Gene Symbol: Tfeb
Description: transcription factor EB
Alias: Tcfeb, bHLHe35, transcription factor EB
Species: mouse
Products:     Tfeb

Top Publications

  1. Settembre C, Di Malta C, Polito V, Garcia Arencibia M, Vetrini F, Erdin S, et al. TFEB links autophagy to lysosomal biogenesis. Science. 2011;332:1429-33 pubmed publisher
    ..The transcription factor EB (TFEB), a master gene for lysosomal biogenesis, coordinated this program by driving expression of ..
  2. Rehli M, den Elzen N, Cassady A, Ostrowski M, Hume D. Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics. 1999;56:111-20 pubmed
    ..MiT) subfamily of basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors, including TFE3, TFEB, TFEC, and Mitf, has been implicated in the regulation of tissue-specific gene expression in several cell lineages...
  3. Fisher D, Carr C, Parent L, Sharp P. TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family. Genes Dev. 1991;5:2342-52 pubmed
    The DNA-binding factor TFEB contains adjacent helix-loop-helix (HLH) and leucine zipper (LZ) domains flanked by an upstream basic region...
  4. Polito V, Li H, Martini Stoica H, Wang B, Yang L, Xu Y, et al. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014;6:1142-60 pubmed publisher
    ..Recently discovered, transcription factor EB (TFEB) is a molecule shown to play central roles in cellular degradative processes...
  5. Settembre C, De Cegli R, Mansueto G, Saha P, Vetrini F, Visvikis O, et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol. 2013;15:647-58 pubmed publisher
    ..Here we show that the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is induced by starvation through an ..
  6. Settembre C, Zoncu R, Medina D, Vetrini F, Erdin S, Erdin S, et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 2012;31:1095-108 pubmed publisher
    ..However, the mechanisms mediating lysosomal adaptation are largely unknown. Here, we show that the Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis, colocalizes with master growth regulator mTOR complex ..
  7. Sardiello M, Palmieri M, di Ronza A, Medina D, Valenza M, Gennarino V, et al. A gene network regulating lysosomal biogenesis and function. Science. 2009;325:473-7 pubmed publisher
    ..We found that most lysosomal genes exhibit coordinated transcriptional behavior and are regulated by the transcription factor EB (TFEB)...
  8. Huan C, Sashital D, Hailemariam T, Kelly M, Roman C. Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin. J Biol Chem. 2005;280:30225-35 pubmed
    Translocations of the genes encoding the related transcription factors TFE3 and TFEB are almost exclusively associated with a rare juvenile subset of renal cell carcinoma and lead to overexpression of TFE3 or TFEB protein sequences...
  9. Visvikis O, Ihuegbu N, Labed S, Luhachack L, Alves A, Wollenberg A, et al. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Immunity. 2014;40:896-909 pubmed publisher
    ..By using an unbiased approach in the model Caenorhabditis elegans, we discovered that HLH-30 (known as TFEB in mammals) is a key transcription factor for host defense...

More Information


  1. Peña Llopis S, Vega Rubin de Celis S, Schwartz J, Wolff N, Tran T, Zou L, et al. Regulation of TFEB and V-ATPases by mTORC1. EMBO J. 2011;30:3242-58 pubmed publisher
    ..V-ATPase regulation by mTORC1 involves a transcription factor translocated in renal cancer, TFEB. TFEB is required for the expression of a large subset of mTORC1 responsive genes...
  2. Voss A, Thomas T, Gruss P. Mice lacking HSP90beta fail to develop a placental labyrinth. Development. 2000;127:1-11 pubmed
    ..The allantois mesoderm is thought to induce trophoblast differentiation. Our results show that Hsp90beta is a necessary component of this induction process. ..
  3. Arsenault P, Song D, Chung Y, Khurana T, Lee F. The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α. Mol Cell Biol. 2016;36:2328-43 pubmed publisher
    ..Thus, these findings have important implications for understanding both the molecular mechanism of the hypoxic response and human adaptation to high altitude. ..
  4. Cortes C, Miranda H, Frankowski H, Batlevi Y, Young J, Le A, et al. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat Neurosci. 2014;17:1180-9 pubmed publisher
    ..regulation of autophagy and observed a functionally significant physical interaction between transcription factor EB (TFEB) and AR. Normal AR promoted, but polyQ-AR interfered with, TFEB transactivation...
  5. McClive P, Pall G, Newton K, Lee M, Mullins J, Forrester L. Gene trap integrations expressed in the developing heart: insertion site affects splicing of the PT1-ATG vector. Dev Dyn. 1998;212:267-76 pubmed
    ..integrated into a gene that is located on chromosome 17 and is homologous to the human transcription factor gene, TFEB. Embryonic and adult cardiac expression of both the fusion transcript and the endogenous gene was confirmed...
  6. Gray M, Choy C, Dayam R, Ospina Escobar E, Somerville A, Xiao X, et al. Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB. Curr Biol. 2016;26:1955-1964 pubmed publisher
    ..Importantly, we show that Fcγ receptor activation causes nuclear translocation of TFEB, a transcription factor that boosts expression of lysosome genes...
  7. Martina J, Diab H, Brady O, Puertollano R. TFEB and TFE3 are novel components of the integrated stress response. EMBO J. 2016;35:479-95 pubmed publisher
    ..The participation of the transcription factors TFEB and TFE3 in cellular adaptation to starvation is well established...
  8. Vega Rubin de Celis S, Peña Llopis S, Konda M, Brugarolas J. Multistep regulation of TFEB by MTORC1. Autophagy. 2017;13:464-472 pubmed publisher
    The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear localization...
  9. Artandi S, Merrell K, Avitahl N, Wong K, Calame K. TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription. Nucleic Acids Res. 1995;23:3865-71 pubmed
    ..TFE3 pro-rich activation domain contains regions of strong homology with the related proteins microphthalmia and TFEB, suggesting that these regions are important for function...
  10. Alghamdi T, Majumder S, Thieme K, Batchu S, White K, Liu Y, et al. Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes. J Am Soc Nephrol. 2017;28:2641-2653 pubmed publisher
    ..Because transcription factor EB (TFEB) has recently emerged as a master regulator of autophagosome-lysosome function, controlling the ..
  11. Cowden Dahl K, Fryer B, Mack F, Compernolle V, Maltepe E, Adelman D, et al. Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol. 2005;25:10479-91 pubmed
    ..This novel genetic approach provides new insights into the role of O2 tension in the development of life-threatening pregnancy-related diseases such as preeclampsia. ..
  12. Saban R, Simpson C, Davis C, Dozmorov I, Maier J, Fowler B, et al. Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol. 2007;8:17 pubmed
    ..Finally, TFEB antibody was used for CHIP/Q-PCR assay and revealed up-regulation of genes known to be downstream of TFEB...
  13. Vodicka P, Chase K, Iuliano M, Tousley A, Valentine D, Sapp E, et al. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016;5:249-260 pubmed
    ..b>Transcription factor EB (TFEB) regulates lysosome biogenesis and autophagy...
  14. Li F, Lang F, Zhang H, Xu L, Wang Y, Hao E. Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice. Oxid Med Cell Longev. 2016;2016:5380319 pubmed publisher
    ..However, a significant age dependent decline in autophagy was observed. Translocation of Transcription Factor EB (TFEB) to nucleus and formation of LC3-II were significantly reduced in LPS administered aged mice ..
  15. Oshima H, Nakano H, Nohara C, Kobata T, Nakajima A, Jenkins N, et al. Characterization of murine CD70 by molecular cloning and mAb. Int Immunol. 1998;10:517-26 pubmed
    ..FR70 will be useful for further investigating the physiological and pathological roles of the CD70-CD27 interaction in T cell development, T-dependent antibody production and various disease models in the murine system. ..
  16. Ferron M, Settembre C, Shimazu J, LaCombe J, Kato S, Rawlings D, et al. A RANKL-PKC?-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes Dev. 2013;27:955-69 pubmed publisher
    ..factor RANKL promotes lysosomal biogenesis once osteoclasts are differentiated through the selective activation of TFEB, a member of the MITF/TFE family of transcription factors...
  17. Kang Y, Sanalkumar R, O Geen H, Linnemann A, Chang C, Bouhassira E, et al. Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol. 2012;32:226-39 pubmed publisher
    ..These results illustrate a novel mechanism by which a master regulator of development establishes a genetic network to instigate cell-type-specific autophagy...
  18. Salma N, Song J, Kawakami A, Devi S, Khaled M, Cacicedo J, et al. Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice. Mol Cell Biol. 2017;37: pubmed publisher
    ..We show that two of these, Tfeb and Tfe3, control the regulator of adipogenesis, peroxisome proliferator-activated receptor γ2 (Pparγ2)...
  19. Tsunemi T, Ashe T, Morrison B, Soriano K, Au J, Roque R, et al. PGC-1? rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci Transl Med. 2012;4:142ra97 pubmed publisher
    ..PGC-1? promoted htt turnover and the elimination of protein aggregates by activating transcription factor EB (TFEB), a master regulator of the autophagy-lysosome pathway...
  20. Huan C, Kelly M, Steele R, Shapira I, Gottesman S, Roman C. Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity. Nat Immunol. 2006;7:1082-91 pubmed
    TFE3 and TFEB are broadly expressed transcription factors related to the transcription factor Mitf. Although they have been linked to cytokine signaling pathways in nonlymphoid cells, their function in T cells is unknown...
  21. Di Malta C, Siciliano D, Calcagnì A, Monfregola J, Punzi S, Pastore N, et al. Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science. 2017;356:1188-1192 pubmed publisher
    ..Thus, this transcriptional regulatory mechanism enables cellular adaptation to nutrient availability and supports the energy-demanding metabolism of cancer cells. ..
  22. Forrester L, Nagy A, Sam M, Watt A, Stevenson L, Bernstein A, et al. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Proc Natl Acad Sci U S A. 1996;93:1677-82 pubmed
    ..These studies demonstrate the potential of this induction gene trap approach for identifying and mutating genes downstream of signal transduction pathways. ..
  23. Bharti K, Liu W, Csermely T, Bertuzzi S, Arnheiter H. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development. 2008;135:1169-78 pubmed publisher
  24. Sha Y, Rao L, Settembre C, Ballabio A, Eissa N. STUB1 regulates TFEB-induced autophagy-lysosome pathway. EMBO J. 2017;36:2544-2552 pubmed publisher
    b>TFEB is a master regulator for transcription of genes involved in autophagy and lysosome biogenesis...
  25. Samie M, Cresswell P. The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways. Nat Immunol. 2015;16:729-36 pubmed publisher
    ..The transcription factor TFEB regulates lysosomal function by inducing lysosomal activation...
  26. Spampanato C, Feeney E, Li L, Cardone M, Lim J, Annunziata F, et al. Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease. EMBO Mol Med. 2013;5:691-706 pubmed publisher
    A recently proposed therapeutic approach for lysosomal storage disorders (LSDs) relies upon the ability of transcription factor EB (TFEB) to stimulate autophagy and induce lysosomal exocytosis leading to cellular clearance...
  27. Steingrimsson E, Tessarollo L, Pathak B, Hou L, Arnheiter H, Copeland N, et al. Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A. 2002;99:4477-82 pubmed
    ..of basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors encodes four family members: Mitf, Tfe3, Tfeb, and Tfec. In vitro, each protein in the family can bind DNA as a homo- or heterodimer with other family members...
  28. Nakayama A, Nguyen M, Chen C, Opdecamp K, Hodgkinson C, Arnheiter H. Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently. Mech Dev. 1998;70:155-66 pubmed
    ..The results show that melanocyte development critically depends on functional Mitf and that Mitf mutations affect the neural crest and the neuroepithelium in different ways. ..
  29. Ugolino J, Ji Y, Conchina K, Chu J, Nirujogi R, Pandey A, et al. Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling. PLoS Genet. 2016;12:e1006443 pubmed publisher
    ..The transcription factor EB (TFEB), a master regulator of lysosomal and autophagy genes, which is negatively regulated by mTOR, is ..
  30. Mansueto G, Armani A, Viscomi C, D Orsi L, De Cegli R, Polishchuk E, et al. Transcription Factor EB Controls Metabolic Flexibility during Exercise. Cell Metab. 2017;25:182-196 pubmed publisher
    The transcription factor EB (TFEB) is an essential component of lysosomal biogenesis and autophagy for the adaptive response to food deprivation...
  31. Reddy K, Cusack C, Nnah I, Khayati K, Saqcena C, Huynh T, et al. Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency. Cell Rep. 2016;14:2166-2179 pubmed publisher
    ..cells, mTORC1 is constitutively tethered to lysosomal membranes, unresponsive to starvation, and inhibitory to TFEB-mediated clearance due to a reduction in Sestrin2 expression...
  32. Yoneshima E, Okamoto K, Sakai E, Nishishita K, Yoshida N, Tsukuba T. The Transcription Factor EB (TFEB) Regulates Osteoblast Differentiation Through ATF4/CHOP-Dependent Pathway. J Cell Physiol. 2016;231:1321-33 pubmed publisher
    ..Here, we demonstrate the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, modulates osteoblast differentiation...
  33. Kim Y, Lee H, Kim J, Yang C, Kim T, Jung M, et al. PPAR-? Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism. J Immunol. 2017;198:3283-3295 pubmed publisher
    ..In this study, we show that PPAR-? is essential for antimycobacterial responses via activation of transcription factor EB (TFEB) transcription and inhibition of lipid body formation...
  34. Murano T, Najibi M, Paulus G, Adiliaghdam F, Valencia Guerrero A, Selig M, et al. Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Sci Rep. 2017;7:13938 pubmed publisher
    ..Recently, transcription factor EB (TFEB) was implicated in expression of autophagy and host defense genes in nematodes and mammalian cells...
  35. Young N, Kamireddy A, Van Nostrand J, Eichner L, Shokhirev M, Dayn Y, et al. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016;30:535-52 pubmed publisher
    ..AMPK(-/-) EBs exhibited reduced levels of Tfeb, a master transcriptional regulator of lysosomes, leading to diminished endolysosomal function...
  36. Thomes P, Trambly C, Fox H, Tuma D, Donohue T. Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB. Alcohol Clin Exp Res. 2015;39:2354-63 pubmed publisher
    ..Autophagy and lysosome biogenesis are linked. Both are regulated by the transcription factor EB (TFEB)...
  37. Iwawaki T, Akai R, Yamanaka S, Kohno K. Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009;106:16657-62 pubmed publisher
    ..These findings reveal that IRE1alpha plays an essential function in extraembryonic tissues and highlight the relationship of physiological ER stress and angiogenesis in the placenta during pregnancy in mammals. ..
  38. Luo W, Ma S, Yang Y, Wang C, Zhang D, Zhang Q, et al. TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1. Int J Biochem Cell Biol. 2016;78:31-42 pubmed publisher
    ..Here, we show that the bHLH family transcription factor TFEB regulates PER3 through the CLOCK/BMAL1 complex. In the liver, TFEB expression displays circadian rhythms...
  39. Li M, Pi H, Yang Z, Reiter R, Xu S, Chen X, et al. Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells. J Pineal Res. 2016;61:353-69 pubmed publisher
    ..In addition, Cd decreases the level of transcription factor EB (TFEB) but induces the nuclear translocation of TFEB, associated with compromised lysosomal function or a ..
  40. Pastore N, Vainshtein A, Klisch T, Armani A, Huynh T, Herz N, et al. TFE3 regulates whole-body energy metabolism in cooperation with TFEB. EMBO Mol Med. 2017;9:605-621 pubmed publisher
    ..However, while Tcfeb knockout (KO) mice die during early embryonic development, no apparent phenotype was reported in Tfe3 ..
  41. Carr C, Sharp P. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol Cell Biol. 1990;10:4384-8 pubmed
    ..The protein encoded by this cDNA, TFEB, probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.
  42. Pastore N, Brady O, Diab H, Martina J, Sun L, Huynh T, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12:1240-58 pubmed publisher
    ..In this study we identify a critical and complementary role of the transcription factors TFEB and TFE3 in innate immune response...
  43. Zhang Y, Zhao J. TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway. DNA Cell Biol. 2015;34:661-8 pubmed publisher
    To investigate whether transcriptional factor EB (TFEB) participates in amyloid-β(1-42) (Aβ(1-42))-induced pathogenesis of Alzheimer's disease (AD) and its underlying mechanisms...
  44. Himes K, Koppes E, Chaillet J. Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013;373:72-82 pubmed publisher
  45. Zhang L, Song N, Chen J, Huang Y, Li H, Ding Y. Satb2 is required for dendritic arborization and soma spacing in mouse cerebral cortex. Cereb Cortex. 2012;22:1510-9 pubmed publisher
    ..Our results indicate a cell autonomous and non-cell autonomous role for Satb2 in regulating the adhesive and/or repulsive properties of cerebral pyramidal neurons. ..
  46. Tompers D, Foreman R, Wang Q, Kumanova M, Labosky P. Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo. Dev Biol. 2005;285:126-37 pubmed
    ..Moreover, this provides support for the hypothesis that there are conserved molecular mechanisms for maintaining the self-renewing properties of diverse progenitor cell types. ..
  47. Steingrimsson E, Tessarollo L, Reid S, Jenkins N, Copeland N. The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Development. 1998;125:4607-16 pubmed
    b>Tfeb is a member of the basic Helix-Loop-Helix-Zipper family of transcription factors. In vitro studies have shown that TFEB can bind DNA as a homodimer or as a heterodimer with three closely related family members: MITF, TFE3 and TFEC...
  48. Genetta T, Kadesch T. Cloning of a cDNA encoding a mouse transcriptional repressor displaying striking sequence conservation across vertebrates. Gene. 1996;169:289-90 pubmed
    ..An alignment of the deduced amino-acid sequences of the putative functional domains of MEB1 with those from the human, hamster and chicken homologues reveals a dramatic degree of conservation. ..
  49. Najibi M, Labed S, Visvikis O, IRAZOQUI J. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016;15:1728-42 pubmed publisher
    ..We previously identified TFEB as a transcription factor important for host defense, but the mechanisms that regulate TFEB during infection ..
  50. Scott I, Webster B, Chan C, Okonkwo J, Han K, Sack M. GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy. J Biol Chem. 2014;289:2864-72 pubmed publisher
    ..deletion of GCN5L1 has a direct positive effect on the expression and activity of Transcriptional Factor EB (TFEB), which acts as a master regulator of autophagy...
  51. Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, et al. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008;453:1117-21 pubmed publisher
  52. Shin S, Vogt E, Jimenez Movilla M, Baibakov B, Dean J. Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017;8:1643 pubmed publisher
    ..Thus, the N-terminus of DPPA3 has a significant role in cytoplasmic vesicular trafficking in addition to its previously reported nuclear function. ..