Genomes and Genes
Gene Symbol: Thbs1
Description: thrombospondin 1
Alias: TSP-1, TSP1, Thbs-1, tbsp1, thrombospondin-1
Publications127 found, 100 shown here
- Restricted localization of thrombospondin-2 protein during mouse embryogenesis: a comparison to thrombospondin-1P A Tooney
Department of Medicine, University of Wisconsin Madison, 53706, USA
Matrix Biol 17:131-43. 1998Thrombospondin-1 and -2 (TSP1 and TSP2) are multifunctional, multimodular extracellular matrix proteins encoded by separate genes. We compared the distributions of TSP1 and TSP2 in mouse embryos (day 10 and later) by immunohistochemistry...
- Induced thrombospondin expression in the mouse pancreas during pancreatic injuryBrent A Neuschwander-Tetri
Saint Louis University Liver Center and Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA
Int J Biochem Cell Biol 38:102-9. 2006..These modulators of fibrogenesis could play a role in the development of pancreatic fibrosis that characterizes chronic pancreatitis...
- Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1)James Greenaway
Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
J Cell Physiol 210:807-18. 2007..In conclusion, we demonstrate a direct inhibitory effect of TSP-1 on VEGF in the ovary. TSP-1's regulation of VEGF appears to be an important mediator of ovarian angiogenesis and follicle development...
- Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient miceBruce Turpie
Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
Am J Pathol 175:1136-47. 2009..Together, these results indicate that TSP-1 deficiency results in a spontaneous form of chronic dry eye and aberrant histopathology associated with Sjögren's syndrome...
- Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesisCagla Eroglu
Duke University Medical Center, Cell Biology Department, Durham, NC 27710, USA
Cell 139:380-92. 2009..These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation...
- Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injuryJeff S Isenberg
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
Am J Pathol 173:1100-12. 2008..Therefore, thrombospondin-1/CD47 antagonists may have selective radioprotective activity for normal tissues...
- Persistent inflammation subverts thrombospondin-1-induced regulation of retinal angiogenesis and is driven by CCR2 ligationMei Chen
Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
Am J Pathol 180:235-45. 2012..This model offers a new platform to dissect the molecular and cellular pathology of inflammation-induced ocular angiogenesis...
- Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralizationAkemichi Ueno
Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
J Cell Physiol 209:322-32. 2006b>Thrombospondin 1 (TSP1) is a multifunctional extracellular glycoprotein present mainly in the fetal and adult skeleton...
- A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndromeOctavio Garcia
Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, United States of America
PLoS ONE 5:e14200. 2010..In this study, we investigated whether deficits in astrocyte function contribute to DS spine pathology...
- Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47Sukhbir Kaur
Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:38923-32. 2010Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with VEGF and indirectly by engaging several endothelial cell TSP1 receptors...
- Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic miceThomas Hawighorst
Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
Oncogene 21:7945-56. 2002..Our findings indicate the potential use of TSP-1 for the prevention of premalignant stages of tumorigenesis and are likely to have implications for the further development of anti-angiogenic cancer therapies...
- Thrombospondin-1 derived from APCs regulates their capacity for allosensitizationDaniel R Saban
Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
J Immunol 185:4691-7. 2010..Future strategies targeting APCs for TSP-1 upregulation may thus be effective in promoting allograft survival...
- Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activationPhilip P Fitchev
Department of Surgery, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA
Lab Invest 90:1078-90. 2010..Therefore, loss of TSP-1 during tumorigenesis would eliminate two barriers to cancer progression...
- Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53F Su
Department of Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Oncogene 29:421-31. 2010..However, U19/EAF2 transfection alone had little or no effect on the TSP-1 promoter. The above observations together suggest that U19/EAF2 regulates the expression of TSP-1 via blocking p53 repression of the TSP-1 promoter...
- Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytesClaus Cursiefen
Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, 91054 Erlangen, Germany
J Exp Med 208:1083-92. 2011..Inhibition of VEGF-C is not detected in the absence or blockade of CD36. These findings suggest that TSP-1, by ligating CD36 on monocytic cells, acts as an endogenous inhibitor of lymphangiogenesis...
- Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1Philip M Bauer
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Cardiovasc Res 93:682-93. 2012..In this study, we investigated the role activated CD47 plays in promoting PAH...
- Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemiaCharuhas V Thakar
Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
J Clin Invest 115:3451-9. 2005b>Thrombospondin 1 (TSP-1) is a matricellular protein that inhibits angiogenesis and causes apoptosis in vivo and in vitro in several cancerous cells and tissues...
- Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47Elfaridah P Frazier
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, United States
Matrix Biol 30:154-61. 2011..Both CD47 and TSP1 null mice are leaner than WTs, use less oxygen and produce less heat than WT mice...
- Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in miceHiromitsu Hayashi
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Hepatology 55:1562-73. 2012....
- Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degenerationElsa Kermorvant-Duchemin
Department of Pediatrics, Ophthalmology and Pharmacology, Research Center, Hopital Ste Justine, 3175 Côte de Ste Catherine, Montreal, Quebec, H3T1C5, Canada
Nat Med 11:1339-45. 2005....
- Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1Yoon Jin Lee
Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 70:948-56. 2010..Tumor angiogenesis is restrained by a variety of endogenous inhibitors, including thrombospondin 1 (TSP1)...
- Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- miceRute Moura
Center for Molecular and Vascular Biology, Department of Cardiovascular Diseases, University of Leuven, Belgium
Circ Res 103:1181-9. 2008..Therefore, the development of atherosclerosis was compared in ApoE(-/-) and Tsp1(-/-)ApoE(-/-) mice kept on a normocholesterolemic diet...
- Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cellsGema Martin-Manso
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 68:7090-9. 2008..We show that overexpression of TSP1 in melanoma cells increases macrophage recruitment into xenograft tumors grown in nude or beige/nude mice...
- The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1Fatemeh Fouladkou
Program in Cell Biology and the Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
J Biol Chem 285:6770-80. 2010..These results suggest that Nedd4-1 is a suppressor of Tsp1 and that increased levels of Tsp-1 in the Nedd4-1 knock-out mice may have contributed to the developmental defect ..
- Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunitySara McMaken
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 6:e19654. 2011..Because of these observations we sought to determine the importance of TSP-1 in sepsis...
- Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1Elizabeth A Scheef
Dept of Ophthalmology and Visual Sciences, Univ of Wisconsin, 600 Highland Ave, K6 458 CSC, Madison, WI 53792 4673, USA
Am J Physiol Cell Physiol 296:C724-34. 2009..Thrombospondin (TSP)1 is a matricellular protein and an autocrine factor for VSMCs. TSP1 activity, along with that of PDGF, regulates VSMC proliferation and migration...
- Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesisAlexander Zaslavsky
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Blood 115:4605-13. 2010..Further, this work implicates the use of thrombospondin-1 levels in platelets as an indicator of tumor growth and regression...
- Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factorJ C Rodriguez-Manzaneque
Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, CA 90095 1570, USA
Proc Natl Acad Sci U S A 98:12485-90. 2001..To ascertain the participation of the endogenous angiogenic inhibitor thrombospondin-1 (TSP1) in tumor progression, we generated mammary tumor-prone mice that either lack, or specifically overexpress, TSP1 in ..
- Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 geneT Shingu
Department of Biochemistry, University of Washington, Seattle 98195
J Biol Chem 269:32551-7. 1994..which functions synergistically with a distal serum-response element to mediate the serum response of the human TSP1 gene...
- Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switchSylvie Giuriato
Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, CCSR Building, Room 1120, 269 Campus Drive, Stanford, CA 94305 5151, USA
Proc Natl Acad Sci U S A 103:16266-71. 2006..Therefore, the combined inactivation of oncogenes and angiogenesis may be a more clinically effective treatment of cancer. We conclude that angiogenesis is an essential component of oncogene addiction...
- Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic propertiesDavid M Smadja
Universite Paris Descartes, Paris, France
Arterioscler Thromb Vasc Biol 31:551-9. 2011..We examined whether plasma levels of angiogenic factors are altered in plasma of patients with peripheral arterial disease (PAD) and whether these factors affect endothelial progenitor cell-induced angiogenesis...
- Thrombospondin-1 is a major activator of TGF-beta1 in vivoS E Crawford
Robert H Lurie Cancer Center, Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Cell 93:1159-70. 1998....
- Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemiaJeff S Isenberg
MPH, Laboratory of Pathology, Building 10, 2A33, National Cancer Institute, Bethesda, Maryland 20892 1500, USA
Arterioscler Thromb Vasc Biol 27:2582-8. 2007..Blood vessel diameter and blood flow are limited by the matricellular protein thrombospondin-1 (TSP1) through its ability to block responses to the endogenous vasodilator nitric oxide (NO)...
- Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitisKaiyong Yang
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Autoimmun 32:94-103. 2009..These results demonstrate that TSP-1 participates in the differentiation of Th17 cells through its ability to activate latent TGF-beta, and enhances the inflammatory response in EAE...
- Downregulation of the angiogenesis inhibitor thrombospondin 1 in fibroblasts exposed to platelets and their related phospholipidsWojciech Kalas
Henderson Research Centre, Experimental Thrombosis Research, McMaster University, Hamilton, Ont, Canada
Biochem Biophys Res Commun 334:549-54. 2005..other mediators, though their effects are normally opposed by endogenous angiogenesis inhibitors, including thrombospondin 1 (TSP-1/THSP1)...
- Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factorJ Scott Isenberg
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Building 10, Room 2A33, 10 Center Drive MSC1500 Bethesda, MD 20892 1500, United States
Matrix Biol 24:110-23. 2005We have reexamined the role of endogenous thrombospondin-1 (TSP1) in growth and motility of vascular smooth muscle cells (SMCs)...
- Characterization of integrin beta6 and thrombospondin-1 double-null miceAnna Ludlow
The Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA
J Cell Mol Med 9:421-37. 2005..They also indicate that alphavbeta6 functions as a tumor suppressor gene and that activation of TGFbeta by TSP-1 and alphavbeta6 contributes to normal tissue architecture and function...
- Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor levelXuefeng Zhang
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
FASEB J 23:3368-76. 2009..Moreover, 3TSR significantly decreased VEGF-stimulated VEGFR2 phosphorylation in human dermal microvascular endothelial cells in culture. Taken together, the results indicate that TSP-1 and 3TSR modulate the function of VEGFR2...
- Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migrationSophia M Blake
Department of Medical Biochemistry, Max F Perutz Laboratories, Medical University Vienna, Vienna, Austria
EMBO J 27:3069-80. 2008..Lack of THBS-1 results in anatomical abnormalities of the RMS and leads to a reduction of postnatal neuronal precursors entering the OB...
- Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cellsKati Tarkkonen
Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, 20520, Turku, Finland
Growth Factors 28:256-67. 2010..It was previously shown to regulate expression of thrombospondin 1 (TSP-1), an inhibitor of angiogenesis, in S115 breast cancer cells...
- Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosisSolène Evrard
INSERM, U1009, Université Paris Sud11, Institut Gustave Roussy, Villejuif, France
Blood 117:246-9. 2011..Our results show that TSP-1 is not the major activator of TGF-β1 in TPO-induced myelofibrosis, suggesting the contribution of another mechanism in the megakaryocyte/platelet compartment...
- Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosisMichael E Ezzie
Department of Medicine and the Dorothy M Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
Am J Respir Cell Mol Biol 44:556-61. 2011..These results demonstrate that TSP-1 deficiency does not protect mice from systemic bleomycin challenge, and that TSP-1 deficiency is associated with increased expression of lung collagen and CTGF...
- Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infectionCandice A Johnson
Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, United States of America
PLoS ONE 7:e40614. 2012..cruzi through the NTSP domain and that this interaction enhances cellular infection. Thus surface TcCRT is a virulent factor that enhances the pathogenesis of T. cruzi infection through TSP-1, which is up-regulated by the parasite...
- Expression of thrombospondin-1 in ischemia-induced retinal neovascularizationK Suzuma
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan
Am J Pathol 154:343-54. 1999..VEGF-mediated thrombospondin-1 induction in ischemia-induced angiogenesis may be a negative feedback mechanism...
- Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstructionNaïke Bigé
INSERM Unit 702, Paris, France
Kidney Int 81:1226-38. 2012..Thus, TSP-1 is an important profibrotic and inflammatory mediator of renal disease. Blockade of its action may be a treatment against the development of chronic kidney disease...
- Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxationEileen M Bauer
Vascular Medicine Institute of University of Pittsburgh, Pittsburgh, PA, USA
Cardiovasc Res 88:471-81. 2010Thrombospondin-1 (TSP1), via its necessary receptor CD47, inhibits nitric oxide (NO)-stimulated soluble guanylate cyclase activation in vascular smooth muscle cells, and TSP1-null mice have increased shear-dependent blood flow compared ..
- Deficiency of thrombospondin-1 in mice does not affect adipose tissue developmentG Voros
J Thromb Haemost 4:277-8. 2006
- Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1B Jimenez
Department of Microbiology, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, 60611, USA
Nat Med 6:41-8. 2000..These results indicate that thrombospondin-1, and possibly other broad-spectrum natural inhibitors of angiogenesis, act in vivo by inducing receptor-mediated apoptosis in activated microvascular endothelial cells...
- Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel diseaseSalman Punekar
Wilkes University, Wilkes Barre, PA 18766, USA
Pathobiology 75:9-21. 2008..b>Thrombospondin 1 (TSP-1) is a protein well known for its antiangiogenic and anti-inflammatory properties...
- Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expressionKiichiro Yano
Shiseido Life Science Research Center, Yokohama, Japan
J Invest Dermatol 122:201-8. 2004....
- Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic isletsJohan Olerud
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Diabetes 57:1870-7. 2008..The present study tested the hypothesis that the angiostatic factor thrombospondin-1 (TSP-1), which is normally present in islets, restricts intra-islet vascular expansion posttransplantation...
- The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactionsPaula Velasco
Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
J Invest Dermatol 129:2022-30. 2009..b>Thrombospondin 1 (TSP-1) is a potent endogenous angiogenesis inhibitor thought to play an important role in maintaining ..
- Thrombospondin-1: an islet endothelial cell signal of importance for β-cell functionJohan Olerud
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Diabetes 60:1946-54. 2011..Loss of thrombospondin (TSP)-1 in pancreatic islets has been shown to cause islet hyperplasia. This study tested the hypothesis that endothelial-derived TSP-1 is important for β-cell function...
- Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic miceM Streit
Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
EMBO J 19:3272-82. 2000....
- Role of thrombospondin-1 in control of von Willebrand factor multimer size in miceJohn E Pimanda
Centre for Vascular Research, University of New South Wales and the Department of Haematology, The Prince of Wales Hospital, Sydney, New South Wales 2052, Australia
J Biol Chem 279:21439-48. 2004..These findings indicate that TSP-1 influences plasma and platelet VWF multimeric size differently and may be more relevant for control of the VWF released from platelets...
- Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient miceNicolas Bréchot
INSERM, U833, Paris, France
PLoS ONE 3:e3950. 2008..TSP-1 is a matricellular protein that displays well-known angiostatic properties in cancer, and regulates inflammation in vivo and macrophages properties in vitro. We therefore sought to investigate its function in a mouse model of CLI...
- Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3H Chen
Department of Biomolecular Chemistry, University of Wisconsin, Madison, 53076, USA
FEBS Lett 387:36-41. 1996To analyze the function of TSP family members, we have expressed and purified mouse TSP1 and TSP3 encoded by recombinant baculoviruses in Spodoptera frugiperda cells and compared these TSPs to mouse TSP2 prepared in a similar way...
- Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeatsM L Iruela-Arispe
Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute, UCLA, Los Angeles, Calif 90095, USA
Circulation 100:1423-31. 1999..The antiangiogenic activity of TSP-1, as defined by cornea pocket assays, was previously mapped to the amino-terminal portion of the protein within the procollagen region and the type 1 repeats...
- Differential expression of thrombospondin 1, 2, and 3 during murine developmentM L Iruela-Arispe
Department of Biological Structure, University of Washington, Seattle 98195
Dev Dyn 197:40-56. 1993b>Thrombospondin 1 is a secreted, trimeric glycoprotein that mediates interactions between cells and extracellular matrix and exhibits cell-specific effects on migration and proliferation...
- Role of thrombospondin-1 in T cell response to ocular pigment epithelial cellsYuri Futagami
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
J Immunol 178:6994-7005. 2007..Via the conversion of latent TGFbeta to an active form that appears to be mediated by thrombospondin 1 (TSP-1), cultured iris PE and retinal PE cells induce a PE-induced Treg cell fate...
- Interactions between CD47 and thrombospondin reduce inflammationLaurence Lamy
INSERM Unit 576, Hospitalier de l Université de Nice, University of Nice Sophia Antipolis, hôpital de l Archet I, 151 rue Saint Antoine de Ginestière, Nice, France
J Immunol 178:5930-9. 2007..Overall, these results reveal an important role in vivo for this new CD47/BNIP3 pathway in limiting inflammation by controlling the number of activated T cells...
- Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikisManuel A Pallero
Department of Pathology, VH 668 1530 3rd Ave, South, Birmingham, AL 35294 0019, USA
FASEB J 22:3968-79. 2008..Fibrogenesis is associated with reduced fibroblast apoptosis. The matricellular protein thrombospondin 1 (TSP1) regulates cell adhesion and motility during tissue remodeling and in fibrogenesis...
- Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signalingJeff S Isenberg
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 111:613-23. 2008..Thus, release of thrombospondin-1 from alpha-granules during activation provides positive feedback to promote efficient platelet aggregation and adhesion by overcoming the antithrombotic activity of physiologic NO...
- Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13R S Wymore
Department of Physiology, University of California, Irvine 92717
Genomics 20:191-202. 1994..1, lies approximately 1.8 cM from the Myod-1 gene on mouse chromosome 7, and in situ hybridization localizes KCNC1/hKv3.1 to the homologous region on human chromosome 11p14.3-p15.2. A third gene, KCNA1/hKv1.1, was mapped to human 12p13...
- Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after strokeJason Liauw
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5327, USA
J Cereb Blood Flow Metab 28:1722-32. 2008..Deficiency of TSP-1/2 leads to impaired recovery after stroke mainly due to the role of these proteins in synapse formation and axonal outgrowth...
- Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagenKaren L Posey
Department of Pediatrics, University of Texas Medical School, 6431 Fannin, Houston, TX 77030, USA
Am J Pathol 172:1664-74. 2008..To define the roles of TSP1, TSP3, TSP5, and Col9 in the growth plate, all knockout and combinatorial strains were analyzed using ..
- CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1Jeff S Isenberg
Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:26069-80. 2006..Therefore, ligation of either CD36 or CD47 is sufficient to inhibit NO-stimulated vascular cell responses and cGMP signaling, but only CD47 is necessary for this activity of thrombospondin-1 at physiological concentrations...
- Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signalingZhiping Li
Thomas Jefferson University, Department of Cancer Biology, Kimmel Cancer Center, Bluemle Building, Rm 1050, 233 South 10th St, Philadelphia, PA 19107, USA
Mol Cell Biol 26:4240-56. 2006..arrays identified a subset of genes regulated by cyclin D1, including Rho-activated kinase II (ROCKII) and thrombospondin 1 (TSP-1)...
- Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliterationShoujian Wang
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53792, USA
Dev Dyn 228:630-42. 2003Thrombospondin-1 (TSP1) is a natural inhibitor of angiogenesis. Its expression is most prominent during the late stages of vascular development and in the adult vasculature...
- The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null miceAzin Agah
Department of Biochemistry, University of Washington, Seattle 98195, USA
Am J Pathol 161:831-9. 2002..In an attempt to elucidate their biological roles more clearly, we generated double-TSP1/TSP2-null animals and compared their phenotype to those of TSP1- and TSP2-null mice...
- Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient miceJ Lawler
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Pathol 159:1949-56. 2001In vitro and in vivo data indicate that thrombospondin-1 (TSP1) inhibits tumor progression in several ways including direct effects on cellular growth and apoptosis in the stromal compartment...
- Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritisI Ming Jou
Department of Biochemistry, National Cheng Kung University Medical College, 1 Dashiue Road, Tainan 701, Taiwan
Arthritis Rheum 52:339-44. 2005Because thrombospondin 1 (TSP-1) inhibits angiogenesis and activates latent transforming growth factor beta (TGFbeta), a potent immunosuppressive and antiinflammatory cytokine, we investigated the prophylactic and therapeutic effects of ..
- Attenuation of retinal vascular development and neovascularization in transgenic mice over-expressing thrombospondin-1 in the lensZhifeng Wu
Department of Ophthalmology, University of Wisconsin Medical School, Madison, Wisconsin 53792 4673, USA
Dev Dyn 235:1908-20. 2006Thrombospondin-1 (TSP1) is an endogenous inhibitor of angiogenesis and induces endothelial cell (EC) apoptosis...
- Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient miceK Uno
Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan
Histol Histopathol 20:493-9. 2005..These findings suggest that vitamin A may modulate the expression of TSP-1 in the corneas to accelerate the re-epithelialization of wounded corneas...
- Activation of platelet-transforming growth factor beta-1 in the absence of thrombospondin-1M Abdelouahed
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 275:17933-6. 2000..Because platelet releasates from TSP-1 null mice contain active TGF-beta1, we suggest that other important mechanisms of physiological activation of TGF-beta1 probably exist in platelets...
- Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarctsNikolaos G Frangogiannis
Section of Cardiovascular Sciences, Methodist Hospital and DeBakey Heart Center, Baylor College of Medicine, Houston, Tex, USA
Circulation 111:2935-42. 2005....
- Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1Olga V Volpert
Department of Urology and RH Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
Cancer Cell 2:473-83. 2002..This decrease was completely reversed by a TSP-1 neutralizing antibody. We conclude that TSP-1 is a major target for Id1 effects on angiogenesis...
- Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stressJeff S Isenberg
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, United States
Matrix Biol 28:110-9. 2009..Thus, the matricellular protein thrombospondin-1 and its receptor CD47 serve as acute physiological regulators of blood pressure and exert a vasopressor activity to maintain global hemodynamics under stress...
- Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retinaJingfang Sun
Dept of Pathology, Beth Israel Deaconess Medical Ctr and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
Am J Physiol Heart Circ Physiol 296:H1344-51. 2009..Here we report that TSP1 antagonized microvascular survival to retinal hyperoxia, and Akt signaling in both the retina and in cultured ..
- Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1Toru Nishiwaki
Department of Orthopaedics, School of Medicine, Keio University, Tokyo, Japan
J Bone Miner Res 21:596-604. 2006..We found that expression of Thbs1 and Thbs2 was reduced in Fra1 Tg osteoblasts...
- Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumoniaJ Lawler
Department of Pathology, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 101:982-92. 1998..A thickening and ruffling of the epithelium of the airways results from increasing cell proliferation in TSP-1-deficient mice. These results indicate that TSP-1 is involved in normal lung homeostasis...
- Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13Arnaud Bonnefoy
Center for Molecular and Vascular Biology, Laboratory of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
Blood 107:955-64. 2006The function of thrombospondin-1 (TSP-1) in hemostasis was investigated in wild-type (WT) and Tsp1-/- mice, via dynamic platelet interaction studies with A23187-stimulated mesenteric endothelium and with photochemically injured cecum ..
- Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent mannerJeff S Isenberg
Laboratory of Pathology and Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:13141-6. 2005..explants in 3D culture, we found that explants from mice lacking the angiogenesis inhibitor thrombospondin-1 (TSP1) exhibit exaggerated angiogenic responses to an exogenous NO donor, which could be reversed by providing exogenous ..
- Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse modelLinda S Gutierrez
Walther Cancer Research Center, W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, Freimann Life Sciences Center University of Notre Dame, Notre Dame, IN 46556, USA
Carcinogenesis 24:199-207. 2003b>Thrombospondin 1 (TSP-1) is a multifunctional extracellular matrix protein that is an endogenous regulator of tumor angiogenesis...
- Thrombospondin-1 plays a critical role in the induction of hair follicle involution and vascular regression during the catagen phaseKiichiro Yano
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
J Invest Dermatol 120:14-9. 2003..These results identify a critical role of TSP-1 in the induction of anagen follicle involution, with potential implications for the therapeutic modulation of hair follicle growth...
- Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal regionJosephine C Adams
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Cell Sci 121:784-95. 2008..ECM retention of TSP1 is mediated by the C-terminal region in trimeric form, and not by C-terminal monomer or trimers of the N-terminal ..
- The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1Ali Mallakin
Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Int J Cancer 126:1403-16. 2010..Identification of novel Dmp1 target genes not only provides insights into the effects of Dmp1 on global gene expression, but also sheds light on the mechanism of haploid insufficiency of Dmp1 in tumor suppression...
- Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic miceRiikka Kivela
LIKES Research Center for Sport and Health Sciences, Rautpohjankatu 8a, 40700 Jyväskylä, Finland
Cardiovasc Diabetol 7:13. 2008..The responses in capillaries and muscle fibers, collected from the muscle with laser capture microdissection, were also studied separately...
- Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimersK M O'Rourke
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
J Biol Chem 267:24921-4. 1992There exist two distinct thrombospondin molecules (designated TSP1 and TSP2) which are encoded by separate genes. TSP1 is a trimeric cell surface and extracellular matrix molecule...
- Barx2 functions through distinct corepressor classes to regulate hair follicle remodelingLorin E Olson
Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California at San Diego School of Medicine, La Jolla, CA 92093 0648, USA
Proc Natl Acad Sci U S A 102:3708-13. 2005..Together, our data suggest that the hair-remodeling defect of Barx2 mutant mice could be explained, in part, by failure to repress one or more critical target genes...
- Thrombospondin-1 deficient mice exhibit an altered expression pattern of alternatively spliced PECAM-1 isoforms in retinal vasculature and endothelial cellsYongji Wang
University of Wisconsin, Department of Ophthalmology and Visual Sciences, Madison, Wisconsin, USA
J Cell Physiol 204:352-61. 2005We have previously shown that thrombosponsin-1 (TSP1) and PECAM-1 are components of a regulatory switch whose reciprocal regulation in the endothelial cells (EC) promotes an angiogenic or a differentiated, quiescent phenotype...
- Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokineJ B Smith
Division of Neonatology, UCLA School of Medicine 90095, USA
J Biol Chem 270:16756-65. 1995..The LIX message is strongly induced by LPS in fibroblasts, but not in macrophages, suggesting that LIX may participate in the recruitment of inflammatory cells by injured or infected tissue...
- Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassemblyAnthony Wayne Orr
Department of Pathology, Division of Molecular and Cellular Pathology and The Cell Adhesion and Matrix Research Center, University of Alabama, Birmingham, Alabama 35294 9340, USA
J Biol Chem 279:48983-92. 2004..Cells utilize dynamic interactions with the extracellular matrix to adapt to changing environmental conditions. Thrombospondin 1 (TSP1) induces focal adhesion disassembly and cell migration through a sequence (hep I) in its heparin-..
- Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formationShizuya Saika
Departments of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
Exp Eye Res 79:147-56. 2004..In contrast, in post-operative lens cells differentiating to fiber cells, its expression levels decline. Further study is needed to clarify the roles of TSP-1 in modulating lens cell phenotype expression...
- Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritisKathrin Hochegger
Klinische Abteilung für Nephrologie, Universitätsklinik für Innere Medizin Innsbruck, Innsbruck, Austria
Nephron Exp Nephrol 96:e31-8. 2004Thrombospondin-1 (TSP1), a multifunctional, extracellular matrix protein, regulates cellular attachment, proliferation, migration, and differentiation in vitro, and is expressed de novo in many inflammatory diseases, including ..
- c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progressionTroy A Baudino
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Genes Dev 16:2530-43. 2002..These findings support the model wherein c-Myc promotes cell growth and transformation, as well as vascular and hematopoietic development, by functioning as a master regulator of angiogenic factors...
- Thrombospondin 3 is a developmentally regulated heparin binding proteinA N Qabar
Department of Pathology, University of Michigan Medical School, Ann Arbor 48019
J Biol Chem 269:1262-9. 1994..Finally, a combination of in situ hybridization and immunocytochemistry demonstrated TSP3 to be expressed in a temporal and spatial manner during murine embryogenesis, especially in the gut, cartilage, lung, and central nervous system...
- The evolution of the thrombospondin gene familyJ Lawler
Department of Pathology, Brigham and Women s Hospital, Boston, MA
J Mol Evol 36:509-16. 1993..These results indicate that the members of the thrombospondin gene family have existed throughout the evolution of the animal kingdom and thus probably participate in functions that are common to most of its members...
- A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient miceM A Farmer
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Proc Natl Acad Sci U S A 98:13820-5. 2001..A human ortholog of the Chr. 3 QTL, if one exists, would map to Chr. 4q or 1p...
- Cloning of the murine Drm gene (Cktsf1b1) and characterization of its oncogene suppressible promoterQ Zhang
Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA
Cytogenet Cell Genet 89:242-51. 2000..Our results indicate that the expression of Cktsf1b1, a gene associated with early development and cell transformation, is sensitive to MKK levels and may be regulated via multiple transcription factor complexes...
- Localization of the renal Na-K-Cl cotransporter gene (Slc12a1) on mouse chromosome 2S E Quaggin
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
Mamm Genome 6:557-8. 1995
- VEGF Signaling and Tumor MicroenvironmentLuisa Iruela Arispe; Fiscal Year: 2007..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
- Resolution of inflammation in healing myocardial infarctsNikolaos Frangogiannis; Fiscal Year: 2009..These studies may lead to therapeutic interventions aimed at optimizing cardiac repair by preventing prolongation and extension of the inflammatory injury. ..
- VEGF Signaling and Tumor MicroenvironmentLuisa Iruela Arispe; Fiscal Year: 2010..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
- Upstream Stimulatory Factor 2 regulation of renin in diabetic nephropathyShuxia Wang; Fiscal Year: 2010....
- Notch Signaling in Vascular Development and HomeostasisLuisa Iruela Arispe; Fiscal Year: 2007..Thus, this information is central to the generation of novel and more effective therapies that will enable manipulation of vascular function during pathological conditions. ..
- Regulation of Vascular Function by Progesterone ReceptorLuisa Iruela Arispe; Fiscal Year: 2007..abstract_text> ..
- Fascin Protrusions in ECM-Cytoskeletal NetworkingJosephine Adams; Fiscal Year: 2007....
- Molecular mechanisms of pancreatic fibrogenesisBrent Neuschwander Tetri; Fiscal Year: 2007..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. ..
- Cytoskeletal Mechanisms of Platelet FormationJoseph Italiano; Fiscal Year: 2007....
- SUPPRESSION OF VASCULAR GROWTHLuisa Iruela Arispe; Fiscal Year: 2007..We anticipate that results from these experiments will shed light into the biology of tumor growth and angiogenesis. ..
- Vascular Biology Training GrantLuisa Iruela Arispe; Fiscal Year: 2007..End of Abstract) ..
- INHIBITION OF THE ANGIOGENIC RESPONSELuisa Iruela Arispe; Fiscal Year: 2006..mice (by virtue of c-neu overexpression in the mammary gland) that either over expressed or lack thrombospondin-l (TSP1)...
- Notch Signaling in Vascular Development and HomeostasisLuisa Iruela Arispe; Fiscal Year: 2010..Thus, this information is central to the generation of novel and more effective therapies that will enable manipulation of vascular function during pathological conditions. ..
- Cytoskeletal Mechanisms of Platelet FormationJoseph E Italiano; Fiscal Year: 2010....
- Chemokines in Healing Myocardial InfarctsNikolaos Frangogiannis; Fiscal Year: 2009..Understanding the role of chemokines in infarct healing may identify novel therapeutic targets aiming at optimizing cardiac repair and decreasing adverse remodeling. ..
- VEGF Signaling and Tumor MicroenvironmentLuisa Iruela Arispe; Fiscal Year: 2009..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
- SUPPRESSION OF VASCULAR GROWTHLuisa Iruela Arispe; Fiscal Year: 2003..For several years, we have been working on the protein thrombospondin-1 (TSP1), a glycoprotein that, among many functions, suppresses neovascularization...
- THERAPEUTIC ANTIANGIOGENESISLuisa Iruela Arispe; Fiscal Year: 2002..Finally, we will treat tumors three class of anti- angiogenic therapy, including: (a) soluble fit; (b) TSP1-derived peptides; or (c) METH-l, to assess their effects on TGF-beta1 induced tumor angiogenesis (Aim 3)...
- Cytoskeletal Mechanisms of Platelet FormationJoseph Italiano; Fiscal Year: 2005..Understanding the cytoskeletal mechanics of platelet formation may provide insights into how platelets are produced and yield strategies for treatment of thrombocytopenia. ..
- Modulatory Adhesion Molecules in Tissue OrganizationJosephine Adams; Fiscal Year: 2004..abstract_text> ..
- Angiogenesis and Microcirculation Gordon ConferenceLuisa Iruela Arispe; Fiscal Year: 2005..The conference will be held in Salve Regina University from August 10-15, 2003. ..