Tert

Summary

Gene Symbol: Tert
Description: telomerase reverse transcriptase
Alias: EST2, TCS1, TP2, TRT, telomerase reverse transcriptase, telomerase catalytic subunit, telomerase reverse transcriptase beta
Species: mouse
Products:     Tert

Top Publications

  1. Greenberg R, Allsopp R, Chin L, Morin G, DePinho R. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 1998;16:1723-30 pubmed
    We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog (hTERT), and the presence of reverse transcriptase and telomerase specific motifs...
  2. Horikawa I, Chiang Y, Patterson T, Feigenbaum L, Leem S, Michishita E, et al. Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element. Proc Natl Acad Sci U S A. 2005;102:18437-42 pubmed
    ..basis for this difference, a bacterial artificial chromosome clone containing the entire hTERT (human telomerase reverse transcriptase) gene was introduced in mice...
  3. Allsopp R, Morin G, DePinho R, Harley C, Weissman I. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood. 2003;102:517-20 pubmed
  4. Lee J, Jo Y, Sung Y, Hwang I, Kim H, Kim S, et al. Telomerase deficiency affects normal brain functions in mice. Neurochem Res. 2010;35:211-8 pubmed publisher
    ..b>Telomerase reverse transcriptase (TERT) expression was observed in the hippocampus, the olfactory bulbs, and the cerebellum, but the ..
  5. Meznikova M, Erdmann N, Allsopp R, Harrington L. Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes. Dis Model Mech. 2009;2:620-6 pubmed publisher
    ..Mice that are heterozygous for telomerase genes (Tert or Terc, hereafter referred to as mTert and mTerc) are useful models of telomerase haploinsufficiency, but do not ..
  6. Vidal Cardenas S, Greider C. Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase. Nucleic Acids Res. 2010;38:60-71 pubmed publisher
    Telomerase, the essential enzyme that maintains telomere length, contains two core components, TERT and TR...
  7. Herrera E, Martinez A C, Blasco M. Impaired germinal center reaction in mice with short telomeres. EMBO J. 2000;19:472-81 pubmed
    ..wild-type splenocyte telomeres are elongated and this is accompanied by a high expression of the telomerase catalytic subunit in the spleen GC...
  8. Hu J, Hwang S, Liesa M, Gan B, Sahin E, Jaskelioff M, et al. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012;148:651-63 pubmed publisher
    ..and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele...
  9. Haendeler J, Dröse S, Büchner N, Jakob S, Altschmied J, Goy C, et al. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol. 2009;29:929-35 pubmed publisher
    The enzyme telomerase and its catalytic subunit the telomerase reverse transcriptase (TERT) are important for maintenance of telomere length in the nucleus. Recent studies provided evidence for a mitochondrial localization of TERT...

More Information

Publications85

  1. Liu Y, Kha H, Ungrin M, Robinson M, Harrington L. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc Natl Acad Sci U S A. 2002;99:3597-602 pubmed
    Prolonged growth of murine embryonic stem (ES) cells lacking the telomerase reverse transcriptase, mTert, results in a loss of telomere DNA and an increased incidence of end-to-end fusions and aneuploidy...
  2. Liu T, Chung M, Ullenbruch M, Yu H, Jin H, Hu B, et al. Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice. J Clin Invest. 2007;117:3800-9 pubmed
    ..To identify the pathogenetic importance of telomerase in lung fibrosis, we examined the effects of telomerase reverse transcriptase (TERT) deficiency in a murine model of pulmonary injury...
  3. Bagheri S, Nosrati M, Li S, Fong S, Torabian S, Rangel J, et al. Genes and pathways downstream of telomerase in melanoma metastasis. Proc Natl Acad Sci U S A. 2006;103:11306-11 pubmed
    ..These studies have important implications for understanding the mechanisms by which telomerase promotes tumor invasion and metastasis. ..
  4. Ferron S, Marques Torrejon M, Mira H, Flores I, Taylor K, Blasco M, et al. Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J Neurosci. 2009;29:14394-407 pubmed publisher
  5. Chen J, Opperman K, Greider C. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res. 2002;30:592-7 pubmed
    ..1 stem was required for the RNA-protein interaction between the CR4-CR5 domain and the telomerase reverse transcriptase (TERT) protein. Interestingly, two RNA mutations, one that extends the P6...
  6. Tomás Loba A, Flores I, Fernandez Marcos P, Cayuela M, Maraver A, Tejera A, et al. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008;135:609-22 pubmed publisher
    ..To circumvent this problem, we have constitutively expressed telomerase reverse transcriptase (TERT), one of the components of telomerase, in mice engineered to be cancer resistant by means of ..
  7. Rajaraman S, Choi J, Cheung P, Beaudry V, Moore H, Artandi S. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo. Proc Natl Acad Sci U S A. 2007;104:17747-52 pubmed
    ..Here, we show that telomeres uncap in an S-phase-dependent manner in gastrointestinal progenitors of TERT(-/-) mice...
  8. Lechel A, Holstege H, Begus Y, Schienke A, Kamino K, Lehmann U, et al. Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology. 2007;132:1465-75 pubmed
    ..The function of telomerase during in vivo hepatocarcinogenesis has not been studied in this genetic context...
  9. Jaskelioff M, Muller F, Paik J, Thomas E, Jiang S, Adams A, et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011;469:102-6 pubmed publisher
    ..To this end, we engineered a knock-in allele encoding a 4-hydroxytamoxifen (4-OHT)-inducible telomerase reverse transcriptase-oestrogen receptor (TERT-ER) under transcriptional control of the endogenous TERT promoter...
  10. Breault D, Min I, Carlone D, Farilla L, Ambruzs D, Henderson D, et al. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008;105:10420-5 pubmed publisher
    ..We therefore generated mouse telomerase reverse transcriptase (mTert)-GFP-transgenic mice and assayed the ability of mTert-driven GFP to mark tissue stem cells in ..
  11. Choi J, Southworth L, Sarin K, Venteicher A, Ma W, Chang W, et al. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet. 2008;4:e10 pubmed publisher
    ..repeats in a manner dependent on the reverse transcriptase (RT) function of its protein component telomerase RT (TERT), as well as on a novel pathway whose mechanism is poorly understood...
  12. Zhu L, Hathcock K, Hande P, Lansdorp P, Seldin M, Hodes R. Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A. 1998;95:8648-53 pubmed
    ..This locus is distinct from candidate genes encoding known telomere-binding proteins or telomerase components. These results demonstrate that an unidentified gene(s) mapped to distal chromosome 2 regulates telomere length in the mouse. ..
  13. Sarin K, Cheung P, Gilison D, Lee E, Tennen R, Wang E, et al. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature. 2005;436:1048-52 pubmed
    b>TERT, the protein component of telomerase, serves to maintain telomere function through the de novo addition of telomere repeats to chromosome ends, and is reactivated in 90% of human cancers...
  14. Greenberg R, O Hagan R, Deng H, Xiao Q, Hann S, Adams R, et al. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene. 1999;18:1219-26 pubmed
    The telomerase reverse transcriptase component (TERT) is not expressed in most primary somatic human cells and tissues, but is upregulated in the majority of immortalized cell lines and tumors...
  15. Chiang Y, Hemann M, Hathcock K, Tessarollo L, Feigenbaum L, Hahn W, et al. Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol Cell Biol. 2004;24:7024-31 pubmed
    Telomerase consists of two essential components, the telomerase RNA template (TR) and telomerase reverse transcriptase (TERT)...
  16. Liu Y, Snow B, Hande M, Yeung D, Erdmann N, Wakeham A, et al. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol. 2000;10:1459-62 pubmed
    ..Its catalytic core comprises a reverse transcriptase component (TERT) and an RNA component...
  17. Montgomery R, Carlone D, Richmond C, Farilla L, Kranendonk M, Henderson D, et al. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011;108:179-84 pubmed publisher
    ..Here, we identify a subpopulation of slowly cycling ISCs marked by mouse telomerase reverse transcriptase (mTert) expression that can give rise to Lgr5(+) cells...
  18. Martín Rivera L, Herrera E, Albar J, Blasco M. Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc Natl Acad Sci U S A. 1998;95:10471-6 pubmed
    ..the isolation and characterization of the catalytic subunit of mouse telomerase, mTERT (mouse telomerase reverse transcriptase), an essential protein component of the telomerase complex...
  19. Lee J, Sung Y, Cheong C, Choi Y, Jeon H, Sun W, et al. TERT promotes cellular and organismal survival independently of telomerase activity. Oncogene. 2008;27:3754-60 pubmed publisher
    The expression level of the telomerase catalytic subunit (telomerase reverse transcriptase, TERT) positively correlates with cell survival after exposure to several lethal stresses...
  20. Maser R, WONG K, Sahin E, Xia H, Naylor M, Hedberg H, et al. DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol. 2007;27:2253-65 pubmed
  21. Pericuesta E, Ramirez M, Villa Diaz A, Relaño Ginés A, Torres J, Nieto M, et al. The proximal promoter region of mTert is sufficient to regulate telomerase activity in ES cells and transgenic animals. Reprod Biol Endocrinol. 2006;4:5 pubmed
    The reverse transcriptase of telomerase (Tert) controls telomerase activity maintaining the end of linear chromosomes in eukaryotic cells...
  22. Flores I, Cayuela M, Blasco M. Effects of telomerase and telomere length on epidermal stem cell behavior. Science. 2005;309:1253-6 pubmed
    ..We show through analysis of mouse models that telomere length, as well as the catalytic component of telomerase, Tert, are critical determinants in the mobilization of epidermal stem cells...
  23. Erdmann N, Liu Y, Harrington L. Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci U S A. 2004;101:6080-5 pubmed
    Telomerase is a ribonucleoprotein containing an essential telomerase RNA template and telomerase reverse transcriptase (TERT) that maintains telomeres...
  24. Geserick C, Tejera A, Gonzalez Suarez E, Klatt P, Blasco M. Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-beta signaling. Oncogene. 2006;25:4310-9 pubmed
  25. Takakura M, Kyo S, Inoue M, Wright W, Shay J. Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. Mol Cell Biol. 2005;25:8037-43 pubmed
    The transcriptional regulation of the human telomerase catalytic subunit (hTERT) plays a critical role in telomerase activity...
  26. Yuan X, Ishibashi S, Hatakeyama S, Saito M, Nakayama J, Nikaido R, et al. Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice. Genes Cells. 1999;4:563-72 pubmed
    ..of two essential subunits, the template RNA (TR; telomerase RNA) and the catalytic subunit TERT (telomerase reverse transcriptase). Knockout mice with a mTR (mouse TR) deletion have been described and well characterized...
  27. Park J, Venteicher A, Hong J, Choi J, Jun S, Shkreli M, et al. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature. 2009;460:66-72 pubmed publisher
    ..The telomerase protein component TERT (telomerase reverse transcriptase) interacts with BRG1 (also called SMARCA4), a SWI/SNF-related chromatin remodelling protein, and ..
  28. Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y, et al. Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Mol Cell Biol. 2014;34:1576-93 pubmed publisher
    ..In association with the telomerase RNA component (TERC), the telomerase reverse transcriptase (TERT) forms telomerase and counteracts telomere attrition, and without TERC, TERT has been ..
  29. Farazi P, Glickman J, Horner J, Depinho R. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res. 2006;66:4766-73 pubmed
    ..the cooperative interactions of germ line p53 mutation and telomere dysfunction [produced by telomerase reverse transcriptase (mTERT) gene knockout]...
  30. Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del Valle I, et al. Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. Science. 2012;336:1549-54 pubmed publisher
    ..Here, we report a molecular link between Wnt/?-catenin signaling and the expression of the telomerase subunit Tert. ?-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an ..
  31. Shaheen F, Grammatopoulos D, Muller J, Zammit V, Lehnert H. Extra-nuclear telomerase reverse transcriptase (TERT) regulates glucose transport in skeletal muscle cells. Biochim Biophys Acta. 2014;1842:1762-9 pubmed publisher
    b>Telomerase reverse transcriptase (TERT) is a key component of the telomerase complex. By lengthening telomeres in DNA strands, TERT increases senescent cell lifespan...
  32. Cosme Blanco W, Chang S. Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis. Exp Cell Res. 2008;314:1973-9 pubmed publisher
    ..In this review, we describe the use of mouse models to probe the impact of dysfunctional telomeres on tumor initiation and suppression. ..
  33. Okamoto N, Yasukawa M, Nguyen C, Kasim V, Maida Y, Possemato R, et al. Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. Proc Natl Acad Sci U S A. 2011;108:20388-93 pubmed publisher
    ..GNL3L/NS forms a complex with the telomerase catalytic subunit [human telomerase reverse transcriptase (hTERT)] and the SWItch-Sucrose NonFermentable (SWI-SNF) complex protein brahma-related gene 1 (BRG1),..
  34. Werner C, Fürster T, Widmann T, Pöss J, Roggia C, Hanhoun M, et al. Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation. 2009;120:2438-47 pubmed publisher
    ..Transgenic mouse studies showed that endothelial nitric oxide synthase and telomerase reverse transcriptase synergize to confer endothelial stress resistance after physical activity...
  35. Khattar E, Kumar P, Liu C, Akıncılar S, Raju A, Lakshmanan M, et al. Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression. J Clin Invest. 2016;126:4045-4060 pubmed publisher
    Transcriptional reactivation of telomerase reverse transcriptase (TERT) reconstitutes telomerase activity in the majority of human cancers...
  36. Mai W, Kawakami K, Shakoori A, Kyo S, Miyashita K, Yokoi K, et al. Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. Clin Cancer Res. 2009;15:6810-9 pubmed publisher
    ..The effects of GSK3beta inhibition on human telomerase reverse transcriptase (hTERT) expression and telomerase activity were compared between colon cancer and HEK293 cells...
  37. Huang W, Rha G, Chen L, Seelbach M, Zhang B, Andras I, et al. Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells. Am J Physiol Heart Circ Physiol. 2010;298:H1136-45 pubmed publisher
    Telomerase, via its catalytic component telomerase reverse transcriptase (TERT), extends telomeres of eukaryotic chromosomes...
  38. Vera E, Bernardes de Jesus B, Foronda M, Flores J, Blasco M. Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS ONE. 2013;8:e53760 pubmed publisher
    ..CR significantly decreased tumor incidence in TERT transgenic (TgTERT) mice and extended their lifespan compared to wild-type (WT) controls under the same diet, ..
  39. Vallabhaneni H, O Callaghan N, Sidorova J, Liu Y. Defective repair of oxidative base lesions by the DNA glycosylase Nth1 associates with multiple telomere defects. PLoS Genet. 2013;9:e1003639 pubmed publisher
    ..The fact that telomerase deficiency can exacerbate telomere shortening in Nth1 deficient mouse cells supports that base excision repair cooperates with telomerase to maintain telomere integrity. ..
  40. Farazi P, Zeisberg M, Glickman J, Zhang Y, Kalluri R, Depinho R. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res. 2006;66:6622-7 pubmed
    ..Thus, p53 deficiency, chronic bile duct injury/proliferation, and the fibrotic matrix microenvironment cooperate to induce intrahepatic CCA, highlighting the key role of the ECM microenvironment in this common liver cancer. ..
  41. Wang Y, Erdmann N, Giannone R, Wu J, Gomez M, Liu Y. An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres. Proc Natl Acad Sci U S A. 2005;102:10256-60 pubmed
    ..Our results suggest that animals and cell culture differ in their ability to carry out genomic rearrangements as a means of maintaining telomere integrity when telomeres become critically shortened. ..
  42. Riou L, Bastos H, Lassalle B, Coureuil M, Testart J, Boussin F, et al. The telomerase activity of adult mouse testis resides in the spermatogonial alpha6-integrin-positive side population enriched in germinal stem cells. Endocrinology. 2005;146:3926-32 pubmed
    ..In addition, the telomerase activity of cells in various stages of differentiation was unaffected by aging and, notably, remained high in the alpha6-integrin-positive Side Population. ..
  43. Agarwal M, Pandita S, Hunt C, Gupta A, Yue X, Khan S, et al. Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization. Cancer Res. 2008;68:3370-8 pubmed publisher
    ..in enhanced hyperthermia-mediated IR-induced cell killing, and ectopic expression of catalytic unit of telomerase (TERT) decreased hyperthermia-mediated IR-induced cell killing...
  44. Gu B, Bessler M, Mason P. A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice. Proc Natl Acad Sci U S A. 2008;105:10173-8 pubmed publisher
    ..Their integrity is maintained by telomerase, an enzyme consisting of a reverse transcriptase, TERT and an RNA template, TERC, and other components, including the pseudouridine synthase, dyskerin, the product of the ..
  45. Middleman E, Choi J, Venteicher A, Cheung P, Artandi S. Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Mol Cell Biol. 2006;26:2146-59 pubmed
    ..The reactivation of telomerase through the upregulation of TERT, the telomerase protein subunit, is an important step during cancer development, yet TERT protein function and ..
  46. Chen C, Akiyama K, Yamaza T, You Y, Xu X, Li B, et al. Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression. EMBO Mol Med. 2014;6:322-34 pubmed publisher
    ..Restoration of telomerase activity by telomerase reverse transcriptase (TERT) transfection in TERT(-/-) BMMSCs rescues their immunomodulatory functions...
  47. Gizard F, Heywood E, Findeisen H, Zhao Y, Jones K, Cudejko C, et al. Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages. Arterioscler Thromb Vasc Biol. 2011;31:245-52 pubmed publisher
    ..stimuli activate telomerase in macrophages by inducing the expression of the catalytic subunit telomerase reverse transcriptase (TERT)...
  48. Kasiappan R, Shen Z, Tse A, Jinwal U, Tang J, Lungchukiet P, et al. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. J Biol Chem. 2012;287:41297-309 pubmed publisher
    ..Regulation of the promoter activity of the gene encoding its catalytic subunit, the telomerase reverse transcriptase, is established as the dominant mechanism conferring the high telomerase activity in proliferating ..
  49. Madonna R, Wu D, Wassler M, De Caterina R, Willerson J, Geng Y. Myocardin-A enhances expression of promyogenic genes without depressing telomerase activity in adipose tissue-derived mesenchymal stem cells. Int J Cardiol. 2013;167:2912-21 pubmed publisher
    ..consists of mesenchymal stem cells (MSCs) characterized by co-expression of myocardin-A (McA) and telomerase reverse transcriptase (TERT)...
  50. von Figura G, Wagner M, Nalapareddy K, Hartmann D, Kleger A, Guachalla L, et al. Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice. PLoS ONE. 2011;6:e17122 pubmed publisher
    ..Our results indicate that pancreatic regeneration is limited in the context of telomere dysfunction without evidence for p53 checkpoint activation. ..
  51. Li J, Lei H, Xu Y, Tao Z. miR-512-5p suppresses tumor growth by targeting hTERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo. PLoS ONE. 2015;10:e0135265 pubmed publisher
    ..telomerase activity, decrease of telomere-binding proteins and shortening of telomere length by human telomerase reverse transcriptase (hTERT) downregulation...
  52. Kuramoto M, Ohsumi K, Kishimoto T, Ishikawa F. Identification and analyses of the Xenopus TERT gene that encodes the catalytic subunit of telomerase. Gene. 2001;277:101-10 pubmed
    The Xenopus telomerase catalytic component gene, xTERT (Xenopus telomerase reverse transcriptase), has been cloned. The production of xTERT recombinant protein together with the proposed Xenopus telomerase RNA (xTR) (Chen et al., 2000...
  53. Wu X, Yang Y, Li W, Cheng Y, Li X, Huang C, et al. Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease. Sci Rep. 2016;6:18685 pubmed publisher
    ..occurs at critical stages of myeloid and lymphoid cell activation, we herein investigated the role of telomerase reverse transcriptase (TERT), the determining factor of telomerase, in macrophage activation during ALD...
  54. Vuong L, Brobst D, Saadi A, Ivanovic I, Al Ubaidi M. Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina. Invest Ophthalmol Vis Sci. 2012;53:4821-31 pubmed publisher
    ..Downregulation of p53 in the post-mitotic retina suggests that, although p53 may be involved in ocular and retinal development, it may play a minimal role in healthy adult retinal function. ..
  55. Chiu W, Shen S, Yang L, Chow J, Wu C, Chen Y. Inhibition of HSP90-dependent telomerase activity in amyloid ?-induced apoptosis of cerebral endothelial cells. J Cell Physiol. 2011;226:2041-51 pubmed publisher
    ..telomerase activity by A?(1-40) and A?(25-35) was detected; meanwhile, reduced telomerase activity by telomerase reverse transcriptase (TERT) siRNA enhanced the cytotoxic effect of A?...
  56. Malik H, Burke W, Eickbush T. Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans. Gene. 2000;251:101-8 pubmed
    ..We present the sequence of a putative telomerase catalytic subunit from the diplomonad parasite, Giardia lamblia. The G...
  57. Rhee D, Wang Y, Mizesko M, Zhou F, Haneline L, Liu Y. FANCC suppresses short telomere-initiated telomere sister chromatid exchange. Hum Mol Genet. 2010;19:879-87 pubmed publisher
    ..When Fancc(-/-) mice were crossed into a telomerase reverse transcriptase heterozygous or null background (Tert(+/-) or Tert(-/-)) with short telomeres, Fancc deficiency led ..
  58. Shkreli M, Sarin K, Pech M, Papeta N, Chang W, Brockman S, et al. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nat Med. 2011;18:111-9 pubmed publisher
    ..lose differentiation markers and enter the cell cycle in adult mice in which the telomerase protein component TERT is conditionally expressed...
  59. Zhou Q, Wu H, Zhou H, Liu M, Lee H, Liu X, et al. Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice. Transl Psychiatry. 2016;6:e836 pubmed publisher
    The role of telomerase reverse transcriptase (TERT) has been extensively investigated in the contexts of aging and cancer...
  60. Gao B, Li K, Wei Y, Zhang J, Li J, Zhang L, et al. Zinc finger protein 637 protects cells against oxidative stress-induced premature senescence by mTERT-mediated telomerase activity and telomere maintenance. Cell Death Dis. 2014;5:e1334 pubmed publisher
    ..In this study, we show that the endogenous expression levels of Zfp637 and mouse telomerase reverse transcriptase (mTERT) are downregulated during oxidative stress-induced premature senescence and in senescent ..
  61. Park K, Seong S, Park Y, Choi Y, Park J, Lee S, et al. Telomerase reverse transcriptase related with telomerase activity regulates tumorigenic potential of mouse embryonic stem cells. Stem Cells Dev. 2011;20:149-57 pubmed publisher
    ..of oncogenes did not show a significant change during differentiation steps, but the expression of telomerase reverse transcriptase (TERT) and telomerase activity correlated with mouse ESCs differentiation...
  62. Bu D, Johansson M, Ren J, Xu D, Johnson F, Edfeldt K, et al. Nuclear factor {kappa}B-mediated transactivation of telomerase prevents intimal smooth muscle cell from replicative senescence during vascular repair. Arterioscler Thromb Vasc Biol. 2010;30:2604-10 pubmed publisher
    ..interferes with the repair process by investigating expression and function of the catalytic telomerase reverse transcriptase (TERT) subunit after vascular injury...
  63. Liu T, Ullenbruch M, Young Choi Y, Yu H, Ding L, Xaubet A, et al. Telomerase and telomere length in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2013;49:260-8 pubmed publisher
    ..induced in murine bleomycin (BLM)-induced pulmonary fibrosis with increased levels of telomerase transcriptase (TERT) expression, which is essential for fibrosis...
  64. Al Ajmi N, Saretzki G, Miles C, Spyridopoulos I. Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype. Exp Gerontol. 2014;58:113-9 pubmed publisher
    ..However, an additional increase in erythroid colonies (BFU-E) was also evident. Mice lacking telomerase reverse transcriptase without shortened telomeres, TERT(-/-), also presented with augmented haematopoietic ageing which was ..
  65. Eitan E, Braverman C, Tichon A, Gitler D, Hutchison E, Mattson M, et al. Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons. Cerebellum. 2016;15:509-17 pubmed publisher
    b>Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase, an enzyme that elongates telomeres at the ends of chromosomes during DNA replication...
  66. Chen R, Zhang K, Chen H, Zhao X, Wang J, Li L, et al. Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs. J Biol Chem. 2015;290:30813-29 pubmed publisher
    Mutations of human telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) are associated with a subset of lung aging diseases, but the mechanisms by which TERC and TERT participate in lung diseases remain unclear...
  67. Wang Y, Giannone R, Liu Y. Telomere sister chromatid exchange in telomerase deficient murine cells. Cell Cycle. 2005;4:1320-2 pubmed
  68. Gizard F, Nomiyama T, Zhao Y, Findeisen H, Heywood E, Jones K, et al. The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation. Circ Res. 2008;103:1155-63 pubmed publisher
    ..activation inhibited mitogen-induced telomerase activity by repressing the catalytic subunit telomerase reverse transcriptase (TERT) through negative cross-talk with an E2F-1-dependent trans-activation of the TERT promoter...
  69. Moriarty T, Huard S, Dupuis S, Autexier C. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol Cell Biol. 2002;22:1253-65 pubmed
    ..complexes are minimally composed of the human telomerase RNA (hTR) and a catalytic subunit (human telomerase reverse transcriptase [hTERT]) containing reverse transcriptase (RT)-like motifs...
  70. Franco S, Canela A, Klatt P, Blasco M. Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models. Carcinogenesis. 2005;26:1613-26 pubmed
  71. Rolyan H, Scheffold A, Heinrich A, Begus Nahrmann Y, Langkopf B, Holter S, et al. Telomere shortening reduces Alzheimer's disease amyloid pathology in mice. Brain. 2011;134:2044-56 pubmed publisher
  72. Shats I, Milyavsky M, Erez N, Rotter V. The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein. FEBS Lett. 2003;546:321-4 pubmed
    ..The existence of a shared epitope between mutant p53 and telomerase may suggest that the two proteins contribute to malignant transformation through a common pathway. ..
  73. Xiong J, Fan S, Meng Q, Schramm L, Wang C, Bouzahza B, et al. BRCA1 inhibition of telomerase activity in cultured cells. Mol Cell Biol. 2003;23:8668-90 pubmed
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