Gene Symbol: Tfap2e
Description: transcription factor AP-2, epsilon
Alias: AI505200, AP-2e, Tcfap2e, transcription factor AP-2-epsilon, AP2-epsilon, activating enhancer-binding protein 2-epsilon
Species: mouse
Products:     Tfap2e

Top Publications

  1. Wenke A, Grassel S, Moser M, Bosserhoff A. The cartilage-specific transcription factor Sox9 regulates AP-2epsilon expression in chondrocytes. FEBS J. 2009;276:2494-504 pubmed publisher
    ..This is the first study to prove the direct regulation of AP-2epsilon by the transcription factor Sox9, and to indicate that AP-2epsilon potentially has an important role as a modulator of hypertrophic cartilage. ..
  2. Feng W, Williams T. Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb. Mol Cell Neurosci. 2003;24:460-75 pubmed
    ..A comparison of AP-2 gene family expression in the olfactory system suggests both distinct and overlapping functions for these transcription factors in forebrain development. ..
  3. Wang H, Vaupel K, Buettner R, Bosserhoff A, Moser M. Identification and embryonic expression of a new AP-2 transcription factor, AP-2 epsilon. Dev Dyn. 2004;231:128-35 pubmed
  4. Winger Q, Huang J, Auman H, Lewandoski M, Williams T. Analysis of transcription factor AP-2 expression and function during mouse preimplantation development. Biol Reprod. 2006;75:324-33 pubmed
    ..Four AP-2 genes are differentially expressed during the preimplantation period,Tcfap2a, Tcfap2b, Tcfap2c, and Tcfap2e. Furthermore, with the exception of Tcfap2a, these genes are also expressed in unfertilized oocytes, indicating ..
  5. Saha B, Hari P, Huilgol D, Tole S. Dual role for LIM-homeodomain gene Lhx2 in the formation of the lateral olfactory tract. J Neurosci. 2007;27:2290-7 pubmed
    ..In addition, the expression of Sema6A is aberrantly upregulated. Together, these findings reveal a dual role for Lhx2, in the OB as well as in the lateral telencephalon, for establishing the LOT projection. ..
  6. Bassett E, Pontoriero G, Feng W, Marquardt T, Fini M, Williams T, et al. Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development. Mol Cell Biol. 2007;27:7497-510 pubmed
    ..Additional expression analyses showed that multiple AP-2 proteins are present in the developing retina, which will be important to future studies. ..
  7. Feng W, Simoes de Souza F, Finger T, Restrepo D, Williams T. Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2epsilon. Mol Cell Neurosci. 2009;42:161-71 pubmed publisher
    ..We also show that Cre recombinase expression directed by the AP-2epsilon locus can specifically target floxed genes within the olfactory bulb, extending the utility of this AK allele. ..
  8. Niebler S, Schubert T, Hunziker E, Bosserhoff A. Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development. Arthritis Res Ther. 2015;17:119 pubmed publisher
    The transcription factor activating enhancer binding protein 2 epsilon (AP-2ε) was recently shown to be expressed during chondrogenesis as well as in articular chondrocytes of humans and mice...
  9. Amaniti E, Kelman A, Mason J, Theil T. Cerebral Cortex Expression of Gli3 Is Required for Normal Development of the Lateral Olfactory Tract. PLoS ONE. 2015;10:e0141525 pubmed publisher

More Information


  1. Inokuchi K, Imamura F, Takeuchi H, Kim R, Okuno H, Nishizumi H, et al. Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses. Nat Commun. 2017;8:15977 pubmed publisher
    ..In utero, electroporation demonstrates that activation of the Nrp2 gene in MCs is sufficient to instruct their circuit formation from the PV MOB to the anterior MeA. ..
  2. Tummala R, Romano R, Fuchs E, Sinha S. Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 family. Gene. 2003;321:93-102 pubmed
    ..Our study establishes AP-2 epsilon as a novel member of the AP-2 family, and suggests that it may play an important role in skin biology. ..