Thbs1

Summary

Gene Symbol: Thbs1
Description: thrombospondin 1
Alias: TSP-1, TSP1, Thbs-1, tbsp1, thrombospondin-1
Species: mouse

Top Publications

  1. ncbi Restricted localization of thrombospondin-2 protein during mouse embryogenesis: a comparison to thrombospondin-1
    P A Tooney
    Department of Medicine, University of Wisconsin Madison, 53706, USA
    Matrix Biol 17:131-43. 1998
  2. ncbi Induced thrombospondin expression in the mouse pancreas during pancreatic injury
    Brent A Neuschwander-Tetri
    Saint Louis University Liver Center and Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA
    Int J Biochem Cell Biol 38:102-9. 2006
  3. pmc Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1)
    James Greenaway
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    J Cell Physiol 210:807-18. 2007
  4. pmc Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice
    Bruce Turpie
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Am J Pathol 175:1136-47. 2009
  5. pmc Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis
    Cagla Eroglu
    Duke University Medical Center, Cell Biology Department, Durham, NC 27710, USA
    Cell 139:380-92. 2009
  6. pmc Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Am J Pathol 173:1100-12. 2008
  7. doi Persistent inflammation subverts thrombospondin-1-induced regulation of retinal angiogenesis and is driven by CCR2 ligation
    Mei Chen
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
    Am J Pathol 180:235-45. 2012
  8. ncbi Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralization
    Akemichi Ueno
    Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Cell Physiol 209:322-32. 2006
  9. pmc A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome
    Octavio Garcia
    Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 5:e14200. 2010
  10. pmc Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47
    Sukhbir Kaur
    Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:38923-32. 2010

Research Grants

  1. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2007
  2. Resolution of inflammation in healing myocardial infarcts
    Nikolaos Frangogiannis; Fiscal Year: 2009
  3. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2010
  4. Upstream Stimulatory Factor 2 regulation of renin in diabetic nephropathy
    Shuxia Wang; Fiscal Year: 2010
  5. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2007
  6. Regulation of Vascular Function by Progesterone Receptor
    Luisa Iruela Arispe; Fiscal Year: 2007
  7. Fascin Protrusions in ECM-Cytoskeletal Networking
    Josephine Adams; Fiscal Year: 2007
  8. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2007
  9. Cytoskeletal Mechanisms of Platelet Formation
    Joseph Italiano; Fiscal Year: 2007
  10. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi Restricted localization of thrombospondin-2 protein during mouse embryogenesis: a comparison to thrombospondin-1
    P A Tooney
    Department of Medicine, University of Wisconsin Madison, 53706, USA
    Matrix Biol 17:131-43. 1998
    Thrombospondin-1 and -2 (TSP1 and TSP2) are multifunctional, multimodular extracellular matrix proteins encoded by separate genes. We compared the distributions of TSP1 and TSP2 in mouse embryos (day 10 and later) by immunohistochemistry...
  2. ncbi Induced thrombospondin expression in the mouse pancreas during pancreatic injury
    Brent A Neuschwander-Tetri
    Saint Louis University Liver Center and Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA
    Int J Biochem Cell Biol 38:102-9. 2006
    ..These modulators of fibrogenesis could play a role in the development of pancreatic fibrosis that characterizes chronic pancreatitis...
  3. pmc Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1)
    James Greenaway
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    J Cell Physiol 210:807-18. 2007
    ..In conclusion, we demonstrate a direct inhibitory effect of TSP-1 on VEGF in the ovary. TSP-1's regulation of VEGF appears to be an important mediator of ovarian angiogenesis and follicle development...
  4. pmc Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice
    Bruce Turpie
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Am J Pathol 175:1136-47. 2009
    ..Together, these results indicate that TSP-1 deficiency results in a spontaneous form of chronic dry eye and aberrant histopathology associated with Sjögren's syndrome...
  5. pmc Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis
    Cagla Eroglu
    Duke University Medical Center, Cell Biology Department, Durham, NC 27710, USA
    Cell 139:380-92. 2009
    ..These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation...
  6. pmc Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Am J Pathol 173:1100-12. 2008
    ..Therefore, thrombospondin-1/CD47 antagonists may have selective radioprotective activity for normal tissues...
  7. doi Persistent inflammation subverts thrombospondin-1-induced regulation of retinal angiogenesis and is driven by CCR2 ligation
    Mei Chen
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
    Am J Pathol 180:235-45. 2012
    ..This model offers a new platform to dissect the molecular and cellular pathology of inflammation-induced ocular angiogenesis...
  8. ncbi Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralization
    Akemichi Ueno
    Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Cell Physiol 209:322-32. 2006
    b>Thrombospondin 1 (TSP1) is a multifunctional extracellular glycoprotein present mainly in the fetal and adult skeleton...
  9. pmc A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome
    Octavio Garcia
    Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 5:e14200. 2010
    ..In this study, we investigated whether deficits in astrocyte function contribute to DS spine pathology...
  10. pmc Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47
    Sukhbir Kaur
    Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:38923-32. 2010
    Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with VEGF and indirectly by engaging several endothelial cell TSP1 receptors...
  11. ncbi Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice
    Thomas Hawighorst
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Oncogene 21:7945-56. 2002
    ..Our findings indicate the potential use of TSP-1 for the prevention of premalignant stages of tumorigenesis and are likely to have implications for the further development of anti-angiogenic cancer therapies...
  12. pmc Thrombospondin-1 derived from APCs regulates their capacity for allosensitization
    Daniel R Saban
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 185:4691-7. 2010
    ..Future strategies targeting APCs for TSP-1 upregulation may thus be effective in promoting allograft survival...
  13. pmc Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation
    Philip P Fitchev
    Department of Surgery, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA
    Lab Invest 90:1078-90. 2010
    ..Therefore, loss of TSP-1 during tumorigenesis would eliminate two barriers to cancer progression...
  14. pmc Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53
    F Su
    Department of Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Oncogene 29:421-31. 2010
    ..However, U19/EAF2 transfection alone had little or no effect on the TSP-1 promoter. The above observations together suggest that U19/EAF2 regulates the expression of TSP-1 via blocking p53 repression of the TSP-1 promoter...
  15. pmc Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, 91054 Erlangen, Germany
    J Exp Med 208:1083-92. 2011
    ..Inhibition of VEGF-C is not detected in the absence or blockade of CD36. These findings suggest that TSP-1, by ligating CD36 on monocytic cells, acts as an endogenous inhibitor of lymphangiogenesis...
  16. pmc Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1
    Philip M Bauer
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cardiovasc Res 93:682-93. 2012
    ..In this study, we investigated the role activated CD47 plays in promoting PAH...
  17. pmc Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia
    Charuhas V Thakar
    Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
    J Clin Invest 115:3451-9. 2005
    b>Thrombospondin 1 (TSP-1) is a matricellular protein that inhibits angiogenesis and causes apoptosis in vivo and in vitro in several cancerous cells and tissues...
  18. pmc Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47
    Elfaridah P Frazier
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, United States
    Matrix Biol 30:154-61. 2011
    ..Both CD47 and TSP1 null mice are leaner than WTs, use less oxygen and produce less heat than WT mice...
  19. pmc Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice
    Hiromitsu Hayashi
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 55:1562-73. 2012
    ....
  20. ncbi Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration
    Elsa Kermorvant-Duchemin
    Department of Pediatrics, Ophthalmology and Pharmacology, Research Center, Hopital Ste Justine, 3175 Côte de Ste Catherine, Montreal, Quebec, H3T1C5, Canada
    Nat Med 11:1339-45. 2005
    ....
  21. pmc Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1
    Yoon Jin Lee
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 70:948-56. 2010
    ..Tumor angiogenesis is restrained by a variety of endogenous inhibitors, including thrombospondin 1 (TSP1)...
  22. doi Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice
    Rute Moura
    Center for Molecular and Vascular Biology, Department of Cardiovascular Diseases, University of Leuven, Belgium
    Circ Res 103:1181-9. 2008
    ..Therefore, the development of atherosclerosis was compared in ApoE(-/-) and Tsp1(-/-)ApoE(-/-) mice kept on a normocholesterolemic diet...
  23. pmc Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells
    Gema Martin-Manso
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:7090-9. 2008
    ..We show that overexpression of TSP1 in melanoma cells increases macrophage recruitment into xenograft tumors grown in nude or beige/nude mice...
  24. pmc The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1
    Fatemeh Fouladkou
    Program in Cell Biology and the Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    J Biol Chem 285:6770-80. 2010
    ..These results suggest that Nedd4-1 is a suppressor of Tsp1 and that increased levels of Tsp-1 in the Nedd4-1 knock-out mice may have contributed to the developmental defect ..
  25. pmc Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity
    Sara McMaken
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e19654. 2011
    ..Because of these observations we sought to determine the importance of TSP-1 in sepsis...
  26. pmc Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1
    Elizabeth A Scheef
    Dept of Ophthalmology and Visual Sciences, Univ of Wisconsin, 600 Highland Ave, K6 458 CSC, Madison, WI 53792 4673, USA
    Am J Physiol Cell Physiol 296:C724-34. 2009
    ..Thrombospondin (TSP)1 is a matricellular protein and an autocrine factor for VSMCs. TSP1 activity, along with that of PDGF, regulates VSMC proliferation and migration...
  27. pmc Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis
    Alexander Zaslavsky
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 115:4605-13. 2010
    ..Further, this work implicates the use of thrombospondin-1 levels in platelets as an indicator of tumor growth and regression...
  28. pmc Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor
    J C Rodriguez-Manzaneque
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, CA 90095 1570, USA
    Proc Natl Acad Sci U S A 98:12485-90. 2001
    ..To ascertain the participation of the endogenous angiogenic inhibitor thrombospondin-1 (TSP1) in tumor progression, we generated mammary tumor-prone mice that either lack, or specifically overexpress, TSP1 in ..
  29. ncbi Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene
    T Shingu
    Department of Biochemistry, University of Washington, Seattle 98195
    J Biol Chem 269:32551-7. 1994
    ..which functions synergistically with a distal serum-response element to mediate the serum response of the human TSP1 gene...
  30. pmc Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch
    Sylvie Giuriato
    Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, CCSR Building, Room 1120, 269 Campus Drive, Stanford, CA 94305 5151, USA
    Proc Natl Acad Sci U S A 103:16266-71. 2006
    ..Therefore, the combined inactivation of oncogenes and angiogenesis may be a more clinically effective treatment of cancer. We conclude that angiogenesis is an essential component of oncogene addiction...
  31. doi Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties
    David M Smadja
    Universite Paris Descartes, Paris, France
    Arterioscler Thromb Vasc Biol 31:551-9. 2011
    ..We examined whether plasma levels of angiogenic factors are altered in plasma of patients with peripheral arterial disease (PAD) and whether these factors affect endothelial progenitor cell-induced angiogenesis...
  32. ncbi Thrombospondin-1 is a major activator of TGF-beta1 in vivo
    S E Crawford
    Robert H Lurie Cancer Center, Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cell 93:1159-70. 1998
    ....
  33. ncbi Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia
    Jeff S Isenberg
    MPH, Laboratory of Pathology, Building 10, 2A33, National Cancer Institute, Bethesda, Maryland 20892 1500, USA
    Arterioscler Thromb Vasc Biol 27:2582-8. 2007
    ..Blood vessel diameter and blood flow are limited by the matricellular protein thrombospondin-1 (TSP1) through its ability to block responses to the endogenous vasodilator nitric oxide (NO)...
  34. pmc Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis
    Kaiyong Yang
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Autoimmun 32:94-103. 2009
    ..These results demonstrate that TSP-1 participates in the differentiation of Th17 cells through its ability to activate latent TGF-beta, and enhances the inflammatory response in EAE...
  35. ncbi Downregulation of the angiogenesis inhibitor thrombospondin 1 in fibroblasts exposed to platelets and their related phospholipids
    Wojciech Kalas
    Henderson Research Centre, Experimental Thrombosis Research, McMaster University, Hamilton, Ont, Canada
    Biochem Biophys Res Commun 334:549-54. 2005
    ..other mediators, though their effects are normally opposed by endogenous angiogenesis inhibitors, including thrombospondin 1 (TSP-1/THSP1)...
  36. ncbi Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor
    J Scott Isenberg
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Building 10, Room 2A33, 10 Center Drive MSC1500 Bethesda, MD 20892 1500, United States
    Matrix Biol 24:110-23. 2005
    We have reexamined the role of endogenous thrombospondin-1 (TSP1) in growth and motility of vascular smooth muscle cells (SMCs)...
  37. ncbi Characterization of integrin beta6 and thrombospondin-1 double-null mice
    Anna Ludlow
    The Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA
    J Cell Mol Med 9:421-37. 2005
    ..They also indicate that alphavbeta6 functions as a tumor suppressor gene and that activation of TGFbeta by TSP-1 and alphavbeta6 contributes to normal tissue architecture and function...
  38. pmc Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level
    Xuefeng Zhang
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    FASEB J 23:3368-76. 2009
    ..Moreover, 3TSR significantly decreased VEGF-stimulated VEGFR2 phosphorylation in human dermal microvascular endothelial cells in culture. Taken together, the results indicate that TSP-1 and 3TSR modulate the function of VEGFR2...
  39. pmc Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
    Sophia M Blake
    Department of Medical Biochemistry, Max F Perutz Laboratories, Medical University Vienna, Vienna, Austria
    EMBO J 27:3069-80. 2008
    ..Lack of THBS-1 results in anatomical abnormalities of the RMS and leads to a reduction of postnatal neuronal precursors entering the OB...
  40. doi Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cells
    Kati Tarkkonen
    Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, 20520, Turku, Finland
    Growth Factors 28:256-67. 2010
    ..It was previously shown to regulate expression of thrombospondin 1 (TSP-1), an inhibitor of angiogenesis, in S115 breast cancer cells...
  41. doi Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosis
    Solène Evrard
    INSERM, U1009, Université Paris Sud11, Institut Gustave Roussy, Villejuif, France
    Blood 117:246-9. 2011
    ..Our results show that TSP-1 is not the major activator of TGF-β1 in TPO-induced myelofibrosis, suggesting the contribution of another mechanism in the megakaryocyte/platelet compartment...
  42. pmc Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis
    Michael E Ezzie
    Department of Medicine and the Dorothy M Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Am J Respir Cell Mol Biol 44:556-61. 2011
    ..These results demonstrate that TSP-1 deficiency does not protect mice from systemic bleomycin challenge, and that TSP-1 deficiency is associated with increased expression of lung collagen and CTGF...
  43. pmc Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection
    Candice A Johnson
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, United States of America
    PLoS ONE 7:e40614. 2012
    ..cruzi through the NTSP domain and that this interaction enhances cellular infection. Thus surface TcCRT is a virulent factor that enhances the pathogenesis of T. cruzi infection through TSP-1, which is up-regulated by the parasite...
  44. pmc Expression of thrombospondin-1 in ischemia-induced retinal neovascularization
    K Suzuma
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan
    Am J Pathol 154:343-54. 1999
    ..VEGF-mediated thrombospondin-1 induction in ischemia-induced angiogenesis may be a negative feedback mechanism...
  45. doi Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction
    Naïke Bigé
    INSERM Unit 702, Paris, France
    Kidney Int 81:1226-38. 2012
    ..Thus, TSP-1 is an important profibrotic and inflammatory mediator of renal disease. Blockade of its action may be a treatment against the development of chronic kidney disease...
  46. pmc Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation
    Eileen M Bauer
    Vascular Medicine Institute of University of Pittsburgh, Pittsburgh, PA, USA
    Cardiovasc Res 88:471-81. 2010
    Thrombospondin-1 (TSP1), via its necessary receptor CD47, inhibits nitric oxide (NO)-stimulated soluble guanylate cyclase activation in vascular smooth muscle cells, and TSP1-null mice have increased shear-dependent blood flow compared ..
  47. ncbi Deficiency of thrombospondin-1 in mice does not affect adipose tissue development
    G Voros
    J Thromb Haemost 4:277-8. 2006
  48. ncbi Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
    B Jimenez
    Department of Microbiology, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, 60611, USA
    Nat Med 6:41-8. 2000
    ..These results indicate that thrombospondin-1, and possibly other broad-spectrum natural inhibitors of angiogenesis, act in vivo by inducing receptor-mediated apoptosis in activated microvascular endothelial cells...
  49. doi Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease
    Salman Punekar
    Wilkes University, Wilkes Barre, PA 18766, USA
    Pathobiology 75:9-21. 2008
    ..b>Thrombospondin 1 (TSP-1) is a protein well known for its antiangiogenic and anti-inflammatory properties...
  50. ncbi Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression
    Kiichiro Yano
    Shiseido Life Science Research Center, Yokohama, Japan
    J Invest Dermatol 122:201-8. 2004
    ....
  51. pmc Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets
    Johan Olerud
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 57:1870-7. 2008
    ..The present study tested the hypothesis that the angiostatic factor thrombospondin-1 (TSP-1), which is normally present in islets, restricts intra-islet vascular expansion posttransplantation...
  52. doi The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactions
    Paula Velasco
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Invest Dermatol 129:2022-30. 2009
    ..b>Thrombospondin 1 (TSP-1) is a potent endogenous angiogenesis inhibitor thought to play an important role in maintaining ..
  53. pmc Thrombospondin-1: an islet endothelial cell signal of importance for β-cell function
    Johan Olerud
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 60:1946-54. 2011
    ..Loss of thrombospondin (TSP)-1 in pancreatic islets has been shown to cause islet hyperplasia. This study tested the hypothesis that endothelial-derived TSP-1 is important for β-cell function...
  54. pmc Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice
    M Streit
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    EMBO J 19:3272-82. 2000
    ....
  55. ncbi Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice
    John E Pimanda
    Centre for Vascular Research, University of New South Wales and the Department of Haematology, The Prince of Wales Hospital, Sydney, New South Wales 2052, Australia
    J Biol Chem 279:21439-48. 2004
    ..These findings indicate that TSP-1 influences plasma and platelet VWF multimeric size differently and may be more relevant for control of the VWF released from platelets...
  56. pmc Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice
    Nicolas Bréchot
    INSERM, U833, Paris, France
    PLoS ONE 3:e3950. 2008
    ..TSP-1 is a matricellular protein that displays well-known angiostatic properties in cancer, and regulates inflammation in vivo and macrophages properties in vitro. We therefore sought to investigate its function in a mouse model of CLI...
  57. ncbi Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3
    H Chen
    Department of Biomolecular Chemistry, University of Wisconsin, Madison, 53076, USA
    FEBS Lett 387:36-41. 1996
    To analyze the function of TSP family members, we have expressed and purified mouse TSP1 and TSP3 encoded by recombinant baculoviruses in Spodoptera frugiperda cells and compared these TSPs to mouse TSP2 prepared in a similar way...
  58. ncbi Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats
    M L Iruela-Arispe
    Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute, UCLA, Los Angeles, Calif 90095, USA
    Circulation 100:1423-31. 1999
    ..The antiangiogenic activity of TSP-1, as defined by cornea pocket assays, was previously mapped to the amino-terminal portion of the protein within the procollagen region and the type 1 repeats...
  59. ncbi Differential expression of thrombospondin 1, 2, and 3 during murine development
    M L Iruela-Arispe
    Department of Biological Structure, University of Washington, Seattle 98195
    Dev Dyn 197:40-56. 1993
    b>Thrombospondin 1 is a secreted, trimeric glycoprotein that mediates interactions between cells and extracellular matrix and exhibits cell-specific effects on migration and proliferation...
  60. ncbi Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells
    Yuri Futagami
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    J Immunol 178:6994-7005. 2007
    ..Via the conversion of latent TGFbeta to an active form that appears to be mediated by thrombospondin 1 (TSP-1), cultured iris PE and retinal PE cells induce a PE-induced Treg cell fate...
  61. ncbi Interactions between CD47 and thrombospondin reduce inflammation
    Laurence Lamy
    INSERM Unit 576, Hospitalier de l Université de Nice, University of Nice Sophia Antipolis, hôpital de l Archet I, 151 rue Saint Antoine de Ginestière, Nice, France
    J Immunol 178:5930-9. 2007
    ..Overall, these results reveal an important role in vivo for this new CD47/BNIP3 pathway in limiting inflammation by controlling the number of activated T cells...
  62. pmc Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis
    Manuel A Pallero
    Department of Pathology, VH 668 1530 3rd Ave, South, Birmingham, AL 35294 0019, USA
    FASEB J 22:3968-79. 2008
    ..Fibrogenesis is associated with reduced fibroblast apoptosis. The matricellular protein thrombospondin 1 (TSP1) regulates cell adhesion and motility during tissue remodeling and in fibrogenesis...
  63. pmc Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:613-23. 2008
    ..Thus, release of thrombospondin-1 from alpha-granules during activation provides positive feedback to promote efficient platelet aggregation and adhesion by overcoming the antithrombotic activity of physiologic NO...
  64. ncbi Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13
    R S Wymore
    Department of Physiology, University of California, Irvine 92717
    Genomics 20:191-202. 1994
    ..1, lies approximately 1.8 cM from the Myod-1 gene on mouse chromosome 7, and in situ hybridization localizes KCNC1/hKv3.1 to the homologous region on human chromosome 11p14.3-p15.2. A third gene, KCNA1/hKv1.1, was mapped to human 12p13...
  65. doi Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke
    Jason Liauw
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5327, USA
    J Cereb Blood Flow Metab 28:1722-32. 2008
    ..Deficiency of TSP-1/2 leads to impaired recovery after stroke mainly due to the role of these proteins in synapse formation and axonal outgrowth...
  66. pmc Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen
    Karen L Posey
    Department of Pediatrics, University of Texas Medical School, 6431 Fannin, Houston, TX 77030, USA
    Am J Pathol 172:1664-74. 2008
    ..To define the roles of TSP1, TSP3, TSP5, and Col9 in the growth plate, all knockout and combinatorial strains were analyzed using ..
  67. ncbi CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1
    Jeff S Isenberg
    Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:26069-80. 2006
    ..Therefore, ligation of either CD36 or CD47 is sufficient to inhibit NO-stimulated vascular cell responses and cGMP signaling, but only CD47 is necessary for this activity of thrombospondin-1 at physiological concentrations...
  68. pmc Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling
    Zhiping Li
    Thomas Jefferson University, Department of Cancer Biology, Kimmel Cancer Center, Bluemle Building, Rm 1050, 233 South 10th St, Philadelphia, PA 19107, USA
    Mol Cell Biol 26:4240-56. 2006
    ..arrays identified a subset of genes regulated by cyclin D1, including Rho-activated kinase II (ROCKII) and thrombospondin 1 (TSP-1)...
  69. ncbi Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration
    Shoujian Wang
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53792, USA
    Dev Dyn 228:630-42. 2003
    Thrombospondin-1 (TSP1) is a natural inhibitor of angiogenesis. Its expression is most prominent during the late stages of vascular development and in the adult vasculature...
  70. pmc The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice
    Azin Agah
    Department of Biochemistry, University of Washington, Seattle 98195, USA
    Am J Pathol 161:831-9. 2002
    ..In an attempt to elucidate their biological roles more clearly, we generated double-TSP1/TSP2-null animals and compared their phenotype to those of TSP1- and TSP2-null mice...
  71. pmc Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice
    J Lawler
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Pathol 159:1949-56. 2001
    In vitro and in vivo data indicate that thrombospondin-1 (TSP1) inhibits tumor progression in several ways including direct effects on cellular growth and apoptosis in the stromal compartment...
  72. ncbi Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis
    I Ming Jou
    Department of Biochemistry, National Cheng Kung University Medical College, 1 Dashiue Road, Tainan 701, Taiwan
    Arthritis Rheum 52:339-44. 2005
    Because thrombospondin 1 (TSP-1) inhibits angiogenesis and activates latent transforming growth factor beta (TGFbeta), a potent immunosuppressive and antiinflammatory cytokine, we investigated the prophylactic and therapeutic effects of ..
  73. ncbi Attenuation of retinal vascular development and neovascularization in transgenic mice over-expressing thrombospondin-1 in the lens
    Zhifeng Wu
    Department of Ophthalmology, University of Wisconsin Medical School, Madison, Wisconsin 53792 4673, USA
    Dev Dyn 235:1908-20. 2006
    Thrombospondin-1 (TSP1) is an endogenous inhibitor of angiogenesis and induces endothelial cell (EC) apoptosis...
  74. ncbi Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice
    K Uno
    Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan
    Histol Histopathol 20:493-9. 2005
    ..These findings suggest that vitamin A may modulate the expression of TSP-1 in the corneas to accelerate the re-epithelialization of wounded corneas...
  75. ncbi Activation of platelet-transforming growth factor beta-1 in the absence of thrombospondin-1
    M Abdelouahed
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:17933-6. 2000
    ..Because platelet releasates from TSP-1 null mice contain active TGF-beta1, we suggest that other important mechanisms of physiological activation of TGF-beta1 probably exist in platelets...
  76. ncbi Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Methodist Hospital and DeBakey Heart Center, Baylor College of Medicine, Houston, Tex, USA
    Circulation 111:2935-42. 2005
    ....
  77. ncbi Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1
    Olga V Volpert
    Department of Urology and RH Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Cell 2:473-83. 2002
    ..This decrease was completely reversed by a TSP-1 neutralizing antibody. We conclude that TSP-1 is a major target for Id1 effects on angiogenesis...
  78. pmc Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, United States
    Matrix Biol 28:110-9. 2009
    ..Thus, the matricellular protein thrombospondin-1 and its receptor CD47 serve as acute physiological regulators of blood pressure and exert a vasopressor activity to maintain global hemodynamics under stress...
  79. pmc Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina
    Jingfang Sun
    Dept of Pathology, Beth Israel Deaconess Medical Ctr and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 296:H1344-51. 2009
    ..Here we report that TSP1 antagonized microvascular survival to retinal hyperoxia, and Akt signaling in both the retina and in cultured ..
  80. ncbi Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1
    Toru Nishiwaki
    Department of Orthopaedics, School of Medicine, Keio University, Tokyo, Japan
    J Bone Miner Res 21:596-604. 2006
    ..We found that expression of Thbs1 and Thbs2 was reduced in Fra1 Tg osteoblasts...
  81. pmc Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia
    J Lawler
    Department of Pathology, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 101:982-92. 1998
    ..A thickening and ruffling of the epithelium of the airways results from increasing cell proliferation in TSP-1-deficient mice. These results indicate that TSP-1 is involved in normal lung homeostasis...
  82. pmc Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13
    Arnaud Bonnefoy
    Center for Molecular and Vascular Biology, Laboratory of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Blood 107:955-64. 2006
    The function of thrombospondin-1 (TSP-1) in hemostasis was investigated in wild-type (WT) and Tsp1-/- mice, via dynamic platelet interaction studies with A23187-stimulated mesenteric endothelium and with photochemically injured cecum ..
  83. pmc Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner
    Jeff S Isenberg
    Laboratory of Pathology and Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13141-6. 2005
    ..explants in 3D culture, we found that explants from mice lacking the angiogenesis inhibitor thrombospondin-1 (TSP1) exhibit exaggerated angiogenic responses to an exogenous NO donor, which could be reversed by providing exogenous ..
  84. ncbi Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model
    Linda S Gutierrez
    Walther Cancer Research Center, W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, Freimann Life Sciences Center University of Notre Dame, Notre Dame, IN 46556, USA
    Carcinogenesis 24:199-207. 2003
    b>Thrombospondin 1 (TSP-1) is a multifunctional extracellular matrix protein that is an endogenous regulator of tumor angiogenesis...
  85. ncbi Thrombospondin-1 plays a critical role in the induction of hair follicle involution and vascular regression during the catagen phase
    Kiichiro Yano
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Invest Dermatol 120:14-9. 2003
    ..These results identify a critical role of TSP-1 in the induction of anagen follicle involution, with potential implications for the therapeutic modulation of hair follicle growth...
  86. doi Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Sci 121:784-95. 2008
    ..ECM retention of TSP1 is mediated by the C-terminal region in trimeric form, and not by C-terminal monomer or trimers of the N-terminal ..
  87. pmc The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1
    Ali Mallakin
    Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Int J Cancer 126:1403-16. 2010
    ..Identification of novel Dmp1 target genes not only provides insights into the effects of Dmp1 on global gene expression, but also sheds light on the mechanism of haploid insufficiency of Dmp1 in tumor suppression...
  88. pmc Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice
    Riikka Kivela
    LIKES Research Center for Sport and Health Sciences, Rautpohjankatu 8a, 40700 Jyväskylä, Finland
    Cardiovasc Diabetol 7:13. 2008
    ..The responses in capillaries and muscle fibers, collected from the muscle with laser capture microdissection, were also studied separately...
  89. ncbi Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers
    K M O'Rourke
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 267:24921-4. 1992
    There exist two distinct thrombospondin molecules (designated TSP1 and TSP2) which are encoded by separate genes. TSP1 is a trimeric cell surface and extracellular matrix molecule...
  90. pmc Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling
    Lorin E Olson
    Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California at San Diego School of Medicine, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 102:3708-13. 2005
    ..Together, our data suggest that the hair-remodeling defect of Barx2 mutant mice could be explained, in part, by failure to repress one or more critical target genes...
  91. ncbi Thrombospondin-1 deficient mice exhibit an altered expression pattern of alternatively spliced PECAM-1 isoforms in retinal vasculature and endothelial cells
    Yongji Wang
    University of Wisconsin, Department of Ophthalmology and Visual Sciences, Madison, Wisconsin, USA
    J Cell Physiol 204:352-61. 2005
    We have previously shown that thrombosponsin-1 (TSP1) and PECAM-1 are components of a regulatory switch whose reciprocal regulation in the endothelial cells (EC) promotes an angiogenic or a differentiated, quiescent phenotype...
  92. ncbi Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine
    J B Smith
    Division of Neonatology, UCLA School of Medicine 90095, USA
    J Biol Chem 270:16756-65. 1995
    ..The LIX message is strongly induced by LPS in fibroblasts, but not in macrophages, suggesting that LIX may participate in the recruitment of inflammatory cells by injured or infected tissue...
  93. ncbi Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly
    Anthony Wayne Orr
    Department of Pathology, Division of Molecular and Cellular Pathology and The Cell Adhesion and Matrix Research Center, University of Alabama, Birmingham, Alabama 35294 9340, USA
    J Biol Chem 279:48983-92. 2004
    ..Cells utilize dynamic interactions with the extracellular matrix to adapt to changing environmental conditions. Thrombospondin 1 (TSP1) induces focal adhesion disassembly and cell migration through a sequence (hep I) in its heparin-..
  94. ncbi Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation
    Shizuya Saika
    Departments of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Exp Eye Res 79:147-56. 2004
    ..In contrast, in post-operative lens cells differentiating to fiber cells, its expression levels decline. Further study is needed to clarify the roles of TSP-1 in modulating lens cell phenotype expression...
  95. ncbi Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis
    Kathrin Hochegger
    Klinische Abteilung für Nephrologie, Universitätsklinik für Innere Medizin Innsbruck, Innsbruck, Austria
    Nephron Exp Nephrol 96:e31-8. 2004
    Thrombospondin-1 (TSP1), a multifunctional, extracellular matrix protein, regulates cellular attachment, proliferation, migration, and differentiation in vitro, and is expressed de novo in many inflammatory diseases, including ..
  96. pmc c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
    Troy A Baudino
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 16:2530-43. 2002
    ..These findings support the model wherein c-Myc promotes cell growth and transformation, as well as vascular and hematopoietic development, by functioning as a master regulator of angiogenic factors...
  97. ncbi Thrombospondin 3 is a developmentally regulated heparin binding protein
    A N Qabar
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48019
    J Biol Chem 269:1262-9. 1994
    ..Finally, a combination of in situ hybridization and immunocytochemistry demonstrated TSP3 to be expressed in a temporal and spatial manner during murine embryogenesis, especially in the gut, cartilage, lung, and central nervous system...
  98. ncbi The evolution of the thrombospondin gene family
    J Lawler
    Department of Pathology, Brigham and Women s Hospital, Boston, MA
    J Mol Evol 36:509-16. 1993
    ..These results indicate that the members of the thrombospondin gene family have existed throughout the evolution of the animal kingdom and thus probably participate in functions that are common to most of its members...
  99. pmc A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
    M A Farmer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 98:13820-5. 2001
    ..A human ortholog of the Chr. 3 QTL, if one exists, would map to Chr. 4q or 1p...
  100. ncbi Cloning of the murine Drm gene (Cktsf1b1) and characterization of its oncogene suppressible promoter
    Q Zhang
    Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA
    Cytogenet Cell Genet 89:242-51. 2000
    ..Our results indicate that the expression of Cktsf1b1, a gene associated with early development and cell transformation, is sensitive to MKK levels and may be regulated via multiple transcription factor complexes...
  101. ncbi Localization of the renal Na-K-Cl cotransporter gene (Slc12a1) on mouse chromosome 2
    S E Quaggin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Mamm Genome 6:557-8. 1995

Research Grants64

  1. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  2. Resolution of inflammation in healing myocardial infarcts
    Nikolaos Frangogiannis; Fiscal Year: 2009
    ..These studies may lead to therapeutic interventions aimed at optimizing cardiac repair by preventing prolongation and extension of the inflammatory injury. ..
  3. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2010
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  4. Upstream Stimulatory Factor 2 regulation of renin in diabetic nephropathy
    Shuxia Wang; Fiscal Year: 2010
    ....
  5. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..Thus, this information is central to the generation of novel and more effective therapies that will enable manipulation of vascular function during pathological conditions. ..
  6. Regulation of Vascular Function by Progesterone Receptor
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..abstract_text> ..
  7. Fascin Protrusions in ECM-Cytoskeletal Networking
    Josephine Adams; Fiscal Year: 2007
    ....
  8. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2007
    ..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. ..
  9. Cytoskeletal Mechanisms of Platelet Formation
    Joseph Italiano; Fiscal Year: 2007
    ....
  10. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..We anticipate that results from these experiments will shed light into the biology of tumor growth and angiogenesis. ..
  11. Vascular Biology Training Grant
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..End of Abstract) ..
  12. INHIBITION OF THE ANGIOGENIC RESPONSE
    Luisa Iruela Arispe; Fiscal Year: 2006
    ..mice (by virtue of c-neu overexpression in the mammary gland) that either over expressed or lack thrombospondin-l (TSP1)...
  13. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2010
    ..Thus, this information is central to the generation of novel and more effective therapies that will enable manipulation of vascular function during pathological conditions. ..
  14. Cytoskeletal Mechanisms of Platelet Formation
    Joseph E Italiano; Fiscal Year: 2010
    ....
  15. Chemokines in Healing Myocardial Infarcts
    Nikolaos Frangogiannis; Fiscal Year: 2009
    ..Understanding the role of chemokines in infarct healing may identify novel therapeutic targets aiming at optimizing cardiac repair and decreasing adverse remodeling. ..
  16. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2009
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  17. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2003
    ..For several years, we have been working on the protein thrombospondin-1 (TSP1), a glycoprotein that, among many functions, suppresses neovascularization...
  18. THERAPEUTIC ANTIANGIOGENESIS
    Luisa Iruela Arispe; Fiscal Year: 2002
    ..Finally, we will treat tumors three class of anti- angiogenic therapy, including: (a) soluble fit; (b) TSP1-derived peptides; or (c) METH-l, to assess their effects on TGF-beta1 induced tumor angiogenesis (Aim 3)...
  19. Cytoskeletal Mechanisms of Platelet Formation
    Joseph Italiano; Fiscal Year: 2005
    ..Understanding the cytoskeletal mechanics of platelet formation may provide insights into how platelets are produced and yield strategies for treatment of thrombocytopenia. ..
  20. Modulatory Adhesion Molecules in Tissue Organization
    Josephine Adams; Fiscal Year: 2004
    ..abstract_text> ..
  21. Angiogenesis and Microcirculation Gordon Conference
    Luisa Iruela Arispe; Fiscal Year: 2005
    ..The conference will be held in Salve Regina University from August 10-15, 2003. ..