Tfrc

Summary

Gene Symbol: Tfrc
Description: transferrin receptor
Alias: 2610028K12Rik, CD71, E430033M20Rik, Mtvr1, TFR, TFR1, Trfr, p90, transferrin receptor protein 1, mammary tumor virus receptor 1
Species: mouse
Products:     Tfrc

Top Publications

  1. Matsui T, Itoh T, Fukuda M. Small GTPase Rab12 regulates constitutive degradation of transferrin receptor. Traffic. 2011;12:1432-43 pubmed publisher
    Transferrin receptor (TfR) is a well-characterized plasma membrane protein that travels between the plasma membrane and intracellular membrane compartments...
  2. Hradilek A, Fuchs O, Neuwirt J. Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells. J Cell Physiol. 1992;150:327-33 pubmed
    The coordination of transferrin receptor (TfR) expression and heme synthesis was investigated in mouse erythroleukemia (MEL) cells of line 707 treated with heme synthesis inhibitors or in a variant line Fw genetically deficient in heme ..
  3. Yoon D, Pastore Y, Divoky V, Liu E, Mlodnicka A, Rainey K, et al. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 2006;281:25703-11 pubmed
    ..These results identify a novel role for HIF-1 in the regulation of iron homeostasis and reveal unexpected regulatory differences in Epo/EpoR signaling in yolk sac and embryonic erythropoiesis. ..
  4. Mochida G, Mahajnah M, Hill A, Basel Vanagaite L, Gleason D, Hill R, et al. A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly. Am J Hum Genet. 2009;85:897-902 pubmed publisher
    ..This suggests essential roles of TRAPPC9 in human brain development, possibly through its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the cerebral cortex. ..
  5. Chirasani S, Markovic D, Synowitz M, Eichler S, Wisniewski P, Kaminska B, et al. Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells. J Mol Med (Berl). 2009;87:153-67 pubmed publisher
    Transferrin receptors (TfR) are overexpressed in brain tumors, but the pathological relevance has not been fully explored...
  6. Wang E, Obeng Adjei N, Ying Q, Meertens L, Dragic T, Davey R, et al. Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. Virology. 2008;381:230-40 pubmed publisher
    Mouse mammary tumor virus (MMTV) is a pH-dependent virus that uses mouse transferrin receptor 1 (TfR1) for entry into cells. Previous studies demonstrated that MMTV could induce pH 5-dependent fusion-from-with of mouse cells...
  7. Steinle A. Transferrin' activation: bonding with transferrin receptors tunes KLRG1 function. Eur J Immunol. 2014;44:1600-3 pubmed publisher
    ..Subsequent to identification of the transferrin receptor (TfR) as a component of a high molecular mass KLRG1 complex, they demonstrate that a fraction of mouse KLRG1 molecules ..
  8. Ross S, Schofield J, Farr C, Bucan M. Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virus. Proc Natl Acad Sci U S A. 2002;99:12386-90 pubmed
    ....
  9. Manceau V, Kremmer E, Nabel E, Maucuer A. The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS ONE. 2012;7:e43946 pubmed publisher
    ..This difference suggests that disregulation of gene expression due to KIS inactivation affects specific brain functions. ..
  10. Moos T. Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol. 1996;375:675-92 pubmed
    ..The clinical importance of the intraneuronal transferrin receptor expression is discussed. ..

Detail Information

Publications62

  1. Matsui T, Itoh T, Fukuda M. Small GTPase Rab12 regulates constitutive degradation of transferrin receptor. Traffic. 2011;12:1432-43 pubmed publisher
    Transferrin receptor (TfR) is a well-characterized plasma membrane protein that travels between the plasma membrane and intracellular membrane compartments...
  2. Hradilek A, Fuchs O, Neuwirt J. Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells. J Cell Physiol. 1992;150:327-33 pubmed
    The coordination of transferrin receptor (TfR) expression and heme synthesis was investigated in mouse erythroleukemia (MEL) cells of line 707 treated with heme synthesis inhibitors or in a variant line Fw genetically deficient in heme ..
  3. Yoon D, Pastore Y, Divoky V, Liu E, Mlodnicka A, Rainey K, et al. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 2006;281:25703-11 pubmed
    ..These results identify a novel role for HIF-1 in the regulation of iron homeostasis and reveal unexpected regulatory differences in Epo/EpoR signaling in yolk sac and embryonic erythropoiesis. ..
  4. Mochida G, Mahajnah M, Hill A, Basel Vanagaite L, Gleason D, Hill R, et al. A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly. Am J Hum Genet. 2009;85:897-902 pubmed publisher
    ..This suggests essential roles of TRAPPC9 in human brain development, possibly through its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the cerebral cortex. ..
  5. Chirasani S, Markovic D, Synowitz M, Eichler S, Wisniewski P, Kaminska B, et al. Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells. J Mol Med (Berl). 2009;87:153-67 pubmed publisher
    Transferrin receptors (TfR) are overexpressed in brain tumors, but the pathological relevance has not been fully explored...
  6. Wang E, Obeng Adjei N, Ying Q, Meertens L, Dragic T, Davey R, et al. Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. Virology. 2008;381:230-40 pubmed publisher
    Mouse mammary tumor virus (MMTV) is a pH-dependent virus that uses mouse transferrin receptor 1 (TfR1) for entry into cells. Previous studies demonstrated that MMTV could induce pH 5-dependent fusion-from-with of mouse cells...
  7. Steinle A. Transferrin' activation: bonding with transferrin receptors tunes KLRG1 function. Eur J Immunol. 2014;44:1600-3 pubmed publisher
    ..Subsequent to identification of the transferrin receptor (TfR) as a component of a high molecular mass KLRG1 complex, they demonstrate that a fraction of mouse KLRG1 molecules ..
  8. Ross S, Schofield J, Farr C, Bucan M. Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virus. Proc Natl Acad Sci U S A. 2002;99:12386-90 pubmed
    ....
  9. Manceau V, Kremmer E, Nabel E, Maucuer A. The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS ONE. 2012;7:e43946 pubmed publisher
    ..This difference suggests that disregulation of gene expression due to KIS inactivation affects specific brain functions. ..
  10. Moos T. Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol. 1996;375:675-92 pubmed
    ..The clinical importance of the intraneuronal transferrin receptor expression is discussed. ..
  11. Barrientos T, Laothamatas I, Koves T, Soderblom E, Bryan M, Moseley M, et al. Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle. EBioMedicine. 2015;2:1705-17 pubmed publisher
    Transferrin receptor (Tfr1) is ubiquitously expressed, but its roles in non-hematopoietic cells are incompletely understood...
  12. Boda E, Pini A, Hoxha E, Parolisi R, Tempia F. Selection of reference genes for quantitative real-time RT-PCR studies in mouse brain. J Mol Neurosci. 2009;37:238-53 pubmed publisher
    ..common housekeeping genes (such as Gapdh, 18s, and B2m) and of some relatively new control genes (such as Pgk1, Tfrc, and Gusb) during mouse brain maturation...
  13. Flanagan M, Oldenburg J, Reignier T, Holt N, Hamilton G, Martin V, et al. New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1. J Virol. 2008;82:938-48 pubmed publisher
    ..that are used by different pathogenic viruses, alpha-dystroglycan by Lassa fever virus and transferrin receptor 1 (TfR1) by certain New World clade B viruses...
  14. Kato U, Inadome H, Yamamoto M, Emoto K, Kobayashi T, Umeda M. Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. J Biol Chem. 2013;288:4922-34 pubmed publisher
    ....
  15. Habtemichael E, Brewer P, Romenskaia I, Mastick C. Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin. J Biol Chem. 2011;286:10115-25 pubmed publisher
    ..Using mathematical modeling and simulation, we show that the reported decrease in Glut4 k(en) can be entirely accounted for by the well established increase in Glut4 k(ex). ..
  16. Shivdasani R, Orkin S. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995;92:8690-4 pubmed
    ..Thus, regulation of globin gene transcription through NF-E2 binding sites in vivo is more complex than has been previously appreciated. ..
  17. Zhu B, McLaughlin S, Na R, Liu J, Cui Y, Martin C, et al. Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood. 2008;112:2071-80 pubmed publisher
    ..to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythrocytes and reduced Tfr1 expression is associated with anemia...
  18. Xu X, Sutak R, Richardson D. Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking. Mol Pharmacol. 2008;73:833-44 pubmed
    ..of cells with doxorubicin (DOX) up-regulated mRNA levels of the iron-regulated genes transferrin receptor-1 (TfR1) and N-myc downstream-regulated gene-1 (Ndrg1)...
  19. Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, et al. Development of a transferrin receptor-targeting HVJ-E vector. Biochem Biophys Res Commun. 2007;364:423-8 pubmed
    ..The modified vectors containing Q-dots demonstrated 32-fold greater tumor-targeting efficiency than wild-type HVJ-E. ..
  20. Chung Y, Robert C, Gough S, Rassool F, Aplan P. Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome. Leuk Res. 2014;38:95-102 pubmed publisher
    ..Increased levels of ROS were detected in bone marrow nucleated cells (BMNC) that express CD71, a marker for cell proliferation, as well as immature, lineage negative bone marrow nucleated cells from NHD13 mice...
  21. Bhoiwala D, Song Y, Cwanger A, Clark E, Zhao L, Wang C, et al. CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet. Invest Ophthalmol Vis Sci. 2015;56:5344-52 pubmed publisher
    ..This suggests regulation of retinal iron uptake at the blood-retinal barriers. ..
  22. Coumailleau F, Das V, Alcover A, Raposo G, Vandormael Pournin S, Le Bras S, et al. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell. 2004;15:4444-56 pubmed
    ..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane. ..
  23. Jabara H, Boyden S, Chou J, Ramesh N, Massaad M, Benson H, et al. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016;48:74-8 pubmed publisher
    ..Tyr20His substitution in transferrin receptor 1 (TfR1), encoded by TFRC...
  24. Komada M, Soriano P. Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 1999;13:1475-85 pubmed
    ..The vesicular localization of Hrs was disrupted in cells treated with wortmannin, implicating Hrs in the phosphatidylinositol 3-kinase pathway of membrane trafficking. ..
  25. Jurado S, Goswami D, Zhang Y, Molina A, Sudhof T, Malenka R. LTP requires a unique postsynaptic SNARE fusion machinery. Neuron. 2013;77:542-58 pubmed publisher
    ..Thus, postsynaptic exocytosis of AMPARs during LTP is mediated by a unique fusion machinery that is distinct from that used during presynaptic neurotransmitter release. ..
  26. Wang J, Chen G, Pantopoulos K. Inhibition of transferrin receptor 1 transcription by a cell density response element. Biochem J. 2005;392:383-8 pubmed
    b>TfR1 (transferrin receptor 1) mediates the uptake of transferrin-bound iron and thereby plays a critical role in cellular iron metabolism...
  27. Whitnall M, Suryo Rahmanto Y, Sutak R, Xu X, Becker E, Mikhael M, et al. The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation. Proc Natl Acad Sci U S A. 2008;105:9757-62 pubmed publisher
    ..In summary, we show that loss of Fxn markedly alters cellular Fe trafficking and that Fe chelation limits myocardial hypertrophy in the mutant. ..
  28. Liu K, Lei R, Li Q, Wang X, Wu Q, An P, et al. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Sci Rep. 2016;6:21019 pubmed publisher
    Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis...
  29. Garrick M, Garrick L. Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd mice. Biochim Biophys Acta. 2007;1773:105-8 pubmed
    ..Endocytosis and initial iron incorporation were relatively unaffected, but exocytosis was unexpectedly slowed. These data indicate that rapid transferrin recycling is defective after pSec15l1 has mutated. ..
  30. Chen C, Garcia Santos D, Ishikawa Y, Seguin A, Li L, Fegan K, et al. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab. 2013;17:343-52 pubmed publisher
    ..Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors...
  31. Sirohi K, Chalasani M, Sudhakar C, Kumari A, Radha V, Swarup G. M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy. 2013;9:510-27 pubmed publisher
    ..These results also show that transferrin receptor degradation and autophagy play a crucial role in RGC-5 cell death induced by M98K variant of OPTN. ..
  32. Pang C, Lemsaddek W, Alhashem Y, Bondzi C, Redmond L, Ah Son N, et al. Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol. 2012;32:2628-44 pubmed publisher
    ..5 and E11.5. This study reveals a novel regulatory network by which KLF1 and KLF2 regulate Myc to control the primitive erythropoietic program. ..
  33. Bayeva M, Khechaduri A, Puig S, Chang H, Patial S, Blackshear P, et al. mTOR regulates cellular iron homeostasis through tristetraprolin. Cell Metab. 2012;16:645-57 pubmed publisher
    ..that the mammalian target of rapamycin (mTOR) regulates iron homeostasis by modulating transferrin receptor 1 (TfR1) stability and altering cellular iron flux...
  34. Schweier O, Hofmann M, Pircher H. KLRG1 activity is regulated by association with the transferrin receptor. Eur J Immunol. 2014;44:1851-6 pubmed publisher
    ..A5 T-cell line and in IL-2-activated NK cells forms disulfide-linked heteromers with the transferrin receptor (TfR)...
  35. Grant G, Robinson S, Edwards R, Clothier B, Davies R, Judah D, et al. Multiple polymorphic loci determine basal hepatic and splenic iron status in mice. Hepatology. 2006;44:174-85 pubmed
    ..In conclusion, the findings show the location of polymorphic genes that determine basal iron status in wild-type mice. Human equivalents may be pertinent in predisposition to hepatic and other disorders. ..
  36. Wang E, Albritton L, Ross S. Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection. J Biol Chem. 2006;281:10243-9 pubmed
    ..The beta retrovirus mouse mammary tumor virus (MMTV) uses transferrin receptor 1 (TfR1) to enter cells in a pH-dependent mechanism, probably co-trafficking with TfR1 to an acidic compartment where virus ..
  37. Brekelmans P, Van Soest P, Voerman J, Platenburg P, Leenen P, van Ewijk W. Transferrin receptor expression as a marker of immature cycling thymocytes in the mouse. Cell Immunol. 1994;159:331-9 pubmed
    Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron...
  38. Guo Xiaoqiang -, Li Wenjie -, Xin Qiliang -, Ding Hui -, Zhang Caiyun -, Chang Yanzhong -, et al. Vitamin C protective role for alcoholic liver disease in mice through regulating iron metabolism. Toxicol Ind Health. 2011;27:341-8 pubmed publisher
    ..Vc increases the expression of the iron-regulated hormone hepcidin and decreases transferrin receptor 1 (TfR1) expression in liver...
  39. Milstone L, Adams B, Zhou J, Bruegel Sanchez V, Shofner J. Stratum-specific expression of human transferrin receptor increases iron in mouse epidermis. J Invest Dermatol. 2006;126:648-52 pubmed
    ..These data show that control of transferrin receptor expression is sufficient to regulate iron content in proliferating or differentiating keratinocytes in the epidermis. ..
  40. Bayer A, Baliga P, Woodward J. Transferrin receptor in T cell activation and transplantation. J Leukoc Biol. 1998;64:19-24 pubmed
    Transferrin receptor (TfR) expression is up-regulated during T cell activation after the interaction of the T cell receptor with the antigen-major histocompatibility complex and the expression of interleukin-2 (IL-2) receptor...
  41. Bien Ly N, Yu Y, Bumbaca D, Elstrott J, Boswell C, Zhang Y, et al. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. J Exp Med. 2014;211:233-44 pubmed publisher
    Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain...
  42. Dutchak P, Laxman S, Estill S, Wang C, Wang Y, Wang Y, et al. Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015;12:371-9 pubmed publisher
    ....
  43. Fotticchia I, Guarnieri D, Fotticchia T, Falanga A, Vecchione R, Giancola C, et al. Energetics of ligand-receptor binding affinity on endothelial cells: An in vitro model. Colloids Surf B Biointerfaces. 2016;144:250-256 pubmed publisher
    ..The revealed affinity between transferrin (Tf) and transferrin receptor (TfR) in both systems is very high, Kd values are in the order of nM...
  44. Xing J, Weng L, Yuan B, Wang Z, Jia L, Jin R, et al. Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract. Nat Immunol. 2016;17:1373-1380 pubmed publisher
    ..These data identify TRIM29 as a key negative regulator of alveolar macrophages and might have important clinical implications for local immunity and immunopathology. ..
  45. Mohammad Panah R, Wellhauser L, Steinberg B, Wang Y, Huan L, Liu X, et al. An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice. J Cell Sci. 2009;122:1229-37 pubmed publisher
    ..These observations provide direct evidence supporting an essential role for ClC-4 in the modulation of Tfn receptor accessibility at the cell surface through its role in endosomal acidification. ..
  46. Kim B, Wang F, Dufner Beattie J, Andrews G, Eide D, Petris M. Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem. 2004;279:4523-30 pubmed
    ..These findings suggest that zinc-regulated trafficking of human and mouse ZIP4 is a key mechanism controlling dietary zinc absorption and cellular zinc homeostasis. ..
  47. Inoue S, Yokota M, Nakada K, Miyoshi H, Hayashi J. Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation. FEBS Lett. 2007;581:1910-6 pubmed
    ..These observations suggest that hematopoietic cell-specific respiration defects caused by mtDNAs with pathogenic mutations are responsible for anemia by inducing abnormalities in erythropoiesis. ..
  48. Hilkens J, van der Zeijst B, Buijs F, Kroezen V, Bleumink N, Hilgers J. Identification of a cellular receptor for mouse mammary tumor virus and mapping of its gene to chromosome 16. J Virol. 1983;45:140-7 pubmed
    ..From the analysis of the isoenzymes and chromosomes of the hybrid cell lines we conclude that the gene for the receptor (MTVR-1) is located on mouse chromosome 16. ..
  49. Levy J, Montross L, Andrews N. Genes that modify the hemochromatosis phenotype in mice. J Clin Invest. 2000;105:1209-16 pubmed
    ..In addition to providing insight into the pathogenesis of HH, our results suggest that each of these genes might be a candidate modifier of the human hemochromatosis phenotype. ..
  50. Cartón García F, Overeem A, Nieto R, Bazzocco S, Dopeso H, Macaya I, et al. Myo5b knockout mice as a model of microvillus inclusion disease. Sci Rep. 2015;5:12312 pubmed publisher
    ....
  51. Best D, Sahlender D, Walther N, Peden A, Adams I. Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice. Development. 2008;135:1415-25 pubmed publisher
    ..These data suggest that changes that occur in the cell biology of embryonic Sertoli cells may facilitate the communication of male sex-determining decisions to the germ cells during embryonic development. ..
  52. Rausa M, Pagani A, Nai A, Campanella A, Gilberti M, Apostoli P, et al. Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?. PLoS ONE. 2015;10:e0122696 pubmed publisher
    ..With manipulation of dietary iron in wild-type mice, Bmp6 and Tfr1 expression in both HCs and NPCs was inversely related, as expected...
  53. Blanc L, Liu J, Vidal M, Chasis J, An X, Mohandas N. The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. Blood. 2009;114:3928-34 pubmed publisher
    ..These results lead us to suggest that AQP-1 sorting into exosomes may be the mechanism by which the reticulocyte adapts to environmental changes during its maturation...
  54. Martin F, Xu X, von Löhneysen K, Gilmartin T, Friedman J. SOD2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolism. PLoS ONE. 2011;6:e16894 pubmed publisher
    ..SA is primarily an acquired, clonal marrow disorder occurring in individuals over 60 years of age with uncertain etiology...
  55. Flanagan J, Peng H, Wang L, Gelbart T, Lee P, Johnson Sasu B, et al. Soluble transferrin receptor-1 levels in mice do not affect iron absorption. Acta Haematol. 2006;116:249-54 pubmed
    ..Thus, despite its attractiveness as a potential modifier of iron absorption, sTfR1 levels do not exert a regulatory effect on iron absorption. ..
  56. Bogan J, Lodish H. Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol. 1999;146:609-20 pubmed
    ....
  57. Matak P, Matak A, Moustafa S, Aryal D, Benner E, Wetsel W, et al. Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proc Natl Acad Sci U S A. 2016;113:3428-35 pubmed publisher
    ..We demonstrate that loss of transferrin receptor 1, but not loss of ferroportin, can cause neurodegeneration in a subset of dopaminergic neurons in mice. ..
  58. Kaneko H, Kobayashi E, Yamamoto M, Shimizu R. N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program. J Biol Chem. 2012;287:21439-49 pubmed publisher
    ..These results thus demonstrate that GATA1 has two independent transactivation domains, N-TAD and C-TAD. Both N-TAD and C-TAD retain redundant as well as specific activities for proper hematopoiesis in vivo. ..
  59. Newell Litwa K, Salazar G, Smith Y, Faundez V. Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles. Mol Biol Cell. 2009;20:1441-53 pubmed publisher
    ..Our results demonstrate that lysosomal and lysosome-related organelle biogenesis mechanisms regulate steady-state synaptic vesicle protein composition from shared early endosomes. ..
  60. Wiley D, Webster P, Gale A, Davis M. Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor. Proc Natl Acad Sci U S A. 2013;110:8662-7 pubmed publisher
    ..This transport is aided by tuning the nanoparticle avidity to Tf receptor (TfR), which is correlated with nanoparticle size and total amount of Tf decorating the nanoparticle surface...
  61. Zhang D, Senecal T, Ghosh M, Ollivierre Wilson H, Tu T, Rouault T. Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts. Blood. 2011;118:2868-77 pubmed publisher
    ..Our results may explain why iron deficiency anemia is the most pronounced early manifestation of mammalian iron deficiency...
  62. Muller R, Verma I, Adamson E. Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J. 1983;2:679-84 pubmed
    ..It is suggested that the c-fos and c-fms proteins may participate in differentiation, growth or transport processes occurring in mouse extra-embryonal tissues. ..