tenascin C


Gene Symbol: tenascin C
Description: tenascin C
Alias: AI528729, C130033P17Rik, Hxb, TN-C, Ten, cytotactin, tenascin-C, tenascin, hexabrachion, tnc
Species: mouse
Products:     tenascin C

Top Publications

  1. Kalembey I, Yoshida T, Iriyama K, Sakakura T. Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study. Int J Dev Biol. 1997;41:569-73 pubmed
    The expression of tenascin gene during murine mammary gland development was analyzed by in situ hybridization with non-radioactive cRNA probes. The aim was to identify whether cells that synthesize tenascin are mesenchymal or epithelial...
  2. Gotz M, Stoykova A, Gruss P. Pax6 controls radial glia differentiation in the cerebral cortex. Neuron. 1998;21:1031-44 pubmed
    ..In Pax6-deficient mice, cortical radial glia cells were altered in their morphology, number, tenascin-C (TN-C) expression, and cell cycle...
  3. Aufderheide E, Ekblom P. Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions. J Cell Biol. 1988;107:2341-9 pubmed
    b>Tenascin, an extracellular matrix protein, is expressed in the mesenchyme around growing epithelia in the embryo. We therefore investigated whether epithelial cells can stimulate expression of tenascin in embryonic mesenchyme...
  4. Koyama Y, Kusubata M, Yoshiki A, Hiraiwa N, Ohashi T, Irie S, et al. Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse. J Invest Dermatol. 1998;111:930-5 pubmed
    b>Tenascin-C is a large extracellular matrix glycoprotein characterized by its spatiotemporal expression during embryogenesis, carcinogenesis, and wound healing...
  5. von Holst A, Egbers U, Prochiantz A, Faissner A. Neural stem/progenitor cells express 20 tenascin C isoforms that are differentially regulated by Pax6. J Biol Chem. 2007;282:9172-81 pubmed
    b>Tenascin C (Tnc) is an alternatively spliced, multimodular extracellular matrix glycoprotein present in the ventricular zone of the developing brain. Pax6-deficient small eye (sey) mouse mutants show an altered Tnc expression pattern...
  6. Cifuentes Diaz C, Velasco E, Meunier F, Goudou D, Belkadi L, Faille L, et al. The peripheral nerve and the neuromuscular junction are affected in the tenascin-C-deficient mouse. Cell Mol Biol (Noisy-le-grand). 1998;44:357-79 pubmed
    A thorough examination of the structure and plasticity of the neuromuscular system was performed in tenascin-C mutant mice deficient in tenascin-C. The study of the peripheral nerve revealed a number of abnormal features...
  7. Midwood K, Sacre S, Piccinini A, Inglis J, Trebaul A, Chan E, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med. 2009;15:774-80 pubmed publisher
    ..b>Tenascin-C (encoded by Tnc) is an extracellular matrix glycoprotein specifically expressed at areas of inflammation and ..
  8. Asparuhova M, Ferralli J, Chiquet M, Chiquet Ehrismann R. The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress. FASEB J. 2011;25:3477-88 pubmed publisher
    The extracellular matrix protein tenascin-C (TNC) is up-regulated in processes influenced by mechanical stress, such as inflammation, tissue remodeling, wound healing, and tumorigenesis...
  9. Nakahara H, Gabazza E, Fujimoto H, Nishii Y, D Alessandro Gabazza C, Bruno N, et al. Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse. Eur J Immunol. 2006;36:3334-45 pubmed
    b>Tenascin C (TN-C) is an extracellular matrix glycoprotein whose expression is increased in several inflammatory diseases of the lung, including bronchial asthma...

More Information


  1. Saga Y, Tsukamoto T, Jing N, Kusakabe M, Sakakura T. Murine tenascin: cDNA cloning, structure and temporal expression of isoforms. Gene. 1991;104:177-85 pubmed
    Mouse tenascin (TN)-encoding cDNA clones were isolated from a cDNA library of the 2H6GR mammary tumor cell line...
  2. Barry G, Piper M, Lindwall C, Moldrich R, Mason S, Little E, et al. Specific glial populations regulate hippocampal morphogenesis. J Neurosci. 2008;28:12328-40 pubmed publisher
    ..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis. ..
  3. Kazanis I, Belhadi A, Faissner A, Ffrench Constant C. The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C. J Neurosci. 2007;27:13991-6 pubmed
    ..b>Tenascin-C is a large extracellular matrix glycoprotein present in the SEZ that has been shown to regulate the development ..
  4. Yuasa S. Bergmann glial development in the mouse cerebellum as revealed by tenascin expression. Anat Embryol (Berl). 1996;194:223-34 pubmed
    b>Tenascin, an astroglia-derived extracellular matrix molecule, is also expressed by radial glia of the embryonic mouse cerebellum...
  5. Settles D, Cihak R, Erickson H. Tenascin-C expression in dystrophin-related muscular dystrophy. Muscle Nerve. 1996;19:147-54 pubmed
    ..We investigated whether regenerating mdx skeletal muscle contains the extracellular matrix protein tenascin-C (TN-C), which is expressed in wound healing and nerve regeneration...
  6. Copertino D, Edelman G, Jones F. Multiple promoter elements differentially regulate the expression of the mouse tenascin gene. Proc Natl Acad Sci U S A. 1997;94:1846-51 pubmed
    b>Tenascin (TN) is an extracellular matrix glycoprotein that is expressed in a characteristic spatiotemporal pattern during development and is up-regulated in the adult during tumorigenesis, wound healing, and nerve regeneration...
  7. Maier S, Lutz R, Gelman L, Sarasa Renedo A, Schenk S, Grashoff C, et al. Tenascin-C induction by cyclic strain requires integrin-linked kinase. Biochim Biophys Acta. 2008;1783:1150-62 pubmed publisher
    Induction of tenascin-C mRNA by cyclic strain in fibroblasts depends on RhoA and Rho dependent kinase (ROCK). Here we show that integrin-linked kinase (ILK) is required upstream of this pathway...
  8. Pacifici M. Tenascin-C and the development of articular cartilage. Matrix Biol. 1995;14:689-98 pubmed
    ..this minireview, we summarize recent studies from our laboratory suggesting that the extracellular matrix protein tenascin-C is involved in the genesis and function of articular chondrocytes...
  9. Matsuda A, Yoshiki A, Tagawa Y, Matsuda H, Kusakabe M. Corneal wound healing in tenascin knockout mouse. Invest Ophthalmol Vis Sci. 1999;40:1071-80 pubmed
    b>Tenascin (TN) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has also been reported that TN is expressed in the embryonic cornea and during corneal wound healing...
  10. Hiremath M, Dann P, Fischer J, Butterworth D, Boras Granic K, Hens J, et al. Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme. Development. 2012;139:4239-49 pubmed publisher
    ..Therefore, we conclude that a mesenchymal, canonical Wnt pathway mediates the PTHrP-dependent specification of the mammary mesenchyme...
  11. Mackie E, Tucker R. The tenascin-C knockout revisited. J Cell Sci. 1999;112 ( Pt 22):3847-53 pubmed
    In the past seven years, two groups have independently produced tenascin-C-knockout mice. These mice are born alive and, originally, were described as showing no abnormalities...
  12. Imanaka Yoshida K, Matsumoto K, Hara M, Sakakura T, Yoshida T. The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse. Differentiation. 2003;71:291-8 pubmed
    One of a family of extracellular matrix proteins, tenascin-C (TNC) is expressed in a spatiotemporally restricted pattern associated with tissue remodeling during embryonic development, wound healing, cancer invasion and tissue ..
  13. Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway J, Pryce B, et al. Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell. 2009;17:861-73 pubmed publisher
    ..This study establishes a mechanistic basis for tendon-skeleton regulatory interactions during musculoskeletal assembly and bone secondary patterning. ..
  14. Liu C, Aschbacher Smith L, Barthelery N, Dyment N, Butler D, Wylie C. Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon. Tissue Eng Part A. 2012;18:598-608 pubmed publisher
    ..We found that collagen I, fibromodulin, and tenomodulin were expressed throughout the tendon, whereas tenascin-C, biglycan, and cartilage oligomeric protein were concentrated in the insertion site during this period...
  15. Roth Kleiner M, Hirsch E, Schittny J. Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture. Am J Respir Cell Mol Biol. 2004;30:360-6 pubmed
    b>Tenascin-C (TNC) is a multidomain extracellular matrix protein that contributes to organogenesis and tumorgenesis...
  16. Brellier F, Hostettler K, Hotz H, Ozcakir C, Çöloğlu S, Togbe D, et al. Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator. FEBS Lett. 2011;585:913-20 pubmed publisher
    We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression...
  17. Forsberg E, Hirsch E, Frohlich L, Meyer M, Ekblom P, Aszodi A, et al. Skin wounds and severed nerves heal normally in mice lacking tenascin-C. Proc Natl Acad Sci U S A. 1996;93:6594-9 pubmed
    A large number of functions have been demonstrated for tenascin-C by antibody perturbation assays and in vitro cell culture experiments...
  18. Kimura T, Yoshimura K, Aoki H, Imanaka Yoshida K, Yoshida T, Ikeda Y, et al. Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process. Pathol Int. 2011;61:559-64 pubmed publisher
    ..Currently no biomarkers have been established to indicate the disease status of AAA. Tenascin-C (TN-C) is a matricellular protein that is synthesized under pathological conditions...
  19. Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S. Mice develop normally without tenascin. Genes Dev. 1992;6:1821-31 pubmed
    b>Tenascin, an extracellular matrix protein, is expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena...
  20. Carey W, Taylor G, Dean W, BRISTOW J. Tenascin-C deficiency attenuates TGF-ß-mediated fibrosis following murine lung injury. Am J Physiol Lung Cell Mol Physiol. 2010;299:L785-93 pubmed publisher
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein of unknown function that is highly expressed in adult lung parenchyma following acute lung injury (ALI)...
  21. Scherberich A, Tucker R, Samandari E, Brown Luedi M, Martin D, Chiquet Ehrismann R. Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development. J Cell Sci. 2004;117:571-81 pubmed
    We cloned and characterized a novel member of the tenascin family of extracellular matrix proteins--the murine orthologue of zebrafish tenascin-W. Full-length recombinant tenascin-W was expressed and purified from mammalian cell cultures...
  22. Dunbar M, Dann P, Robinson G, Hennighausen L, Zhang J, Wysolmerski J. Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development. 1999;126:3485-93 pubmed
    ..In addition, the expression of tenascin C, another marker of the mammary mesenchyme, is also dependent on PTHrP...
  23. El Karef A, Yoshida T, Gabazza E, Nishioka T, Inada H, Sakakura T, et al. Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice. J Pathol. 2007;211:86-94 pubmed
    b>Tenascin-C (TNC), an extracellular matrix glycoprotein, is upregulated in chronic liver disease...
  24. Levay A, Peacock J, Lu Y, Koch M, Hinton R, Kadler K, et al. Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. Circ Res. 2008;103:948-56 pubmed publisher
    ..Collectively, our studies have identified an in vivo requirement for scx during valvulogenesis and demonstrate its role in cell lineage differentiation and matrix distribution in remodeling valve structures. ..
  25. Valenti G, Quinn H, Heynen G, Lan L, Holland J, Vogel R, et al. Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors. Cancer Res. 2017;77:2134-2147 pubmed publisher
    ..Targeting CAFs with Hedgehog inhibitors may offer a novel therapeutic strategy against breast cancer. Cancer Res; 77(8); 2134-47. ©2017 AACR. ..
  26. Meier F, Giesert F, Delic S, Faus Kessler T, Matheus F, Simeone A, et al. FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum. PLoS ONE. 2014;9:e101124 pubmed publisher
    ..Altogether, our findings reveal the specific functions of the FGFR2-mediated signaling pathway in the generation and positioning of Bergmann glia cells during cerebellar development in the mouse. ..
  27. Xie K, Liu Y, Hao W, Walter S, Penke B, Hartmann T, et al. Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice. Neurobiol Aging. 2013;34:2389-98 pubmed publisher
    ..b>Tenascin-C (tnc) is an extracellular matrix protein that is upregulated in inflammation and induces further inflammatory ..
  28. Besser M, Jagatheaswaran M, Reinhard J, Schaffelke P, Faissner A. Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Müller glia by influencing growth factor responsiveness and the extracellular matrix compartment. Dev Biol. 2012;369:163-76 pubmed publisher
    ..This study focused on the functional analysis of the extracellular matrix (ECM) molecule Tenascin C (Tnc) in the retinal stem/progenitor cell environment...
  29. Thesleff I, Mackie E, Vainio S, Chiquet Ehrismann R. Changes in the distribution of tenascin during tooth development. Development. 1987;101:289-96 pubmed
    b>Tenascin is an extracellular matrix molecule that was earlier shown to be enriched in embryonic mesenchyme surrounding the budding epithelium in various organs including the tooth...
  30. Liu C, Breidenbach A, Aschbacher Smith L, Butler D, Wylie C. A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse. PLoS ONE. 2013;8:e65411 pubmed publisher
    ..These studies provide new insights into the role of Hh signaling during tendon development. ..
  31. Mettouchi A, Cabon F, Montreau N, Dejong V, Vernier P, Gherzi R, et al. The c-Jun-induced transformation process involves complex regulation of tenascin-C expression. Mol Cell Biol. 1997;17:3202-9 pubmed
    ..We identified c-Jun-upregulated cDNA clones homologous to the tenascin-C gene by differential screening of a cDNA library from REF...
  32. Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, et al. Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2010;298:H1072-8 pubmed publisher
    b>Tenascin-C (TN-C) is an extracellular matrix glycoprotein with high bioactivity. It is expressed at low levels in normal adult heart, but upregulated under pathological conditions, such as myocardial infarction (MI). Recently, we (Ref...
  33. Stamenkovic V, Stamenkovic S, Jaworski T, Gawlak M, Jovanović M, Jakovcevski I, et al. The extracellular matrix glycoprotein tenascin-C and matrix metalloproteinases modify cerebellar structural plasticity by exposure to an enriched environment. Brain Struct Funct. 2017;222:393-415 pubmed publisher
    The importance of the extracellular matrix (ECM) glycoprotein tenascin-C (TnC) and the ECM degrading enzymes, matrix metalloproteinases (MMPs) -2 and -9, in cerebellar histogenesis is well established...
  34. Pilz A, Fountain J, Peters J, Abbott C. Linkage mapping of the Aldo-2, Pax-5, Ambp, and D4h9S3E loci on mouse chromosome 4 in the region of homology with human chromosome 9. Genomics. 1993;18:705-8 pubmed
    ..DNAs had previously been typed for delta-amino levulinate dehydratase (Lv), orosomucoid-1 (Orm-1), and hexabrachion (Hxb), the human homologues of which map to HSA9q...
  35. Shinohara Y, Okamoto K, Goh Y, Kiga N, Tojyo I, Fujita S. Inhibition of fibrous adhesion formation in the temporomandibular joint of tenascin-C knockout mice. Eur J Histochem. 2014;58:2337 pubmed publisher
    b>Tenascin-C (TNC) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors...
  36. Decker R, Um H, Dyment N, Cottingham N, Usami Y, Enomoto Iwamoto M, et al. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Dev Biol. 2017;426:56-68 pubmed publisher
    ..Synovial Prg4+ lineage progenitors are exquisitely responsive to acute injury and may represent pioneers in joint tissue repair. ..
  37. Cui S, Schwartz L, Quaggin S. Pod1 is required in stromal cells for glomerulogenesis. Dev Dyn. 2003;226:512-22 pubmed
    ..Most strikingly, the glomerulogenesis defect was rescued by the presence of wild-type stromal cells, suggesting a non-cell autonomous role for Pod1 in this cell population. ..
  38. Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, et al. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 2005;280:19185-95 pubmed
  39. Stepp M. Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids. Dev Dyn. 1999;214:216-28 pubmed
    ..The presence of tenascin-C and laminin-5 at the epithelial junction site suggests that alpha9: tenascin-C and beta4: laminin-5 ..
  40. Valenzuela D, Stitt T, DiStefano P, Rojas E, Mattsson K, Compton D, et al. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury. Neuron. 1995;15:573-84 pubmed
    ..Identification of MuSK introduces a novel receptor-factor system that seems sure to play an important and selective role in many aspects of skeletal muscle development and function. ..
  41. Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, et al. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem. 2010;285:2028-39 pubmed publisher
    ..Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture of the ECM...
  42. Irintchev A, Rollenhagen A, Troncoso E, Kiss J, Schachner M. Structural and functional aberrations in the cerebral cortex of tenascin-C deficient mice. Cereb Cortex. 2005;15:950-62 pubmed
    The extracellular matrix glycoprotein tenascin-C (TNC) has been implicated in neural development and plasticity but many of its functions in vivo remain obscure...
  43. Fleming J, Rogers M, Brown S, Steel K. Linkage analysis of the whirler deafness gene on mouse chromosome 4. Genomics. 1994;21:42-8 pubmed
    ..has positioned the wi locus in the interval between the genes for delta-aminolevulinate dehydratase (Lv) and hexabrachion (Hxb). The human homologues of these genes, ALAD and HXB, both lie on human chromosome 9q32-q34...
  44. Ueta C, Iwamoto M, Kanatani N, Yoshida C, Liu Y, Enomoto Iwamoto M, et al. Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol. 2001;153:87-100 pubmed
    ..These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis, including formation of joints, permanent cartilages, and endochondral bones. ..
  45. Makarenkova H, Sugiura H, Yamagata K, Owens G. Alternatively spliced variants of protocadherin 8 exhibit distinct patterns of expression during mouse development. Biochim Biophys Acta. 2005;1681:150-6 pubmed
    ..The differential expression of two alternative cytoplasmic domain variants suggests that Pcdh8 may regulate cell adhesion in a variety of developmental processes, and that this may involve different intracellular interactions. ..
  46. Butterfield N, Qian C, Logan M. Pitx1 determines characteristic hindlimb morphologies in cartilage micromass culture. PLoS ONE. 2017;12:e0180453 pubmed publisher
    ..Our results demonstrate that the micromass culture system is ideally suited to study cues governing morphogenesis of limb skeletal elements in a simple and experimentally tractable in vitro system that reflects in vivo potential. ..
  47. Ellis S, Heazlewood S, Williams B, Reitsma A, Grassinger J, Borg J, et al. The role of Tenascin C in the lymphoid progenitor cell niche. Exp Hematol. 2013;41:1050-61 pubmed publisher
    ..Mice devoid of the extracellular matrix molecule Tenascin-C (TNC) were reported to develop normally...
  48. Piper M, Moldrich R, Lindwall C, Little E, Barry G, Mason S, et al. Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice. Neural Dev. 2009;4:43 pubmed publisher
  49. Fukushi J, Inatani M, Yamaguchi Y, Stallcup W. Expression of NG2 proteoglycan during endochondral and intramembranous ossification. Dev Dyn. 2003;228:143-8 pubmed
    ..chondrocytes, NG2 was up-regulated during primary ossification, colocalizing with alkaline phosphatase and tenascin C. In the epiphyseal growth plates of newborn mouse tibia, NG2 and alkaline phosphatase exhibited overlapping ..
  50. Zhu X, Yuan X, Wang M, Fang Y, Liu Y, Zhang X, et al. A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development. J Biol Chem. 2017;292:9409-9419 pubmed publisher
  51. Tanaka K, Hiraiwa N, Hashimoto H, Yamazaki Y, Kusakabe M. Tenascin-C regulates angiogenesis in tumor through the regulation of vascular endothelial growth factor expression. Int J Cancer. 2004;108:31-40 pubmed
    In order to verify whether tenascin-C (TN-C) is involved in angiogenesis as an extracellular signal molecule during tumorigenesis, cancerous cell transplantation experiments and coculture experiments were carried out, focusing on the ..
  52. Zhou X, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, et al. Neurocan is dispensable for brain development. Mol Cell Biol. 2001;21:5970-8 pubmed
    ..These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain. ..
  53. Fantauzzo K, Christiano A. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development. 2012;139:203-14 pubmed publisher
    ..Our findings identify Trps1 as a novel regulator of the Wnt signaling pathway and of early hair follicle progenitors in the developing vibrissa follicle. ..