Gene Symbol: Tfdp2
Description: transcription factor Dp 2
Alias: 1110029I05Rik, A330080J22Rik, DP-3, DP3, transcription factor Dp-2, E2F dimerization partner 2
Ormondroyd E, de la Luna S, La Thangue N. A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF1/E2F. Oncogene. 1995;11:1437-46 pubmed
de la Luna S, Burden M, Lee C, La Thangue N. Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal. J Cell Sci. 1996;109 ( Pt 10):2443-52 pubmed
..These data define a new level of control in the E2F transcription factor whereby interplay between subunits dictates the levels of nuclear DNA binding activity. ..
Gopalkrishnan R, Dolle P, Mattei M, La Thangue N, Kedinger C. Genomic structure and developmental expression of the mouse cell cycle regulatory transcription factor DP1. Oncogene. 1996;13:2671-80 pubmed
Kohn M, Bronson R, Harlow E, Dyson N, Yamasaki L. Dp1 is required for extra-embryonic development. Development. 2003;130:1295-305 pubmed
..Thus, DP1 is absolutely required for extra-embryonic development and consequently embryonic survival, consistent with E2F/DP1 normally acting to promote growth in vivo. ..
Kohn M, Leung S, Criniti V, Agromayor M, Yamasaki L. Dp1 is largely dispensable for embryonic development. Mol Cell Biol. 2004;24:7197-205 pubmed
..5 tissues with the absence of Dp1. Thus, Dp1 is largely dispensable for embryonic development, despite the absolute extraembryonic requirement for Dp1, which is highly reminiscent of the restricted roles for Rb and cyclins E1/E2 in vivo. ..
Milton A, Khaire N, Ingram L, O Donnell A, La Thangue N. 14-3-3 proteins integrate E2F activity with the DNA damage response. EMBO J. 2006;25:1046-57 pubmed
..These results identify a new level of control on E2F activity and, at a more general level, suggest that 14-3-3 proteins integrate E2F activity with the DNA damage response. ..
de la Luna S, Allen K, Mason S, La Thangue N. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J. 1999;18:212-28 pubmed
..Our study defines a new pathway of growth control that is integrated with the E2F pathway through the DP subunit of the heterodimer. ..
Nili E, Cojocaru G, Kalma Y, Ginsberg D, Copeland N, Gilbert D, et al
. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci. 2001;114:3297-307 pubmed
..Co-expression of both LAP2beta and mGCL with the E2F-DP complex resulted in a reduced transcriptional activity equal to that exerted by the pRb protein. ..
Chen C, Lodish H. Global analysis of induced transcription factors and cofactors identifies Tfdp2 as an essential coregulator during terminal erythropoiesis. Exp Hematol. 2014;42:464-76.e5 pubmed publisher
..factor, we pinpoint several co-induced pairs, of which E2f2 and its cofactor transcription factor Dp-2 (Tfdp2) were the most highly induced...