Gene Symbol: Tia1
Description: cytotoxic granule-associated RNA binding protein 1
Alias: 2310050N03Rik, AI256674, TIA-1, mTIA-1, nucleolysin TIA-1, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1
Species: mouse
Products:     Tia1

Top Publications

  1. Zhang T, Delestienne N, Huez G, Kruys V, Gueydan C. Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins. J Cell Sci. 2005;118:5453-63 pubmed
    ..This study demonstrates the importance of TIAR and TIA-1 RNA-binding domains for their subcellular localization and provides the first evidence for distinct functions of TIAR and TIA-1 RRMs. ..
  2. Yamasaki S, Stoecklin G, Kedersha N, Simarro M, Anderson P. T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs. J Biol Chem. 2007;282:30070-7 pubmed
    ..These results suggest that TIA-1-induced polysome disassembly is required for enhanced mRNA decay and that TIA-1-induced translational silencing promotes the decay of selected mRNAs. ..
  3. Piecyk M, Wax S, Beck A, Kedersha N, Gupta M, Maritim B, et al. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J. 2000;19:4154-63 pubmed
    ..Mice lacking TIA-1 are hypersensitive to the toxic effects of LPS, indicating that this translational control pathway may regulate the organismal response to microbial stress. ..
  4. Izquierdo J, Valcarcel J. Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. J Biol Chem. 2007;282:19410-7 pubmed
    ..Taken together, the results reveal distinct functional properties of TIA-1 isoforms and the existence of a regulatory network that controls isoform expression. ..
  5. Phillips K, Kedersha N, Shen L, Blackshear P, Anderson P. Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. Proc Natl Acad Sci U S A. 2004;101:2011-6 pubmed
    ..Our results suggest that TIA-1 and TTP are genetic modifiers of inflammatory arthritis that can alter the spectrum of cells that produce arthritogenic cytokines. ..
  6. Beck A, Medley Q, O BRIEN S, Anderson P, Streuli M. Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res. 1996;24:3829-35 pubmed
    ..Molecular characterization of murine TIA-1 and TIAR RNA binding proteins provides the basis for a genetic analysis of the functional roles of these proteins during mammalian development. ..
  7. Tsai N, Ho P, Wei L. Regulation of stress granule dynamics by Grb7 and FAK signalling pathway. EMBO J. 2008;27:715-26 pubmed publisher
    ..This is the first reported pathway actively regulating the dynamics of SGs. ..
  8. Arimoto Matsuzaki K, Saito H, Takekawa M. TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis. Nat Commun. 2016;7:10252 pubmed publisher
    ..Here we report that reactive oxygen species (ROS) such as H2O2 oxidize the SG-nucleating protein TIA1, thereby inhibiting SG assembly...
  9. Dixon D, Balch G, Kedersha N, Anderson P, Zimmerman G, Beauchamp R, et al. Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med. 2003;198:475-81 pubmed
    ..These findings implicate that TIA-1 functions as a translational silencer of COX-2 expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia. ..

More Information


  1. Schwab K, Patterson L, Hartman H, Song N, Lang R, Lin X, et al. Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 2007;5:15 pubmed
    ..In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity. ..
  2. Kimball S, Horetsky R, Ron D, Jefferson L, Harding H. Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol. 2003;284:C273-84 pubmed
    ..Finally, we also show that stress granules contain many, if not all, of the components of the 48S preinitiation complex, but not 60S ribosomal subunits, suggesting that they represent stalled translation initiation complexes. ..
  3. Kuwasako K, Takahashi M, Tochio N, Abe C, Tsuda K, Inoue M, et al. Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode. Biochemistry. 2008;47:6437-50 pubmed publisher
    ..An investigation of the chemical shift perturbation revealed similarity in the RNA recognition modes between the TIA-1 and U2AF65 RRMs. ..
  4. Schimmer B, Cordova M. Corticotropin (ACTH) regulates alternative RNA splicing in Y1 mouse adrenocortical tumor cells. Mol Cell Endocrinol. 2015;408:5-11 pubmed publisher
    ..this study, we demonstrate that ACTH regulates the alternative splicing of four transcripts - Gnas, Cd151, Dab2 and Tia1. Inasmuch as alternative splicing potentially affects transcripts from more than two-thirds of the mouse genome, we ..
  5. Cook D, Sánchez Carbente M, Lachance C, Radzioch D, Tremblay S, Khandjian E, et al. Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. PLoS ONE. 2011;6:e26120 pubmed publisher
    ..Our data indicate that FXR1P is properly positioned to control local protein synthesis in the dendrite and at synapses in the central nervous system. ..
  6. Mahboubi H, Koromilas A, Stochaj U. AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol Pharmacol. 2016;90:460-8 pubmed publisher
    ..Taken together, we provide mechanistic insights into the regulation of SG formation. We propose that AMPK activation stimulates oxidant-induced SG formation but limits their fusion into larger granules. ..
  7. Katsanou V, Papadaki O, Milatos S, Blackshear P, Anderson P, Kollias G, et al. HuR as a negative posttranscriptional modulator in inflammation. Mol Cell. 2005;19:777-89 pubmed
    ..Our data suggest that HuR acts in a pleiotropic fashion in inflammation through its functional interactions with specific mRNA subsets and negative posttranscriptional modules. ..
  8. Heck M, Azizov M, Stehning T, Walter M, Kedersha N, Auburger G. Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue. Neurogenetics. 2014;15:135-44 pubmed
    ..frontotemporal dementia(FTD), here we studied mouse nervous tissue to identify mRNAs with selective dependence on Tia1 deletion...
  9. Repetto E, Briata P, Kuziner N, Harfe B, McManus M, Gherzi R, et al. Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012;8:e1002823 pubmed publisher
    ..Our study unveils a functional crosstalk between miRNA- and AMD-dependent gene regulation during mammalian organogenesis events. ..
  10. Kunde S, Musante L, Grimme A, Fischer U, Muller E, Wanker E, et al. The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules. Hum Mol Genet. 2011;20:4916-31 pubmed publisher
  11. Díaz Muñoz M, Kiselev V, Le Novère N, Curk T, Ule J, Turner M. Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells. Nat Commun. 2017;8:530 pubmed publisher
    ..are formed upon cell activation with mitogens, including stress granules that contain the RNA binding protein Tia1. Tia1 binds to a subset of transcripts involved in cell stress, including p53 mRNA, and controls translational ..
  12. Carrascoso I, Sánchez Jiménez C, Izquierdo J. Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression. Mol Cancer. 2014;13:90 pubmed publisher
    ..Making use of human and mouse cells with knocked down/out expression of T-cell intracellular antigen 1 (TIA1) and/or TIA1 related/like (TIAR/TIAL1) proteins and classical RNA (e.g...
  13. Pedrotti S, Busà R, Compagnucci C, Sette C. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res. 2012;40:1021-32 pubmed publisher
    ..Thus, our findings identify RBM11 as a novel tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. ..
  14. Sánchez Jiménez C, Izquierdo J. T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy. PLoS ONE. 2013;8:e75127 pubmed publisher
    Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1 related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for these proteins during embryonic development...
  15. Albornoz A, Carletti T, Corazza G, Marcello A. The stress granule component TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation. J Virol. 2014;88:6611-22 pubmed publisher
  16. Choi E, Pintel D. Splicing of the large intron present in the nonstructural gene of minute virus of mice is governed by TIA-1/TIAR binding downstream of the nonconsensus donor. J Virol. 2009;83:6306-11 pubmed publisher
    ..The ISE binds the cellular RNA-processing proteins TIA-1 and TIAR, which enhance usage of the nonconsensus donor. ..
  17. Yu C, York B, Wang S, Feng Q, Xu J, O Malley B. An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response. Mol Cell. 2007;25:765-78 pubmed
    ..Collectively, our studies reveal an essential function of SRC-3 as a coordinator of inflammatory mRNA translation and as a physiologic protective factor against the lethal endotoxic shock triggered by an acute inflammatory response. ..
  18. Lachke S, Alkuraya F, Kneeland S, Ohn T, Aboukhalil A, Howell G, et al. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011;331:1571-6 pubmed publisher
    ..These findings demonstrate a role for RGs in vertebrate organogenesis. ..
  19. Yeowell H, Walker L, Mauger D, Seth P, Garcia Blanco M. TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2. J Invest Dermatol. 2009;129:1402-11 pubmed publisher
    ..Identification of these TIA regulatory factors therefore suggests a tool to manipulate cellular LH2 levels in scleroderma so that potential intervention therapies may be identified. ..
  20. Singh N, Seo J, Ottesen E, Shishimorova M, Bhattacharya D, Singh R. TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy. Mol Cell Biol. 2011;31:935-54 pubmed publisher
    ..Here, we report T-cell-restricted intracellular antigen 1 (TIA1) and TIA1-related (TIAR) proteins as intron-associated positive regulators of SMN2 exon 7 splicing...
  21. Vanderweyde T, Apicco D, Youmans Kidder K, Ash P, Cook C, Lummertz da Rocha E, et al. Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Rep. 2016;15:1455-1466 pubmed publisher
    ..We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the brain-protein interactome network for TIA1...
  22. Simarro M, Giannattasio G, Xing W, Lundequist E, Stewart S, Stevens R, et al. The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett. 2012;146:8-14 pubmed publisher
    ..Our results identify TIA-1 as a negative regulator of allergen-mediated pulmonary inflammation in vivo. Thus, TIA-1 might be an important player in the pathogenesis of bronchial asthma. ..
  23. Lowin B, French L, Martinou J, Tschopp J. Expression of the CTL-associated protein TIA-1 during murine embryogenesis. J Immunol. 1996;157:1448-54 pubmed
    ..The conservation of this RNA-binding protein throughout evolution implicates its importance in embryogenesis, and in particular neuronal development. ..