-containing adaptor inducing interferon-beta (TRIF)-mediated signals are involved in lipopolysaccharide (LPS)-induced MyD88-independent pathways...
  14. Liao J, Jijon H, Kim I, Goel G, Doan A, Sokol H, et al. An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. PLoS ONE. 2014;9:e108777 pubmed publisher
    ..Taken together, our unbiased loss-of-function genetic screen identifies genes that play a role in host antiviral immunity and delineates roles for IL-27 and Tagap in the production of antiviral cytokines. ..
  15. Kolb J, Casella C, SenGupta S, Chilton P, Mitchell T. Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF. Sci Signal. 2014;7:ra108 pubmed publisher
    ..marker 88 (MyD88) or Toll-interleukin-1 (IL-1) receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)...
  16. Rathinam V, Appledorn D, Hoag K, Amalfitano A, Mansfield L. Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes. Infect Immun. 2009;77:2499-507 pubmed publisher
    ..88 (MyD88) and/or Toll-interleukin 1 (IL-1) receptor domain-containing adaptor-inducing beta interferon (IFN-beta) (TRIF) is critical in inducing immunity against pathogens...
  17. Johnson A, Li X, Pearlman E. MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase. J Biol Chem. 2008;283:3988-96 pubmed
    ..Toll-like receptors except TLR3 and a subset of TLR4 signaling events, which are mediated by the adaptor molecule TRIF. To determine the role of TRIF in host inflammatory responses, corneal epithelium of C57BL/6, TLR3(-/-), TRIF(-/-), ..
  18. Sivick K, Arpaia N, Reiner G, Lee B, Russell B, Barton G. Toll-like receptor-deficient mice reveal how innate immune signaling influences Salmonella virulence strategies. Cell Host Microbe. 2014;15:203-13 pubmed publisher
    ..These results demonstrate how pathogens use plasticity in virulence strategies to respond to different host immune environments. ..
  19. Reis J, Hassan F, Guan X, Shen J, Monaco J, Papasian C, et al. The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages. Cell Biochem Biophys. 2011;60:119-26 pubmed publisher
    ..The recent studies suggest that the TRIF/TRAM pathway is defective in LMP knockouts which may explain why iNOS/NO are not robustly induced in LPS-treated ..
  20. Wang J, He G, Wang Y, Zhu Q, Chen W, Guo T. TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury. World J Gastroenterol. 2015;21:8314-25 pubmed publisher
    ..anti-myeloid differentiation gene 88 (MyD88), and anti-translocating-chain-associating membrane protein (TRIF) antibody groups...
  21. Shenderov K, Riteau N, Yip R, Mayer Barber K, Oland S, Hieny S, et al. Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1? in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway. J Immunol. 2014;192:2029-2033 pubmed publisher
    ..Instead, both caspase activation and IL-1? production require the alternative TLR4 adaptor TRIF. This pathway may contribute to IL-1-driven tissue pathology in certain disease settings.
  22. Caucheteux S, Hu Li J, Mohammed R, Ager A, Paul W. Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant. Mucosal Immunol. 2017;10:361-372 pubmed publisher
    ..Our data show that both Myd88 and TRIF are necessary for Th17 induction...
  23. Hsia B, Whitehead G, Thomas S, Nakano K, Gowdy K, Aloor J, et al. Trif-dependent induction of Th17 immunity by lung dendritic cells. Mucosal Immunol. 2015;8:186-97 pubmed publisher
    ..Here, we identify novel roles of the adaptor protein, TRIF (TIR-domain-containing adapter-inducing interferon-β), in neutrophilic responses to inhaled allergens...
  24. Seregin S, Aldhamen Y, Appledorn D, Aylsworth C, Godbehere S, Liu C, et al. TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo. PLoS ONE. 2011;6:e22064 pubmed publisher
    ..Surprisingly, we also found that the TRIF adaptor protein acts as a potent negative regulator of TLR agonist-triggered immune responses...
  25. Lysakova Devine T, Keogh B, Harrington B, Nagpal K, Halle A, Golenbock D, et al. Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. J Immunol. 2010;185:4261-71 pubmed publisher
    ..directly interacted with the TLR4 adaptor proteins MyD88 adaptor-like (Mal) and TRIF-related adaptor molecule (TRAM). Viral proteins target host proteins using evolutionary optimized binding surfaces...
  26. Liu T, Zang N, Zhou N, Li W, Xie X, Deng Y, et al. Resveratrol inhibits the TRIF-dependent pathway by upregulating sterile alpha and armadillo motif protein, contributing to anti-inflammatory effects after respiratory syncytial virus infection. J Virol. 2014;88:4229-36 pubmed publisher
    ..Resveratrol possesses anti-RSV activity and is an inhibitor of the TRIF/TBK1/IRF-3 complex...
  27. Xu Z, Desai M, Philip J, Sivsubramanian N, Bowles N, Vallejo J. Conditional transgenic expression of TIR-domain-containing adaptor-inducing interferon-? (TRIF) in the adult mouse heart is protective in acute viral myocarditis. Basic Res Cardiol. 2011;106:1159-71 pubmed publisher
    TIR-domain-containing adaptor-inducing interferon-? (TRIF) plays a major role in Toll-like receptor 3 (TLR3) mediated signaling...
  28. Watts B, George T, Sherwood E, Good D. Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway. Am J Physiol Renal Physiol. 2017;313:F103-F115 pubmed publisher
    ..PI3K inhibitor and in MTALs from TLR4-/- or Toll/IL-1 receptor domain-containing adaptor-inducing IFN-? (TRIF)-/- mice...
  29. Chen X, Zhang D, Zhang M, Guo M, Zhan Y, Liu F, et al. TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis. Biochem Biophys Res Commun. 2015;464:100-5 pubmed publisher
    ..We provided the evidence for the involvement of Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF), an important inflammation-related molecule, in the pathophysiology of AF...
  30. Chen C, Shi Y, Hearn A, Fitzgerald K, Golenbock D, Reed G, et al. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest. 2006;116:2262-71 pubmed
    ..In contrast, other TIR adaptor molecules, TIRAP/Mal, TRIF, and TRAM, are not required for this process...
  31. Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks B, Schoenemeyer A, et al. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol. 2005;175:5260-8 pubmed
    ..Toll-IL-1 resistance domain containing adapters MyD88, Mal, Toll/IL-1R domain-containing adaptor inducing IFN-beta (TRIF), and TRIF-related adaptor molecule TLR3, or the E3 ubiquitin ligase, TNFR-associated factor 6...
  32. Yanagibashi T, Nagai Y, Watanabe Y, Ikutani M, Hirai Y, Takatsu K. Differential requirements of MyD88 and TRIF pathways in TLR4-mediated immune responses in murine B cells. Immunol Lett. 2015;163:22-31 pubmed publisher
    ..has two main signaling pathways, MyD88 and Toll/IL-1R (TIR)-domain-containing adaptor-inducing interferon-β (TRIF) pathways, but relatively few studies have examined these pathways in B cells...
  33. Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, et al. TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. PLoS ONE. 2012;7:e38423 pubmed publisher
    ..In this study, a direct interaction between MyD88-TIR and another membrane-sorting adaptor, TRAM/TICAM-2, was demonstrated in vitro...
  34. Tsai S, Segovia J, Chang T, Morris I, Berton M, Tessier P, et al. DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway. PLoS Pathog. 2014;10:e1003848 pubmed publisher
    ..Genetic studies showed that the DDX21-TRIF signaling pathway is required for S100A9 gene expression/production during infection...
  35. Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B. TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. J Immunol. 2010;184:5842-8 pubmed publisher
    The adapter protein TRIF mediates signal transduction through TLR3 and TLR4, inducing production of type I IFNs and inflammatory cytokines...
  36. Biondo C, Signorino G, Costa A, Midiri A, Gerace E, Galbo R, et al. Recognition of yeast nucleic acids triggers a host-protective type I interferon response. Eur J Immunol. 2011;41:1969-79 pubmed publisher
    ..These data suggest that recognition of yeast nucleic acids by TLR7 and TLR9 triggers a host-protective IFN-?/? response. ..
  37. Joung S, Park Z, Rani S, Takeuchi O, Akira S, Lee J. Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol. 2011;186:499-507 pubmed publisher
    Toll/IL-1R domain-containing adaptor inducing IFN-? (TRIF) is an adaptor molecule that is recruited to TLR3 and -4 upon agonist stimulation and triggers activation of IFN regulatory factor 3 (IRF3) and expression of type 1 IFNs, which are ..
  38. Bauernfeind F, Horvath G, Stutz A, Alnemri E, MacDonald K, Speert D, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 2009;183:787-91 pubmed publisher
    ..Signals provided by NF-kappaB activators are necessary but not sufficient for NLRP3 activation, and a second stimulus such as ATP or crystal-induced damage is required for NLRP3 activation. ..
  39. Kanagavelu S, Flores C, Termini J, Romero L, Riveron R, Ruiz J, et al. TIR Domain-Containing Adapter-Inducing Beta Interferon (TRIF) Mediates Immunological Memory against Bacterial Pathogens. Infect Immun. 2015;83:4404-15 pubmed publisher
    ..in which innate and adaptive immunity are linked by TIR domain-containing adapter-inducing beta interferon (TRIF) during establishment and reactivation of memory T cells against Gram-negative enteropathogens...
  40. Medina E, Morris I, Berton M. Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain. J Immunol. 2010;185:7562-72 pubmed publisher
    ..This TLR2-independent inhibitory pathway may be an important mechanism by which Francisella suppresses the host's innate immune response...
  41. Hoffman S, Wang H, Pope M, Fleming S. Helicobacter infection alters MyD88 and Trif signalling in response to intestinal ischaemia-reperfusion. Exp Physiol. 2011;96:104-13 pubmed publisher
    ..of DAF mRNA expression in uninfected wild-type,?MyD88(-/-) or TIR-domain-containing adaptor-inducing interferon-? (Trif)-deficient mice...
  42. Abdollahi Roodsaz S, van de Loo F, Koenders M, Helsen M, Walgreen B, van den Bersselaar L, et al. Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice. Arthritis Rheum. 2012;64:1838-47 pubmed publisher
    ..of the two signaling pathways used by TLRs, which are mediated by myeloid differentiation factor 88 (MyD88) and TRIF, remains unclear...
  43. Ruiz J, Kanagavelu S, Flores C, Romero L, Riveron R, Shih D, et al. Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine. Front Cell Infect Microbiol. 2015;5:105 pubmed publisher
    Recognition of Gram-negative bacteria by toll-like receptor (TLR)4 induces MyD88 and TRIF mediated responses. We have shown that TRIF-dependent responses play an important role in intestinal defense against Gram-negative enteropathogens...
  44. Montminy S, Khan N, McGrath S, Walkowicz M, Sharp F, Conlon J, et al. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol. 2006;7:1066-73 pubmed
    ..pestis virulence. Evading TLR4 activation by lipid A alteration may contribute to the virulence of various Gram-negative bacteria. ..
  45. Zhang H, Rodriguez S, Wang L, Wang S, Serezani H, Kapur R, et al. Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88. Stem Cell Reports. 2016;6:940-956 pubmed publisher
    ..Using mice deficient in TLR4 downstream adapters MYD88 or TRIF, we demonstrate that both cell-autonomous and non-cell-autonomous MYD88 activation are major causes of ..
  46. Shim D, Shin H, Han J, Ji Y, Jang C, Koppula S, et al. A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation. Toxicol Appl Pharmacol. 2015;284:227-35 pubmed publisher
    ..of HIS were mediated through the regulation of the TIR domain-containing, adaptor-inducing, interferon-β (TRIF)-dependent signaling pathway from toll-like receptors...
  47. Georgel P, Jiang Z, Kunz S, Janssen E, Mols J, Hoebe K, et al. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology. 2007;362:304-13 pubmed publisher
    ..adapter TRAM has predominant importance, absent any need for MyD88 or Mal, and with only a partial requirement for TRIF. Downstream of TRAM, IRF7 activation leads to a type I IFN response...
  48. Palha De Sousa C, Blum C, Sgroe E, Crespo A, Kurt R. Murine mammary carcinoma cells and CD11c(+) dendritic cells elicit distinct responses to lipopolysaccharide and exhibit differential expression of genes required for TLR4 signaling. Cell Immunol. 2010;266:67-75 pubmed publisher
    ..A potential reason for differential responsiveness was that DC expressed greater levels of TLR4, CD14, Myd88, and TRAM. Despite the low level of TLR signaling proteins, the carcinoma were able to elicit a range of responses contingent ..
  49. Loi P, Yuan Q, Torres D, Delbauve S, Laute M, Lalmand M, et al. Interferon regulatory factor 3 deficiency leads to interleukin-17-mediated liver ischemia-reperfusion injury. Hepatology. 2013;57:351-61 pubmed publisher
    ..IRF3-dependent events downstream of TLR4 control the IL-23/IL-17 axis in the liver and this regulatory role of IRF3 is relevant to liver ischemia-reperfusion injury. ..
  50. Heipertz E, Harper J, Walker W. STING and TRIF Contribute to Mouse Sepsis, Depending on Severity of the Disease Model. Shock. 2017;47:621-631 pubmed publisher
    ..Genes (STING) pathway (that senses cytosolic DNA) and the TIR-domain-containing adapter-inducing interferon-β (TRIF) pathway (that senses dsRNA and LPS via Toll-like receptor 3 and 4)...
  51. Ulrichts P, Lemmens I, Lavens D, Beyaert R, Tavernier J. MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling. Methods Mol Biol. 2009;517:133-44 pubmed publisher
    ..In the subsequent protocol, we describe the use of MAPPIT to study early events in Toll-like receptor (TLR) signalling. We here demonstrate a "signalling interaction cascade" from TLR4 to IRAK-1. ..
  52. Rathinam V, Vanaja S, Waggoner L, Sokolovska A, Becker C, Stuart L, et al. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell. 2012;150:606-19 pubmed publisher
    ..Here, we identify a TRIF pathway that licenses NLRP3 inflammasome activation by all Gram-negative bacteria...
  53. Zhao X, Dong Q, Bindas J, Piganelli J, Magill A, Reiser J, et al. TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol. J Immunol. 2008;181:3049-56 pubmed
    ..As IRF-3 is downstream from the TLR4 adaptor TIR-domain-containing adapter-inducing IFN-beta (Trif), we demonstrate that macrophages from Trif-/- mice are resistant to this dysregulation of TNF-alpha transcription ..
  54. Aubry C, Corr S, Wienerroither S, Goulard C, Jones R, Jamieson A, et al. Both TLR2 and TRIF contribute to interferon-? production during Listeria infection. PLoS ONE. 2012;7:e33299 pubmed publisher
    ..Induction of IFN-? was independent of the Mal/TIRAP adaptor protein but required TRIF and the transcription factors IRF3 and IRF7. These pathways were stimulated to a lesser degree by wild-type L...
  55. Mukherjee S, Chen L, Papadimos T, Huang S, Zuraw B, Pan Z. Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM. J Biol Chem. 2009;284:29391-8 pubmed publisher
    ..Silencing of myeloid differentiation protein (MyD88) and TRIF-related adaptor molecule (TRAM), using small interfering RNA abolished IL-4 induction induced by LPS whereas ..
  56. Kanagavelu S, Flores C, Termini J, Riveron R, Romero L, Chung K, et al. TIR-domain-containing adapter-inducing interferon-? (TRIF) regulates Th17-mediated intestinal immunopathology in colitis. Mucosal Immunol. 2015;8:296-306 pubmed publisher
    ..Here we show that innate TRIF signaling regulates intestinal Th17-cell generation and plasticity during colitis...
  57. Ko R, Park J, Ha H, Choi Y, Lee S. Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun. 2015;6:6765 pubmed publisher
    ..TRAF6 is determined to be a direct E3 ligase for GSK3β, and TRAF6-mediated GSK3β ubiquitination is essential for poly I:C-dependent cytokine production by promoting the TLR3 adaptor protein TRIF-assembled signalling complex.
  58. Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, et al. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Dis Model Mech. 2010;3:92-103 pubmed publisher
    ..In a genetic approach to define the contribution of TLR2 and TLR4, and their adaptor proteins MyD88 and TRIF [Toll/interleukin (IL)-1 receptor domain-containing adaptor-protein inducing interferon beta], to CAD, kidney ..
  59. Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, et al. Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J Exp Med. 2008;205:1967-73 pubmed publisher
    ..These results implicate a novel role for caspase-8 in the production of biologically active IL-1beta in response to TLR3 and TLR4 stimulation. ..
  60. Wiersinga W, Wieland C, Roelofs J, van der Poll T. MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei. PLoS ONE. 2008;3:e3494 pubmed publisher
    ..differentiation primary-response gene 88 (MyD88) and TIR-domain-containing adaptor protein inducing IFNbeta (TRIF) are regarded as the key signaling adaptor proteins for TLRs...
  61. Alugupalli K, Akira S, Lien E, Leong J. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol. 2007;178:3740-9 pubmed
    ..These results suggest that MyD88 specifically promotes T cell-independent BCR signaling and that, in the absence of Btk, this TLR-mediated stimulation is a required component of this signal. ..
  62. Cook P, Tötemeyer S, Stevenson C, Fitzgerald K, Yamamoto M, Akira S, et al. Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif. Immunology. 2007;122:222-9 pubmed
    ..Gram-negative bacteria and is recognized by Toll-like receptor 4, signalling via the adapter proteins Mal, MyD88, Tram and Trif. Here we show that S...
  63. Shah P, Omoluabi O, Moorthy B, Ghose R. Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon β in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016;44:61-7 pubmed publisher
    ..TIR) domain containing adaptor protein (TIRAP) and TIR domain containing adaptor inducing interferon (IFN)-β (TRIF) that eventually leads to induction of proinflammatory cytokines and mitogen-activated protein kinases (MAPKs)...
  64. Piao W, Ru L, Piepenbrink K, Sundberg E, Vogel S, Toshchakov V. Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain. Proc Natl Acad Sci U S A. 2013;110:19036-41 pubmed publisher
    Toll/IL-1R resistance (TIR) domain-containing adapter-inducing IFN-? (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NF?B...
  65. Leichtle A, Hernandez M, Pak K, WEBSTER N, Wasserman S, Ryan A. The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery. BMC Immunol. 2009;10:45 pubmed publisher
    ..effects; MyD88 (Myeloid differentiation primary response gene 88) inducing primarily interleukin expression and TRIF (Tir-domain-containing adaptor inducing interferon beta) mediating type I interferon (IFN) expression...
  66. van Lieshout M, Blok D, Wieland C, de Vos A, Van T Veer C, van der Poll T. Differential roles of MyD88 and TRIF in hematopoietic and resident cells during murine gram-negative pneumonia. J Infect Dis. 2012;206:1415-23 pubmed publisher
    ..Myeloid differentiation primary response gene (88) (MyD88) and TIR-domain-containing adaptor-inducing interferon-? (TRIF)...
  67. Gralinski L, Menachery V, Morgan A, Totura A, Beall A, Kocher J, et al. Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice. G3 (Bethesda). 2017;7:1653-1663 pubmed publisher
    ..We identified Ticam2, an adaptor protein in the TLR signaling pathways, as a candidate driving differential disease at the Chr 18 ..
  68. Hise A, Daehnel K, Gillette Ferguson I, Cho E, McGarry H, Taylor M, et al. Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. J Immunol. 2007;178:1068-76 pubmed
    ..These results establish that the innate inflammatory pathways activated by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal...
  69. Cuenca A, Joiner D, Gentile L, Cuenca A, Wynn J, Kelly Scumpia K, et al. TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. J Immunol. 2015;194:1169-77 pubmed publisher
    ..MyD88, has been shown to be critical for survival to sepsis in adults, little is known about the role of MyD88 or TRIF in neonatal sepsis...
  70. Pihlgren M, Silva A, Madani R, Giriens V, Waeckerle Men Y, Fettelschoss A, et al. TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice. Blood. 2013;121:85-94 pubmed publisher
    ..Surprisingly, the IgG class switch was mediated by TIR-domain-containing adapter inducing interferon-? (TRIF), but not by MyD88...
  71. Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, et al. The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling. J Biol Chem. 2014;289:1364-76 pubmed publisher
    ..Endocytosis of the activated TLR4 allows recruitment of the adaptors Tram and Trif, leading to activation of the transcription factor IRF3 and interferon production...
  72. Brandt E, Gibson A, Bass S, Rydyznski C, Khurana Hershey G. Exacerbation of allergen-induced eczema in TLR4- and TRIF-deficient mice. J Immunol. 2013;191:3519-25 pubmed publisher
    ..MyD88, TLR4, or Toll-IL-1R domain-containing adapter-inducing IFN-? (TRIF)-deficient and wild-type mice were epicutaneously exposed to Aspergillus fumigatus allergen over 3 wk...
  73. Bradley S, Kaminski D, Peters A, Jenuwein T, Stavnezer J. The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA. J Immunol. 2006;177:1179-88 pubmed
    ..Taken together, our results suggest that Suv39h1 activity inhibits the activity of a sequence-specific DNA-binding protein that represses switch recombination to IgA. ..
  74. Costa A, Gupta R, Signorino G, Malara A, Cardile F, Biondo C, et al. Activation of the NLRP3 inflammasome by group B streptococci. J Immunol. 2012;188:1953-60 pubmed publisher
    ..Our data link the production of a major virulence factor by GBS with the activation of a highly effective anti-GBS response triggered by the NLRP3 inflammasome...
  75. Vartanian K, Stevens S, Marsh B, Williams Karnesky R, Lessov N, Stenzel Poore M. LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury. J Neuroinflammation. 2011;8:140 pubmed publisher
    ..Protein expression was determined using Western blot or ELISA. MyD88-/- and TRIF-/- mice were utilized to evaluate signaling in LPS preconditioning-induced neuroprotection...
  76. Shalaby K, Al Heialy S, Tsuchiya K, Farahnak S, McGovern T, Risse P, et al. The TLR4-TRIF pathway can protect against the development of experimental allergic asthma. Immunology. 2017;152:138-149 pubmed publisher
    ..and Toll, interleukin-1 receptor and resistance protein (TIR) domain-containing adaptor inducing interferon-? (TRIF) comprise the two principal limbs of the TLR signalling network...