Gene Symbol: Tgfbi
Description: transforming growth factor, beta induced
Alias: 68kDa, AI181842, AI747162, Beta-ig, big-h3, transforming growth factor-beta-induced protein ig-h3, transforming growth factor, beta induced, 68 kDa
Species: mouse
Products:     Tgfbi

Top Publications

  1. Skonier J, Bennett K, Rothwell V, Kosowski S, Plowman G, Wallace P, et al. beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. DNA Cell Biol. 1994;13:571-84 pubmed
    b>beta ig-h3 is a novel gene first discovered by differential screening of a cDNA library made from A549 human lung adenocarcinoma cells treated with transforming growth factor-beta 1 (TGF-beta 1)...
  2. Yu H, Wergedal J, Zhao Y, Mohan S. Targeted disruption of TGFBI in mice reveals its role in regulating bone mass and bone size through periosteal bone formation. Calcif Tissue Int. 2012;91:81-7 pubmed publisher
    Transforming growth factor-beta induced (TGFBI) and periostin are two closely related proteins in structure as well as in function. A previous study found that periostin positively regulates bone size...
  3. Choi K, Cho B, Kim I, Kim H, Ryoo H. A TGF-beta-induced gene, betaig-h3, is crucial for the apoptotic disappearance of the medial edge epithelium in palate fusion. J Cell Biochem. 2009;107:818-25 pubmed publisher
    ..We conclude that betaig-h3 expression in the MEE is stimulated by TGF-beta3, causes cell death, and consequently results in complete fusion of the apposed palatal shelves. ..
  4. Uekita T, Kim Y, Yamanouchi K, Tojo H, Tachi C. Dynamics of betaig-h3 mRNA expression during pregnancy in the uterus and the placenta of the mouse: a possible regulatory factor for trophoblastic invasion. J Reprod Dev. 2003;49:243-52 pubmed
    ..These findings suggest that betaig-h3 might play a role in regulating the invasiveness of trophoblast cells during implantation and placentation of hemochorial type when extensive trophoblastic invasion of the endometrium takes place. ..
  5. Allaman Pillet N, Oberson A, Bustamante M, Tasinato A, Hummler E, Schorderet D. Tgfbi/Bigh3 silencing activates ERK in mouse retina. Exp Eye Res. 2015;140:159-170 pubmed publisher
    ..This phenomenon was accompanied by an increased activity of the pro-survival ERK pathway. ..
  6. Maeng Y, Lee R, Lee B, Choi S, Kim E. Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells. Sci Rep. 2016;6:20739 pubmed publisher
    ..Collectively, our findings demonstrate a novel role of lithium in the inhibition of colon cancer metastasis by blocking TGFBIp expression, and thereby TGFBIp-induced lymphangiogenesis, in primary tumors. ..
  7. Nam J, Kim J, Jeong H, Lee S, Lee B, Choi J, et al. Identification of the alphavbeta3 integrin-interacting motif of betaig-h3 and its anti-angiogenic effect. J Biol Chem. 2003;278:25902-9 pubmed
    ..Our results reveal that betaig-h3 bears alphavbeta3 integrin-interacting motifs that mediate endothelial cell adhesion and migration and, therefore, may regulate angiogenesis. ..
  8. LU J, Qian J, Izvolsky K, Cardoso W. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev Biol. 2004;273:418-35 pubmed
    ..Our data suggest that these genes may regulate focal developmental events specific of each of these regions during respiratory tract formation. ..
  9. Lindsley A, Li W, Wang J, Maeda N, Rogers R, Conway S. Comparison of the four mouse fasciclin-containing genes expression patterns during valvuloseptal morphogenesis. Gene Expr Patterns. 2005;5:593-600 pubmed

More Information


  1. Günschmann C, Stachelscheid H, Akyuz M, Schmitz A, Missero C, Bruning J, et al. Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev Cell. 2013;26:176-87 pubmed publisher
    ..Collectively, the present study reveals a critical role for IIS-dependent control of p63 activity in coordination of ACD and stratification during epithelial morphogenesis. ..
  2. Pazin D, Gamer L, Cox K, Rosen V. Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012;241:1816-26 pubmed publisher
    ..The knee is enriched for the hindlimb patterning genes Hoxc9, Hoxc10, and Tbx4 and for Tgfbi, Rspo2, and Sfrp2, factors involved in transforming growth factor-beta/bone morphogenetic protein (TGF?/BMP) and ..
  3. Lorda Diez C, Montero J, Diaz Mendoza M, Garcia Porrero J, Hurle J. ?ig-h3 potentiates the profibrogenic effect of TGF? signaling on connective tissue progenitor cells through the negative regulation of master chondrogenic genes. Tissue Eng Part A. 2013;19:448-57 pubmed publisher
  4. Kim H, Kim P, Bae S, Son H, Thoudam D, Kim J, et al. Transforming growth factor-beta-induced protein (TGFBIp/beta ig-h3) activates platelets and promotes thrombogenesis. Blood. 2009;114:5206-15 pubmed publisher
    Transforming growth factor-beta-induced protein (TGFBIp)/beta ig-h3 is a 68-kDa extracellular matrix protein that is functionally associated with the adhesion, migration, proliferation, and differentiation of various cells...
  5. Wilson D, Phamluong K, Lin W, Barck K, Carano R, Diehl L, et al. Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Dev Biol. 2012;363:413-25 pubmed publisher
    ..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1. ..
  6. Contreras Ruiz L, Mir F, Turpie B, Krauss A, Masli S. Sjögren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin α4 antagonist GW559090. Exp Eye Res. 2016;143:1-8 pubmed publisher
    ..We conclude that similar to topical dexamethasone, topically administered GW559090 successfully improved corneal barrier integrity and inflammation in an established ocular surface disease associated with Sjögren's syndrome. ..
  7. Bae J, Lee W, Nam J, Kim J, Kim S, Kim I. Transforming growth factor ?-induced protein promotes severe vascular inflammatory responses. Am J Respir Crit Care Med. 2014;189:779-86 pubmed publisher
    ..Collectively, our findings demonstrate that the TGFBIp-?v?5 axis can elicit severe inflammatory responses, suggesting it to be a potential target for development of diagnostics and therapeutics for sepsis. ..
  8. Snider P, Hinton R, Moreno Rodriguez R, Wang J, Rogers R, Lindsley A, et al. Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res. 2008;102:752-60 pubmed publisher
    ..Thus, peri(lacZ) knockouts provide a new model of viable latent valve disease. ..
  9. Zhang Y, Wen G, Shao G, Wang C, Lin C, Fang H, et al. TGFBI deficiency predisposes mice to spontaneous tumor development. Cancer Res. 2009;69:37-44 pubmed publisher
    Loss of TGFBI, a secreted protein induced by transforming growth factor-beta, has been implicated in cell proliferation, tumor progression, and angiogenesis by in vitro studies...
  10. Juriloff D, Gunn T, Harris M, Mah D, Wu M, Dewell S. Multifactorial genetics of exencephaly in SELH/Bc mice. Teratology. 2001;64:189-200 pubmed
    ..The high risk of exencephaly in SELH/Bc mice is caused by the cumulative effect of two to three semidominant genes. Candidate genes include Msx2, Madh5, Ptch, and Irx1 (Chr 13) and Actb and Rac1 (Chr 5). ..
  11. Mondragon A, Betts Obregon B, Moritz R, Parvathaneni K, Navarro M, Kim H, et al. BIGH3 protein and macrophages in retinal endothelial cell apoptosis. Apoptosis. 2015;20:29-37 pubmed publisher
    ..Our results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFβ released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis. ..
  12. Adikusuma F, Pederick D, McAninch D, Hughes J, Thomas P. Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes. Genetics. 2017;206:1495-1503 pubmed publisher
    ..Together, these in vivo data provide strong evidence that SOX2 and SOX3 proteins are functionally equivalent. ..
  13. Sciandra F, Morlacchi S, Allamand V, De Benedetti G, Macchia G, Petrucci T, et al. First molecular characterization and immunolocalization of keratoepithelin in adult human skeletal muscle. Matrix Biol. 2008;27:360-70 pubmed publisher
  14. Han B, Luo H, Raelson J, Huang J, Li Y, Tremblay J, et al. TGFBI (?IG-H3) is a diabetes-risk gene based on mouse and human genetic studies. Hum Mol Genet. 2014;23:4597-611 pubmed publisher
    Transforming growth factor beta-induced (TGFBI/?IG-H3), also known as ?ig-H3, is a protein inducible by TGF?1 and secreted by many cell types...
  15. Chitra P, Swathi T, Sahay R, Reddy G, Menon R, Kumar P. Growth Hormone Induces Transforming Growth Factor-Beta-Induced Protein in Podocytes: Implications for Podocyte Depletion and Proteinuria. J Cell Biochem. 2015;116:1947-56 pubmed publisher
    ..Therefore, we conclude that the GH-dependent increase in TGFBIp in the podocyte is one of the mechanisms responsible for podocyte depletion in DN. ..
  16. Lee W, Ku S, Bae J. Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses. Inflammation. 2015;38:2166-77 pubmed publisher
    ..Collectively, these results indicate that vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. ..
  17. Tennant B, Chen J, Shih A, Luciani D, Hoffman B. Myt3 Mediates Laminin-V/Integrin-β1-Induced Islet-Cell Migration via Tgfbi. Mol Endocrinol. 2015;29:1254-68 pubmed publisher
    ..RNA-seq) analysis of transduced islets showed that Myt3 suppression results in the up-regulation of Tgfbi, a secreted diabetogenic factor thought to impair cellular adhesion...
  18. Shelton E, Ector G, Galindo C, Hooper C, Brown N, Wilkerson I, et al. Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone. Physiol Genomics. 2014;46:457-66 pubmed publisher
    ..Ion channels that regulate DA tone, including BKCa channels, are promising targets. Specifically, BKCa channel agonists like NS1619 maintain DA patency even in the presence of O2 and may be clinically useful. ..
  19. Kalyani R, Lee J, Min H, Yoon H, Kim M. Genes Frequently Coexpressed with Hoxc8 Provide Insight into the Discovery of Target Genes. Mol Cells. 2016;39:395-402 pubmed publisher
    ..We randomly selected Adam19, Ptpn13, Prkd1, Tgfbi, and Aldh1a3, and validated their coexpression in mouse embryonic tissues and cell lines following TGF-?2 ..
  20. Schwab K, Patterson L, Aronow B, Luckas R, Liang H, Potter S. A catalogue of gene expression in the developing kidney. Kidney Int. 2003;64:1588-604 pubmed
    ..For three genes, Cdrap, Tgfbi, and Col15a1, we observed strikingly similar expression in the developing kidneys and lungs, which both undergo ..
  21. Schorderet D, Menasche M, Morand S, Bonnel S, Buchillier V, Marchant D, et al. Genomic characterization and embryonic expression of the mouse Bigh3 (Tgfbi) gene. Biochem Biophys Res Commun. 2000;274:267-74 pubmed
    ..The characterization of the murine structure is a prerequisite for the making of such models. ..
  22. Brinkmeier M, Davis S, Carninci P, MacDonald J, Kawai J, Ghosh D, et al. Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches. Genomics. 2009;93:449-60 pubmed publisher
    ..These genes are exciting candidates for regulators of pituitary development and function. ..
  23. Bildsoe H, Fan X, Wilkie E, Ashoti A, Jones V, Power M, et al. Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Dev Biol. 2016;418:189-203 pubmed publisher
    ..Three direct transcriptional targets of TWIST1 (Ddr2, Pcolce and Tgfbi) were validated by ChIP-PCR using mouse embryonic tissues and by luciferase assays...
  24. Ferguson J, Mikesh M, Wheeler E, LeBaron R. Developmental expression patterns of Beta-ig (betaIG-H3) and its function as a cell adhesion protein. Mech Dev. 2003;120:851-64 pubmed
    ..Taken together, the results indicate that Beta-ig is expressed principally in collagen-rich tissues where it may interact with cells and ECM molecules, perhaps playing a role in tissue morphogenesis. ..
  25. Thapa N, Kang K, Kim I. Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation. Bone. 2005;36:232-42 pubmed
    ..We suggest that these interacting integrins may play an important role in betaig-h3-mediated inhibition of osteoblast differentiation. ..
  26. Mahoney J, Mori M, Szymaniak A, Varelas X, Cardoso W. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 2014;30:137-50 pubmed publisher
    ..Our data reveal a role for the Hippo-Yap pathway in integrating growth-factor-induced cues in the developing and adult lung potentially key for homeostasis and regeneration repair. ..
  27. Lee J, Lee E, Kim I, Kim J. Tgfbi deficiency leads to a reduction in skeletal size and degradation of the bone matrix. Calcif Tissue Int. 2015;96:56-64 pubmed publisher
    Transforming growth factor-β-induced gene product-h3 (TGFBI/BIGH3) is an extracellular matrix protein expressed in a wide variety of tissues...
  28. Ferguson J, Thoma B, Mikesh M, Kramer R, Bennett K, Purchio A, et al. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003;313:93-105 pubmed
  29. Ahlfeld S, Wang J, Gao Y, Snider P, Conway S. Initial Suppression of Transforming Growth Factor-β Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia. Am J Pathol. 2016;186:777-93 pubmed publisher
    ..Significantly, we found that the TGF-β-induced matricellular protein (TGFBI) was similarly biphasically altered in response to hyperoxia...
  30. Chen F, Desai T, Qian J, Niederreither K, LU J, Cardoso W. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007;134:2969-79 pubmed
    ..Our data support a novel mechanism of RA-Tgfbeta-Fgf10 interactions in the developing foregut, in which endogenous RA controls Tgfbeta activity in the prospective lung field to allow local expression of Fgf10 and induction of lung buds. ..
  31. Allaman Pillet N, Oberson A, Schorderet D. Bigh3 silencing increases retinoblastoma tumor growth in the murine SV40-TAg-Rb model. Oncotarget. 2017;8:15490-15506 pubmed publisher
    ..Taken together, these data suggest that BIGH3 acts as a tumor suppressor in the retina. ..
  32. Han M, Kim J, Shin H, Kim I. Expression patterns of betaig-h3 in chondrocyte differentiation during endochondral ossification. Exp Mol Med. 2008;40:453-60 pubmed
    ..These results suggest that betaig-h3 may play a critical role as a regulator of chondrogenic differentiation in endochondral ossification. ..