tenascin C

Summary

Gene Symbol: tenascin C
Description: tenascin C
Alias: AI528729, C130033P17Rik, Hxb, TN-C, Ten, cytotactin, tenascin-C, hexabrachion, tenascin
Species: mouse

Top Publications

  1. ncbi Migration of dopaminergic neurons in the embryonic mesencephalon of mice
    H Kawano
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    Brain Res Dev Brain Res 86:101-13. 1995
  2. ncbi Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study
    I Kalembey
    Second Department of Surgery, Mie University School of Medicine, Tsu, Japan
    Int J Dev Biol 41:569-73. 1997
  3. pmc Dystrophic muscle in mice chimeric for expression of alpha5 integrin
    D Taverna
    Howard Hughes Medical Institute and Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Biol 143:849-59. 1998
  4. ncbi Pax6 controls radial glia differentiation in the cerebral cortex
    M Gotz
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Federal Republic of Germany
    Neuron 21:1031-44. 1998
  5. ncbi Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration
    E Garcion
    Department of Medical Genetics and Cambridge Center for Brain Repair, University of Cambridge, UK
    Development 128:2485-96. 2001
  6. ncbi Mice develop normally without tenascin
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genes Dev 6:1821-31. 1992
  7. ncbi Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development
    A Scherberich
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Cell Sci 117:571-81. 2004
  8. pmc Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions
    E Aufderheide
    Friederich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:2341-9. 1988
  9. ncbi The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C
    Ilias Kazanis
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    J Neurosci 27:13991-6. 2007
  10. ncbi Tenascin-C expression in dystrophin-related muscular dystrophy
    D L Settles
    Department of Cell Biology, Duke University, Durham, North Carolina 27710, USA
    Muscle Nerve 19:147-54. 1996

Research Grants

Scientific Experts

Detail Information

Publications98

  1. ncbi Migration of dopaminergic neurons in the embryonic mesencephalon of mice
    H Kawano
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    Brain Res Dev Brain Res 86:101-13. 1995
    ..The expression of tenascin was transiently seen on radial glial processes between E10 and E13 coincident with the period of the ventral ..
  2. ncbi Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study
    I Kalembey
    Second Department of Surgery, Mie University School of Medicine, Tsu, Japan
    Int J Dev Biol 41:569-73. 1997
    The expression of tenascin gene during murine mammary gland development was analyzed by in situ hybridization with non-radioactive cRNA probes. The aim was to identify whether cells that synthesize tenascin are mesenchymal or epithelial...
  3. pmc Dystrophic muscle in mice chimeric for expression of alpha5 integrin
    D Taverna
    Howard Hughes Medical Institute and Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Biol 143:849-59. 1998
    ..Increased apoptosis and immunoreactivity for tenascin-C were observed in mutant muscle fibers. All the alterations were already visible at late stages of embryogenesis...
  4. ncbi Pax6 controls radial glia differentiation in the cerebral cortex
    M Gotz
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Federal Republic of Germany
    Neuron 21:1031-44. 1998
    ..In Pax6-deficient mice, cortical radial glia cells were altered in their morphology, number, tenascin-C (TN-C) expression, and cell cycle...
  5. ncbi Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration
    E Garcion
    Department of Medical Genetics and Cambridge Center for Brain Repair, University of Cambridge, UK
    Development 128:2485-96. 2001
    The extracellular matrix glycoprotein tenascin-C is widely expressed in the vertebrate central nervous system (CNS) during development and repair...
  6. ncbi Mice develop normally without tenascin
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genes Dev 6:1821-31. 1992
    b>Tenascin, an extracellular matrix protein, is expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena...
  7. ncbi Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development
    A Scherberich
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Cell Sci 117:571-81. 2004
    We cloned and characterized a novel member of the tenascin family of extracellular matrix proteins--the murine orthologue of zebrafish tenascin-W. Full-length recombinant tenascin-W was expressed and purified from mammalian cell cultures...
  8. pmc Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions
    E Aufderheide
    Friederich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:2341-9. 1988
    b>Tenascin, an extracellular matrix protein, is expressed in the mesenchyme around growing epithelia in the embryo. We therefore investigated whether epithelial cells can stimulate expression of tenascin in embryonic mesenchyme...
  9. ncbi The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C
    Ilias Kazanis
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    J Neurosci 27:13991-6. 2007
    ..b>Tenascin-C is a large extracellular matrix glycoprotein present in the SEZ that has been shown to regulate the development ..
  10. ncbi Tenascin-C expression in dystrophin-related muscular dystrophy
    D L Settles
    Department of Cell Biology, Duke University, Durham, North Carolina 27710, USA
    Muscle Nerve 19:147-54. 1996
    ..We investigated whether regenerating mdx skeletal muscle contains the extracellular matrix protein tenascin-C (TN-C), which is expressed in wound healing and nerve regeneration...
  11. ncbi The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse
    Kyoko Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507 Japan
    Differentiation 71:291-8. 2003
    One of a family of extracellular matrix proteins, tenascin-C (TNC) is expressed in a spatiotemporally restricted pattern associated with tissue remodeling during embryonic development, wound healing, cancer invasion and tissue ..
  12. pmc Skin wounds and severed nerves heal normally in mice lacking tenascin-C
    E Forsberg
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Proc Natl Acad Sci U S A 93:6594-9. 1996
    A large number of functions have been demonstrated for tenascin-C by antibody perturbation assays and in vitro cell culture experiments...
  13. ncbi Tenascin-C and the development of articular cartilage
    M Pacifici
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, USA
    Matrix Biol 14:689-98. 1995
    ..this minireview, we summarize recent studies from our laboratory suggesting that the extracellular matrix protein tenascin-C is involved in the genesis and function of articular chondrocytes...
  14. ncbi Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture
    Matthias Roth-Kleiner
    Institute of Anatomy, University of Bern, Buehlstrasse 26, CH 3000 Bern 9, Switzerland
    Am J Respir Cell Mol Biol 30:360-6. 2004
    b>Tenascin-C (TNC) is a multidomain extracellular matrix protein that contributes to organogenesis and tumorgenesis...
  15. ncbi Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice
    A El-Karef
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan
    J Pathol 211:86-94. 2007
    b>Tenascin-C (TNC), an extracellular matrix glycoprotein, is upregulated in chronic liver disease...
  16. ncbi Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse
    Hiroki Nakahara
    Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu City, Japan
    Eur J Immunol 36:3334-45. 2006
    b>Tenascin C (TN-C) is an extracellular matrix glycoprotein whose expression is increased in several inflammatory diseases of the lung, including bronchial asthma...
  17. ncbi Murine tenascin: cDNA cloning, structure and temporal expression of isoforms
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Ibaraki, Japan
    Gene 104:177-85. 1991
    Mouse tenascin (TN)-encoding cDNA clones were isolated from a cDNA library of the 2H6GR mammary tumor cell line...
  18. ncbi Alternatively spliced variants of protocadherin 8 exhibit distinct patterns of expression during mouse development
    Helen Makarenkova
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Biochim Biophys Acta 1681:150-6. 2005
    ..The differential expression of two alternative cytoplasmic domain variants suggests that Pcdh8 may regulate cell adhesion in a variety of developmental processes, and that this may involve different intracellular interactions...
  19. ncbi Upregulation of alpha 9 integrin and tenascin during epithelial regeneration after debridement in the cornea
    M A Stepp
    Department of Anatomy, George Washington University Medical Center, Washington, DC 20037, USA
    J Histochem Cytochem 45:189-201. 1997
    ..9 beta b1 is one of the newer members of the integrin beta family and has been recently shown to function as a tenascin receptor...
  20. ncbi Expression of the integrin subunit alpha 9 in the murine embryo
    A Wang
    Lung Biology Center, San Francisco General Hospital, University of California 94143, USA
    Dev Dyn 204:421-31. 1995
    ..far, only a single alpha 9-containing integrin has been identified (alpha 9 beta 1) and only a single ligand (tenascin) has been found for this integrin...
  21. pmc Multiple promoter elements differentially regulate the expression of the mouse tenascin gene
    D W Copertino
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 94:1846-51. 1997
    b>Tenascin (TN) is an extracellular matrix glycoprotein that is expressed in a characteristic spatiotemporal pattern during development and is up-regulated in the adult during tumorigenesis, wound healing, and nerve regeneration...
  22. doi Tenascin-C induction by cyclic strain requires integrin-linked kinase
    Silke Maier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, CH 4058 Basel, Switzerland
    Biochim Biophys Acta 1783:1150-62. 2008
    Induction of tenascin-C mRNA by cyclic strain in fibroblasts depends on RhoA and Rho dependent kinase (ROCK). Here we show that integrin-linked kinase (ILK) is required upstream of this pathway...
  23. doi Specific glial populations regulate hippocampal morphogenesis
    Guy Barry
    The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
    J Neurosci 28:12328-40. 2008
    ..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
  24. ncbi Neural stem/progenitor cells express 20 tenascin C isoforms that are differentially regulated by Pax6
    Alexander von Holst
    Department of Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, D 44780 Bochum, Germany
    J Biol Chem 282:9172-81. 2007
    b>Tenascin C (Tnc) is an alternatively spliced, multimodular extracellular matrix glycoprotein present in the ventricular zone of the developing brain. Pax6-deficient small eye (sey) mouse mutants show an altered Tnc expression pattern...
  25. ncbi Corneal wound healing in tenascin knockout mouse
    A Matsuda
    Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 40:1071-80. 1999
    b>Tenascin (TN) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has also been reported that TN is expressed in the embryonic cornea and during corneal wound healing...
  26. ncbi Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1
    Ilunga Kalembeyi
    Department of Pathology, Mie University School of Medicine, Tsu, Mie, Japan
    Int J Cancer 105:53-60. 2003
    b>Tenascin-C (TN-C) and matrix metalloproteinases (MMPs) are highly expressed in cancer tissues and probably promote cell migration during cancer progression...
  27. doi Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation
    Maren Geissler
    Department of Cell Morphology and Molecular Neurobiology, Ruhr University, D 44780 Bochum, Germany
    J Neurosci 33:7742-55. 2013
    ..studied a mouse mutant that lacks four ECM components highly enriched in the developing brain: the glycoproteins tenascin-C and tenascin-R and the chondroitin sulfate proteoglycans brevican and neurocan...
  28. doi Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
    Khalil Kass Youssef
    IRIBHM, Universite Libre de Bruxelles ULB, 808 Route de Lennik, 1070 Brussels, Belgium
    Nat Cell Biol 14:1282-94. 2012
    ..Deletion of β-catenin in adult SmoM2-expressing cells prevents EHFP reprogramming and tumour initiation. Finally, human basal cell carcinomas also express genes of the Wnt signalling and EHFP signatures...
  29. pmc Deletion of tenascin-C gene exacerbates atherosclerosis and induces intraplaque hemorrhage in Apo-E-deficient mice
    Lai Wang
    Oppenheimer Atherosclerosis Research Center and the Division of Cardiology, Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA
    Cardiovasc Pathol 21:398-413. 2012
    b>Tenascin-C (TNC), a matricellular protein, is up-regulated in atherosclerotic plaques. We investigated whether the deletion of TNC gene affects the development of atherosclerosis in a murine model.
  30. pmc Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis
    Rocca d'Amaro
    Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Bern Bern, Switzerland
    Front Physiol 3:377. 2012
    ..In addition, we observed that tenascin-W (but not tenascin-C) was misexpressed in palatal shelves of Bmp7-deficient mouse embryos...
  31. doi Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow
    Dorothy E Pazin
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    Dev Dyn 241:1816-26. 2012
    ..Here, we use microarray analysis to compare knee and elbow formation to identify factors involved in the development of specific joints...
  32. pmc Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses
    Julianne Huegel
    Division of Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Dev Biol 377:100-12. 2013
    ..Alterations in these mechanisms may contribute to exostosis formation in HME, particularly at the expense of regions rich in progenitor cells including the groove of Ranvier...
  33. doi Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process
    Taizo Kimura
    Department of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine, Kurume, Japan
    Pathol Int 61:559-64. 2011
    ..Currently no biomarkers have been established to indicate the disease status of AAA. Tenascin-C (TN-C) is a matricellular protein that is synthesized under pathological conditions...
  34. pmc Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme
    Minoti Hiremath
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Development 139:4239-49. 2012
    ..Therefore, we conclude that a mesenchymal, canonical Wnt pathway mediates the PTHrP-dependent specification of the mammary mesenchyme...
  35. ncbi Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system
    Alice Klausmeyer
    Department of Cellmorphology and Molecular Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany
    J Comp Neurol 504:659-79. 2007
    ..In situ hybridization experiments support the conclusion that at least one of the phosphacan/RPTPbeta isoforms in the retina is expressed by neurons...
  36. ncbi Vascular tenascin-C regulates cardiac endothelial phenotype and neovascularization
    Victoria L T Ballard
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    FASEB J 20:717-9. 2006
    ..pathways, in vivo bone marrow/cardiac phage display biopanning was performed and led to the identification of tenascin-C as a candidate protein...
  37. ncbi Relevance of tenascin-C and matrix metalloproteinases in vascular abnormalities in murine hypoplastic lungs
    Mala R Chinoy
    Lung Development Research Program, Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biol Neonate 90:185-96. 2006
    b>Tenascin-C (TN-C), an extracellular matrix glycoprotein, is crucial to cell-migration, proliferation, apoptosis and remodeling of tissues, with a potential role in pathobiology of pulmonary hypertension...
  38. ncbi Extracellular matrix alterations in brains lacking four of its components
    Uwe Rauch
    Department of Experimental Pathology, University Hospital, Lunds University, Lund, Sweden
    Biochem Biophys Res Commun 328:608-17. 2005
    ..were reported from several mouse strains lacking components of this matrix such as neurocan, brevican, tenascin-R, and tenascin-C...
  39. pmc Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis
    Masahiro Iwamoto
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Dev Biol 305:40-51. 2007
    ..composed of chondrocytes actively expressing collagen IX and aggrecan as well as articular markers such as tenascin-C...
  40. pmc Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4
    Kim S Midwood
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Biol Cell 15:5670-7. 2004
    ..b>Tenascin-C is an extracellular matrix protein that regulates cell response to fibronectin within the provisional matrix...
  41. pmc Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo
    Agata K Levay
    Department of Molecular and Cellular Pharmacology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Circ Res 103:948-56. 2008
    ..Collectively, our studies have identified an in vivo requirement for scx during valvulogenesis and demonstrate its role in cell lineage differentiation and matrix distribution in remodeling valve structures...
  42. pmc VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
    ..with a concomitant decrease in the expression of several ECM molecules and growth factors, particularly Tenascin-C and VEGF-A...
  43. doi The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress
    Maria B Asparuhova
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    FASEB J 25:3477-88. 2011
    The extracellular matrix protein tenascin-C (TNC) is up-regulated in processes influenced by mechanical stress, such as inflammation, tissue remodeling, wound healing, and tumorigenesis...
  44. pmc The basement membrane of hair follicle stem cells is a muscle cell niche
    Hironobu Fujiwara
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, UK
    Cell 144:577-89. 2011
    ..Thus, bulge stem cells, via nephronectin expression, create a smooth muscle cell niche and act as tendon cells for the APM. Our results reveal a functional role for basement membrane heterogeneity in tissue patterning. PAPERCLIP:..
  45. pmc Glypican-1, phosphacan/receptor protein-tyrosine phosphatase-ζ/β and its ligand, tenascin-C, are expressed by neural stem cells and neural cells derived from embryonic stem cells
    Mary Abaskharoun
    Department of Pharmacology, New York University Medical Center, 550 First Avenue, New York, NY 10016, U S A
    ASN Neuro 2:e00039. 2010
    ..phosphacan/RPTP (receptor protein-tyrosine phosphatase)-zeta/beta and the extracellular matrix protein tenascin-C were all found to be expressed by neural stem cells and by neural cells derived from them...
  46. pmc The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration
    Jian Chen
    W M Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers The State University of New Jersey, Piscataway, New Jersey, USA
    Mol Ther 18:1769-77. 2010
    b>Tenascin-C (TNC), a major component of the extracellular matrix, is strongly upregulated after injuries of the central nervous system (CNS) but its role in tissue repair is not understood...
  47. pmc The Mohawk homeobox gene is a critical regulator of tendon differentiation
    Yoshiaki Ito
    Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    Proc Natl Acad Sci U S A 107:10538-42. 2010
    ..These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells...
  48. pmc Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice
    Michael Piper
    Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
    Neural Dev 4:43. 2009
    ..Therefore, we investigate here how Nfib functions to regulate non-cell-autonomous mechanisms of callosal formation...
  49. doi Beta1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells
    Marie A Breau
    UMR144, CNRS Institut Curie, Paris Cedex 05, France
    Development 136:2791-801. 2009
    ..We found that the caecum and proximal hindgut express high levels of fibronectin and tenascin-C, two well-known ligands of integrins...
  50. pmc Defective pulmonary vascular remodeling in Smad8 mutant mice
    Zheng Huang
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 18:2791-801. 2009
    ..pulmonary vasculature had upregulated Activin/Tgfbeta signaling and pathologic remodeling with aberrant Prx1 and Tenascin-C expression...
  51. doi Tenascin-C stimulates contactin-dependent neurite outgrowth via activation of phospholipase C
    Melanie Michele
    Department of Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, Building ND 05 593, Universitatsstrabetae 150, D 44801 Bochum, Germany
    Mol Cell Neurosci 41:397-408. 2009
    b>Tenascin-C (Tnc) is transiently expressed during neural development...
  52. ncbi Role of fibrillar Tenascin-C in metastatic pancreatic cancer
    Jian Chen
    Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, P R China
    Int J Oncol 34:1029-36. 2009
    ..In the tumor, upregulation of Tenascin-C (Tn-C) expression potentially can alter tumor behavior...
  53. doi Implantation of dedifferentiated fat cells ameliorates habu snake venom-induced chronic renal dysfunction in tenascin-C-deficient mice
    Renaguli Nur
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Nihon University, Tokyo, Japan
    Nephron Exp Nephrol 110:e91-8. 2008
    ..In this study, we evaluated the effect of implantation of DFAT cells on habu snake venom (HSV)-induced renal dysfunction in tenascin-C knockout (TC-KO) mice.
  54. doi Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation
    Kenichiro Ishii
    Department of Nephro Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Dev Biol 324:310-9. 2008
    ..Expression of tenascin-C (TN-C), an extracellular matrix (ECM) glycoprotein, is reportedly higher in BPH and PCa as compared with normal ..
  55. pmc SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
    Nesrine El-Bizri
    Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
    Development 135:2981-91. 2008
    ..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
  56. ncbi Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5
    L M Moscoso
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 18:1465-77. 1998
    ..membrane-associated adhesion molecule, neural cell adhesion molecule (N-CAM), an extracellular matrix component, tenascin-C, and a soluble growth factor, fibroblast growth factor-5 (FGF-5)...
  57. ncbi A single cysteine, Cys-64, is essential for assembly of tenascin-C hexabrachions
    J A Luczak
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    J Biol Chem 273:2073-7. 1998
    ..It is secreted from cells as a hexamer of six identical chains called a hexabrachion. Disulfide bonding among tenascin subunits mediates intracellular assembly into hexamers...
  58. pmc The c-Jun-induced transformation process involves complex regulation of tenascin-C expression
    A Mettouchi
    Institut de Recherche sur le Cancer, CNRS UPR9079, Villejuif, France
    Mol Cell Biol 17:3202-9. 1997
    ..We identified c-Jun-upregulated cDNA clones homologous to the tenascin-C gene by differential screening of a cDNA library from REF...
  59. pmc Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis
    A Baumeister
    Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
    J Cell Biol 139:1231-42. 1997
    ....
  60. ncbi Characterization of monoclonal antibodies against tenascin-C: no apparent effect on kidney development in vitro
    J F Talts
    Department of Animal Physiology, Uppsala University, Sweden
    Int J Dev Biol 41:39-48. 1997
    b>Tenascin-C is an extracellular matrix glycoprotein found in embryonic mesenchyme. The precise biological function of tenascin-C is unknown, but different parts of the molecule have effects on cell adhesion and other cellular activities...
  61. ncbi Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury
    D M Valenzuela
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Neuron 15:573-84. 1995
    ..Identification of MuSK introduces a novel receptor-factor system that seems sure to play an important and selective role in many aspects of skeletal muscle development and function...
  62. ncbi Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice
    R Fassler
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Exp Cell Res 222:111-6. 1996
    Expression and distribution of fibulins, nidogen, and tenascin-C were analyzed in healing skin wounds of normal and dexamethasone-treated mice...
  63. ncbi Linkage analysis of the whirler deafness gene on mouse chromosome 4
    J Fleming
    MRC Institute of Hearing Research, Nottingham, United Kingdom
    Genomics 21:42-8. 1994
    ..has positioned the wi locus in the interval between the genes for delta-aminolevulinate dehydratase (Lv) and hexabrachion (Hxb). The human homologues of these genes, ALAD and HXB, both lie on human chromosome 9q32-q34...
  64. ncbi Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions
    H P Erickson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710
    Curr Opin Cell Biol 5:869-76. 1993
    Mice develop normally without tenascin", was a shock to biologists studying the extracellular matrix. Could tenascin be a useless protein? This seems most improbable, as it is conserved in every vertebrate species...
  65. ncbi Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments
    P L Jones
    Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    J Cell Sci 108:519-27. 1995
    The physiological role of tenascin in vivo has remained obscure. Although tenascin is regulated in a stage and tissue-dependent manner, knock-out mice appear normal...
  66. pmc The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C
    K Matsumoto
    Friedrich Miescher Institute, Basel, Switzerland
    J Cell Biol 125:483-93. 1994
    We have isolated a cDNA encoding mouse tenascin-X (TN-X), a new member of the family of tenascin genes. The TN-X gene lies in the major histocompatibility complex (MHC) class III region, as it is the case for its human counterpart...
  67. ncbi In situ localization of tenascin mRNA in developing mouse teeth
    R P Tucker
    Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157
    Arch Oral Biol 38:1025-9. 1993
    b>Tenascin is a large extracellular-matrix glycoprotein found in developing connective tissue...
  68. ncbi A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
    K T Nguyen Ba-Charvet
    Institut Alfred Fessard, CNRS UPR 2212, Avenue de la Terrasse, France
    Development 125:4273-82. 1998
    ..Among the molecules upregulated with increasing levels of OTX2 are NCAM, tenascin-C and DSD-1-PG, which also in situ colocalize with zones of OTX2 expression at boundaries...
  69. ncbi Tenascin-C in developing mouse teeth: expression of splice variants and stimulation by TGFbeta and FGF
    C Sahlberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Eur J Oral Sci 109:114-24. 2001
    b>Tenascin-C is a protein of the extracellular matrix which has been suggested to regulate organogenesis. We have analysed the expression of tenascin-C mRNA during mouse tooth development...
  70. pmc Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes
    C Ueta
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biol 153:87-100. 2001
    ..These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis, including formation of joints, permanent cartilages, and endochondral bones...
  71. ncbi Tenascin glycoproteins in developing neural tissues: only decoration?
    A Faissner
    Department of Neurobiology, University of Heidelberg, Germany
    Perspect Dev Neurobiol 2:53-66. 1994
    b>Tenascin glycoproteins constitute a growing family of extracellular matrix molecules that are transiently expressed by astrocytes during the development of the central nervous system (CNS)...
  72. ncbi Pod1 is required in stromal cells for glomerulogenesis
    Shiying Cui
    The Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 226:512-22. 2003
    ..Most strikingly, the glomerulogenesis defect was rescued by the presence of wild-type stromal cells, suggesting a non-cell autonomous role for Pod1 in this cell population...
  73. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
    ..These data demonstrate a variety of new functions for WT1 and suggest a general requirement for this protein in the formation of organs derived from the intermediate mesoderm...
  74. pmc Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
    Gamze Kilic
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 235:1659-67. 2006
    ..Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses...
  75. pmc Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury
    Masashi Tamaoki
    Department of Pathology and Biology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Am J Pathol 167:71-80. 2005
    b>Tenascin-C (TN-C) is an extracellular matrix molecule that is expressed during wound healing in various tissues. Although not detectable in the normal adult heart, it is expressed under pathological conditions...
  76. ncbi Tenascin variants: ligands and expression
    U Hofer
    Friedrich Miescher Institute, Basel, Switzerland
    Prog Clin Biol Res 383:455-64. 1993
  77. ncbi Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice
    Eva Sykova
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Eur J Neurosci 22:1873-80. 2005
    b>Tenascin-R (TN-R), a large extracellular glycoprotein, is an important component of the adult brain's extracellular matrix (ECM); tenascin-C (TN-C) is expressed mainly during early development, while human natural killer 1 (HNK-1) is a ..
  78. ncbi Linkage mapping of the Aldo-2, Pax-5, Ambp, and D4h9S3E loci on mouse chromosome 4 in the region of homology with human chromosome 9
    A Pilz
    Department of Genetics and Biometry, University College London, United Kingdom
    Genomics 18:705-8. 1993
    ..DNAs had previously been typed for delta-amino levulinate dehydratase (Lv), orosomucoid-1 (Orm-1), and hexabrachion (Hxb), the human homologues of which map to HSA9q...
  79. ncbi Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair
    Orlando Guntinas-Lichius
    Department of Oto Rhino Laryngology, University of Cologne, D 50924 Cologne, Germany
    Eur J Neurosci 22:2171-9. 2005
    The glycoproteins tenascin-C (TNC) and tenascin-R (TNR) are extracellular matrix proteins involved in the development, plasticity and repair of the nervous system...
  80. ncbi Molecular mechanisms of cell and tissue interactions during early tooth development
    I Thesleff
    Institute of Dentistry, University of Helsinki, Finland
    Anat Rec 245:151-61. 1996
    ..The developing tooth is one of the organs in which the molecular mechanisms of such interactions are starting to be elucidated...
  81. ncbi Tenascin-X expression in tumor cells and fibroblasts: glucocorticoids as negative regulators in fibroblasts
    T Sakai
    Division of Hemopoiesis, Jichi Medical School, Tochigi, Japan
    J Cell Sci 109:2069-77. 1996
    b>Tenascin-X has recently been shown to be a novel member of the tenascin family and its distribution is often reciprocal to that of tenascin-C in the developing mouse embryo...
  82. ncbi Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice
    B Ringelmann
    Institute for Experimental Medicine, University of Erlangen Nürnburg, Schwabachanlage 10, Erlangen, Germany
    Exp Cell Res 246:165-82. 1999
    ..patterns of laminin alpha1, alpha2, alpha4, and alpha5 chains, the interstitial proteins fibronectin and tenascin-C, and the adhesion molecules VCAM-1, ICAM-1, and alpha4 integrin were characterized in skeletal muscle of 1- and ..
  83. doi An induction gene trap screen in neural stem cells reveals an instructive function of the niche and identifies the splicing regulator sam68 as a tenascin-C-regulated target gene
    Sören Moritz
    Department for Cell Morphology and Molecular Neurobiology, NDEF 05 339, Universitaetsstrasse 150, D 44780 Bochum, Germany
    Stem Cells 26:2321-31. 2008
    ..The ECM glycoprotein tenascin-C (Tnc) that occurs in more than 25 isoforms represents a major constituent of the privileged NSC milieu...
  84. pmc Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling
    Anand Krishnan V Iyer
    Department of Pathology, University of Pittsburgh, Pittsburgh, Penssylvania 15261, USA
    J Cell Physiol 214:504-12. 2008
    The 14th EGFL-repeat (Ten14) of human tenascin cytotactin activates the epidermal growth factor receptor (EGFR) with micromolar affinity; however, unlike EGF, Ten14-mediated activation of EGFR does not lead to receptor internalization...
  85. ncbi Integrin expression during epithelial migration and restratification in the tenascin-C-deficient mouse cornea
    D D Sta Iglesia
    Department of Anatomy, The George Washington University Medical Center, Washington, DC, USA
    J Histochem Cytochem 48:363-76. 2000
    In the unwounded cornea, tenascin-C localizes to a short stretch of the basement membrane zone at the corneoscleral junction or limbus...
  86. ncbi Paradoxical behavioral response to apomorphine in tenascin-gene knockout mouse
    F Fukamauchi
    Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Eur J Pharmacol 338:7-10. 1997
    b>Tenascin is a large extracellular matrix glycoprotein which is highly expressed in the developing nervous system. To examine the role of tenascin in vivo, we have produced mice in which the tenascin-gene is inactivated...
  87. pmc Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling
    Masaki Ieda
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
    Dev Cell 16:233-44. 2009
    ..These findings reveal a previously unrecognized paracrine function of embryonic cardiac fibroblasts in regulating cardiomyocyte proliferation...
  88. ncbi Paired-related homeobox gene Prx1 is required for pulmonary vascular development
    Kaori Ihida-Stansbury
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Circ Res 94:1507-14. 2004
    ..To understand how Prx1 participates in network formation, we focused on tenascin-C (TN-C), an extracellular matrix (ECM) protein induced by Prx1...
  89. ncbi Spatial and temporal expression of the beta1D integrin during mouse development
    A van Der Flier
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam
    Dev Dyn 210:472-86. 1997
    ..We suggest that beta1D plays a role in the maintenance of the cytoarchitecture of mature muscle and in the functional integrity of the muscle cells...
  90. doi Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity
    George A Wilkinson
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Munich Martinsried, Germany
    Dev Dyn 237:2220-34. 2008
    ..Postnatal day 1 mutant lungs show extracellular matrix alterations without differences in proportions of major distal cell populations. We conclude that lung alveolar formation relies on endothelial ephrinB2 function...
  91. ncbi Structural and functional aberrations in the cerebral cortex of tenascin-C deficient mice
    Andrey Irintchev
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    Cereb Cortex 15:950-62. 2005
    The extracellular matrix glycoprotein tenascin-C (TNC) has been implicated in neural development and plasticity but many of its functions in vivo remain obscure...
  92. pmc Structural and functional similarities between the promoters for mouse tenascin and chicken cytotactin
    D W Copertino
    Scripps Research Institute, Department of Neurobiology, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 92:2131-5. 1995
    b>Cytotactin/tenascin is an extracellular matrix glycoprotein expressed in a restricted anteroposterior pattern during vertebrate development and is reexpressed in the adult during wound healing, tumorigenesis, and nerve regeneration...
  93. ncbi Tenascin-C in the cochlea of the developing mouse
    D S Whitlon
    Audiology and Hearing Sciences Program and Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA
    J Comp Neurol 406:361-74. 1999
    b>Tenascin-C is a glycoprotein of the extracellular matrix that acts in vitro as both a permissive and a nonpermissive substrate for neurite growth...
  94. ncbi Impairment of L-type Ca2+ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C
    Matthias R Evers
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    J Neurosci 22:7177-94. 2002
    The extracellular matrix glycoprotein tenascin-C (TN-C) has been suggested to play important functional roles during neural development, axonal regeneration, and synaptic plasticity...
  95. ncbi Reversal of left-right asymmetry: a situs inversus mutation
    T Yokoyama
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Science 260:679-82. 1993
    ..that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the Tsha and Hxb loci...
  96. ncbi Spatial and temporal changes in chondroitin sulfate distribution in the sclerotome play an essential role in the formation of migration patterns of mouse neural crest cells
    Y Kubota
    Department of Biology, Graduate School of Science, Osaka University, Japan
    Dev Dyn 214:55-65. 1999
    ..We conclude that systematic spatiotemporal changes in the distribution of chondroitin sulfate proteoglycans are a key requisite for the formation of migration patterns of mouse neural crest cells in the sclerotome...

Research Grants41

  1. RUNX2 AND PPAR-GAMMA IN CHONDROCYTE FUNCTION
    Masahiro Iwamoto; Fiscal Year: 2009
    ..abstract_text> ..
  2. Regulation of Skeletal Growth by Nuclear Retinoid Receptors
    Maurizio Pacifici; Fiscal Year: 2010
    ....
  3. Regulation of Skeletal Growth by Nuclear Retinoid Receptors
    Masahiro Iwamoto; Fiscal Year: 2009
    ....
  4. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2006
    ..By examining the mechanism of delayed corneal wound healing in genetically engineered mice, basic concepts regulating healing will be revealed and better treatments for those suffering from poor healing can be developed. ..
  5. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2007
    ..Experiments described in this proposal will determine if disrupting non-canonical Wnt signaling can contribute to congenital heart defects. This.information may lead to new detection or treatment strategies. ..
  6. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2007
    ..We have identified members of the tenascin and chondroitin sulfate proteoglycans (CSPGs) as good candidates for the inhibitory cues that regulate axon ..
  7. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2007
    ..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..
  8. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009
    ..We have identified members of the tenascin and chondroitin sulfate proteoglycans (CSPGs) as good candidates for the inhibitory cues that regulate axon ..
  9. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2010
    ..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..
  10. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2009
    ..Significant progress has been made in understanding how the cornea heals but improved treatment options need to be developed for patients with pathological healing due to trauma. ..
  11. Characterization of Corneal Epithelial Stem Cells
    Mary Ann Stepp; Fiscal Year: 2005
    ..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans. ..
  12. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    MARY STEPP; Fiscal Year: 1992
    ..The proposed studies of integrin expression in corneal epithelium will provide insight into the basic cell biology of migration and the role of integrin:cell matrix interactions in the healing of corneal wounds...
  13. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    MARY STEPP; Fiscal Year: 1993
    ..These experiments will help accomplish our goal of obtaining a better understanding, at the molecular level, of the role of integrins in the normal cornea and in epithelial cell migration during wound healing...
  14. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2005
    ..We have examined the expression patterns of four ECM molecules, tenascin, laminin, perlecan, and chondroitin sulfate proteoglycans (CSPGs)...
  15. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    Mary Ann Stepp; Fiscal Year: 2001
    ..Aim 5 is hemidesmomes after wounding using morphometry and tenascin knockout mice...