Tff3

Summary

Gene Symbol: Tff3
Description: trefoil factor 3, intestinal
Alias: ITF, mITF, intestinal trefoil factor, trefoil factor 3
Species: mouse

Top Publications

  1. pmc Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol 3:11. 2004
  2. doi Lack of Tff3 peptide results in hearing impairment and accelerated presbyacusis
    Maria Lubka
    Division of Molecular Genetics, University of Tubingen, Germany
    Cell Physiol Biochem 21:437-44. 2008
  3. doi Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-α in colon of dextran sodium sulfate-treated C57BL/6 mice
    Huanyi Jiang
    Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA 50011, USA
    J Nutr 141:1239-46. 2011
  4. ncbi An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers
    J Fossella
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    Mamm Genome 11:8-15. 2000
  5. pmc Conditional stabilization of beta-catenin expands the pool of lung stem cells
    Susan D Reynolds
    Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Stem Cells 26:1337-46. 2008
  6. doi Trefoil factor family protein 3 (TFF3) is present in cartilage during endochondral ossification in the developing mouse fetus
    Nikola Bijelić
    Department of Histology and Embryology, School of Medicine, University of Osijek, J Huttlera 4, 31000 Osijek, Croatia
    Acta Histochem 115:204-8. 2013
  7. doi Neuropeptide Trefoil factor 3 improves learning and retention of novel object recognition memory in mice
    Hai shui Shi
    Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China
    Behav Brain Res 227:265-9. 2012
  8. doi Cdx regulates Dll1 in multiple lineages
    Stephanie Grainger
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Dev Biol 361:1-11. 2012
  9. doi Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice
    M Lubka-Pathak
    Division of Molecular Genetics, Institute of Human Genetics, University of Tubingen, Wilhelmstraße, Germany
    Cell Mol Life Sci 68:2739-49. 2011
  10. ncbi Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota
    Elena M Comelli
    Department of Nutrition and Health, Nestle Research Center, 1000 Lausanne 26, Switzerland
    Genomics 91:70-7. 2008

Scientific Experts

  • Maria Lubka
  • Nikola Bijelić
  • Elena Maria Comelli
  • Paul L Beck
  • W R Otto
  • Tadashi Okubo
  • F Paulsen
  • Pia Nyeng
  • R Chinery
  • Hai shui Shi
  • Stephanie Grainger
  • Aftab Ali Shah
  • M Lubka-Pathak
  • Huanyi Jiang
  • Takaaki Kawashima
  • Jean Philippe Babeu
  • Daniel K Podolsky
  • Alex Gregorieff
  • C Tomasetto
  • Vivian Kont
  • Susan D Reynolds
  • Yuzhen Zhang
  • Byeong Moo Kim
  • Jun Shen
  • O Lefebvre
  • Young Kyu Park
  • Haruhiko Okada
  • J Fossella
  • S A Samant
  • M C Rio
  • Niall C Tebbutt
  • H Itoh
  • Qing Jun Guo
  • Filippo M Rijli
  • David Lohnes
  • H Mashimo
  • Jennifer Lam
  • Joanne G A Savory
  • Xiang Heng Luo
  • Alan J Mears
  • T Marchbank
  • Xi Yin
  • S Ribieras
  • Li Song
  • Andreas Keller
  • U Zimmermann
  • Petra Leidinger
  • Joseph Przybyszewski
  • Mirela Baus-Loncar
  • Anke Wendschlag
  • Byron Brehm-Stecher
  • A A Shah
  • Ruth S MacDonald
  • Eckart Meese
  • T Schimmang
  • N Blin
  • M Pfister
  • Chad Becker
  • Nikolaus Blin
  • H Löwenheim
  • Debjani Mitra
  • Christina Backes
  • M Knipper
  • M Gallozzi
  • Amy Tentinger
  • M Muller
  • Yoshihiro Shidoji
  • Kyoko Okamoto
  • Tsuneyuki Oku
  • D K Podolsky
  • Takashi Muraguchi
  • Peter J Peters
  • Maaike van den Born
  • Harry Begthel
  • Pekka Kujala
  • Carine R Lussier
  • Francois Boudreau
  • Mathieu Darsigny
  • Daniel E Stange
  • Guido Gerken
  • Annette Eyking
  • S H Pilder
  • Jeroen Korving
  • L M Silver
  • Hans Clevers
  • Elke Cario
  • Kai Kisand
  • Michael S Parmacek
  • Hamish S Scott
  • Anna C Zemke

Detail Information

Publications39

  1. pmc Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol 3:11. 2004
    ..The full range of effects of this pathway, which includes the transcription factor Lef1, has not been explored, however...
  2. doi Lack of Tff3 peptide results in hearing impairment and accelerated presbyacusis
    Maria Lubka
    Division of Molecular Genetics, University of Tubingen, Germany
    Cell Physiol Biochem 21:437-44. 2008
    ..Here we present new data about Tff3 expression in the cochlea of the rodent inner ear...
  3. doi Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-α in colon of dextran sodium sulfate-treated C57BL/6 mice
    Huanyi Jiang
    Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA 50011, USA
    J Nutr 141:1239-46. 2011
    ..There was no overall effect of LGG on these measurements. In conclusion, soy protein suppressed the DSS-induced inflammatory stimulation of MUC, TFF, and TNFα gene expression independently of LGG...
  4. ncbi An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers
    J Fossella
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    Mamm Genome 11:8-15. 2000
    ..Our results argue that Dnahc8 is fundamental to flagellar organization and function in Domesticus, but not Spretus, and suggest that Dnahc8 is integral to both Hst6- and t-specific male infertility...
  5. pmc Conditional stabilization of beta-catenin expands the pool of lung stem cells
    Susan D Reynolds
    Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Stem Cells 26:1337-46. 2008
    ..Our data demonstrate that the differentiation-modulating activities of stabilized beta-catenin account for expansion of tissue stem cells...
  6. doi Trefoil factor family protein 3 (TFF3) is present in cartilage during endochondral ossification in the developing mouse fetus
    Nikola Bijelić
    Department of Histology and Embryology, School of Medicine, University of Osijek, J Huttlera 4, 31000 Osijek, Croatia
    Acta Histochem 115:204-8. 2013
    Trefoil factor family protein 3 (TFF3) is found in cartilage affected by osteoarthritis and septic arthritis, whereas no TFF3 presence is observed in healthy cartilage...
  7. doi Neuropeptide Trefoil factor 3 improves learning and retention of novel object recognition memory in mice
    Hai shui Shi
    Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China
    Behav Brain Res 227:265-9. 2012
    ..However, to date, no study has investigated the effects of neuropeptide Trefoil factor 3 (TFF3) on the process of learning and memory...
  8. doi Cdx regulates Dll1 in multiple lineages
    Stephanie Grainger
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Dev Biol 361:1-11. 2012
    ..These findings suggest that Cdx members operate upstream of Dll1 to convey different functions in two distinct lineages...
  9. doi Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice
    M Lubka-Pathak
    Division of Molecular Genetics, Institute of Human Genetics, University of Tubingen, Wilhelmstraße, Germany
    Cell Mol Life Sci 68:2739-49. 2011
    b>Tff3 peptide exerts important functions in cytoprotection and restitution of the gastrointestinal (GI) tract epithelia. Moreover, its presence in the rodent inner ear and involvement in the hearing process was demonstrated recently...
  10. ncbi Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota
    Elena M Comelli
    Department of Nutrition and Health, Nestle Research Center, 1000 Lausanne 26, Switzerland
    Genomics 91:70-7. 2008
    ..We found that the expression of mucins 1 to 4 and trefoil factor 3 was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free ..
  11. pmc FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia
    Pia Nyeng
    Cleveland Clinic Foundation, Lerner Research Institute, Stem Cell Biology and Regenerative Medicine, 9500 Euclid Avenue, Cleveland Ohio, USA
    BMC Dev Biol 8:2. 2008
    ..Previous studies have shown that this requirement for Fgf10 is due in part to its role as a chemotactic factor during branching morphogenesis. In other endodermal organs Fgf10 also plays a role in regulating differentiation...
  12. pmc Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds
    Friedrich P Paulsen
    Department of Anatomy, Martin Luther University Halle Wittenberg, D 06097 Halle, Germany
    J Biol Chem 283:13418-27. 2008
    ..study using cornea as a model, we demonstrate the importance of trefoil factor 3 (TFF3, also known as intestinal trefoil factor) in re-epithelialization of wounds...
  13. pmc A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
    Yuzhen Zhang
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 40:862-70. 2008
    ..Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration...
  14. pmc Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency
    Daniel K Podolsky
    Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Gastroenterology 137:209-20. 2009
    ..The aim of this study was to determine whether Toll-like receptor (TLR) 2 and modulation of GC-derived trefoil factor (TFF) 3 are functionally linked in the intestine...
  15. ncbi The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism
    Aftab Ali Shah
    Division of Molecular Genetics, Institute of Human Genetics, University of Tubingen, Germany
    RNA Biol 8:77-81. 2011
    ..The trefoil peptides also appear involved in caloric metabolism. Monitoring global miRNA expression of Tff3 deficient mice points to an interplay of Tff3 with a miRNA regulatory network...
  16. doi Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation
    Jean Philippe Babeu
    Département d Anatomie et de Biologie Cellulaire, Universite de Sherbrooke, Canadian Institutes of Health Research Team on Digestive Epithelium, Sherbrooke, QC J1H 5N4, Canada
    Am J Physiol Gastrointest Liver Physiol 297:G124-34. 2009
    ....
  17. doi The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium
    Alex Gregorieff
    Hubrecht Institute, Utrecht, The Netherlands
    Gastroenterology 137:1333-45.e1-3. 2009
    ..In this study, we investigated the role of the Wnt-responsive, Ets-domain transcription factor Spdef in the differentiation of goblet and Paneth cells...
  18. pmc Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3
    P L Beck
    Gastrointestinal Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Gastrointest Liver Physiol 299:G43-53. 2010
    ..b>Trefoil factor 3 (TFF3) is involved in both protecting the intestinal epithelium against injury as well as aiding in wound ..
  19. ncbi Downregulation of trefoil factor 3 gene expression in the colon of the senescence-accelerated mouse (SAM)-P6 revealed by oligonucleotide microarray analysis
    Takaaki Kawashima
    Public Health and Nutrition, Graduate School of Human Health Science, Siebold University of Nagasaki
    Biomed Res 31:169-75. 2010
    ..These results suggest that a diminution of the intestinal trefoil factor system may be involved in the acceleration of aging in SAM-P6 mice.
  20. ncbi Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen
    Byeong Moo Kim
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 134:3603-13. 2007
    ..These observations place Barx1 proximally within a Wt1 pathway of spleen development and reveal how a homeotic regulator employs different molecular mechanisms to mold neighboring organs...
  21. pmc Modulation of Aire regulates the expression of tissue-restricted antigens
    Vivian Kont
    Molecular Pathology, Biomedicum, Tartu University, Ravila 19, 50411 Tartu, Estonia
    Mol Immunol 45:25-33. 2008
    ..The data underline a direct role for Aire in TRA expression and suggest that modulation of Aire has a potential to control central tolerance and autoimmunity...
  22. pmc Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure
    Jun Shen
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 95:313-20. 2007
    ..These data provide evidence that arsenic-induced aberrant ER signaling could disrupt early life stage genetic programing in the lung leading eventually to lung tumor formation much later in adulthood...
  23. ncbi Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression
    H Mashimo
    Gastrointestinal Unit, Massachusetts General Hospital, Boston 02114, USA
    Biochem Biophys Res Commun 210:31-7. 1995
    b>Intestinal Trefoil Factor (ITF) is a member of a family of gastrointestinal tract peptides with region-specific expression which are enhanced at sites of injury and repair...
  24. ncbi The gene encoding mouse intestinal trefoil factor: structural organization, partial sequence analysis and mapping to murine chromosome 17q
    R Chinery
    Histopathology Unit, Imperial Cancer Research Fund, London, UK
    Gene 171:249-53. 1996
    ..In the present study, the nucleotide sequence of a large portion (81%) of the gene encoding murine intestinal trefoil factor (mITF) and its whole genomic organization were determined...
  25. ncbi Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein
    O Lefebvre
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, Communaute Urbaine de Strasbourg, France
    Science 274:259-62. 1996
    ..These results indicate that mpS2 is essential for normal differentiation of the antral and pyloric gastric mucosa and may function as a gastric-specific tumor suppressor gene...
  26. ncbi Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
    H Mashimo
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Jackson 7, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Science 274:262-5. 1996
    ..The gene encoding intestinal trefoil factor (ITF), a protein secreted throughout the small intestine and colon, was rendered nonfunctional in mice ..
  27. ncbi The trefoil gene maps to mouse chromosome 17
    M Burmeister
    Mental Health Research Institute, Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, Michigan 48109 0720, USA
    Mamm Genome 8:223-4. 1997
  28. ncbi Mapping and cloning recombinant breakpoints demarcating the hybrid sterility 6-specific sperm tail assembly defect
    S A Samant
    Department of Anatomy and Cell Biology, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Mamm Genome 10:88-94. 1999
    ..In addition, we have provided increased high-resolution mapping of the Stop1p and Ccub factors. These new data enhance our ability to isolate and characterize candidates for Tcd/Tcs2...
  29. ncbi Genomic structure and chromosomal mapping of the mouse transcription factor TEF-5 (Tead3) gene
    P Jacquemin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, F 67404 Illkirch Cedex, France
    Mamm Genome 10:632-4. 1999
  30. ncbi Trefoil factor family (TFF)-domain peptides in the mouse: embryonic gastrointestinal expression and wounding response
    W R Otto
    Histopathology Unit, Imperial Cancer Research Fund, London, UK
    Anat Embryol (Berl) 199:499-508. 1999
    ..Afterwards, TFF2 was confined to the gastric region. TFF3 was in the stomach at E13. On E15 and 16 TFF3 was ubiquitous, except for E15 caecum...
  31. pmc Goblet-cell-specific transcription of mouse intestinal trefoil factor gene results from collaboration of complex series of positive and negative regulatory elements
    H Itoh
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street, Boston, MA 02114, USA
    Biochem J 341:461-72. 1999
    b>Intestinal trefoil factor (ITF) is expressed selectively in intestinal goblet cells...
  32. ncbi pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins
    C Tomasetto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM Unité 184 ULP, Illkirch, France
    Gastroenterology 118:70-80. 2000
    ..Moreover, pS2/TFF1 is essential for normal differentiation of the gastric mucosa because deficient mice develop antropyloric adenomas. To date, it is unclear how TFFs mediate their functions...
  33. ncbi Mouse Trefoil factor genes: genomic organization, sequences and methylation analyses
    S Ribieras
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM U184 ULP, BP 163, 67404 Illkirch Cedex, C U de, Strasbourg, France
    Gene 266:67-75. 2001
    The mammalian Trefoil Factors (TFFs), TFF1/pS2, TFF2/SP and TFF3/ITF, are expressed and secreted throughout the gastrointestinal tract with a specific and complementary pattern...
  34. ncbi Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice
    T Marchbank
    Department of Gastroenterology, Hammersmith Hospital, Imperial College School of Medicine, London W12 0NN, United Kingdom
    J Biol Chem 276:24088-96. 2001
    ..of which is up-regulated at sites of injury, we have produced transgenic mice that chronically express rat TFF3 within the jejunum (using a rat fatty acid-binding protein promoter)...
  35. ncbi Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
    Niall C Tebbutt
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Nat Med 8:1089-97. 2002
    ..are highly similar to the phenotypes exhibited by mice deficient in trefoil factor 1 (pS2/TFF1) and intestinal trefoil factor (ITF)/TFF3, respectively, and corresponded closely with the capacity of the two pathways to stimulate ..
  36. ncbi Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor
    P L Beck
    Gastrointestinal Research Group, University of Calgary, Alberta, Canada
    Gastroenterology 126:796-808. 2004
    ..Studies were undertaken to define the role of intestinal trefoil factor in modulating the intestinal response to chemotherapy and radiation.
  37. pmc Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas
    Haruhiko Okada
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Oncol 26:369-77. 2005
    Expression profiling analysis revealed ectopic high expression of mouse TFF3 in non-tumor liver tissues from the hepatocellular carcinoma (HCC) susceptible PWK/Rbrc strain...
  38. ncbi Gene expression profile analysis of mouse colon embryonic development
    Young Kyu Park
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Genesis 41:1-12. 2005
    ....
  39. pmc Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes
    M Tomita
    Department of Parasitology, Miyazaki Medical College, Japan
    Biochem J 311:293-7. 1995
    A cDNA encoding mouse intestinal trefoil factor (mITF) was successfully cloned and sequenced from the small intestine of C57BL/6 mouse by using the combination of reverse transcription-PCR and rapid amplification of cDNA ends methods...