Tet1

Summary

Gene Symbol: Tet1
Description: tet methylcytosine dioxygenase 1
Alias: 2510010B09Rik, AA517754, BB001228, Cxxc6, D10Ertd17e, LCX, mKIAA1676, methylcytosine dioxygenase TET1, CXXC finger 6, CXXC-type zinc finger protein 6, ten-eleven translocation 1 gene protein homolog, tet oncogene 1
Species: mouse
Products:     Tet1

Top Publications

  1. Tahiliani M, Koh K, Shen Y, Pastor W, Bandukwala H, Brudno Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324:930-5 pubmed publisher
    ..We show here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme ..
  2. Rudenko A, Dawlaty M, Seo J, Cheng A, Meng J, Le T, et al. Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron. 2013;79:1109-1122 pubmed publisher
    ..Here, we analyzed Tet1 knockout mice (Tet1KO) and found downregulation of multiple neuronal activity-regulated genes, including Npas4, c-..
  3. Dawlaty M, Ganz K, Powell B, Hu Y, Markoulaki S, Cheng A, et al. Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell. 2011;9:166-75 pubmed publisher
    The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 and have an elevated level of 5hmC...
  4. Piccolo F, Bağci H, Brown K, Landeira D, Soza Ried J, Feytout A, et al. Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion. Mol Cell. 2013;49:1023-33 pubmed publisher
    ..Here, we show that the Ten-Eleven Translocation proteins Tet1 and Tet2 participate in the efficient erasure of imprints in this model system...
  5. Iqbal K, Jin S, Pfeifer G, SZABO P. Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A. 2011;108:3642-7 pubmed publisher
    ..It is likely that 5mC oxidation is carried out by the Tet3 oxidase. Tet3, but not Tet1 or Tet2, was expressed at high levels in oocytes and zygotes, with rapidly declining levels at the two-cell stage...
  6. Yamaguchi S, Hong K, Liu R, Shen L, Inoue A, Diep D, et al. Tet1 controls meiosis by regulating meiotic gene expression. Nature. 2012;492:443-7 pubmed publisher
    ..Using a loss-of-function approach in mice, here we show that the 5mC-specific dioxygenase Tet1 has an important role in regulating meiosis in mouse oocytes...
  7. KAAS G, Zhong C, Eason D, Ross D, Vachhani R, Ming G, et al. TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron. 2013;79:1086-93 pubmed publisher
    ..However, little is known about how these changes in 5mC are regulated in the adult brain. The enzyme methylcytosine dioxygenase TET1 (TET1) has been shown to promote active DNA demethylation in the nervous system...
  8. Wu H, D Alessio A, Ito S, Wang Z, Cui K, Zhao K, et al. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev. 2011;25:679-84 pubmed publisher
    ..A combined analysis of global 5hmC distribution and gene expression profile in wild-type and Tet1-depleted ES cells suggests that 5hmC is enriched at both gene bodies of actively transcribed genes and extended ..
  9. Costa Y, Ding J, Theunissen T, Faiola F, Hore T, Shliaha P, et al. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013;495:370-4 pubmed publisher
    ..that have not been reported before, including the ten-eleven translocation (TET) family methylcytosine hydroxylase TET1. We confirm physical association of NANOG with TET1, and demonstrate that TET1, in synergy with NANOG, enhances the ..

More Information

Publications79

  1. Xu Y, Wu F, Tan L, Kong L, Xiong L, Deng J, et al. Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell. 2011;42:451-64 pubmed publisher
    ..Here we report that Tet1 binds to unmodified C or 5mC- or 5hmC-modified CpG-rich DNA through its CXXC domain...
  2. Ito S, Shen L, Dai Q, Wu S, Collins L, Swenberg J, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011;333:1300-3 pubmed publisher
    ..Thus, we identify two previously unknown cytosine derivatives in genomic DNA as the products of Tet proteins. Our study raises the possibility that DNA demethylation may occur through Tet-catalyzed oxidation followed by decarboxylation. ..
  3. Wu H, D Alessio A, Ito S, Xia K, Wang Z, Cui K, et al. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature. 2011;473:389-93 pubmed publisher
    ..We have recently demonstrated that Tet1 is specifically expressed in murine embryonic stem (ES) cells and is required for ES cell maintenance...
  4. Tan L, Shi Y. Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development. 2012;139:1895-902 pubmed publisher
    ..In this Primer we provide an overview of the role of Tet family proteins and 5hmC in development and cancer. ..
  5. Yamaguchi S, Shen L, Liu Y, Sendler D, Zhang Y. Role of Tet1 in erasure of genomic imprinting. Nature. 2013;504:460-4 pubmed publisher
    ..b>Tet1 is one of the ten-eleven translocation family proteins, which have the capacity to oxidize 5-methylcytosine (5mC), ..
  6. Dawlaty M, Breiling A, Le T, Raddatz G, Barrasa M, Cheng A, et al. Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell. 2013;24:310-23 pubmed publisher
    Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues...
  7. Guo J, Su Y, Zhong C, Ming G, Song H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 2011;145:423-34 pubmed publisher
    ..Here, we show that 5-methylcytosine (5mC) hydroxylase TET1, by converting 5mCs to 5-hydroxymethylcytosines (5hmCs), promotes DNA demethylation in mammalian cells through a ..
  8. Williams K, Christensen J, Pedersen M, Johansen J, Cloos P, Rappsilber J, et al. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011;473:343-8 pubmed publisher
    ..Recently, TET1 was found to hydroxylate the methyl group of mC, converting it to 5-hydroxymethyl cytosine (hmC)...
  9. Koh K, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, et al. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011;8:200-13 pubmed publisher
    TET family enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. Here, we show that Tet1 and Tet2 are Oct4-regulated enzymes that together sustain 5hmC in mouse embryonic stem cells (ESCs) and are induced ..
  10. Ito S, D Alessio A, Taranova O, Hong K, Sowers L, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010;466:1129-33 pubmed publisher
    ..A recent study indicates that the human TET1 protein could catalyse the conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC), raising ..
  11. Inoue S, Li W, Tseng A, Beerman I, Elia A, Bendall S, et al. Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer Cell. 2016;30:337-348 pubmed publisher
    ..ATM expression is also decreased in human IDH1-mutated AML. These findings may have implications for treatment of IDH-mutant leukemia. ..
  12. Zhu X, Girardo D, Govek E, John K, Mellén M, Tamayo P, et al. Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation. Neuron. 2016;89:100-12 pubmed publisher
    ..Knockdown of Tet1 and Tet3 by RNAi in ex vivo cerebellar slice cultures inhibits dendritic arborization of developing GCs, a ..
  13. Wiehle L, Raddatz G, Musch T, Dawlaty M, Jaenisch R, Lyko F, et al. Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation. Mol Cell Biol. 2016;36:452-61 pubmed publisher
    ..b>Tet1/Tet2 double-knockout mice are characterized by developmental defects and epigenetic instability, suggesting a ..
  14. Arioka Y, Watanabe A, Saito K, Yamada Y. Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins. PLoS ONE. 2012;7:e45031 pubmed publisher
    ..We found that overexpressed Aid is mainly localized in the cytoplasm, whereas Tet1 and Tet2 are localized in the nucleus, and Tet3 is localized in both the cytoplasm and the nucleus...
  15. Welling M, Chen H, Muñoz J, Musheev M, Kester L, Junker J, et al. DAZL regulates Tet1 translation in murine embryonic stem cells. EMBO Rep. 2015;16:791-802 pubmed publisher
    ..We demonstrate that DAZL associates with mRNA of Tet1, a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 mRNA translation...
  16. Chikenji A, Ando H, Nariyama M, Suga T, Iida R, Gomi K. MyoD is regulated by the miR-29a-Tet1 pathway in C2C12 myoblast cells. J Oral Sci. 2016;58:219-29 pubmed publisher
    ..Microarray analysis demonstrated upregulation of ten-eleven translocation enzyme-1 (Tet1) mRNA in response to miR-29a inhibition in C2C12 murine myoblast cells...
  17. Dai H, Wang B, Yang L, Chen J, Zhu G, Sun M, et al. TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016;538:528-532 pubmed publisher
    ..These findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation and demethylation crucial to regulation of key signalling pathways in early body plan formation. ..
  18. Dzitoyeva S, Chen H, Manev H. Effect of aging on 5-hydroxymethylcytosine in brain mitochondria. Neurobiol Aging. 2012;33:2881-91 pubmed publisher
    ..In the frontal cortex, aging decreased mtDNMT1 messenger RNA (mRNA) levels without affecting TET1-TET3 mRNAs. In the cerebellum, TET2 and TET3 mRNA content was increased but mtDNMT1 mRNA was unaffected...
  19. Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, et al. Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming. Stem Cell Reports. 2014;2:253-61 pubmed publisher
    ..We find that OySyNyK factors significantly increase Tet1 expression at the early stage and interact with Tet1/2 to promote reprogramming...
  20. Zhang Q, Liu X, Gao W, Li P, Hou J, Li J, et al. Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked ?-N-acetylglucosamine transferase (OGT). J Biol Chem. 2014;289:5986-96 pubmed publisher
    The ten-eleven translocation (TET) family of dioxygenases (TET1/2/3) converts 5-methylcytosine to 5-hydroxymethylcytosine and provides a vital mechanism for DNA demethylation. However, how TET proteins are regulated is largely unknown...
  21. Yang J, Guo R, Wang H, Ye X, Zhou Z, Dan J, et al. Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs. Cell Rep. 2016;15:1809-21 pubmed publisher
    ..We show that mouse embryonic stem cells (ESCs) depleted of Tet1 and/or Tet2 by RNAi exhibit short telomeres and chromosomal instability, concomitant with reduced telomere ..
  22. Pfaffeneder T, Spada F, Wagner M, Brandmayr C, Laube S, Eisen D, et al. Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA. Nat Chem Biol. 2014;10:574-81 pubmed publisher
  23. Zhenwei J, Shuxin G, Yongchun Z, Xianhua Z. Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development. Yi Chuan. 2015;37:34-40 pubmed publisher
    TET (ten-eleven translocation) protein family includes three members TET1, TET2 and TET3, which belong to alpha-ketoglutaric acid ( α-KG )- and Fe(2+)-dependent dioxygenase superfamily, and have the capacity to convert 5-methylcytosine ..
  24. Huang H, Jiang X, Li Z, Li Y, Song C, He C, et al. TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci U S A. 2013;110:11994-9 pubmed publisher
    The ten-eleven translocation 1 (TET1) gene is the founding member of the TET family of enzymes (TET1/2/3) that convert 5-methylcytosine to 5-hydroxymethylcytosine...
  25. Freudenberg J, Ghosh S, Lackford B, Yellaboina S, Zheng X, Li R, et al. Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity. Nucleic Acids Res. 2012;40:3364-77 pubmed publisher
    The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine...
  26. Lorsbach R, Moore J, Mathew S, Raimondi S, Mukatira S, Downing J. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia. 2003;17:637-41 pubmed
  27. Bermejo Álvarez P, Ramos Ibeas P, Park K, Powell A, Vansandt L, Derek B, et al. Tet-mediated imprinting erasure in H19 locus following reprogramming of spermatogonial stem cells to induced pluripotent stem cells. Sci Rep. 2015;5:13691 pubmed publisher
    ..Reprogramming of SSC from Tet1 and Tet2 double knockout mice however lacked demethylation of H19 ICR...
  28. Tamanaha E, Guan S, Marks K, Saleh L. Distributive Processing by the Iron(II)/α-Ketoglutarate-Dependent Catalytic Domains of the TET Enzymes Is Consistent with Epigenetic Roles for Oxidized 5-Methylcytosine Bases. J Am Chem Soc. 2016;138:9345-8 pubmed publisher
    ..In this study, we present kinetic evidence showing that the catalytic domains (CDs) of TET2 and TET1 from mouse and their homologue from Naegleria gruberi, the full-length protein NgTET1, are distributive in both ..
  29. Li W, Tian E, Chen Z, Sun G, Ye P, Yang S, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012;109:20853-8 pubmed publisher
    ..OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation.
  30. Keil K, Altmann H, Mehta V, Abler L, Elton E, Vezina C. Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract. Gene Expr Patterns. 2013;13:413-24 pubmed publisher
    ..Future investigation into how DNA methylation patterns are established, maintained and remodeled during the course of embryonic prostatic bud formation may provide insight into prostate morphogenesis and disease. ..
  31. Zhao B, Yang Y, Wang X, Chong Z, Yin R, Song S, et al. Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res. 2014;42:1593-605 pubmed publisher
    ..Moreover, both Tet1/Tet2 knockout and dimethyloxalylglycine-induced Tet inhibition diminished the 5 hmC increase...
  32. Hassan H, Kolendowski B, Isovic M, Böse K, Dranse H, Sampaio A, et al. Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex. Cell Rep. 2017;19:1685-1697 pubmed publisher
    ..These findings suggest that the catalytic and scaffolding activities of TDG are essential for RA-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG complexes. ..
  33. Zhang R, Cui Q, Murai K, Lim Y, Smith Z, Jin S, et al. Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell. 2013;13:237-45 pubmed publisher
    ..However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain...
  34. Fidalgo M, Huang X, Guallar D, Sanchez Priego C, Valdes V, Saunders A, et al. Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States. Cell Stem Cell. 2016;19:355-69 pubmed publisher
    ..Mechanistically, Zfp281 interacts with Tet1, but not Tet2, and its direct transcriptional target, miR-302/367, to negatively regulate Tet2 expression to ..
  35. Vella P, Scelfo A, Jammula S, Chiacchiera F, Williams K, Cuomo A, et al. Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell. 2013;49:645-56 pubmed publisher
    ..characterized the biochemical features of nuclear Ogt and identified the ten-eleven translocation (TET) proteins Tet1 and Tet2 as stable partners of Ogt in the nucleus of ESCs...
  36. Liu X, Wu H, Ji X, Stelzer Y, Wu X, Czauderna S, et al. Editing DNA Methylation in the Mammalian Genome. Cell. 2016;167:233-247.e17 pubmed publisher
    ..Here, we demonstrate that fusion of Tet1 or Dnmt3a with a catalytically inactive Cas9 (dCas9) enables targeted DNA methylation editing...
  37. Henderson Pozzi M, Fitzpatrick P. A lysine conserved in the monoamine oxidase family is involved in oxidation of the reduced flavin in mouse polyamine oxidase. Arch Biochem Biophys. 2010;498:83-8 pubmed publisher
    ..In the mutant enzyme the lysine amine would be replaced by a water chain. ..
  38. Khoueiry R, Sohni A, Thienpont B, Luo X, Velde J, Bartoccetti M, et al. Lineage-specific functions of TET1 in the postimplantation mouse embryo. Nat Genet. 2017;49:1061-1072 pubmed publisher
    ..Here we define non-redundant roles for TET1 at an early postimplantation stage of the mouse embryo, when its paralogs Tet2 and Tet3 are not detectably ..
  39. Etchegaray J, Chavez L, Huang Y, Ross K, Choi J, Martinez Pastor B, et al. The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine. Nat Cell Biol. 2015;17:545-57 pubmed publisher
    ..We demonstrate that SIRT6 functions as a chromatin regulator safeguarding the balance between pluripotency and differentiation through Tet-mediated production of 5hmC. ..
  40. Neri F, Incarnato D, Krepelova A, Rapelli S, Pagnani A, Zecchina R, et al. Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells. Genome Biol. 2013;14:R91 pubmed publisher
    ..b>Tet1 is expressed at high levels in mouse embryonic stem cells (ESCs), where it mediates the induction of 5hmC ..
  41. Dillman A, Hauser D, Gibbs J, Nalls M, McCoy M, Rudenko I, et al. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013;16:499-506 pubmed publisher
    ..We provide this data set and analysis as a resource for understanding gene expression in the embryonic and adult cerebral cortex. ..
  42. Yang H, Wang H, Shivalila C, Cheng A, Shi L, Jaenisch R. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell. 2013;154:1370-9 pubmed publisher
    ..Finally, we analyzed potential off-targets of five sgRNAs in gene-modified mice and ESC lines and identified off-target mutations in only rare instances. ..
  43. Kang J, Lienhard M, Pastor W, Chawla A, Novotny M, Tsagaratou A, et al. Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A. 2015;112:E4236-45 pubmed publisher
    ..Here we show data suggesting that TET proteins maintain the consistency of gene transcription. Embryos lacking Tet1 and Tet3 (Tet1/3 DKO) displayed a strong loss of 5-hydroxymethylcytosine (5hmC) and a concurrent increase in 5-..
  44. Feng J, Pena C, Purushothaman I, Engmann O, Walker D, Brown A, et al. Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors. Neuropsychopharmacology. 2017;42:1657-1669 pubmed publisher
    ..Here we examined a possible role for the DNA dioxygenase, ten-eleven translocation protein 1 (TET1), in depression-related behavioral abnormalities...
  45. Wang H, Yang H, Shivalila C, Dawlaty M, Cheng A, Zhang F, et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell. 2013;153:910-8 pubmed publisher
    ..We demonstrate that CRISPR/Cas-mediated gene editing allows the simultaneous disruption of five genes (Tet1, 2, 3, Sry, Uty--8 alleles) in mouse embryonic stem (ES) cells with high efficiency...
  46. Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, et al. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Mol Cell. 2016;61:153-60 pubmed publisher
    ..Mechanistically, Lin28A recruits 5-methylcytosine-dioxygenase Tet1 to genomic binding sites to orchestrate 5-methylcytosine and 5-hydroxymethylcytosine dynamics...
  47. Vincent J, Huang Y, Chen P, Feng S, Calvopina J, Nee K, et al. Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell. 2013;12:470-8 pubmed publisher
    ..The role of the 5-methylcytosine (5mC) dioxygenases Tet1 and Tet2 in the initial genome-wide DNA demethylation process has not been examined directly...
  48. Okashita N, Sakashita N, Ito K, Mitsuya A, Suwa Y, Seki Y. PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation. Biochem Biophys Res Commun. 2015;466:138-45 pubmed publisher
    ..Further, knockdown of Tet1/Tet2 and administration of base excision repair (BER) pathway inhibitors impairs the PRDM14-induced resistance of ..
  49. Gerdes P, Richardson S, Faulkner G. TET enzymes: double agents in the transposable element-host genome conflict. Genome Biol. 2016;17:259 pubmed
    ..Please see related Research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1096-8. ..
  50. Tu J, Ng S, Luk A, Liao J, Jiang X, Feng B, et al. MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res. 2015;43:7805-22 pubmed publisher
    ..regulation during ESCs differentiation, which is suggested by microRNA-29b (miR-29b) binding sites on the Tet1 3' untranslated region (3' UTR)...
  51. Fong K, Hufnagel R, Khadka V, Corley M, Maunakea A, Fogelgren B, et al. A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016;9:585-96 pubmed publisher
    ..Here, through whole-genome sequencing, we identified a nonsense mutation in the Tet1 gene, which encodes a methylcytosine dioxygenase (TET1), co-segregating with the tuft phenotype...
  52. Neri F, Incarnato D, Krepelova A, Dettori D, Rapelli S, Maldotti M, et al. TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues. Nucleic Acids Res. 2015;43:6814-26 pubmed publisher
    ..b>Tet1 is highly expressed in mouse embryonic stem cells (ESCs) where it plays a critical role the pluripotency ..
  53. Cui Y, Li T, Yang D, Li S, Le W. miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs. Oncotarget. 2016;7:64932-64941 pubmed publisher
    The ten-eleven translocation-1 (Tet1), which converts 5-methylcytosine (5mC) to 5-hydroxymethycytosine (5hmC), plays important roles in many important biological processes, such as mouse embryonic stem cells (ESCs) maintenance...
  54. Nakagawa T, Lv L, Nakagawa M, Yu Y, Yu C, D Alessio A, et al. CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Mol Cell. 2015;57:247-260 pubmed publisher
    ..Cumulatively, our data demonstrate that CRL4(VprBP) is a critical regulator of TET dioxygenases during development and in tumor suppression. ..
  55. Zhang P, Rausch C, Hastert F, Boneva B, Filatova A, Patil S, et al. Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. Nucleic Acids Res. 2017;45:7118-7136 pubmed publisher
    ..Here, we focus on the interplay of the 5-methylcytosine reader Mbd1 and modifier Tet1 by analyzing their dynamic subcellular localization and the formation of the Tet oxidation product 5-..
  56. Minor E, Court B, Young J, Wang G. Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J Biol Chem. 2013;288:13669-74 pubmed publisher
    ..Further, blocking ascorbate entry into cells by phloretin and knocking down Tet (Tet1, Tet2, and Tet3) expression by short interference RNAs (siRNA) significantly inhibit the effect of ascorbate on 5-..
  57. Kim H, Jang W, Kang M, Jeong J, Choi M, Sung Y, et al. TET1 contributes to neurogenesis onset time during fetal brain development in mice. Biochem Biophys Res Commun. 2016;471:437-43 pubmed publisher
    ..Ten-eleven translocation 1 (TET1) regulates DNA demethylation by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC)...
  58. Shimozaki K. Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells. Cell Mol Neurobiol. 2017;37:995-1008 pubmed publisher
    ..In recent years, emerging evidence has revealed that ten-eleven translocation (TET) family DNA dioxygenases TET1 and TET2 play important roles in the central nervous system...
  59. Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, et al. Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet. 2013;45:1504-9 pubmed publisher
    ..TET hydroxylases are also dioxygenases implicated in active DNA demethylation. Here we report that TET1 either positively or negatively regulates somatic cell reprogramming depending on the absence or presence of ..
  60. Wang J, Zhang D, Du J, Zhou C, Li Z, Liu X, et al. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-? proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Res. 2017;45:12700-12714 pubmed publisher
    ..Here, we identify that Tet1, one member of the ten-eleven translocation (TET) family of methylcytosine dioxygenases, is required for hypoxia ..
  61. Thomson J, Ottaviano R, Unterberger E, Lempiäinen H, Muller A, Terranova R, et al. Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer. Cancer Res. 2016;76:3097-108 pubmed publisher
    ..In livers from mice deficient in Tet1, a tumor suppressor involved in cytosine demethylation, we observed a similar loss of promoter core 5hmC, ..
  62. Chen J, Gao Y, Huang H, Xu K, Chen X, Jiang Y, et al. The combination of Tet1 with Oct4 generates high-quality mouse-induced pluripotent stem cells. Stem Cells. 2015;33:686-98 pubmed publisher
    The DNA dioxygenase Tet1 has recently been proposed to play an important role in the reprogramming of somatic cells to pluripotency...
  63. Fong K, Cooper T, Drumhiller W, Somponpun S, Yang S, Ernst T, et al. Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse. Birth Defects Res A Clin Mol Teratol. 2012;94:102-13 pubmed publisher
    ..Identifying the gene(s) and mutation(s) causing this early developmental defect will help us understand the pathogenesis of FND and related craniofacial disorders. ..
  64. Zhang W, Xia W, Wang Q, Towers A, Chen J, Gao R, et al. Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development. Mol Cell. 2016;64:1062-1073 pubmed publisher
    ..Interestingly, we found that, in mice, the full-length TET1 isoform (TET1e) is restricted to early embryos, embryonic stem cells (ESCs), and primordial germ cells (PGCs)...
  65. Yang R, Qu C, Zhou Y, Konkel J, Shi S, Liu Y, et al. Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity. 2015;43:251-63 pubmed publisher
    ..H2S maintained expression of methylcytosine dioxygenases Tet1 and Tet2 by sulfhydrating nuclear transcription factor Y subunit beta (NFYB) to facilitate its binding to Tet1 and ..
  66. Shi F, Kim H, Lu W, He Q, Liu D, Goodell M, et al. Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells. J Biol Chem. 2013;288:20776-84 pubmed publisher
    ..translocation) family proteins that can convert 5-methylcytosine (5mC) to 5-hydroxylmethylcytosine (5hmC), Tet1 has been implicated in regulating global DNA demethylation and gene expression...
  67. Zhang P, Ludwig A, Hastert F, Rausch C, Lehmkuhl A, Hellmann I, et al. L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins. Nucleus. 2017;8:548-562 pubmed publisher
    ..We show that Tet1 activates both, endogenous and engineered L1 retrotransposons...
  68. Kong L, Tan L, Lv R, Shi Z, Xiong L, Wu F, et al. A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands. Nucleic Acids Res. 2016;44:8682-8692 pubmed
    ..On the other hand, deletion of Tet1 and Tet2 in mouse embryonic stem (ES) cells results in an apparent loss of H3K27me3 at bivalent domains, which are ..
  69. Kang E, Wu G, Ma H, Li Y, Tippner Hedges R, Tachibana M, et al. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014;509:101-4 pubmed publisher
    ..The ability to use interphase cytoplasm in SCNT could aid efforts to generate autologous human ES cells for regenerative applications, as donated or discarded embryos are more accessible than unfertilized MII oocytes. ..
  70. Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, et al. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell. 2013;12:453-69 pubmed publisher
    ..Here, we demonstrate that the DNA hydroxylase Tet1 facilitates pluripotent stem cell induction by promoting Oct4 demethylation and reactivation...