Gene Symbol: Thbs1
Description: thrombospondin 1
Alias: TSP-1, TSP1, Thbs-1, tbsp1, thrombospondin-1
Species: mouse
Products:     Thbs1

Top Publications

  1. Zamiri P, Masli S, Kitaichi N, Taylor A, Streilein J. Thrombospondin plays a vital role in the immune privilege of the eye. Invest Ophthalmol Vis Sci. 2005;46:908-19 pubmed
  2. Turpie B, Yoshimura T, Gulati A, Rios J, Dartt D, Masli S. Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. Am J Pathol. 2009;175:1136-47 pubmed publisher
    ..Together, these results indicate that TSP-1 deficiency results in a spontaneous form of chronic dry eye and aberrant histopathology associated with Sjögren's syndrome. ..
  3. Smadja D, d Audigier C, Bieche I, Evrard S, Mauge L, Dias J, et al. Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties. Arterioscler Thromb Vasc Biol. 2011;31:551-9 pubmed publisher
    ..TSP-1 is a potential biomarker of PAD and ECFC-induced angiogenesis, suggesting that TSP-1 modulation might improve local tissue ischemia in this setting. ( NCT00377897.). ..
  4. Eroglu C, Allen N, Susman M, O Rourke N, Park C, Ozkan E, et al. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 2009;139:380-92 pubmed publisher
    ..These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation. ..
  5. Abdelouahed M, Ludlow A, Brunner G, Lawler J. Activation of platelet-transforming growth factor beta-1 in the absence of thrombospondin-1. J Biol Chem. 2000;275:17933-6 pubmed
    ..Because platelet releasates from TSP-1 null mice contain active TGF-beta1, we suggest that other important mechanisms of physiological activation of TGF-beta1 probably exist in platelets. ..
  6. Bauer P, Bauer E, Rogers N, Yao M, Feijóo Cuaresma M, Pilewski J, et al. Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Cardiovasc Res. 2012;93:682-93 pubmed publisher
    ..We report high-level expression of thrombospondin-1 (TSP1) and CD47 in the lungs of human subjects with PAH and increased expression of TSP1 and activated CD47 in ..
  7. Liauw J, Hoang S, Choi M, Eroglu C, Choi M, Sun G, et al. Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab. 2008;28:1722-32 pubmed publisher
    ..Deficiency of TSP-1/2 leads to impaired recovery after stroke mainly due to the role of these proteins in synapse formation and axonal outgrowth. ..
  8. Olerud J, Mokhtari D, Johansson M, Christoffersson G, Lawler J, Welsh N, et al. Thrombospondin-1: an islet endothelial cell signal of importance for ?-cell function. Diabetes. 2011;60:1946-54 pubmed publisher
    ..Thus, endothelial-derived TSP-1 activates islet TGF?-1 of importance for ?-cells. Our study indicates a novel role for endothelial cells as functional paracrine support for pancreatic ?-cells. ..
  9. Voros G, Lijnen H. Deficiency of thrombospondin-1 in mice does not affect adipose tissue development. J Thromb Haemost. 2006;4:277-8 pubmed

More Information


  1. Martin Manso G, Galli S, Ridnour L, Tsokos M, Wink D, Roberts D. Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res. 2008;68:7090-9 pubmed publisher
    ..We show that overexpression of TSP1 in melanoma cells increases macrophage recruitment into xenograft tumors grown in nude or beige/nude mice...
  2. Cui W, Maimaitiyiming H, Qi X, Norman H, Wang S. Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity. Am J Physiol Renal Physiol. 2013;305:F871-80 pubmed publisher
    Obesity is prevalent worldwide and is a major risk factor for many diseases including renal complications. Thrombospondin 1 (TSP1), a multifunctional extracellular matrix protein, plays an important role in diabetic kidney diseases...
  3. Gutierrez L, Suckow M, Lawler J, Ploplis V, Castellino F. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis. 2003;24:199-207 pubmed
    b>Thrombospondin 1 (TSP-1) is a multifunctional extracellular matrix protein that is an endogenous regulator of tumor angiogenesis...
  4. Johnson C, Kleshchenko Y, Ikejiani A, Udoko A, Cardenas T, Pratap S, et al. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS ONE. 2012;7:e40614 pubmed publisher
    ..cruzi through the NTSP domain and that this interaction enhances cellular infection. Thus surface TcCRT is a virulent factor that enhances the pathogenesis of T. cruzi infection through TSP-1, which is up-regulated by the parasite. ..
  5. Frazier E, Isenberg J, Shiva S, Zhao L, Schlesinger P, Dimitry J, et al. Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. Matrix Biol. 2011;30:154-61 pubmed publisher
    ..Both CD47 and TSP1 null mice are leaner than WTs, use less oxygen and produce less heat than WT mice...
  6. Moura R, Tjwa M, Vandervoort P, Van Kerckhoven S, Holvoet P, Hoylaerts M. Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice. Circ Res. 2008;103:1181-9 pubmed publisher
    ..Therefore, the development of atherosclerosis was compared in ApoE(-/-) and Tsp1(-/-)ApoE(-/-) mice kept on a normocholesterolemic diet...
  7. Punekar S, Zak S, Kalter V, Dobransky L, Punekar I, LAWLER J, et al. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008;75:9-21 pubmed publisher
    ..b>Thrombospondin 1 (TSP-1) is a protein well known for its antiangiogenic and anti-inflammatory properties...
  8. Isenberg J, Hyodo F, Pappan L, Abu Asab M, Tsokos M, Krishna M, et al. Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia. Arterioscler Thromb Vasc Biol. 2007;27:2582-8 pubmed
    ..Blood vessel diameter and blood flow are limited by the matricellular protein thrombospondin-1 (TSP1) through its ability to block responses to the endogenous vasodilator nitric oxide (NO)...
  9. Kaur S, Martin Manso G, Pendrak M, Garfield S, Isenberg J, Roberts D. Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47. J Biol Chem. 2010;285:38923-32 pubmed publisher
    Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with VEGF and indirectly by engaging several endothelial cell TSP1 receptors...
  10. Ezzie M, Piper M, Montague C, Newland C, Opalek J, Baran C, et al. Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011;44:556-61 pubmed publisher
    ..These results demonstrate that TSP-1 deficiency does not protect mice from systemic bleomycin challenge, and that TSP-1 deficiency is associated with increased expression of lung collagen and CTGF. ..
  11. Isenberg J, Hyodo F, Matsumoto K, Romeo M, Abu Asab M, Tsokos M, et al. Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood. 2007;109:1945-52 pubmed
    ..These findings demonstrate an important antagonistic relation between NO/cGMP signaling and thrombospondin-1 in vascular smooth muscle cells to regulate vascular tone and tissue perfusion. ..
  12. Li Y, Tong X, Rumala C, Clemons K, Wang S. Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model. PLoS ONE. 2011;6:e26656 pubmed publisher
    ..b>Thrombospondin 1 (TSP1) is a multifunctional extracellular matrix protein that is up-regulated in inflamed adipose tissue...
  13. Agah A, Kyriakides T, Lawler J, Bornstein P. The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice. Am J Pathol. 2002;161:831-9 pubmed
    ..In an attempt to elucidate their biological roles more clearly, we generated double-TSP1/TSP2-null animals and compared their phenotype to those of TSP1- and TSP2-null mice...
  14. Jimenez B, Volpert O, Crawford S, Febbraio M, Silverstein R, Bouck N. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med. 2000;6:41-8 pubmed
    ..These results indicate that thrombospondin-1, and possibly other broad-spectrum natural inhibitors of angiogenesis, act in vivo by inducing receptor-mediated apoptosis in activated microvascular endothelial cells. ..
  15. Cursiefen C, Masli S, Ng T, Dana M, Bornstein P, Lawler J, et al. Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis. Invest Ophthalmol Vis Sci. 2004;45:1117-24 pubmed
    ..By contrast, TSP-1, more than TSP-2, helps to suppress inflammation-induced corneal angiogenesis postnatally, implying that angiogenic privilege in the cornea is actively maintained. ..
  16. Lu A, Miao M, Schoeb T, Agarwal A, Murphy Ullrich J. Blockade of TSP1-dependent TGF-? activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy. Am J Pathol. 2011;178:2573-86 pubmed publisher
    Transforming growth factor-? (TGF-?) is key in the pathogenesis of diabetic nephropathy. Thrombospondin 1 (TSP1) expression is increased in diabetes, and TSP1 regulates latent TGF-? activation in vitro and in diabetic animal models...
  17. Rodriguez Manzaneque J, Lane T, Ortega M, Hynes R, Lawler J, Iruela Arispe M. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A. 2001;98:12485-90 pubmed
    ..To ascertain the participation of the endogenous angiogenic inhibitor thrombospondin-1 (TSP1) in tumor progression, we generated mammary tumor-prone mice that either lack, or specifically overexpress, TSP1 in ..
  18. Evrard S, Bluteau O, Tulliez M, Rameau P, Gonin P, Zetterberg E, et al. Thrombospondin-1 is not the major activator of TGF-?1 in thrombopoietin-induced myelofibrosis. Blood. 2011;117:246-9 pubmed publisher
    ..Our results show that TSP-1 is not the major activator of TGF-?1 in TPO-induced myelofibrosis, suggesting the contribution of another mechanism in the megakaryocyte/platelet compartment. ..
  19. Streit M, Velasco P, Riccardi L, Spencer L, Brown L, Janes L, et al. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice. EMBO J. 2000;19:3272-82 pubmed
  20. Olerud J, Johansson M, Lawler J, Welsh N, Carlsson P. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes. 2008;57:1870-7 pubmed publisher
    ..Our findings demonstrate that inhibition of TSP-1 in islets intended for transplantation may be a feasible strategy to improve islet graft revascularization and function. ..
  21. Isenberg J, Maxhimer J, Hyodo F, Pendrak M, Ridnour L, DeGraff W, et al. Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. Am J Pathol. 2008;173:1100-12 pubmed publisher
    ..Therefore, thrombospondin-1/CD47 antagonists may have selective radioprotective activity for normal tissues...
  22. Inoue M, Jiang Y, Barnes R, Tokunaga M, Martinez Santibañez G, Geletka L, et al. Thrombospondin 1 mediates high-fat diet-induced muscle fibrosis and insulin resistance in male mice. Endocrinology. 2013;154:4548-59 pubmed publisher
    b>Thrombospondin 1 (THBS1 or TSP-1) is a circulating glycoprotein highly expressed in hypertrophic visceral adipose tissues of humans and mice...
  23. Thakar C, Zahedi K, Revelo M, Wang Z, Burnham C, Barone S, et al. Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia. J Clin Invest. 2005;115:3451-9 pubmed
    b>Thrombospondin 1 (TSP-1) is a matricellular protein that inhibits angiogenesis and causes apoptosis in vivo and in vitro in several cancerous cells and tissues...
  24. Lawler J, Sunday M, Thibert V, Duquette M, George E, Rayburn H, et al. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest. 1998;101:982-92 pubmed
    ..A thickening and ruffling of the epithelium of the airways results from increasing cell proliferation in TSP-1-deficient mice. These results indicate that TSP-1 is involved in normal lung homeostasis. ..
  25. Masli S, Turpie B, Streilein J. Thrombospondin orchestrates the tolerance-promoting properties of TGFbeta-treated antigen-presenting cells. Int Immunol. 2006;18:689-99 pubmed
    ..We conclude that TSP-1, an ECM protein induced by TGFbeta treatment, orchestrates the changes in APC functional programs that equip these cells to promote tolerance of the eye-derived type. ..
  26. Kong P, Gonzalez Quesada C, Li N, Cavalera M, Lee D, Frangogiannis N. Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation. Am J Physiol Endocrinol Metab. 2013;305:E439-50 pubmed publisher
    ..The effects of TSP-1 may involve stimulation of adipocyte proliferation, activation of inflammatory signaling, and facilitated fatty acid uptake by adipocytes. ..
  27. McMaken S, Exline M, Mehta P, Piper M, Wang Y, Fischer S, et al. Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity. PLoS ONE. 2011;6:e19654 pubmed publisher
    ..These data support the contention that TSP-1 should be more fully explored in the human condition. ..
  28. Hayashi H, Sakai K, Baba H, Sakai T. Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice. Hepatology. 2012;55:1562-73 pubmed publisher
    ..Our work defines TSP-1 as a novel immediate early gene that could be a potential therapeutic target to accelerate liver regeneration. ..
  29. Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy J, Dvorak H, et al. Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009;23:3368-76 pubmed publisher
    ..Moreover, 3TSR significantly decreased VEGF-stimulated VEGFR2 phosphorylation in human dermal microvascular endothelial cells in culture. Taken together, the results indicate that TSP-1 and 3TSR modulate the function of VEGFR2. ..
  30. Frangogiannis N, Ren G, Dewald O, Zymek P, Haudek S, Koerting A, et al. Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts. Circulation. 2005;111:2935-42 pubmed
    ..The selective endogenous expression of TSP-1 in the infarct border zone may serve as a "barrier," limiting expansion of granulation tissue and protecting the noninfarcted myocardium from fibrotic remodeling. ..
  31. Isenberg J, Romeo M, Abu Asab M, Tsokos M, Oldenborg A, Pappan L, et al. Increasing survival of ischemic tissue by targeting CD47. Circ Res. 2007;100:712-20 pubmed
    Thrombospondin-1 (TSP1) limits the angiogenic and vasodilator activities of NO...
  32. Crawford S, Stellmach V, Murphy Ullrich J, Ribeiro S, Lawler J, Hynes R, et al. Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell. 1998;93:1159-70 pubmed
  33. Lamy L, Foussat A, Brown E, Bornstein P, Ticchioni M, Bernard A. Interactions between CD47 and thrombospondin reduce inflammation. J Immunol. 2007;178:5930-9 pubmed
    ..Overall, these results reveal an important role in vivo for this new CD47/BNIP3 pathway in limiting inflammation by controlling the number of activated T cells. ..
  34. Blake S, Strasser V, Andrade N, Duit S, Hofbauer R, Schneider W, et al. Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration. EMBO J. 2008;27:3069-80 pubmed publisher
    ..Lack of THBS-1 results in anatomical abnormalities of the RMS and leads to a reduction of postnatal neuronal precursors entering the OB. ..
  35. Bréchot N, Gomez E, Bignon M, Khallou Laschet J, Dussiot M, Cazes A, et al. Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice. PLoS ONE. 2008;3:e3950 pubmed publisher
    ..Finally, our results describe TSP-1 as a new relevant physiological target during critical leg ischemia. ..
  36. Hawighorst T, Oura H, Streit M, Janes L, Nguyen L, Brown L, et al. Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice. Oncogene. 2002;21:7945-56 pubmed
    ..Our findings indicate the potential use of TSP-1 for the prevention of premalignant stages of tumorigenesis and are likely to have implications for the further development of anti-angiogenic cancer therapies. ..
  37. Shaked Y, Bertolini F, Man S, Rogers M, Cervi D, Foutz T, et al. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell. 2005;7:101-11 pubmed
    ..Finally, treatment with a targeted VEGFR-2 antibody caused a dose-dependent reduction in viable CEPs that precisely paralleled its previously and empirically determined antitumor activity. ..
  38. Nishiwaki T, Yamaguchi T, Zhao C, Amano H, Hankenson K, Bornstein P, et al. Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1. J Bone Miner Res. 2006;21:596-604 pubmed
    ..We found that expression of Thbs1 and Thbs2 was reduced in Fra1 Tg osteoblasts...
  39. Cursiefen C, Maruyama K, Bock F, Saban D, Sadrai Z, Lawler J, et al. Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. J Exp Med. 2011;208:1083-92 pubmed publisher
    ..Inhibition of VEGF-C is not detected in the absence or blockade of CD36. These findings suggest that TSP-1, by ligating CD36 on monocytic cells, acts as an endogenous inhibitor of lymphangiogenesis. ..
  40. Saban D, Bock F, Chauhan S, Masli S, Dana R. Thrombospondin-1 derived from APCs regulates their capacity for allosensitization. J Immunol. 2010;185:4691-7 pubmed publisher
    ..Future strategies targeting APCs for TSP-1 upregulation may thus be effective in promoting allograft survival. ..
  41. Kim D, Li K, Boroujerdi A, Peter Yu Y, Zhou C, Deng P, et al. Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. J Neurosci. 2012;32:8977-87 pubmed publisher
    ..Development of TSP4 antagonists has the therapeutic potential for target-specific neuropathic pain management. ..
  42. Miller T, Kaur S, Ivins O Keefe K, Roberts D. Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation. Matrix Biol. 2013;32:316-24 pubmed publisher
    ..Thus, thrombospondin-1 signaling through CD47 is the first identified endogenous inhibitor of H2S signaling and constitutes a novel mechanism that negatively regulates T cell activation. ..
  43. Contreras Ruiz L, Regenfuss B, Mir F, Kearns J, Masli S. Conjunctival inflammation in thrombospondin-1 deficient mouse model of Sjögren's syndrome. PLoS ONE. 2013;8:e75937 pubmed publisher
    ..These results not only reveal potential immunopathogenic mechanisms underlying KCS in SS but also highlight the therapeutic potential of TSP-1. ..
  44. Prakash P, Kulkarni P, Chauhan A. Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice. Blood. 2015;125:399-406 pubmed publisher
    b>Thrombospondin 1 (TSP1) has been suggested as a counter receptor to platelet glycoprotein Ibα that supports initial platelet adhesion in absence of von Willebrand factor (VWF)...
  45. Ko C, Chu Y, Narumiya S, Chi J, Furuyashiki T, Aoki T, et al. CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease. Neurobiol Aging. 2015;36:1356-68 pubmed publisher
    ..We showed that miR135a was responsive to the induction of CEBPD and further negatively regulated thrombospondin 1 (THBS1) transcription by directly targeting its 3'-untranslated region (3'UTR) in astrocytes...
  46. Lopez Dee Z, Chittur S, Patel H, Chinikaylo A, Lippert B, Patel B, et al. Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis. PLoS ONE. 2015;10:e0139918 pubmed publisher
    ..Understanding the mechanisms involved is essential in order to ameliorate inflammation and prevent CRC. Thrombospondin 1 (TSP-1) is a multidomain glycoprotein with important roles in angiogenesis...
  47. Kim J, Willetts L, Ochkur S, Srivastava N, Hamburg R, Shayeganpour A, et al. An essential role for Rab27a GTPase in eosinophil exocytosis. J Leukoc Biol. 2013;94:1265-74 pubmed publisher
    ..These findings suggest that Rab27a has a key role in eosinophil degranulation. Furthermore, these findings have implications for Rab27a-dependent eosinophil degranulation in airway inflammation. ..
  48. Isenberg J, Romeo M, Yu C, Yu C, Nghiem K, Monsale J, et al. Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood. 2008;111:613-23 pubmed
    ..Thus, release of thrombospondin-1 from alpha-granules during activation provides positive feedback to promote efficient platelet aggregation and adhesion by overcoming the antithrombotic activity of physiologic NO. ..
  49. Kim D, Christofidou E, Keene D, Hassan Milde M, Adams J. Intermolecular interactions of thrombospondins drive their accumulation in extracellular matrix. Mol Biol Cell. 2015;26:2640-54 pubmed publisher
    ..We find that collagen fibrils are disorganized in multiple tissues of Thbs1(-/-) mice...
  50. Volpert O, Pili R, Sikder H, Nelius T, Zaichuk T, Morris C, et al. Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell. 2002;2:473-83 pubmed
    ..This decrease was completely reversed by a TSP-1 neutralizing antibody. We conclude that TSP-1 is a major target for Id1 effects on angiogenesis. ..
  51. Lawler J, Miao W, Duquette M, Bouck N, Bronson R, Hynes R. Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am J Pathol. 2001;159:1949-56 pubmed
    In vitro and in vivo data indicate that thrombospondin-1 (TSP1) inhibits tumor progression in several ways including direct effects on cellular growth and apoptosis in the stromal compartment...
  52. Scott Drew S, ffrench Constant C. Expression and function of thrombospondin-1 in myelinating glial cells of the central nervous system. J Neurosci Res. 1997;50:202-14 pubmed
    ..Taken together, these results suggest that the extracellular matrix molecule TSP-1 plays a role in normal central nervous system development by contributing to the regulation of oligodendrocyte precursor migration. ..
  53. Liska D, Hawkins R, Wikstrom K, Bornstein P. Modulation of thrombospondin expression during differentiation of embryonal carcinoma cells. J Cell Physiol. 1994;158:495-505 pubmed
    ..We report that both TSP1 and TSP2 mRNA and protein synthesis are induced during the differentiation of P19EC cells into neurons, glial cells,..
  54. Iruela Arispe M, Liska D, Sage E, Bornstein P. Differential expression of thrombospondin 1, 2, and 3 during murine development. Dev Dyn. 1993;197:40-56 pubmed
    b>Thrombospondin 1 is a secreted, trimeric glycoprotein that mediates interactions between cells and extracellular matrix and exhibits cell-specific effects on migration and proliferation...
  55. Xie L, Duncan M, Pahler J, Sugimoto H, Martino M, Lively J, et al. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A. 2011;108:9939-44 pubmed publisher
    ..The results demonstrate that EAIs are part of a balance mechanism regulating tumor angiogenesis, serving as intrinsic microenvironmental barriers to tumorigenesis. ..
  56. Sheibani N, Scheef E, Dimaio T, Wang Y, Kondo S, Sorenson C. Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells. J Cell Physiol. 2007;210:616-25 pubmed
    ..Taken together, these data suggest that bcl-2 is required for the proper regulation of cell adhesive and migratory mechanisms, perhaps through modulation of the cellular microenvironment. ..
  57. Wang Y, Su X, Wu Z, Sheibani N. Thrombospondin-1 deficient mice exhibit an altered expression pattern of alternatively spliced PECAM-1 isoforms in retinal vasculature and endothelial cells. J Cell Physiol. 2005;204:352-61 pubmed
    We have previously shown that thrombosponsin-1 (TSP1) and PECAM-1 are components of a regulatory switch whose reciprocal regulation in the endothelial cells (EC) promotes an angiogenic or a differentiated, quiescent phenotype...
  58. Csanyi G, Yao M, Rodriguez A, Al Ghouleh I, Sharifi Sanjani M, Frazziano G, et al. Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1. Arterioscler Thromb Vasc Biol. 2012;32:2966-73 pubmed publisher
    Although the matricellular protein thrombospondin-1 (TSP1) is highly expressed in the vessel wall in response to injury, its pathophysiological role in the development of vascular disease is poorly understood...
  59. Gandhi N, Su Z, Zhang X, Volpe E, Pelegrino F, Rahman S, et al. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013;94:1293-301 pubmed publisher
    ..Reconstitution of TSP-1KO mice with WT DCs prior to DS reversed the resistance of the TSP-1KO to DS-induced immunopathology. In conclusion, DC-derived TSP-1 is critical for generating the Th17 ocular surface response to DS. ..
  60. Feng W, Madajka M, Kerr B, Mahabeleshwar G, Whiteheart S, Byzova T. A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing. Blood. 2011;117:3893-902 pubmed publisher
    ..Our data demonstrate that platelets stimulate BMDC homing in a VAMP-8-dependent manner, revealing a previously unknown role for platelets as key mediators between hypoxic tissues and the bone marrow during angiogenesis. ..
  61. Saika S, Miyamoto T, Ishida I, Barbour W, Ohnishi Y, Ooshima A. Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation. Exp Eye Res. 2004;79:147-56 pubmed
    ..In contrast, in post-operative lens cells differentiating to fiber cells, its expression levels decline. Further study is needed to clarify the roles of TSP-1 in modulating lens cell phenotype expression. ..
  62. Fitchev P, Wcislak S, Lee C, Bergh A, Brendler C, Stellmach V, et al. Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation. Lab Invest. 2010;90:1078-90 pubmed publisher
    ..Therefore, loss of TSP-1 during tumorigenesis would eliminate two barriers to cancer progression. ..
  63. Ueno A, Miwa Y, Miyoshi K, Horiguchi T, Inoue H, Ruspita I, et al. Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralization. J Cell Physiol. 2006;209:322-32 pubmed
    b>Thrombospondin 1 (TSP1) is a multifunctional extracellular glycoprotein present mainly in the fetal and adult skeleton...
  64. Wang Y, Wang S, Sheibani N. Enhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells. Microvasc Res. 2006;71:143-51 pubmed
    Thrombospondin-1 (TSP1) is an endogenous inhibitor of angiogenesis, which limits blood vessel density in normal tissues and curtails tumor growth...
  65. Xu X, Song N, Zhang X, Jiao X, Hu J, Liang M, et al. Renal Protection Mediated by Hypoxia Inducible Factor-1α Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1. Transplantation. 2017;101:1811-1819 pubmed publisher
    ..the angiogenesis induced by hypoxia inducible factor (HIF)-1α through inhibiting a predicted target gene thrombospondin 1 (TSP-1)...
  66. Audet G, Meek T, Garland T, Olfert I. Expression of angiogenic regulators and skeletal muscle capillarity in selectively bred high aerobic capacity mice. Exp Physiol. 2011;96:1138-50 pubmed publisher
    ..e. VEGF versus TSP-1, respectively). Based on the greater capillarity and significant VEGF response to exercise in MM mice, these data suggest that VEGF expression may, at least in part, be genetically determined. ..